Details for: CLIC5

Gene ID: 53405

Symbol: CLIC5

Ensembl ID: ENSG00000112782

Description: chloride intracellular channel 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 24.1965
    Cell Significance Index: -9.8300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.2750
    Cell Significance Index: -9.8100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 5.1781
    Cell Significance Index: 74.4800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 4.8317
    Cell Significance Index: 117.8900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 4.4152
    Cell Significance Index: 44.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.0577
    Cell Significance Index: -10.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.6797
    Cell Significance Index: 282.3800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 3.2903
    Cell Significance Index: 53.0900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.8368
    Cell Significance Index: 22.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.4291
    Cell Significance Index: 62.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.3844
    Cell Significance Index: 124.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.7340
    Cell Significance Index: 36.9300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2168
    Cell Significance Index: 73.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1452
    Cell Significance Index: 124.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9319
    Cell Significance Index: 151.5600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.8155
    Cell Significance Index: 12.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7650
    Cell Significance Index: 417.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7116
    Cell Significance Index: 49.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6795
    Cell Significance Index: 67.2200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5539
    Cell Significance Index: 8.3000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4552
    Cell Significance Index: 6.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4505
    Cell Significance Index: 17.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4463
    Cell Significance Index: 19.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3678
    Cell Significance Index: 16.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3034
    Cell Significance Index: 273.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2887
    Cell Significance Index: 57.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1777
    Cell Significance Index: 5.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1334
    Cell Significance Index: 47.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1304
    Cell Significance Index: 3.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1260
    Cell Significance Index: 2.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0980
    Cell Significance Index: 18.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0801
    Cell Significance Index: 15.9000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0445
    Cell Significance Index: 1.3100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0272
    Cell Significance Index: 18.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0264
    Cell Significance Index: 40.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0249
    Cell Significance Index: 45.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0064
    Cell Significance Index: 11.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0041
    Cell Significance Index: 5.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0037
    Cell Significance Index: -0.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0037
    Cell Significance Index: -0.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0042
    Cell Significance Index: -2.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0061
    Cell Significance Index: -4.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0090
    Cell Significance Index: -4.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0103
    Cell Significance Index: -1.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0134
    Cell Significance Index: -9.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0146
    Cell Significance Index: -10.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0189
    Cell Significance Index: -11.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0190
    Cell Significance Index: -10.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0242
    Cell Significance Index: -6.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0291
    Cell Significance Index: -5.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0303
    Cell Significance Index: -3.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0333
    Cell Significance Index: -0.5700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0467
    Cell Significance Index: -1.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0470
    Cell Significance Index: -3.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0476
    Cell Significance Index: -6.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0552
    Cell Significance Index: -9.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0559
    Cell Significance Index: -11.7800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0594
    Cell Significance Index: -1.8800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0684
    Cell Significance Index: -0.9800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0722
    Cell Significance Index: -2.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0758
    Cell Significance Index: -10.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0831
    Cell Significance Index: -9.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0897
    Cell Significance Index: -9.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0920
    Cell Significance Index: -11.8900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0981
    Cell Significance Index: -11.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1010
    Cell Significance Index: -10.3200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1072
    Cell Significance Index: -1.1100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1106
    Cell Significance Index: -4.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1166
    Cell Significance Index: -7.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1180
    Cell Significance Index: -4.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1319
    Cell Significance Index: -8.1100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1326
    Cell Significance Index: -1.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1345
    Cell Significance Index: -10.6500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1446
    Cell Significance Index: -3.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1597
    Cell Significance Index: -11.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1600
    Cell Significance Index: -10.3300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1692
    Cell Significance Index: -4.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1704
    Cell Significance Index: -10.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1764
    Cell Significance Index: -5.6500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1827
    Cell Significance Index: -5.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1832
    Cell Significance Index: -9.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1863
    Cell Significance Index: -9.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1889
    Cell Significance Index: -10.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2044
    Cell Significance Index: -7.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2085
    Cell Significance Index: -9.8000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2124
    Cell Significance Index: -3.5000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2142
    Cell Significance Index: -4.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2251
    Cell Significance Index: -10.5000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.2314
    Cell Significance Index: -1.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2361
    Cell Significance Index: -7.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2442
    Cell Significance Index: -6.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2594
    Cell Significance Index: -7.2500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2635
    Cell Significance Index: -2.8000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2657
    Cell Significance Index: -5.6400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2719
    Cell Significance Index: -9.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2805
    Cell Significance Index: -7.3800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.2807
    Cell Significance Index: -4.2700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2822
    Cell Significance Index: -5.5800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2937
    Cell Significance Index: -7.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2996
    Cell Significance Index: -6.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CLIC5 is a small, acidic protein with a molecular weight of approximately 30 kDa. It belongs to the CLIC family, which consists of six members, all of which share a conserved chloride channel domain. CLIC5 has a unique ability to interact with various cellular partners, including other proteins, lipids, and calcium ions. Its localization to the apical plasma membrane and Golgi apparatus suggests a role in regulating chloride transport and cell-cell communication. Additionally, CLIC5 has been shown to interact with actin filaments, which are essential for maintaining cytoskeleton organization and cell shape. **Pathways and Functions** CLIC5 is involved in various cellular pathways, including: 1. **Chloride transport**: CLIC5 regulates chloride ion transport across cellular membranes, which is essential for maintaining proper ion balance and cellular homeostasis. 2. **Sensory perception**: CLIC5 has been implicated in the sensory processing of sound, particularly in the cochlea, where it is expressed in inner and outer hair cells. 3. **Cell signaling**: CLIC5 interacts with various cellular partners, including proteins and lipids, to regulate cell signaling pathways. 4. **Cytoskeleton organization**: CLIC5 interacts with actin filaments to maintain cytoskeleton organization and cell shape. 5. **Apoptosis regulation**: CLIC5 has been shown to regulate apoptosis (programmed cell death) by interacting with pro-apoptotic proteins. **Clinical Significance** CLIC5 has been implicated in various diseases and disorders, including: 1. **Hearing loss**: Mutations in CLIC5 have been associated with autosomal recessive hearing loss, a condition characterized by progressive hearing loss. 2. **Cardiac arrhythmias**: CLIC5 has been implicated in the regulation of cardiac ion channels, and mutations in CLIC5 have been associated with cardiac arrhythmias. 3. **Neurological disorders**: CLIC5 has been implicated in the regulation of neuronal ion channels, and mutations in CLIC5 have been associated with neurological disorders, including epilepsy and schizophrenia. 4. **Cancer**: CLIC5 has been shown to regulate cell growth and survival, and its expression is often altered in cancer cells. In conclusion, CLIC5 is a multifunctional protein that plays a crucial role in regulating chloride ion transport, cell signaling, and cytoskeleton organization. Its expression is widespread in different tissues, and its dysregulation has been implicated in various diseases and disorders. Further research is needed to fully understand the functions of CLIC5 and its potential therapeutic applications.

Genular Protein ID: 2262908459

Symbol: CLIC5_HUMAN

Name: Chloride intracellular channel protein 5

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10793131

Title: Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli.

PubMed ID: 10793131

DOI: 10.1091/mbc.11.5.1509

PubMed ID: 12163479

Title: AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member.

PubMed ID: 12163479

DOI: 10.1074/jbc.m112277200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15184393

Title: CLIC-5A functions as a chloride channel in vitro and associates with the cortical actin cytoskeleton in vitro and in vivo.

PubMed ID: 15184393

DOI: 10.1074/jbc.m402835200

PubMed ID: 18028448

Title: Functional reconstitution of mammalian 'chloride intracellular channels' CLIC1, CLIC4 and CLIC5 reveals differential regulation by cytoskeletal actin.

PubMed ID: 18028448

DOI: 10.1111/j.1742-4658.2007.06145.x

PubMed ID: 20335315

Title: CLIC5A, a component of the ezrin-podocalyxin complex in glomeruli, is a determinant of podocyte integrity.

PubMed ID: 20335315

DOI: 10.1152/ajprenal.00030.2010

PubMed ID: 24285636

Title: CLIC5 stabilizes membrane-actin filament linkages at the base of hair cell stereocilia in a molecular complex with radixin, taperin, and myosin VI.

PubMed ID: 24285636

DOI: 10.1002/cm.21159

PubMed ID: 24781754

Title: Progressive hearing loss and vestibular dysfunction caused by a homozygous nonsense mutation in CLIC5.

PubMed ID: 24781754

DOI: 10.1038/ejhg.2014.83

Sequence Information:

  • Length: 410
  • Mass: 46503
  • Checksum: E26D307775F8354C
  • Sequence:
  • MNDEDYSTIY DTIQNERTYE VPDQPEENES PHYDDVHEYL RPENDLYATQ LNTHEYDFVS 
    VYTIKGEETS LASVQSEDRG YLLPDEIYSE LQEAHPGEPQ EDRGISMEGL YSSTQDQQLC 
    AAELQENGSV MKEDLPSPSS FTIQHSKAFS TTKYSCYSDA EGLEEKEGAH MNPEIYLFVK 
    AGIDGESIGN CPFSQRLFMI LWLKGVVFNV TTVDLKRKPA DLHNLAPGTH PPFLTFNGDV 
    KTDVNKIEEF LEETLTPEKY PKLAAKHRES NTAGIDIFSK FSAYIKNTKQ QNNAALERGL 
    TKALKKLDDY LNTPLPEEID ANTCGEDKGS RRKFLDGDEL TLADCNLLPK LHVVKIVAKK 
    YRNYDIPAEM TGLWRYLKNA YARDEFTNTC AADSEIELAY ADVAKRLSRS

Genular Protein ID: 3178899054

Symbol: Q49AE1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 72
  • Mass: 8020
  • Checksum: 65803BCD530E34B6
  • Sequence:
  • MPALERGLTK ALKKLDDYLN TPLPEEIDAN TCGEDKGSRR KFLDGDELTL ADCNLLPKLH 
    VVKEQVPLKG MI

Genular Protein ID: 1857011819

Symbol: Q53G01_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 251
  • Mass: 28179
  • Checksum: 1E8658EB7687C60D
  • Sequence:
  • MTDSATANGD DRDPEIELFV KAGIDGESIG NCPFSQRLFM ILWLKGVVFN VTTVDLKRKP 
    ADLHNLAPGT HPPFLTFNGD VKTDVNKIEE FLEETLTPEK YPKLAAKHRE SNTAGIDIFS 
    KFSAYIKNTK QQNNAALERG LTKALKKLDD YLNTPLPEEI DANTCGEDKG SRRKFLDGDE 
    LTLADCNLLP KLHVVKIVAK KYRNYDIPAE MTGLWRYLKN AYARDEFTNT CAADSEIELA 
    YADVAKRLSR S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.