Details for: PI4KB

Gene ID: 5298

Symbol: PI4KB

Ensembl ID: ENSG00000143393

Description: phosphatidylinositol 4-kinase beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 178.0833
    Cell Significance Index: -27.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 114.4520
    Cell Significance Index: -29.0300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 66.1158
    Cell Significance Index: -26.8600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 58.8469
    Cell Significance Index: -30.2700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.2275
    Cell Significance Index: -26.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.5508
    Cell Significance Index: -30.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.7284
    Cell Significance Index: -28.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.8382
    Cell Significance Index: -30.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 6.9274
    Cell Significance Index: 1318.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.8583
    Cell Significance Index: -15.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0778
    Cell Significance Index: 28.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0011
    Cell Significance Index: 200.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9573
    Cell Significance Index: 104.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9558
    Cell Significance Index: 155.4500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9095
    Cell Significance Index: 8.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8056
    Cell Significance Index: 41.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7925
    Cell Significance Index: 47.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7875
    Cell Significance Index: 156.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7205
    Cell Significance Index: 15.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6201
    Cell Significance Index: 17.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5228
    Cell Significance Index: 187.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4715
    Cell Significance Index: 32.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3951
    Cell Significance Index: 48.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3762
    Cell Significance Index: 67.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3371
    Cell Significance Index: 9.4200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3342
    Cell Significance Index: 231.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3316
    Cell Significance Index: 8.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3144
    Cell Significance Index: 43.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3041
    Cell Significance Index: 13.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2540
    Cell Significance Index: 19.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2511
    Cell Significance Index: 137.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2374
    Cell Significance Index: 11.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2262
    Cell Significance Index: 16.8600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2050
    Cell Significance Index: 90.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2035
    Cell Significance Index: 10.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1736
    Cell Significance Index: 17.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1711
    Cell Significance Index: 21.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1589
    Cell Significance Index: 20.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1470
    Cell Significance Index: 2.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1391
    Cell Significance Index: 3.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1321
    Cell Significance Index: 6.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1284
    Cell Significance Index: 6.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1040
    Cell Significance Index: 2.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1017
    Cell Significance Index: 11.9900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0830
    Cell Significance Index: 1.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0786
    Cell Significance Index: 13.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0626
    Cell Significance Index: 2.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0436
    Cell Significance Index: 2.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0357
    Cell Significance Index: 67.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0233
    Cell Significance Index: 1.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0198
    Cell Significance Index: 0.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0135
    Cell Significance Index: 12.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0121
    Cell Significance Index: 0.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0115
    Cell Significance Index: 7.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0061
    Cell Significance Index: 9.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0038
    Cell Significance Index: 5.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0029
    Cell Significance Index: 5.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0015
    Cell Significance Index: 0.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0137
    Cell Significance Index: -10.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0194
    Cell Significance Index: -14.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0226
    Cell Significance Index: -17.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0234
    Cell Significance Index: -0.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0250
    Cell Significance Index: -14.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0252
    Cell Significance Index: -15.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0295
    Cell Significance Index: -0.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0316
    Cell Significance Index: -4.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0461
    Cell Significance Index: -2.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0535
    Cell Significance Index: -5.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0804
    Cell Significance Index: -16.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0858
    Cell Significance Index: -6.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0892
    Cell Significance Index: -5.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0947
    Cell Significance Index: -27.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1093
    Cell Significance Index: -12.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1258
    Cell Significance Index: -14.4100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1282
    Cell Significance Index: -2.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1989
    Cell Significance Index: -8.8000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2005
    Cell Significance Index: -4.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2050
    Cell Significance Index: -5.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2075
    Cell Significance Index: -6.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2262
    Cell Significance Index: -7.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2435
    Cell Significance Index: -6.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2504
    Cell Significance Index: -26.0700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2633
    Cell Significance Index: -30.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2697
    Cell Significance Index: -3.6800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2844
    Cell Significance Index: -3.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3296
    Cell Significance Index: -12.4800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3365
    Cell Significance Index: -6.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3384
    Cell Significance Index: -26.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3428
    Cell Significance Index: -9.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4095
    Cell Significance Index: -11.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4257
    Cell Significance Index: -10.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4537
    Cell Significance Index: -14.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4610
    Cell Significance Index: -9.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5061
    Cell Significance Index: -31.0300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5449
    Cell Significance Index: -13.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5944
    Cell Significance Index: -13.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6299
    Cell Significance Index: -20.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6326
    Cell Significance Index: -20.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6431
    Cell Significance Index: -22.5300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6441
    Cell Significance Index: -10.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PI4KB is a type II transmembrane protein that belongs to the phosphatidylinositol kinase (PIK) family. It is characterized by its ability to phosphorylate phosphatidylinositol (PI) to generate phosphatidylinositol 4-phosphate (PIP). PI4KB is specifically localized to the Golgi apparatus and endosomes, where it plays a critical role in regulating the PI biosynthetic pathway. The enzyme is also involved in the phosphorylation of various proteins, including receptors and signaling proteins, which modulates their activity and cellular response. **Pathways and Functions:** PI4KB is involved in several key signaling pathways, including: 1. **Phosphatidylinositol-mediated signaling**: PI4KB generates PIP, which serves as a second messenger in cellular signaling. PIP interacts with various proteins, including receptors, kinases, and phosphatases, to regulate cellular responses. 2. **Metabolism of lipids**: PI4KB is involved in the regulation of lipid metabolism, including the synthesis of PIP and phosphatidylinositol 3-phosphate (PIP3). 3. **Signal transduction**: PI4KB modulates the activity of various signaling proteins, including receptors and kinases, which regulates cellular responses to external stimuli. 4. **Receptor-mediated endocytosis**: PI4KB is involved in the regulation of receptor-mediated endocytosis, which is essential for cellular signaling and uptake of nutrients. **Clinical Significance:** Dysregulation of PI4KB has been implicated in various diseases, including: 1. **Neurological disorders**: PI4KB has been shown to play a critical role in the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: PI4KB has been implicated in the regulation of cell growth and survival, and its dysregulation has been linked to cancer development and progression. 3. **Metabolic disorders**: PI4KB has been shown to play a critical role in the regulation of lipid metabolism, and its dysregulation has been linked to metabolic disorders, such as obesity and insulin resistance. In conclusion, PI4KB is a critical enzyme involved in the regulation of lipid metabolism and cellular signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of PI4KB in maintaining cellular homeostasis and preventing disease. Further research is needed to fully understand the mechanisms of PI4KB and its role in human disease.

Genular Protein ID: 1895961750

Symbol: PI4KB_HUMAN

Name: NPIK

UniProtKB Accession Codes:

Q9UBF8 B4DGI2 O15096 P78405 Q5VWB9 Q5VWC0 Q5VWC1 Q9BWR6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CPTAC 2 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 11 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 18 PDBsum 18 PIR 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 8 Rhea 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9405935

Title: Identification and characterization of a novel human phosphatidylinositol 4-kinase.

PubMed ID: 9405935

DOI: 10.1093/dnares/4.4.273

PubMed ID: 9405938

Title: Complementary DNA cloning and chromosomal mapping of a novel phosphatidylinositol kinase gene.

PubMed ID: 9405938

DOI: 10.1093/dnares/4.4.301

PubMed ID: 9020160

Title: Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase.

PubMed ID: 9020160

DOI: 10.1074/jbc.272.7.4384

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23572552

Title: ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.

PubMed ID: 23572552

DOI: 10.1128/mbio.00098-13

PubMed ID: 9148941

Title: Subcellular locations of phosphatidylinositol 4-kinase isoforms.

PubMed ID: 9148941

DOI: 10.1074/jbc.272.20.13236

PubMed ID: 10559940

Title: ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex.

PubMed ID: 10559940

DOI: 10.1038/12993

PubMed ID: 11277933

Title: Human phosphatidylinositol 4-kinase isoform PI4K92. Expression of the recombinant enzyme and determination of multiple phosphorylation sites.

PubMed ID: 11277933

DOI: 10.1046/j.1432-1327.2001.02089.x

PubMed ID: 12749687

Title: Mammalian phosphatidylinositol 4-kinases.

PubMed ID: 12749687

DOI: 10.1002/tbmb.718540873

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17555535

Title: Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta.

PubMed ID: 17555535

DOI: 10.1111/j.1600-0854.2007.00594.x

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22124328

Title: ACBD3-mediated recruitment of PI4KB to picornavirus RNA replication sites.

PubMed ID: 22124328

DOI: 10.1038/emboj.2011.429

PubMed ID: 22253445

Title: Phosphatidylinositol 4-kinase IIIbeta is required for severe acute respiratory syndrome coronavirus spike-mediated cell entry.

PubMed ID: 22253445

DOI: 10.1074/jbc.m111.312561

PubMed ID: 22258260

Title: The 3A protein from multiple picornaviruses utilizes the golgi adaptor protein ACBD3 to recruit PI4KIIIbeta.

PubMed ID: 22258260

DOI: 10.1128/jvi.06778-11

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24672044

Title: A complex comprising phosphatidylinositol 4-kinase IIIbeta, ACBD3, and Aichi virus proteins enhances phosphatidylinositol 4-phosphate synthesis and is critical for formation of the viral replication complex.

PubMed ID: 24672044

DOI: 10.1128/jvi.00208-14

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28289207

Title: Conserved role for Gga proteins in phosphatidylinositol 4-kinase localization to the trans-Golgi network.

PubMed ID: 28289207

DOI: 10.1073/pnas.1615163114

PubMed ID: 27989622

Title: The molecular basis of Aichi virus 3A protein activation of phosphatidylinositol 4 kinase IIIbeta, PI4KB, through ACBD3.

PubMed ID: 27989622

DOI: 10.1016/j.str.2016.11.016

PubMed ID: 30917996

Title: ATG9A shapes the forming autophagosome through Arfaptin 2 and phosphatidylinositol 4-kinase IIIbeta.

PubMed ID: 30917996

DOI: 10.1083/jcb.201901115

PubMed ID: 33358777

Title: Phosphatidylinositol 4-kinase beta mutations cause nonsyndromic sensorineural deafness and inner ear malformation.

PubMed ID: 33358777

DOI: 10.1016/j.jgg.2020.07.008

PubMed ID: 27009356

Title: Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein.

PubMed ID: 27009356

DOI: 10.1038/srep23641

Sequence Information:

  • Length: 816
  • Mass: 91379
  • Checksum: CAD8791729BB4308
  • Sequence:
    • MGDTVVEPAP LKPTSEPTSG PPGNNGGSLL SVITEGVGEL SVIDPEVAQK ACQEVLEKVK 
LLHGGVAVSS RGTPLELVNG DGVDSEIRCL DDPPAQIREE EDEMGAAVAS GTAKGARRRR 
QNNSAKQSWL LRLFESKLFD ISMAISYLYN SKEPGVQAYI GNRLFCFRNE DVDFYLPQLL 
NMYIHMDEDV GDAIKPYIVH RCRQSINFSL QCALLLGAYS SDMHISTQRH SRGTKLRKLI 
LSDELKPAHR KRELPSLSPA PDTGLSPSKR THQRSKSDAT ASISLSSNLK RTASNPKVEN 
EDEELSSSTE SIDNSFSSPV RLAPEREFIK SLMAIGKRLA TLPTKEQKTQ RLISELSLLN 
HKLPARVWLP TAGFDHHVVR VPHTQAVVLN SKDKAPYLIY VEVLECENFD TTSVPARIPE 
NRIRSTRSVE NLPECGITHE QRAGSFSTVP NYDNDDEAWS VDDIGELQVE LPEVHTNSCD 
NISQFSVDSI TSQESKEPVF IAAGDIRRRL SEQLAHTPTA FKRDPEDPSA VALKEPWQEK 
VRRIREGSPY GHLPNWRLLS VIVKCGDDLR QELLAFQVLK QLQSIWEQER VPLWIKPYKI 
LVISADSGMI EPVVNAVSIH QVKKQSQLSL LDYFLQEHGS YTTEAFLSAQ RNFVQSCAGY 
CLVCYLLQVK DRHNGNILLD AEGHIIHIDF GFILSSSPRN LGFETSAFKL TTEFVDVMGG 
LDGDMFNYYK MLMLQGLIAA RKHMDKVVQI VEIMQQGSQL PCFHGSSTIR NLKERFHMSM 
TEEQLQLLVE QMVDGSMRSI TTKLYDGFQY LTNGIM

Genular Protein ID: 3981079943

Symbol: A0A0B4J1S8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0B4J1S8

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 HGNC 1 IntAct 1 InterPro 7 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PeptideAtlas 2 Pfam 2 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 2 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 828
  • Mass: 92725
  • Checksum: 10A80407CAD70B60
  • Sequence:
    • MRFLEARSLA VAMGDTVVEP APLKPTSEPT SGPPGNNGGS LLSVITEGVG ELSVIDPEVA 
QKACQEVLEK VKLLHGGVAV SSRGTPLELV NGDGVDSEIR CLDDPPAQIR EEEDEMGAAV 
ASGTAKGARR RRQNNSAKQS WLLRLFESKL FDISMAISYL YNSKEPGVQA YIGNRLFCFR 
NEDVDFYLPQ LLNMYIHMDE DVGDAIKPYI VHRCRQSINF SLQCALLLGA YSSDMHISTQ 
RHSRGTKLRK LILSDELKPA HRKRELPSLS PAPDTGLSPS KRTHQRSKSD ATASISLSSN 
LKRTASNPKV ENEDEELSSS TESIDNSFSS PVRLAPEREF IKSLMAIGKR LATLPTKEQK 
TQRLISELSL LNHKLPARVW LPTAGFDHHV VRVPHTQAVV LNSKDKAPYL IYVEVLECEN 
FDTTSVPARI PENRIRSTRS VENLPECGIT HEQRAGSFST VPNYDNDDEA WSVDDIGELQ 
VELPEVHTNS CDNISQFSVD SITSQESKEP VFIAAGDIRR RLSEQLAHTP TAFKRDPEDP 
SAVALKEPWQ EKVRRIREGS PYGHLPNWRL LSVIVKCGDD LRQELLAFQV LKQLQSIWEQ 
ERVPLWIKPY KILVISADSG MIEPVVNAVS IHQVKKQSQL SLLDYFLQEH GSYTTEAFLS 
AQRNFVQSCA GYCLVCYLLQ VKDRHNGNIL LDAEGHIIHI DFGFILSSSP RNLGFETSAF 
KLTTEFVDVM GGLDGDMFNY YKMLMLQGLI AARKHMDKVV QIVEIMQQGS QLPCFHGSST 
IRNLKERFHM SMTEEQLQLL VEQMVDGSMR SITTKLYDGF QYLTNGIM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.