Details for: S100A12

Gene ID: 6283

Symbol: S100A12

Ensembl ID: ENSG00000163221

Description: S100 calcium binding protein A12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 33.1736
    Cell Significance Index: -5.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 26.5333
    Cell Significance Index: -6.7300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 12.7920
    Cell Significance Index: -6.5800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.0073
    Cell Significance Index: 111.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.2767
    Cell Significance Index: -4.0400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.3030
    Cell Significance Index: 19.7900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.8356
    Cell Significance Index: 28.4000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.7232
    Cell Significance Index: -6.8000
  • Cell Name: CD14-positive, CD16-low monocyte (CL0001055)
    Fold Change: 1.3596
    Cell Significance Index: 13.0800
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.8717
    Cell Significance Index: 7.4300
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.4814
    Cell Significance Index: 1.2700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.1257
    Cell Significance Index: 1.1700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.1055
    Cell Significance Index: 0.7000
  • Cell Name: mature neutrophil (CL0000096)
    Fold Change: 0.0916
    Cell Significance Index: 0.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0280
    Cell Significance Index: 0.7200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.0169
    Cell Significance Index: 0.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0168
    Cell Significance Index: 0.4700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0002
    Cell Significance Index: -0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0030
    Cell Significance Index: -5.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0042
    Cell Significance Index: -1.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0047
    Cell Significance Index: -8.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0054
    Cell Significance Index: -8.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0063
    Cell Significance Index: -8.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0097
    Cell Significance Index: -7.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0098
    Cell Significance Index: -6.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0103
    Cell Significance Index: -5.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0126
    Cell Significance Index: -7.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0151
    Cell Significance Index: -6.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0188
    Cell Significance Index: -6.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0204
    Cell Significance Index: -3.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0233
    Cell Significance Index: -2.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0251
    Cell Significance Index: -5.0500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0253
    Cell Significance Index: -0.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0309
    Cell Significance Index: -6.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0344
    Cell Significance Index: -7.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0350
    Cell Significance Index: -5.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0362
    Cell Significance Index: -4.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0402
    Cell Significance Index: -2.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0408
    Cell Significance Index: -5.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0411
    Cell Significance Index: -5.9800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0432
    Cell Significance Index: -4.4100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0469
    Cell Significance Index: -1.9200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0490
    Cell Significance Index: -5.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0564
    Cell Significance Index: -6.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0572
    Cell Significance Index: -1.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0587
    Cell Significance Index: -6.1100
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.0660
    Cell Significance Index: -0.4600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0678
    Cell Significance Index: -0.4500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0720
    Cell Significance Index: -1.0500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0772
    Cell Significance Index: -0.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0873
    Cell Significance Index: -5.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0984
    Cell Significance Index: -7.5500
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.1054
    Cell Significance Index: -0.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1105
    Cell Significance Index: -7.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1129
    Cell Significance Index: -1.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1165
    Cell Significance Index: -5.4800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1174
    Cell Significance Index: -4.3100
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1227
    Cell Significance Index: -1.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1254
    Cell Significance Index: -3.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1261
    Cell Significance Index: -6.5500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1377
    Cell Significance Index: -1.8300
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1382
    Cell Significance Index: -1.8100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1391
    Cell Significance Index: -1.6000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1396
    Cell Significance Index: -1.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1456
    Cell Significance Index: -8.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1476
    Cell Significance Index: -5.1700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1496
    Cell Significance Index: -2.5400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1497
    Cell Significance Index: -3.7400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1532
    Cell Significance Index: -1.7400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1536
    Cell Significance Index: -3.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1561
    Cell Significance Index: -7.2800
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: -0.1667
    Cell Significance Index: -1.2700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1729
    Cell Significance Index: -2.5100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1736
    Cell Significance Index: -5.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1741
    Cell Significance Index: -5.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1770
    Cell Significance Index: -7.8300
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.1862
    Cell Significance Index: -1.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1935
    Cell Significance Index: -4.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1985
    Cell Significance Index: -5.3000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1998
    Cell Significance Index: -1.8400
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.2040
    Cell Significance Index: -2.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2057
    Cell Significance Index: -7.7900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2060
    Cell Significance Index: -1.9600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2068
    Cell Significance Index: -2.5600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2114
    Cell Significance Index: -3.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2125
    Cell Significance Index: -6.2600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2171
    Cell Significance Index: -5.5300
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.2241
    Cell Significance Index: -2.0900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2293
    Cell Significance Index: -2.9100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2329
    Cell Significance Index: -5.8100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2341
    Cell Significance Index: -5.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2480
    Cell Significance Index: -6.5200
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2502
    Cell Significance Index: -2.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2516
    Cell Significance Index: -5.5100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2601
    Cell Significance Index: -6.4900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.2643
    Cell Significance Index: -2.6800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2652
    Cell Significance Index: -5.7300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2653
    Cell Significance Index: -7.5700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2657
    Cell Significance Index: -1.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** S100A12 is a small, acidic protein that is characterized by its ability to bind calcium ions. It is a member of the S100 family of proteins, which are known to be involved in various cellular processes. S100A12 is specifically expressed in immune cells, and its expression is induced by bacterial and fungal pathogens. It is also involved in the regulation of inflammatory responses, and has been shown to be a key player in the innate immune response. **Pathways and Functions** S100A12 is involved in several key pathways and functions, including: 1. **Antimicrobial Humoral Immune Response Mediated by Antimicrobial Peptide**: S100A12 has been shown to induce the production of antimicrobial peptides, which are essential for the elimination of pathogens. 2. **Cytokine Signaling in Immune System**: S100A12 is involved in the regulation of cytokine signaling, which is essential for the activation and differentiation of immune cells. 3. **Inflammatory Response**: S100A12 plays a key role in the regulation of inflammatory responses, and has been shown to be involved in the production of pro-inflammatory cytokines. 4. **Defense Response to Bacterium and Fungus**: S100A12 is involved in the defense response to bacterial and fungal pathogens, and has been shown to be a key player in the innate immune response. **Clinical Significance** S100A12 has significant clinical implications, particularly in the context of immune-related disorders. Its expression has been shown to be elevated in various diseases, including: 1. **Inflammatory Bowel Disease**: S100A12 has been shown to be elevated in patients with inflammatory bowel disease, and has been implicated in the pathogenesis of the disease. 2. **Rheumatoid Arthritis**: S100A12 has been shown to be elevated in patients with rheumatoid arthritis, and has been implicated in the regulation of inflammatory responses. 3. **Cancer**: S100A12 has been shown to be elevated in various types of cancer, and has been implicated in the regulation of tumor growth and metastasis. In conclusion, S100A12 is a protein that plays a crucial role in the innate immune response, and has significant clinical implications in the context of immune-related disorders. Its expression is induced by bacterial and fungal pathogens, and it has been shown to be involved in the regulation of inflammatory responses and the production of antimicrobial peptides. Further research is needed to fully understand the role of S100A12 in the immune system and its clinical implications.

Genular Protein ID: 3035574166

Symbol: S10AC_HUMAN

Name: Protein S100-A12

UniProtKB Accession Codes:

P80511 P83219 Q5SY66 Q7M4R1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CPTC 1 CTD 1 ChEBI 18 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 8 Ensembl 1 EvolutionaryTrace 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8619860

Title: Human CAAF1 gene -- molecular cloning, gene structure, and chromosome mapping.

PubMed ID: 8619860

DOI: 10.1006/bbrc.1996.0600

PubMed ID: 8985590

Title: Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21.

PubMed ID: 8985590

DOI: 10.1016/s0143-4160(96)90087-1

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8619876

Title: Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin.

PubMed ID: 8619876

DOI: 10.1006/bbrc.1996.0616

PubMed ID: 8769108

Title: Amino acid sequence determination of human S100A12 (P6, calgranulin C, CGRP, CAAF1) by tandem mass spectrometry.

PubMed ID: 8769108

DOI: 10.1006/bbrc.1996.1144

PubMed ID: 7626002

Title: Identification and characterization of a novel human neutrophil protein related to the S100 family.

PubMed ID: 7626002

DOI: 10.1042/bj3090395

PubMed ID: 1860454

Title: Identification, isolation, and partial characterization of a 7.5-kDa surfactant-associated protein.

PubMed ID: 1860454

DOI: 10.3109/01902149109062865

PubMed ID: 11522286

Title: Calcitermin, a novel antimicrobial peptide isolated from human airway secretions.

PubMed ID: 11522286

DOI: 10.1016/s0014-5793(01)02731-4

PubMed ID: 12042313

Title: CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family.

PubMed ID: 12042313

DOI: 10.1074/jbc.m203602200

PubMed ID: 12645006

Title: Multiple structural states of S100A12: A key to its functional diversity.

PubMed ID: 12645006

DOI: 10.1002/jemt.10300

PubMed ID: 17208591

Title: S100A12 provokes mast cell activation: a potential amplification pathway in asthma and innate immunity.

PubMed ID: 17208591

DOI: 10.1016/j.jaci.2006.08.021

PubMed ID: 18292089

Title: Mast cell and monocyte recruitment by S100A12 and its hinge domain.

PubMed ID: 18292089

DOI: 10.1074/jbc.m710388200

PubMed ID: 18443896

Title: Human S100A12: a novel key player in inflammation?

PubMed ID: 18443896

DOI: 10.1007/s00726-008-0097-7

PubMed ID: 20523765

Title: Anti-infective protective properties of S100 calgranulins.

PubMed ID: 20523765

DOI: 10.2174/187152309789838975

PubMed ID: 19386136

Title: Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function.

PubMed ID: 19386136

DOI: 10.1186/1471-2091-10-11

PubMed ID: 19935766

Title: S100 Calgranulins in inflammatory arthritis.

PubMed ID: 19935766

DOI: 10.1038/icb.2009.88

PubMed ID: 20213444

Title: Inflammation-associated S100 proteins: new mechanisms that regulate function.

PubMed ID: 20213444

DOI: 10.1007/s00726-010-0528-0

PubMed ID: 22811950

Title: The role of S100A12 as a systemic marker of inflammation.

PubMed ID: 22811950

DOI: 10.1155/2012/907078

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 11134923

Title: The three-dimensional structure of human S100A12.

PubMed ID: 11134923

DOI: 10.1107/s090744490001458x

PubMed ID: 12777802

Title: Structure of the human S100A12-copper complex: implications for host-parasite defence.

PubMed ID: 12777802

DOI: 10.1107/s0907444903004700

PubMed ID: 19501594

Title: The crystal structures of human S100A12 in apo form and in complex with zinc: new insights into S100A12 oligomerisation.

PubMed ID: 19501594

DOI: 10.1016/j.jmb.2009.06.004

Sequence Information:

  • Length: 92
  • Mass: 10575
  • Checksum: 52AF75A31BDC222A
  • Sequence:
    • MTKLEEHLEG IVNIFHQYSV RKGHFDTLSK GELKQLLTKE LANTIKNIKD KAVIDEIFQG 
LDANQDEQVD FQEFISLVAI ALKAAHYHTH KE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.