Details for: RGS4

Gene ID: 5999

Symbol: RGS4

Ensembl ID: ENSG00000117152

Description: regulator of G protein signaling 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 6.5921
    Cell Significance Index: 56.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.5955
    Cell Significance Index: 220.4400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.5241
    Cell Significance Index: 54.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.8800
    Cell Significance Index: 60.2200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.4026
    Cell Significance Index: 18.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3769
    Cell Significance Index: 276.2000
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.9825
    Cell Significance Index: 10.8400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.8635
    Cell Significance Index: 11.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5453
    Cell Significance Index: 492.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5333
    Cell Significance Index: 52.7600
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: 0.5132
    Cell Significance Index: 5.5400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: 0.4881
    Cell Significance Index: 5.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3063
    Cell Significance Index: 49.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2935
    Cell Significance Index: 31.9200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2831
    Cell Significance Index: 8.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2752
    Cell Significance Index: 10.4200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2652
    Cell Significance Index: 4.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2523
    Cell Significance Index: 11.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1691
    Cell Significance Index: 10.1500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1591
    Cell Significance Index: 18.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1410
    Cell Significance Index: 26.8400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.1259
    Cell Significance Index: 2.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0911
    Cell Significance Index: 6.1300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0889
    Cell Significance Index: 1.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0676
    Cell Significance Index: 1.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0659
    Cell Significance Index: 4.5600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0656
    Cell Significance Index: 2.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0226
    Cell Significance Index: 8.1000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0104
    Cell Significance Index: 0.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0072
    Cell Significance Index: 5.3200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0045
    Cell Significance Index: 0.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0020
    Cell Significance Index: 1.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0018
    Cell Significance Index: 0.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0022
    Cell Significance Index: -4.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0063
    Cell Significance Index: -3.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0102
    Cell Significance Index: -0.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0110
    Cell Significance Index: -20.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0133
    Cell Significance Index: -20.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0151
    Cell Significance Index: -20.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0184
    Cell Significance Index: -0.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0207
    Cell Significance Index: -3.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0243
    Cell Significance Index: -18.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0255
    Cell Significance Index: -18.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0261
    Cell Significance Index: -16.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0297
    Cell Significance Index: -13.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0306
    Cell Significance Index: -6.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0340
    Cell Significance Index: -18.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0479
    Cell Significance Index: -2.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0505
    Cell Significance Index: -14.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0511
    Cell Significance Index: -5.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0554
    Cell Significance Index: -9.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0722
    Cell Significance Index: -3.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0724
    Cell Significance Index: -14.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0893
    Cell Significance Index: -16.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0945
    Cell Significance Index: -12.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1291
    Cell Significance Index: -15.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1329
    Cell Significance Index: -13.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1345
    Cell Significance Index: -15.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1492
    Cell Significance Index: -19.2800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1636
    Cell Significance Index: -2.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1653
    Cell Significance Index: -4.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1655
    Cell Significance Index: -10.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1669
    Cell Significance Index: -5.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1726
    Cell Significance Index: -9.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1746
    Cell Significance Index: -18.1800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1763
    Cell Significance Index: -2.5700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1769
    Cell Significance Index: -7.6900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1775
    Cell Significance Index: -5.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1926
    Cell Significance Index: -12.1400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1996
    Cell Significance Index: -4.8400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2141
    Cell Significance Index: -5.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2359
    Cell Significance Index: -18.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2431
    Cell Significance Index: -18.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2584
    Cell Significance Index: -5.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2615
    Cell Significance Index: -9.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2633
    Cell Significance Index: -19.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2946
    Cell Significance Index: -4.4400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3163
    Cell Significance Index: -6.3500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3298
    Cell Significance Index: -7.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3318
    Cell Significance Index: -18.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3338
    Cell Significance Index: -9.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3627
    Cell Significance Index: -18.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3870
    Cell Significance Index: -18.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4101
    Cell Significance Index: -19.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4107
    Cell Significance Index: -10.8000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4378
    Cell Significance Index: -6.2700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4648
    Cell Significance Index: -5.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4852
    Cell Significance Index: -13.0000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4980
    Cell Significance Index: -18.2800
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.5027
    Cell Significance Index: -5.0800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5407
    Cell Significance Index: -5.1300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5838
    Cell Significance Index: -6.3600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.6071
    Cell Significance Index: -19.2000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.6277
    Cell Significance Index: -13.1000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6308
    Cell Significance Index: -16.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6340
    Cell Significance Index: -10.6100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.6372
    Cell Significance Index: -15.8900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6392
    Cell Significance Index: -13.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6520
    Cell Significance Index: -17.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6631
    Cell Significance Index: -17.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RGS4 is a 444-amino acid protein that belongs to the RGS family, which is characterized by the presence of a conserved RGS domain. This domain is responsible for the interaction with Gα subunits and the acceleration of their GTPase activity. RGS4 is expressed in a wide range of tissues, including the immune system, nervous system, and cardiovascular system. Its expression is tightly regulated by various signaling pathways, including the calmodulin-binding pathway, which is crucial for its function in modulating GPCR signaling. **Pathways and Functions:** RGS4 interacts with Gα subunits, accelerating their GTPase activity and terminating the signaling cascade. This action has a negative regulatory effect on GPCR signaling, which is involved in various cellular processes, including: 1. **Immune response:** RGS4 modulates the signaling of GPCRs on the surface of immune cells, such as dendritic cells and enterocytes, influencing the activation and proliferation of these cells. 2. **Neuronal signaling:** RGS4 regulates the signaling of GPCRs in the nervous system, including the modulation of excitatory postsynaptic potentials and the regulation of heart rate. 3. **Cardiovascular function:** RGS4 modulates the signaling of GPCRs in the cardiovascular system, influencing the regulation of calcium ion transport and the contraction of cardiac muscle cells. **Clinical Significance:** Dysregulation of RGS4 has been implicated in various diseases, including: 1. **Cardiovascular disorders:** RGS4 deficiency has been associated with hypertension and cardiac arrhythmias. 2. **Neurological conditions:** RGS4 dysregulation has been linked to neurological disorders, such as Parkinson's disease and schizophrenia. 3. **Immune system disorders:** RGS4 deficiency has been associated with impaired immune function and increased susceptibility to infections. In conclusion, RGS4 is a critical regulator of GPCR signaling, and its dysregulation has significant implications for various diseases. Further research is needed to fully understand the mechanisms of RGS4 regulation and its role in modulating cellular processes. **Potential Therapeutic Applications:** RGS4 has been identified as a potential therapeutic target for the treatment of various diseases, including cardiovascular disorders and neurological conditions. Modulating RGS4 activity could provide a novel approach to treating these conditions by targeting the negative regulatory effects of RGS4 on GPCR signaling. **Future Directions:** Further research is needed to fully understand the mechanisms of RGS4 regulation and its role in modulating cellular processes. Studies on the molecular mechanisms of RGS4 regulation and its interactions with Gα subunits could provide valuable insights into the development of novel therapeutic strategies for RGS4-related diseases.

Genular Protein ID: 2352905171

Symbol: RGS4_HUMAN

Name: Regulator of G-protein signaling 4

UniProtKB Accession Codes:

P49798 A7XA56 A7XA58 A7XA59 A7YVV7 B1APZ3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 Ensembl 5 ExpressionAtlas 1 GO 23 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 3 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8602223

Title: Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family.

PubMed ID: 8602223

DOI: 10.1038/379742a0

PubMed ID: 17707117

Title: Full length cloning and expression analysis of splice variants of regulator of G-protein signaling RGS4 in human and murine brain.

PubMed ID: 17707117

DOI: 10.1016/j.gene.2007.07.002

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10608901

Title: Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10.

PubMed ID: 10608901

DOI: 10.1074/jbc.274.53.38260

PubMed ID: 9748280

Title: RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz GTPase-activating protein subfamily.

PubMed ID: 9748280

DOI: 10.1074/jbc.273.40.26014

PubMed ID: 12023979

Title: Association and linkage analyses of RGS4 polymorphisms in schizophrenia.

PubMed ID: 12023979

DOI: 10.1093/hmg/11.12.1373

PubMed ID: 14755443

Title: Confirming RGS4 as a susceptibility gene for schizophrenia.

PubMed ID: 14755443

DOI: 10.1002/ajmg.b.20109

Sequence Information:

  • Length: 205
  • Mass: 23256
  • Checksum: 7713F1F7496A698B
  • Sequence:
    • MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHNSSHN KKDKVVICQR VSQEEVKKWA 
ESLENLISHE CGLAAFKAFL KSEYSEENID FWISCEEYKK IKSPSKLSPK AKKIYNEFIS 
VQATKEVNLD SCTREETSRN MLEPTITCFD EAQKKIFNLM EKDSYRRFLK SRFYLDLVNP 
SSCGAEKQKG AKSSADCASL VPQCA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.