Details for: RFX1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 149.3456
Cell Significance Index: -23.2300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 96.4740
Cell Significance Index: -24.4700 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 54.8667
Cell Significance Index: -22.2900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 50.1375
Cell Significance Index: -25.7900 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 20.3495
Cell Significance Index: -25.0900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 9.6496
Cell Significance Index: -25.8500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.5128
Cell Significance Index: -25.7000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 5.5853
Cell Significance Index: -17.1600 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.5883
Cell Significance Index: 21.6700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.4630
Cell Significance Index: 237.9500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.2910
Cell Significance Index: 150.4500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.9516
Cell Significance Index: 190.8900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8166
Cell Significance Index: 88.8200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7844
Cell Significance Index: 47.0900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.6612
Cell Significance Index: 29.9700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.6326
Cell Significance Index: 39.8700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6251
Cell Significance Index: 124.0600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6138
Cell Significance Index: 17.6900 - Cell Name: decidual cell (CL2000002)
Fold Change: 0.6099
Cell Significance Index: 9.7900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5710
Cell Significance Index: 204.8000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5708
Cell Significance Index: 394.8200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.5648
Cell Significance Index: 16.1900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5304
Cell Significance Index: 11.4900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4386
Cell Significance Index: 53.9300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4324
Cell Significance Index: 77.9400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4309
Cell Significance Index: 59.1700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4181
Cell Significance Index: 28.9200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3202
Cell Significance Index: 31.6700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.3046
Cell Significance Index: 8.2900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2917
Cell Significance Index: 128.9800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2655
Cell Significance Index: 13.7900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2630
Cell Significance Index: 12.2600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2354
Cell Significance Index: 6.5800 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2309
Cell Significance Index: 29.6000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2103
Cell Significance Index: 40.0200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2068
Cell Significance Index: 112.9500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2023
Cell Significance Index: 11.3500 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.2005
Cell Significance Index: 2.3900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1588
Cell Significance Index: 5.5800 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.1552
Cell Significance Index: 1.6200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1073
Cell Significance Index: 5.0500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1049
Cell Significance Index: 7.4200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0977
Cell Significance Index: 7.5000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.0852
Cell Significance Index: 3.7700 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0510
Cell Significance Index: 6.6000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0175
Cell Significance Index: 33.0000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0076
Cell Significance Index: 14.0500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0048
Cell Significance Index: 7.3700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0015
Cell Significance Index: 0.0400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0049
Cell Significance Index: -6.6500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0050
Cell Significance Index: -0.5700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0078
Cell Significance Index: -4.9500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0078
Cell Significance Index: -4.8600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0114
Cell Significance Index: -0.4300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0134
Cell Significance Index: -9.8600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0158
Cell Significance Index: -11.7300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0160
Cell Significance Index: -2.7300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0241
Cell Significance Index: -18.2400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0255
Cell Significance Index: -14.3700 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0294
Cell Significance Index: -0.6100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0349
Cell Significance Index: -15.8600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0384
Cell Significance Index: -2.8600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0545
Cell Significance Index: -2.7600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0630
Cell Significance Index: -4.0700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0653
Cell Significance Index: -13.7600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0721
Cell Significance Index: -1.5400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0779
Cell Significance Index: -22.4100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0792
Cell Significance Index: -8.0900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0967
Cell Significance Index: -14.0500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1058
Cell Significance Index: -12.4800 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.1329
Cell Significance Index: -2.9100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1389
Cell Significance Index: -2.3300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1432
Cell Significance Index: -3.5800 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1794
Cell Significance Index: -20.4800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2064
Cell Significance Index: -6.6100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2188
Cell Significance Index: -3.7500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2246
Cell Significance Index: -23.3900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2306
Cell Significance Index: -12.1100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2649
Cell Significance Index: -20.9800 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.2759
Cell Significance Index: -3.9200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3177
Cell Significance Index: -11.0400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3414
Cell Significance Index: -20.9300 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3443
Cell Significance Index: -4.9300 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.3672
Cell Significance Index: -2.8300 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3724
Cell Significance Index: -11.8600 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3797
Cell Significance Index: -12.4300 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3841
Cell Significance Index: -7.1000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3995
Cell Significance Index: -20.8100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.3996
Cell Significance Index: -10.7100 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4006
Cell Significance Index: -10.5400 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.4075
Cell Significance Index: -8.7100 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.4272
Cell Significance Index: -6.3100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.4284
Cell Significance Index: -17.5500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.4290
Cell Significance Index: -8.9800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4299
Cell Significance Index: -11.0500 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.4501
Cell Significance Index: -3.6700 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.4683
Cell Significance Index: -9.9400 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.4683
Cell Significance Index: -5.3200 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.4687
Cell Significance Index: -6.9200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4693
Cell Significance Index: -16.4400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1400448858
Symbol: RFX1_HUMAN
Name: MHC class II regulatory factor RFX1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2253877
Title: MHC class II regulatory factor RFX has a novel DNA-binding domain and a functionally independent dimerization domain.
PubMed ID: 2253877
DOI: 10.1101/gad.4.9.1528
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8413236
Title: RFX1 is identical to enhancer factor C and functions as a transactivator of the hepatitis B virus enhancer.
PubMed ID: 8413236
PubMed ID: 8224874
Title: Transcription factor RFX1 helps control the promoter of the mouse ribosomal protein-encoding gene rpL30 by binding to its alpha element.
PubMed ID: 8224874
PubMed ID: 10330134
Title: Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.
PubMed ID: 10330134
PubMed ID: 1508204
Title: The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters.
PubMed ID: 1508204
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 10706293
Title: Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding.
PubMed ID: 10706293
DOI: 10.1038/35002634
Sequence Information:
- Length: 979
- Mass: 104758
- Checksum: 4FD8EA9C4AB1A411
- Sequence:
MATQAYTELQ AAPPPSQPPQ APPQAQPQPP PPPPPAAPQP PQPPTAAATP QPQYVTELQS PQPQAQPPGG QKQYVTELPA VPAPSQPTGA PTPSPAPQQY IVVTVSEGAM RASETVSEAS PGSTASQTGV PTQVVQQVQG TQQRLLVQTS VQAKPGHVSP LQLTNIQVPQ QALPTQRLVV QSAAPGSKGG QVSLTVHGTQ QVHSPPEQSP VQANSSSSKT AGAPTGTVPQ QLQVHGVQQS VPVTQERSVV QATPQAPKPG PVQPLTVQGL QPVHVAQEVQ QLQQVPVPHV YSSQVQYVEG GDASYTASAI RSSTYSYPET PLYTQTASTS YYEAAGTATQ VSTPATSQAV ASSGSMPMYV SGSQVVASST STGAGASNSS GGGGSGGGGG GGGGGGGGGS GSTGGGGSGA GTYVIQGGYM LGSASQSYSH TTRASPATVQ WLLDNYETAE GVSLPRSTLY CHYLLHCQEQ KLEPVNAASF GKLIRSVFMG LRTRRLGTRG NSKYHYYGLR IKASSPLLRL MEDQQHMAMR GQPFSQKQRL KPIQKMEGMT NGVAVGQQPS TGLSDISAQV QQYQQFLDAS RSLPDFTELD LQGKVLPEGV GPGDIKAFQV LYREHCEAIV DVMVNLQFTL VETLWKTFWR YNLSQPSEAP PLAVHDEAEK RLPKAILVLL SKFEPVLQWT KHCDNVLYQG LVEILIPDVL RPIPSALTQA IRNFAKSLES WLTHAMVNIP EEMLRVKVAA AGAFAQTLRR YTSLNHLAQA ARAVLQNTAQ INQMLSDLNR VDFANVQEQA SWVCRCEDRV VQRLEQDFKV TLQQQNSLEQ WAAWLDGVVS QVLKPYQGSA GFPKAAKLFL LKWSFYSSMV IRDLTLRSAA SFGSFHLIRL LYDEYMYYLI EHRVAQAKGE TPIAVMGEFA NLATSLNPLD PDKDEEEEEE EESEDELPQD ISLAAGGESP ALGPETLEPP AKLARTDARG LFVQALPSS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.