Details for: CLIC5
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 24.1965
Cell Significance Index: -9.8300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 10.2750
Cell Significance Index: -9.8100 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 5.1781
Cell Significance Index: 74.4800 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 4.8317
Cell Significance Index: 117.8900 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 4.4152
Cell Significance Index: 44.5400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 4.0577
Cell Significance Index: -10.8700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 3.6797
Cell Significance Index: 282.3800 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 3.2903
Cell Significance Index: 53.0900 - Cell Name: kidney cell (CL1000497)
Fold Change: 2.8368
Cell Significance Index: 22.6500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.4291
Cell Significance Index: 62.4400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.3844
Cell Significance Index: 124.2000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.7340
Cell Significance Index: 36.9300 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.2168
Cell Significance Index: 73.0500 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.1452
Cell Significance Index: 124.5600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9319
Cell Significance Index: 151.5600 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.8155
Cell Significance Index: 12.0400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.7650
Cell Significance Index: 417.8100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.7116
Cell Significance Index: 49.2100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6795
Cell Significance Index: 67.2200 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.5539
Cell Significance Index: 8.3000 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.4552
Cell Significance Index: 6.8600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.4505
Cell Significance Index: 17.0600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.4463
Cell Significance Index: 19.7400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3678
Cell Significance Index: 16.6700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3034
Cell Significance Index: 273.9900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2887
Cell Significance Index: 57.9100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1777
Cell Significance Index: 5.1200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1334
Cell Significance Index: 47.8400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1304
Cell Significance Index: 3.2600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1260
Cell Significance Index: 2.7300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0980
Cell Significance Index: 18.6500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0801
Cell Significance Index: 15.9000 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.0445
Cell Significance Index: 1.3100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0272
Cell Significance Index: 18.8100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0264
Cell Significance Index: 40.7000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0249
Cell Significance Index: 45.9400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0064
Cell Significance Index: 11.9800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0041
Cell Significance Index: 5.5400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0037
Cell Significance Index: -0.1300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0037
Cell Significance Index: -0.4300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0042
Cell Significance Index: -2.6600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0061
Cell Significance Index: -4.5900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0090
Cell Significance Index: -4.0900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0103
Cell Significance Index: -1.4900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0134
Cell Significance Index: -9.9300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0146
Cell Significance Index: -10.6700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0189
Cell Significance Index: -11.7800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0190
Cell Significance Index: -10.6900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0242
Cell Significance Index: -6.9700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0291
Cell Significance Index: -5.2400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0303
Cell Significance Index: -3.7300 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0333
Cell Significance Index: -0.5700 - Cell Name: peg cell (CL4033014)
Fold Change: -0.0467
Cell Significance Index: -1.0800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0470
Cell Significance Index: -3.1600 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0476
Cell Significance Index: -6.1000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0552
Cell Significance Index: -9.4200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0559
Cell Significance Index: -11.7800 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.0594
Cell Significance Index: -1.8800 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0684
Cell Significance Index: -0.9800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0722
Cell Significance Index: -2.0600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0758
Cell Significance Index: -10.4100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0831
Cell Significance Index: -9.5200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0897
Cell Significance Index: -9.3400 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0920
Cell Significance Index: -11.8900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0981
Cell Significance Index: -11.5700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1010
Cell Significance Index: -10.3200 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.1072
Cell Significance Index: -1.1100 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1106
Cell Significance Index: -4.8100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1166
Cell Significance Index: -7.3500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1180
Cell Significance Index: -4.1000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1319
Cell Significance Index: -8.1100 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.1326
Cell Significance Index: -1.7000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1345
Cell Significance Index: -10.6500 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.1446
Cell Significance Index: -3.0900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1597
Cell Significance Index: -11.9000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1600
Cell Significance Index: -10.3300 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.1692
Cell Significance Index: -4.2200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1704
Cell Significance Index: -10.4500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1764
Cell Significance Index: -5.6500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1827
Cell Significance Index: -5.8200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1832
Cell Significance Index: -9.6200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1863
Cell Significance Index: -9.6800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1889
Cell Significance Index: -10.6000 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2044
Cell Significance Index: -7.1600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2085
Cell Significance Index: -9.8000 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.2124
Cell Significance Index: -3.5000 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.2142
Cell Significance Index: -4.1800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2251
Cell Significance Index: -10.5000 - Cell Name: Mueller cell (CL0000636)
Fold Change: -0.2314
Cell Significance Index: -1.7800 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2361
Cell Significance Index: -7.7300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2442
Cell Significance Index: -6.5200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2594
Cell Significance Index: -7.2500 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.2635
Cell Significance Index: -2.8000 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2657
Cell Significance Index: -5.6400 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2719
Cell Significance Index: -9.9800 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2805
Cell Significance Index: -7.3800 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.2807
Cell Significance Index: -4.2700 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.2822
Cell Significance Index: -5.5800 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.2937
Cell Significance Index: -7.1200 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2996
Cell Significance Index: -6.5600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2262908459
Symbol: CLIC5_HUMAN
Name: Chloride intracellular channel protein 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10793131
Title: Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli.
PubMed ID: 10793131
PubMed ID: 12163479
Title: AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member.
PubMed ID: 12163479
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16303743
Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.
PubMed ID: 16303743
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15184393
Title: CLIC-5A functions as a chloride channel in vitro and associates with the cortical actin cytoskeleton in vitro and in vivo.
PubMed ID: 15184393
PubMed ID: 18028448
Title: Functional reconstitution of mammalian 'chloride intracellular channels' CLIC1, CLIC4 and CLIC5 reveals differential regulation by cytoskeletal actin.
PubMed ID: 18028448
PubMed ID: 20335315
Title: CLIC5A, a component of the ezrin-podocalyxin complex in glomeruli, is a determinant of podocyte integrity.
PubMed ID: 20335315
PubMed ID: 24285636
Title: CLIC5 stabilizes membrane-actin filament linkages at the base of hair cell stereocilia in a molecular complex with radixin, taperin, and myosin VI.
PubMed ID: 24285636
DOI: 10.1002/cm.21159
PubMed ID: 24781754
Title: Progressive hearing loss and vestibular dysfunction caused by a homozygous nonsense mutation in CLIC5.
PubMed ID: 24781754
DOI: 10.1038/ejhg.2014.83
Sequence Information:
- Length: 410
- Mass: 46503
- Checksum: E26D307775F8354C
- Sequence:
MNDEDYSTIY DTIQNERTYE VPDQPEENES PHYDDVHEYL RPENDLYATQ LNTHEYDFVS VYTIKGEETS LASVQSEDRG YLLPDEIYSE LQEAHPGEPQ EDRGISMEGL YSSTQDQQLC AAELQENGSV MKEDLPSPSS FTIQHSKAFS TTKYSCYSDA EGLEEKEGAH MNPEIYLFVK AGIDGESIGN CPFSQRLFMI LWLKGVVFNV TTVDLKRKPA DLHNLAPGTH PPFLTFNGDV KTDVNKIEEF LEETLTPEKY PKLAAKHRES NTAGIDIFSK FSAYIKNTKQ QNNAALERGL TKALKKLDDY LNTPLPEEID ANTCGEDKGS RRKFLDGDEL TLADCNLLPK LHVVKIVAKK YRNYDIPAEM TGLWRYLKNA YARDEFTNTC AADSEIELAY ADVAKRLSRS
Genular Protein ID: 3178899054
Symbol: Q49AE1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 72
- Mass: 8020
- Checksum: 65803BCD530E34B6
- Sequence:
MPALERGLTK ALKKLDDYLN TPLPEEIDAN TCGEDKGSRR KFLDGDELTL ADCNLLPKLH VVKEQVPLKG MI
Genular Protein ID: 1857011819
Symbol: Q53G01_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8125298
Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
PubMed ID: 8125298
PubMed ID: 9373149
Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
PubMed ID: 9373149
PubMed ID: 11181995
Sequence Information:
- Length: 251
- Mass: 28179
- Checksum: 1E8658EB7687C60D
- Sequence:
MTDSATANGD DRDPEIELFV KAGIDGESIG NCPFSQRLFM ILWLKGVVFN VTTVDLKRKP ADLHNLAPGT HPPFLTFNGD VKTDVNKIEE FLEETLTPEK YPKLAAKHRE SNTAGIDIFS KFSAYIKNTK QQNNAALERG LTKALKKLDD YLNTPLPEEI DANTCGEDKG SRRKFLDGDE LTLADCNLLP KLHVVKIVAK KYRNYDIPAE MTGLWRYLKN AYARDEFTNT CAADSEIELA YADVAKRLSR S
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.