Details for: ACSM3

Gene ID: 6296

Symbol: ACSM3

Ensembl ID: ENSG00000005187

Description: acyl-CoA synthetase medium chain family member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 88.1416
    Cell Significance Index: -13.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.0275
    Cell Significance Index: -10.6600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 32.6394
    Cell Significance Index: -13.2600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.9095
    Cell Significance Index: -13.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.7887
    Cell Significance Index: -14.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 11.2807
    Cell Significance Index: 302.2700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 7.0417
    Cell Significance Index: 41.3700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 6.9431
    Cell Significance Index: 99.7100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.6871
    Cell Significance Index: -15.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.5767
    Cell Significance Index: 94.0500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.3394
    Cell Significance Index: -5.1200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.9782
    Cell Significance Index: 17.5600
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 1.9632
    Cell Significance Index: 2.5400
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.8822
    Cell Significance Index: 9.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.5584
    Cell Significance Index: 36.0100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.5064
    Cell Significance Index: 21.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4715
    Cell Significance Index: 145.5600
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.4009
    Cell Significance Index: 11.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3169
    Cell Significance Index: 261.3500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2764
    Cell Significance Index: 76.6300
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.0594
    Cell Significance Index: 3.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0157
    Cell Significance Index: 917.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9478
    Cell Significance Index: 25.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8078
    Cell Significance Index: 41.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7890
    Cell Significance Index: 128.3200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6620
    Cell Significance Index: 9.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6232
    Cell Significance Index: 118.6100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5548
    Cell Significance Index: 4.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5405
    Cell Significance Index: 37.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3959
    Cell Significance Index: 10.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2565
    Cell Significance Index: 46.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2497
    Cell Significance Index: 29.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2332
    Cell Significance Index: 7.4700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.2155
    Cell Significance Index: 1.4600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2139
    Cell Significance Index: 1.9700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2069
    Cell Significance Index: 2.6500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2014
    Cell Significance Index: 3.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1646
    Cell Significance Index: 23.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1589
    Cell Significance Index: 4.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1501
    Cell Significance Index: 6.8100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.1487
    Cell Significance Index: 0.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1399
    Cell Significance Index: 23.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1350
    Cell Significance Index: 3.8900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1279
    Cell Significance Index: 2.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1257
    Cell Significance Index: 15.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1201
    Cell Significance Index: 83.0900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1073
    Cell Significance Index: 1.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0960
    Cell Significance Index: 52.4300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0866
    Cell Significance Index: 1.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0865
    Cell Significance Index: 6.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0701
    Cell Significance Index: 43.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0699
    Cell Significance Index: 30.9100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0636
    Cell Significance Index: 1.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0521
    Cell Significance Index: 2.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0512
    Cell Significance Index: 1.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0403
    Cell Significance Index: 29.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0374
    Cell Significance Index: 5.1400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0280
    Cell Significance Index: 0.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0207
    Cell Significance Index: 38.9600
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0170
    Cell Significance Index: 0.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0159
    Cell Significance Index: 24.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0147
    Cell Significance Index: 27.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0133
    Cell Significance Index: 10.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0078
    Cell Significance Index: 4.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0027
    Cell Significance Index: 3.7000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0020
    Cell Significance Index: -0.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0030
    Cell Significance Index: -0.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0051
    Cell Significance Index: -1.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0062
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0063
    Cell Significance Index: -4.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0072
    Cell Significance Index: -0.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0078
    Cell Significance Index: -4.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0181
    Cell Significance Index: -3.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0222
    Cell Significance Index: -2.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0241
    Cell Significance Index: -2.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0269
    Cell Significance Index: -3.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0284
    Cell Significance Index: -8.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0296
    Cell Significance Index: -2.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0396
    Cell Significance Index: -1.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0409
    Cell Significance Index: -3.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0416
    Cell Significance Index: -8.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0483
    Cell Significance Index: -6.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0612
    Cell Significance Index: -1.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0668
    Cell Significance Index: -4.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0811
    Cell Significance Index: -5.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1017
    Cell Significance Index: -6.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1020
    Cell Significance Index: -4.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1113
    Cell Significance Index: -13.1300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1113
    Cell Significance Index: -12.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1170
    Cell Significance Index: -12.1900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1274
    Cell Significance Index: -1.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1288
    Cell Significance Index: -3.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1409
    Cell Significance Index: -5.3400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1663
    Cell Significance Index: -2.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1680
    Cell Significance Index: -7.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1688
    Cell Significance Index: -9.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1868
    Cell Significance Index: -3.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1876
    Cell Significance Index: -12.1000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1995
    Cell Significance Index: -2.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Mitochondrial localization**: The ACSM3 protein is exclusively localized to the mitochondrial matrix, where it catalyzes the conversion of medium-chain fatty acids into acetyl-CoA. 2. **Fatty acid metabolism**: ACSM3 is involved in the beta-oxidation of medium-chain fatty acids, which is a critical step in the breakdown of fatty acids for energy production. 3. **Acyl-CoA synthetase activity**: The ACSM3 protein possesses acyl-CoA synthetase activity, which is essential for the activation of fatty acids for subsequent metabolic processes. 4. **Regulation of blood pressure**: ACSM3 has been implicated in the regulation of blood pressure, suggesting a potential role in cardiovascular disease. **Pathways and Functions** 1. **Mitochondrial fatty acid beta-oxidation**: ACSM3 is a key player in the mitochondrial beta-oxidation of medium-chain fatty acids, which is a critical step in the breakdown of fatty acids for energy production. 2. **Acyl-CoA metabolic process**: The ACSM3 protein is involved in the activation of fatty acids for subsequent metabolic processes, including beta-oxidation and fatty acid synthesis. 3. **Fatty acid biosynthetic process**: ACSM3 is required for the synthesis of fatty acids, which is essential for various cellular processes, including energy production and membrane synthesis. 4. **Cholesterol homeostasis**: The ACSM3 protein has been implicated in the regulation of cholesterol homeostasis, suggesting a potential role in lipid metabolism disorders. **Clinical Significance** 1. **Cardiovascular disease**: Abnormalities in ACSM3 expression have been linked to various cardiovascular diseases, including hypertension and atherosclerosis. 2. **Diabetes**: ACSM3 has been implicated in the regulation of blood glucose levels, suggesting a potential role in the development of diabetes. 3. **Neurodegenerative diseases**: The ACSM3 protein has been linked to neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, highlighting the importance of this gene in maintaining neuronal function. 4. **Cancer**: ACSM3 has been implicated in the regulation of cancer cell growth and metabolism, suggesting a potential role in cancer development and progression. In conclusion, the ACSM3 gene is a critical component of the mitochondrial fatty acid metabolism pathway, and its dysregulation has been linked to various diseases. Further research is necessary to fully understand the role of ACSM3 in maintaining cellular homeostasis and to develop therapeutic strategies for the treatment of associated diseases.

Genular Protein ID: 946944853

Symbol: ACSM3_HUMAN

Name: Acyl-coenzyme A synthetase ACSM3, mitochondrial

UniProtKB Accession Codes:

Q53FZ2 O60363 Q13732 Q15425 Q7KYM6 Q9BUA2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 43 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 12 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7907320

Title: Human SA gene locus as a candidate locus for essential hypertension.

PubMed ID: 7907320

DOI: 10.1161/01.hyp.23.3.375

PubMed ID: 7843754

Title: Evaluation of the SA locus in human hypertension.

PubMed ID: 7843754

DOI: 10.1161/01.hyp.25.1.6

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27351777

Title: Xenobiotic/medium chain fatty acid: CoA ligase - a critical review on its role in fatty acid metabolism and the detoxification of benzoic acid and aspirin.

PubMed ID: 27351777

DOI: 10.1080/17425255.2016.1206888

PubMed ID: 11772874

Title: Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension.

PubMed ID: 11772874

DOI: 10.1161/hc0102.101780

PubMed ID: 17278971

Title: SAH gene variants are associated with obesity-related hypertension in Caucasians: the PEGASE Study.

PubMed ID: 17278971

DOI: 10.1097/hjh.0b013e3280144779

Sequence Information:

  • Length: 586
  • Mass: 66153
  • Checksum: 329967C751F11F1D
  • Sequence:
    • MLARVTRKML RHAKCFQRLA IFGSVRALHK DNRTATPQNF SNYESMKQDF KLGIPEYFNF 
AKDVLDQWTD KEKAGKKPSN PAFWWINRNG EEMRWSFEEL GSLSRKFANI LSEACSLQRG 
DRVILILPRV PEWWLANVAC LRTGTVLIPG TTQLTQKDIL YRLQSSKANC IITNDVLAPA 
VDAVASKCEN LHSKLIVSEN SREGWGNLKE LMKHASDSHT CVKTKHNEIM AIFFTSGTSG 
YPKMTAHTHS SFGLGLSVNG RFWLDLTPSD VMWNTSDTGW AKSAWSSVFS PWIQGACVFT 
HHLPRFEPTS ILQTLSKYPI TVFCSAPTVY RMLVQNDITS YKFKSLKHCV SAGEPITPDV 
TEKWRNKTGL DIYEGYGQTE TVLICGNFKG MKIKPGSMGK PSPAFDVKIV DVNGNVLPPG 
QEGDIGIQVL PNRPFGLFTH YVDNPSKTAS TLRGNFYITG DRGYMDKDGY FWFVARADDV 
ILSSGYRIGP FEVENALNEH PSVAESAVVS SPDPIRGEVV KAFVVLNPDY KSHDQEQLIK 
EIQEHVKKTT APYKYPRKVE FIQELPKTIS GKTKRNELRK KEWKTI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.