Details for: REN

Gene ID: 5972

Symbol: REN

Ensembl ID: ENSG00000143839

Description: renin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 15.0999
    Cell Significance Index: -3.8300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 3.9751
    Cell Significance Index: 63.7800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 3.0889
    Cell Significance Index: 77.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.1714
    Cell Significance Index: 112.8000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2423
    Cell Significance Index: 11.4400
  • Cell Name: glomerular mesangial cell (CL1000742)
    Fold Change: 1.1252
    Cell Significance Index: 3.3800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1134
    Cell Significance Index: 26.9700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.0972
    Cell Significance Index: 8.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.0052
    Cell Significance Index: 61.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3401
    Cell Significance Index: 4.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3305
    Cell Significance Index: 59.5800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3150
    Cell Significance Index: 4.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3042
    Cell Significance Index: 57.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2227
    Cell Significance Index: 9.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1945
    Cell Significance Index: 12.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1793
    Cell Significance Index: 6.7900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.1612
    Cell Significance Index: 1.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1582
    Cell Significance Index: 15.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1553
    Cell Significance Index: 140.2000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.1407
    Cell Significance Index: 0.9500
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.0962
    Cell Significance Index: 0.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0839
    Cell Significance Index: 9.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0827
    Cell Significance Index: 13.4500
  • Cell Name: kidney granular cell (CL0000648)
    Fold Change: 0.0705
    Cell Significance Index: 0.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0678
    Cell Significance Index: 4.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0491
    Cell Significance Index: 9.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0470
    Cell Significance Index: 1.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0414
    Cell Significance Index: 0.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0323
    Cell Significance Index: 2.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0240
    Cell Significance Index: 1.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0190
    Cell Significance Index: 6.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0167
    Cell Significance Index: 3.3400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0123
    Cell Significance Index: 0.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0094
    Cell Significance Index: 5.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0092
    Cell Significance Index: 17.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0058
    Cell Significance Index: 0.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0023
    Cell Significance Index: 0.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0015
    Cell Significance Index: 2.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0013
    Cell Significance Index: 2.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0004
    Cell Significance Index: -0.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0015
    Cell Significance Index: -2.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0022
    Cell Significance Index: -0.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0033
    Cell Significance Index: -2.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0033
    Cell Significance Index: -2.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0042
    Cell Significance Index: -0.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0051
    Cell Significance Index: -1.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0059
    Cell Significance Index: -4.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0063
    Cell Significance Index: -2.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0076
    Cell Significance Index: -4.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0097
    Cell Significance Index: -0.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0133
    Cell Significance Index: -1.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0152
    Cell Significance Index: -0.3800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0216
    Cell Significance Index: -0.3100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0220
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0233
    Cell Significance Index: -4.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0240
    Cell Significance Index: -4.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0247
    Cell Significance Index: -2.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0328
    Cell Significance Index: -3.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0342
    Cell Significance Index: -3.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0358
    Cell Significance Index: -4.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0369
    Cell Significance Index: -4.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0460
    Cell Significance Index: -3.0900
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: -0.0461
    Cell Significance Index: -0.2300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0464
    Cell Significance Index: -0.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0474
    Cell Significance Index: -3.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0478
    Cell Significance Index: -2.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0505
    Cell Significance Index: -4.0000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0548
    Cell Significance Index: -0.7600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0605
    Cell Significance Index: -2.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0616
    Cell Significance Index: -2.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0616
    Cell Significance Index: -4.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0665
    Cell Significance Index: -4.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0683
    Cell Significance Index: -1.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0708
    Cell Significance Index: -1.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0716
    Cell Significance Index: -4.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0721
    Cell Significance Index: -1.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0745
    Cell Significance Index: -3.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0770
    Cell Significance Index: -2.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0789
    Cell Significance Index: -4.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0812
    Cell Significance Index: -2.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0860
    Cell Significance Index: -2.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0909
    Cell Significance Index: -4.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0920
    Cell Significance Index: -2.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0945
    Cell Significance Index: -3.3100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0946
    Cell Significance Index: -3.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0981
    Cell Significance Index: -2.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0987
    Cell Significance Index: -3.2300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0995
    Cell Significance Index: -1.5000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1053
    Cell Significance Index: -3.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1142
    Cell Significance Index: -3.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1149
    Cell Significance Index: -3.0200
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.1153
    Cell Significance Index: -0.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1170
    Cell Significance Index: -2.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1190
    Cell Significance Index: -4.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1191
    Cell Significance Index: -3.1900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1250
    Cell Significance Index: -1.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1308
    Cell Significance Index: -3.5600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1321
    Cell Significance Index: -1.9800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1331
    Cell Significance Index: -3.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** Renin is a proteolytic enzyme that cleaves angiotensinogen to form angiotensin I, which is then converted to angiotensin II by angiotensin-converting enzyme (ACE). Angiotensin II is a potent vasoconstrictor that regulates blood pressure and promotes sodium retention. 2. **Cellular Expression:** Renin is expressed in various tissues, including the kidney, adrenal gland, and brain, where it plays distinct roles in regulating blood pressure, electrolyte balance, and hormone secretion. 3. **Regulation:** Renin production is tightly regulated by the RAS, with feedback mechanisms involving angiotensin II, aldosterone, and prostaglandins. **Pathways and Functions:** 1. **Renin-Angiotensin System (RAS):** Renin initiates the RAS cascade, which regulates blood pressure, electrolyte balance, and fluid homeostasis. 2. **Cell Maturation:** Renin has been implicated in the regulation of cell maturation, particularly in the development of the kidney and mesonephros. 3. **Hormone Regulation:** Renin influences hormone secretion, including insulin-like growth factor (IGF) and gastrin, which regulate growth, development, and digestion. 4. **Immune Response:** Renin has been shown to modulate the immune response, particularly in the context of inflammation and xenobiotic stress. 5. **Neurotransmission:** Renin has been implicated in neurotransmission, particularly in the regulation of dopamine and serotonin levels. **Clinical Significance:** 1. **Hypertension:** Renin is a key player in the development of hypertension, with elevated renin levels often associated with increased blood pressure. 2. **Cardiovascular Disease:** Renin's role in the RAS has been linked to cardiovascular disease, including heart failure, stroke, and kidney disease. 3. **Kidney Disease:** Renin has been implicated in kidney disease, particularly in the regulation of blood pressure and electrolyte balance. 4. **Cancer:** Renin has been shown to influence tumor growth and metastasis, particularly in the context of renal cell carcinoma. 5. **Neurological Disorders:** Renin's role in neurotransmission has been linked to neurological disorders, including Parkinson's disease, Alzheimer's disease, and schizophrenia. In conclusion, the REN gene and its encoded enzyme renin have far-reaching implications for our understanding of blood pressure regulation, kidney function, and immune response. Further research is needed to fully elucidate the complex roles of renin in various cellular processes and to develop targeted therapies for the treatment of related diseases.

Genular Protein ID: 1784445486

Symbol: RENI_HUMAN

Name: Angiotensinogenase

UniProtKB Accession Codes:

P00797 Q6FI38 Q6T5C2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 21 DrugCentral 1 EC 1 ELM 1 EMBL 28 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 91 PDBsum 91 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 6324167

Title: Cloning and sequence analysis of cDNA for human renin precursor.

PubMed ID: 6324167

DOI: 10.1073/pnas.80.24.7405

PubMed ID: 3530608

Title: New possibilities for intracellular renin and inactive renin now that the structure of the human renin gene has been elucidated.

PubMed ID: 3530608

DOI: 10.1042/cs0710345

PubMed ID: 6391881

Title: Primary structure of the human renin gene.

PubMed ID: 6391881

DOI: 10.1089/dna.1.1984.3.457

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6138751

Title: Molecular cloning and nucleotide sequence of a human renin cDNA fragment.

PubMed ID: 6138751

DOI: 10.1093/nar/11.20.7181

PubMed ID: 3032746

Title: Human renin gene of renin-secreting tumor.

PubMed ID: 3032746

DOI: 10.1016/0378-1119(86)90393-8

PubMed ID: 2540188

Title: Identification of negative and positive regulatory elements in the human renin gene.

PubMed ID: 2540188

DOI: 10.1016/s0021-9258(18)83241-0

PubMed ID: 3516796

Title: Segmental homology between the promoter region of the human renin gene and the mouse ren1 and ren2 promoter regions.

PubMed ID: 3516796

DOI: 10.1016/0378-1119(86)90270-2

PubMed ID: 2016271

Title: Isolation and characterization of recombinant human prorenin in Chinese hamster ovary cells.

PubMed ID: 2016271

DOI: 10.1093/oxfordjournals.jbchem.a123347

PubMed ID: 12045255

Title: Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin.

PubMed ID: 12045255

DOI: 10.1172/jci14276

PubMed ID: 2493678

Title: Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5-A resolution.

PubMed ID: 2493678

DOI: 10.1126/science.2493678

PubMed ID: 1608447

Title: X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins.

PubMed ID: 1608447

DOI: 10.1038/357466a0

PubMed ID: 20927107

Title: A redox switch in angiotensinogen modulates angiotensin release.

PubMed ID: 20927107

DOI: 10.1038/nature09505

PubMed ID: 16116425

Title: Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis.

PubMed ID: 16116425

DOI: 10.1038/ng1623

PubMed ID: 19664745

Title: Dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic kidney failure.

PubMed ID: 19664745

DOI: 10.1016/j.ajhg.2009.07.010

Sequence Information:

  • Length: 406
  • Mass: 45057
  • Checksum: 5AFDF8E973B21EDA
  • Sequence:
    • MDGWRRMPRW GLLLLLWGSC TFGLPTDTTT FKRIFLKRMP SIRESLKERG VDMARLGPEW 
SQPMKRLTLG NTTSSVILTN YMDTQYYGEI GIGTPPQTFK VVFDTGSSNV WVPSSKCSRL 
YTACVYHKLF DASDSSSYKH NGTELTLRYS TGTVSGFLSQ DIITVGGITV TQMFGEVTEM 
PALPFMLAEF DGVVGMGFIE QAIGRVTPIF DNIISQGVLK EDVFSFYYNR DSENSQSLGG 
QIVLGGSDPQ HYEGNFHYIN LIKTGVWQIQ MKGVSVGSST LLCEDGCLAL VDTGASYISG 
STSSIEKLME ALGAKKRLFD YVVKCNEGPT LPDISFHLGG KEYTLTSADY VFQESYSSKK 
LCTLAIHAMD IPPPTGPTWA LGATFIRKFY TEFDRRNNRI GFALAR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.