Details for: RFX1

Gene ID: 5989

Symbol: RFX1

Ensembl ID: ENSG00000132005

Description: regulatory factor X1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 149.3456
    Cell Significance Index: -23.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 96.4740
    Cell Significance Index: -24.4700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 54.8667
    Cell Significance Index: -22.2900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 50.1375
    Cell Significance Index: -25.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.3495
    Cell Significance Index: -25.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.6496
    Cell Significance Index: -25.8500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.5128
    Cell Significance Index: -25.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.5853
    Cell Significance Index: -17.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5883
    Cell Significance Index: 21.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4630
    Cell Significance Index: 237.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2910
    Cell Significance Index: 150.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9516
    Cell Significance Index: 190.8900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8166
    Cell Significance Index: 88.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7844
    Cell Significance Index: 47.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6612
    Cell Significance Index: 29.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6326
    Cell Significance Index: 39.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6251
    Cell Significance Index: 124.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6138
    Cell Significance Index: 17.6900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.6099
    Cell Significance Index: 9.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5710
    Cell Significance Index: 204.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5708
    Cell Significance Index: 394.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5648
    Cell Significance Index: 16.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5304
    Cell Significance Index: 11.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4386
    Cell Significance Index: 53.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4324
    Cell Significance Index: 77.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4309
    Cell Significance Index: 59.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4181
    Cell Significance Index: 28.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3202
    Cell Significance Index: 31.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3046
    Cell Significance Index: 8.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2917
    Cell Significance Index: 128.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2655
    Cell Significance Index: 13.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2630
    Cell Significance Index: 12.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2354
    Cell Significance Index: 6.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2309
    Cell Significance Index: 29.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2103
    Cell Significance Index: 40.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2068
    Cell Significance Index: 112.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2023
    Cell Significance Index: 11.3500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2005
    Cell Significance Index: 2.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1588
    Cell Significance Index: 5.5800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.1552
    Cell Significance Index: 1.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1073
    Cell Significance Index: 5.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1049
    Cell Significance Index: 7.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0977
    Cell Significance Index: 7.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0852
    Cell Significance Index: 3.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0510
    Cell Significance Index: 6.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0175
    Cell Significance Index: 33.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0076
    Cell Significance Index: 14.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0048
    Cell Significance Index: 7.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0015
    Cell Significance Index: 0.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0049
    Cell Significance Index: -6.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0050
    Cell Significance Index: -0.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0078
    Cell Significance Index: -4.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0078
    Cell Significance Index: -4.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0114
    Cell Significance Index: -0.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0134
    Cell Significance Index: -9.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0158
    Cell Significance Index: -11.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0160
    Cell Significance Index: -2.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0241
    Cell Significance Index: -18.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0255
    Cell Significance Index: -14.3700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0294
    Cell Significance Index: -0.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0349
    Cell Significance Index: -15.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0384
    Cell Significance Index: -2.8600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0545
    Cell Significance Index: -2.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0630
    Cell Significance Index: -4.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0653
    Cell Significance Index: -13.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0721
    Cell Significance Index: -1.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0779
    Cell Significance Index: -22.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0792
    Cell Significance Index: -8.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0967
    Cell Significance Index: -14.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1058
    Cell Significance Index: -12.4800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1329
    Cell Significance Index: -2.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1389
    Cell Significance Index: -2.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1432
    Cell Significance Index: -3.5800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1794
    Cell Significance Index: -20.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2064
    Cell Significance Index: -6.6100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2188
    Cell Significance Index: -3.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2246
    Cell Significance Index: -23.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2306
    Cell Significance Index: -12.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2649
    Cell Significance Index: -20.9800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2759
    Cell Significance Index: -3.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3177
    Cell Significance Index: -11.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3414
    Cell Significance Index: -20.9300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3443
    Cell Significance Index: -4.9300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3672
    Cell Significance Index: -2.8300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3724
    Cell Significance Index: -11.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3797
    Cell Significance Index: -12.4300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3841
    Cell Significance Index: -7.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3995
    Cell Significance Index: -20.8100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3996
    Cell Significance Index: -10.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4006
    Cell Significance Index: -10.5400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4075
    Cell Significance Index: -8.7100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4272
    Cell Significance Index: -6.3100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4284
    Cell Significance Index: -17.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4290
    Cell Significance Index: -8.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4299
    Cell Significance Index: -11.0500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4501
    Cell Significance Index: -3.6700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4683
    Cell Significance Index: -9.9400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4683
    Cell Significance Index: -5.3200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4687
    Cell Significance Index: -6.9200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4693
    Cell Significance Index: -16.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RFX1 is a transcription factor that belongs to the RFX family, which consists of three members: RFX1, RFX2, and RFX5. RFX1 is characterized by its ability to bind to specific DNA sequences and regulate the expression of target genes. It is a dimeric transcription factor, composed of two identical subunits, and is known to interact with other transcription factors and co-regulators to modulate gene expression. **Pathways and Functions:** RFX1 is involved in various cellular processes, including: 1. **Immune Response:** RFX1 regulates the expression of genes involved in immune response, such as those encoding cytokines, chemokines, and histocompatibility complex (MHC) class II molecules. It is also involved in the regulation of T-cell development and function. 2. **Neurodevelopment:** RFX1 is expressed in neurons and regulates the expression of genes involved in neuronal development, differentiation, and function. It is also involved in the regulation of synaptic plasticity and learning. 3. **Transcriptional Regulation:** RFX1 regulates the expression of target genes by binding to specific DNA sequences and recruiting co-regulators, such as RNA polymerase II and histone-modifying enzymes. **Clinical Significance:** Dysregulation of RFX1 has been implicated in various immune-related disorders and neurological conditions, including: 1. **Autoimmune Diseases:** RFX1 has been shown to play a role in the regulation of T-cell function and the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Neurological Disorders:** RFX1 has been implicated in the regulation of synaptic plasticity and learning in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Developmental Disorders:** RFX1 is involved in the regulation of neuronal development and differentiation, and dysregulation of RFX1 has been implicated in developmental disorders, such as autism spectrum disorder. In conclusion, RFX1 is a critical transcription factor that plays a pivotal role in regulating gene expression in immune cells and neurons. Its dysregulation has been implicated in various immune-related disorders and neurological conditions, highlighting the importance of RFX1 in maintaining normal immune function and neuronal development. Further research is needed to fully elucidate the mechanisms by which RFX1 regulates gene expression and to explore its therapeutic potential in treating immune-related disorders and neurological conditions.

Genular Protein ID: 1400448858

Symbol: RFX1_HUMAN

Name: MHC class II regulatory factor RFX1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2253877

Title: MHC class II regulatory factor RFX has a novel DNA-binding domain and a functionally independent dimerization domain.

PubMed ID: 2253877

DOI: 10.1101/gad.4.9.1528

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8413236

Title: RFX1 is identical to enhancer factor C and functions as a transactivator of the hepatitis B virus enhancer.

PubMed ID: 8413236

DOI: 10.1128/mcb.13.10.6375-6384.1993

PubMed ID: 8224874

Title: Transcription factor RFX1 helps control the promoter of the mouse ribosomal protein-encoding gene rpL30 by binding to its alpha element.

PubMed ID: 8224874

DOI: 10.1016/0378-1119(93)90208-k

PubMed ID: 10330134

Title: Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.

PubMed ID: 10330134

DOI: 10.1128/mcb.19.6.3940

PubMed ID: 1508204

Title: The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters.

PubMed ID: 1508204

DOI: 10.1128/mcb.12.9.4076-4083.1992

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10706293

Title: Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding.

PubMed ID: 10706293

DOI: 10.1038/35002634

Sequence Information:

  • Length: 979
  • Mass: 104758
  • Checksum: 4FD8EA9C4AB1A411
  • Sequence:
  • MATQAYTELQ AAPPPSQPPQ APPQAQPQPP PPPPPAAPQP PQPPTAAATP QPQYVTELQS 
    PQPQAQPPGG QKQYVTELPA VPAPSQPTGA PTPSPAPQQY IVVTVSEGAM RASETVSEAS 
    PGSTASQTGV PTQVVQQVQG TQQRLLVQTS VQAKPGHVSP LQLTNIQVPQ QALPTQRLVV 
    QSAAPGSKGG QVSLTVHGTQ QVHSPPEQSP VQANSSSSKT AGAPTGTVPQ QLQVHGVQQS 
    VPVTQERSVV QATPQAPKPG PVQPLTVQGL QPVHVAQEVQ QLQQVPVPHV YSSQVQYVEG 
    GDASYTASAI RSSTYSYPET PLYTQTASTS YYEAAGTATQ VSTPATSQAV ASSGSMPMYV 
    SGSQVVASST STGAGASNSS GGGGSGGGGG GGGGGGGGGS GSTGGGGSGA GTYVIQGGYM 
    LGSASQSYSH TTRASPATVQ WLLDNYETAE GVSLPRSTLY CHYLLHCQEQ KLEPVNAASF 
    GKLIRSVFMG LRTRRLGTRG NSKYHYYGLR IKASSPLLRL MEDQQHMAMR GQPFSQKQRL 
    KPIQKMEGMT NGVAVGQQPS TGLSDISAQV QQYQQFLDAS RSLPDFTELD LQGKVLPEGV 
    GPGDIKAFQV LYREHCEAIV DVMVNLQFTL VETLWKTFWR YNLSQPSEAP PLAVHDEAEK 
    RLPKAILVLL SKFEPVLQWT KHCDNVLYQG LVEILIPDVL RPIPSALTQA IRNFAKSLES 
    WLTHAMVNIP EEMLRVKVAA AGAFAQTLRR YTSLNHLAQA ARAVLQNTAQ INQMLSDLNR 
    VDFANVQEQA SWVCRCEDRV VQRLEQDFKV TLQQQNSLEQ WAAWLDGVVS QVLKPYQGSA 
    GFPKAAKLFL LKWSFYSSMV IRDLTLRSAA SFGSFHLIRL LYDEYMYYLI EHRVAQAKGE 
    TPIAVMGEFA NLATSLNPLD PDKDEEEEEE EESEDELPQD ISLAAGGESP ALGPETLEPP 
    AKLARTDARG LFVQALPSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.