Details for: PPEF1

Gene ID: 5475

Symbol: PPEF1

Ensembl ID: ENSG00000086717

Description: protein phosphatase with EF-hand domain 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.4632
    Cell Significance Index: 212.6900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3545
    Cell Significance Index: 32.8100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.7414
    Cell Significance Index: 9.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2246
    Cell Significance Index: 45.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0730
    Cell Significance Index: 50.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0610
    Cell Significance Index: 21.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0494
    Cell Significance Index: 9.8100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0420
    Cell Significance Index: 0.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0411
    Cell Significance Index: 1.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0244
    Cell Significance Index: 46.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0201
    Cell Significance Index: 12.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0164
    Cell Significance Index: 2.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0152
    Cell Significance Index: 28.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0106
    Cell Significance Index: 0.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0101
    Cell Significance Index: 0.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0086
    Cell Significance Index: 13.2800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0074
    Cell Significance Index: 0.0500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0053
    Cell Significance Index: 0.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0030
    Cell Significance Index: 0.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0021
    Cell Significance Index: 2.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0035
    Cell Significance Index: -1.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0037
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0070
    Cell Significance Index: -5.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0074
    Cell Significance Index: -5.4600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0078
    Cell Significance Index: -5.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0084
    Cell Significance Index: -4.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0086
    Cell Significance Index: -5.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0090
    Cell Significance Index: -5.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0098
    Cell Significance Index: -1.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0124
    Cell Significance Index: -1.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0149
    Cell Significance Index: -4.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0176
    Cell Significance Index: -1.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0189
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0238
    Cell Significance Index: -5.0100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0242
    Cell Significance Index: -0.6900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0242
    Cell Significance Index: -0.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0330
    Cell Significance Index: -1.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0338
    Cell Significance Index: -4.6400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0357
    Cell Significance Index: -0.8900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0373
    Cell Significance Index: -0.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0375
    Cell Significance Index: -2.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0391
    Cell Significance Index: -4.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0392
    Cell Significance Index: -3.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0445
    Cell Significance Index: -5.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0456
    Cell Significance Index: -4.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0458
    Cell Significance Index: -4.7700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0468
    Cell Significance Index: -0.5100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0556
    Cell Significance Index: -1.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0570
    Cell Significance Index: -3.2000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0601
    Cell Significance Index: -1.9000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0682
    Cell Significance Index: -2.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0741
    Cell Significance Index: -3.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0768
    Cell Significance Index: -4.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0782
    Cell Significance Index: -2.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0784
    Cell Significance Index: -1.0700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0794
    Cell Significance Index: -1.5700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0796
    Cell Significance Index: -1.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0804
    Cell Significance Index: -3.7500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0806
    Cell Significance Index: -0.9400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0819
    Cell Significance Index: -1.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0825
    Cell Significance Index: -4.3300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0832
    Cell Significance Index: -1.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0895
    Cell Significance Index: -2.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0898
    Cell Significance Index: -1.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0902
    Cell Significance Index: -5.8200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0903
    Cell Significance Index: -1.9500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0909
    Cell Significance Index: -1.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0988
    Cell Significance Index: -2.6900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1015
    Cell Significance Index: -1.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1027
    Cell Significance Index: -4.8300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1037
    Cell Significance Index: -2.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1057
    Cell Significance Index: -1.2600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1250
    Cell Significance Index: -1.8500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1253
    Cell Significance Index: -4.6000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1255
    Cell Significance Index: -1.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1295
    Cell Significance Index: -4.5500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1310
    Cell Significance Index: -1.8400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1351
    Cell Significance Index: -2.8200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1402
    Cell Significance Index: -2.7600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1402
    Cell Significance Index: -3.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1423
    Cell Significance Index: -3.8000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1458
    Cell Significance Index: -1.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1503
    Cell Significance Index: -4.3300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1524
    Cell Significance Index: -2.0600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1566
    Cell Significance Index: -2.2300
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.1585
    Cell Significance Index: -1.6300
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1650
    Cell Significance Index: -1.5800
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.1749
    Cell Significance Index: -1.9300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1770
    Cell Significance Index: -2.3600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1822
    Cell Significance Index: -4.5500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1845
    Cell Significance Index: -3.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1884
    Cell Significance Index: -4.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1890
    Cell Significance Index: -3.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1905
    Cell Significance Index: -5.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1905
    Cell Significance Index: -5.4600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1919
    Cell Significance Index: -2.9200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1939
    Cell Significance Index: -4.9400
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1940
    Cell Significance Index: -2.7600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1955
    Cell Significance Index: -1.8600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -0.1991
    Cell Significance Index: -2.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **EF-hand domain:** PPEF1 possesses an EF-hand domain, a calcium-binding motif that is characteristic of EF-hand proteins. This domain is crucial for the regulation of protein phosphatase activity in response to calcium ion binding. 2. **Serine/threonine-protein phosphatase activity:** PPEF1 exhibits serine/threonine-protein phosphatase activity, which involves the removal of phosphate groups from serine and threonine residues on target proteins, thereby regulating their activity. 3. **Diverse expression patterns:** PPEF1 is expressed in a wide range of cell types, including pancreatic, kidney, lung, cardiac, and immune cells, indicating its involvement in various physiological processes. 4. **Implicated in sensory perception:** PPEF1 has been implicated in the detection of stimulus involved in sensory perception, particularly in the visual phototransduction cascade. **Pathways and Functions:** 1. **Calcium ion binding:** PPEF1's EF-hand domain allows it to bind calcium ions, which regulates its phosphatase activity and modulates the activity of downstream targets. 2. **Myosin phosphatase activity:** PPEF1 has been shown to exhibit myosin phosphatase activity, which is essential for regulating muscle contraction and relaxation. 3. **Protein dephosphorylation:** PPEF1's phosphatase activity involves the removal of phosphate groups from target proteins, which regulates their activity and maintains cellular homeostasis. 4. **Sensory perception:** PPEF1 has been implicated in the detection of stimulus involved in sensory perception, particularly in the visual phototransduction cascade. **Clinical Significance:** 1. **Visual disorders:** Alterations in PPEF1 expression or function may contribute to visual disorders, such as photoreceptor degeneration or visual acuity loss. 2. **Neurological disorders:** PPEF1's involvement in sensory perception and calcium ion binding may also contribute to neurological disorders, such as epilepsy or Alzheimer's disease. 3. **Cancer:** PPEF1's expression in various cell types, including cancer cells, suggests its potential involvement in cancer development and progression. 4. **Regulatory T cells:** PPEF1's expression in regulatory T cells may also contribute to its immunomodulatory functions and its role in maintaining immune homeostasis. In conclusion, PPEF1 is a complex protein phosphatase with EF-hand domain 1 that plays a crucial role in regulating various signaling pathways, including calcium and iron ion binding, myosin phosphatase activity, and protein dephosphorylation. Its diverse expression patterns and functional implications suggest its involvement in multiple physiological processes, including sensory perception, visual disorders, neurological disorders, cancer, and immune homeostasis. Further research is necessary to fully elucidate the mechanisms of PPEF1 and its potential therapeutic applications.

Genular Protein ID: 3157218193

Symbol: PPE1_HUMAN

Name: Serine/threonine-protein phosphatase with EF-hands 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9326663

Title: Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C.

PubMed ID: 9326663

DOI: 10.1073/pnas.94.21.11639

PubMed ID: 9215685

Title: A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin.

PubMed ID: 9215685

DOI: 10.1093/hmg/6.7.1137

PubMed ID: 9430683

Title: Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC).

PubMed ID: 9430683

DOI: 10.1074/jbc.273.3.1462

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

Sequence Information:

  • Length: 653
  • Mass: 75792
  • Checksum: DF7B78C444EE6484
  • Sequence:
  • MGCSSSSTKT RRSDTSLRAA LIIQNWYRGY KARLKARQHY ALTIFQSIEY ADEQGQMQLS 
    TFFSFMLENY THIHKEELEL RNQSLESEQD MRDRWDYVDS IDVPDSYNGP RLQFPLTCTD 
    IDLLLEAFKE QQILHAHYVL EVLFETKKVL KQMPNFTHIQ TSPSKEVTIC GDLHGKLDDL 
    FLIFYKNGLP SERNPYVFNG DFVDRGKNSI EILMILCVSF LVYPNDLHLN RGNHEDFMMN 
    LRYGFTKEIL HKYKLHGKRI LQILEEFYAW LPIGTIVDNE ILVIHGGISE TTDLNLLHRV 
    ERNKMKSVLI PPTETNRDHD TDSKHNKVGV TFNAHGRIKT NGSPTEHLTE HEWEQIIDIL 
    WSDPRGKNGC FPNTCRGGGC YFGPDVTSKI LNKYQLKMLI RSHECKPEGY EICHDGKVVT 
    IFSASNYYEE GSNRGAYIKL CSGTTPRFFQ YQVTKATCFQ PLRQRVDTME NSAIKILRER 
    VISRKSDLTR AFQLQDHRKS GKLSVSQWAF CMENILGLNL PWRSLSSNLV NIDQNGNVEY 
    MSSFQNIRIE KPVQEAHSTL VETLYRYRSD LEIIFNAIDT DHSGLISVEE FRAMWKLFSS 
    HYNVHIDDSQ VNKLANIMDL NKDGSIDFNE FLKAFYVVHR YEDLMKPDVT NLG

Genular Protein ID: 3006102564

Symbol: A0A8I5KXD3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

  • Length: 563
  • Mass: 65195
  • Checksum: 5D2D600F9694B5AA
  • Sequence:
  • MRDRWDYVDS IDVPDSYNGP RLQFPLTCTD IDLLLEAFKE QQILHAHYVL EVLFETKKVL 
    KQMPNFTHIQ TSPSKEVTIC GDLHGKLDDL FLIFYKNGLP SERNPYVFNG DFVDRGKNSI 
    EILMILCVSF LVYPNDLHLN RGNHEDFMMN LRYGFTKEIL HKYKLHGKRI LQILEEFYAW 
    LPIGTIVDNE ILVIHGGISE TTDLNLLHRV ERNKMKSVLI PPTETNRDHD TDSKHNKVGV 
    TFNAHGRIKT NGSPTEHLTE HEWEQIIDIL WSDPRGKNGC FPNTCRGGGC YFGPDVTSKI 
    LNKYQLKMLI RSHECKPEGY EICHDGKVVT IFSASNYYEE GSNRGAYIKL CSGTTPRFFQ 
    YQVTKATCFQ PLRQRVDTME NSAIKILRER VISRKSDLTR AFQLQDHRKS GKLSVSQWAF 
    CMENILGLNL PWRSLSSNLV NIDQNGNVEY MSSFQNIRIE KPVQEAHSTL VETLYRYRSD 
    LEIIFNAIDT DHSGLISVEE FRAMWKLFSS HYNVHIDDSQ VNKLANIMDL NKDGSIDFNE 
    FLKAFYVVHR YEDLMKPDVT NLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.