Details for: CCL3

Gene ID: 6348

Symbol: CCL3

Ensembl ID: ENSG00000277632

Description: C-C motif chemokine ligand 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 64.2630
    Cell Significance Index: -30.3400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 58.9053
    Cell Significance Index: -30.3000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 33.2508
    Cell Significance Index: 89.0800
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 31.1248
    Cell Significance Index: 129.5400
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 9.0449
    Cell Significance Index: 23.8600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.6753
    Cell Significance Index: -23.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.4108
    Cell Significance Index: 63.0400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.6468
    Cell Significance Index: 40.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.6421
    Cell Significance Index: 43.9300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.5594
    Cell Significance Index: 31.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5375
    Cell Significance Index: 68.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.5317
    Cell Significance Index: 54.3100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0514
    Cell Significance Index: 0.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0430
    Cell Significance Index: 32.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0336
    Cell Significance Index: 3.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0262
    Cell Significance Index: 16.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0113
    Cell Significance Index: 0.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0004
    Cell Significance Index: 0.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0017
    Cell Significance Index: -0.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0075
    Cell Significance Index: -4.2500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0153
    Cell Significance Index: -0.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0154
    Cell Significance Index: -28.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0305
    Cell Significance Index: -5.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0407
    Cell Significance Index: -29.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0464
    Cell Significance Index: -29.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0697
    Cell Significance Index: -31.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0854
    Cell Significance Index: -30.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1002
    Cell Significance Index: -4.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1333
    Cell Significance Index: -26.4500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1374
    Cell Significance Index: -0.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1396
    Cell Significance Index: -28.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1428
    Cell Significance Index: -25.7400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1532
    Cell Significance Index: -2.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1621
    Cell Significance Index: -22.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1636
    Cell Significance Index: -4.6900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1767
    Cell Significance Index: -7.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1838
    Cell Significance Index: -23.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1854
    Cell Significance Index: -5.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1998
    Cell Significance Index: -29.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2256
    Cell Significance Index: -27.7400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2277
    Cell Significance Index: -26.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2278
    Cell Significance Index: -26.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2731
    Cell Significance Index: -17.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3382
    Cell Significance Index: -17.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3408
    Cell Significance Index: -25.4000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.3960
    Cell Significance Index: -4.3400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4137
    Cell Significance Index: -4.7000
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.4598
    Cell Significance Index: -7.9000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.4775
    Cell Significance Index: -8.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4972
    Cell Significance Index: -30.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5127
    Cell Significance Index: -39.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5425
    Cell Significance Index: -30.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5537
    Cell Significance Index: -29.0700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5653
    Cell Significance Index: -4.6100
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.5872
    Cell Significance Index: -5.9700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.5928
    Cell Significance Index: -11.5900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.6199
    Cell Significance Index: -9.0000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6262
    Cell Significance Index: -15.6200
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.6797
    Cell Significance Index: -1.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6923
    Cell Significance Index: -14.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7019
    Cell Significance Index: -24.5900
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.7132
    Cell Significance Index: -10.6700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7358
    Cell Significance Index: -27.0100
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.7554
    Cell Significance Index: -8.0900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.7689
    Cell Significance Index: -7.8500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7921
    Cell Significance Index: -21.5600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7944
    Cell Significance Index: -15.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8596
    Cell Significance Index: -29.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8626
    Cell Significance Index: -28.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8691
    Cell Significance Index: -27.6800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.8760
    Cell Significance Index: -21.2200
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.8773
    Cell Significance Index: -10.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9066
    Cell Significance Index: -34.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9248
    Cell Significance Index: -29.6200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9399
    Cell Significance Index: -27.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9410
    Cell Significance Index: -24.0400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.9829
    Cell Significance Index: -13.5900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -1.0167
    Cell Significance Index: -13.5100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -1.0246
    Cell Significance Index: -8.6600
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -1.0385
    Cell Significance Index: -11.9600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -1.0457
    Cell Significance Index: -16.5900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.0506
    Cell Significance Index: -20.9500
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -1.0794
    Cell Significance Index: -9.6100
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -1.0993
    Cell Significance Index: -10.0600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -1.1031
    Cell Significance Index: -11.4400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.1035
    Cell Significance Index: -23.0300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.1263
    Cell Significance Index: -28.1300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.1269
    Cell Significance Index: -28.7100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -1.1277
    Cell Significance Index: -12.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.1310
    Cell Significance Index: -29.7400
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -1.1601
    Cell Significance Index: -14.8500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.1988
    Cell Significance Index: -34.5400
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -1.2030
    Cell Significance Index: -15.1500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.2199
    Cell Significance Index: -30.4200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.2524
    Cell Significance Index: -21.5900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.3008
    Cell Significance Index: -28.1100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -1.3119
    Cell Significance Index: -18.8000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.3227
    Cell Significance Index: -14.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.3229
    Cell Significance Index: -22.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CCL3 is a 8-kDa protein consisting of 70-80 amino acids, with a characteristic C-C motif chemokine structure. It is primarily produced by monocytes, macrophages, and other immune cells, but can also be expressed by other cell types, such as astrocytes, neurons, and decidual natural killer cells. CCL3 is a potent chemoattractant for various immune cells, including T cells, B cells, neutrophils, and macrophages, and is involved in the recruitment of these cells to sites of inflammation. **Pathways and Functions** CCL3 is involved in several signaling pathways, including: 1. **Chemokine-mediated signaling pathway**: CCL3 binds to its receptors, CCR1 and CCR5, on the surface of immune cells, triggering a signaling cascade that regulates chemotaxis, cell activation, and cytokine production. 2. **Calcium-mediated signaling**: CCL3 can activate calcium channels, leading to an increase in intracellular calcium concentrations, which regulates various cellular processes, including cell migration, proliferation, and differentiation. 3. **G-protein coupled receptor signaling pathway**: CCL3 binds to G protein-coupled receptors, triggering a signaling cascade that regulates cell migration, proliferation, and differentiation. 4. **Interleukin-1 signaling pathway**: CCL3 can regulate the production of interleukin-1 (IL-1), a pro-inflammatory cytokine, by binding to its receptor, IL-1R. 5. **Tumor necrosis factor signaling pathway**: CCL3 can regulate the production of tumor necrosis factor (TNF), a pro-inflammatory cytokine, by binding to its receptor, TNFR. CCL3 plays a crucial role in various biological processes, including: 1. **Immune cell trafficking**: CCL3 is involved in the recruitment of immune cells to sites of inflammation, infection, and cancer. 2. **Inflammation**: CCL3 is a potent pro-inflammatory cytokine, involved in the regulation of inflammatory responses and the development of autoimmune disorders. 3. **Cell migration**: CCL3 regulates the migration of immune cells, including T cells, B cells, and macrophages, to sites of inflammation and infection. 4. **Neuroprotection**: CCL3 has been shown to have neuroprotective effects, regulating the migration and activation of microglial cells, which are involved in the regulation of neuronal function and survival. **Clinical Significance** CCL3 has been implicated in various diseases, including: 1. **Autoimmune disorders**: CCL3 has been shown to play a role in the development of autoimmune disorders, such as multiple sclerosis, rheumatoid arthritis, and lupus. 2. **Cancer**: CCL3 has been implicated in the development and progression of various cancers, including breast cancer, lung cancer, and colon cancer. 3. **Cardiovascular diseases**: CCL3 has been shown to play a role in the development of cardiovascular diseases, including atherosclerosis and heart failure. 4. **Neurological disorders**: CCL3 has been implicated in the development of neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. In conclusion, CCL3 is a small cytokine that plays a crucial role in the regulation of immune responses, inflammation, and cell migration. Its dysregulation has been implicated in various diseases, including autoimmune disorders, cancer, and cardiovascular diseases. Further research is needed to fully understand the role of CCL3 in human health and disease.

Genular Protein ID: 1035102067

Symbol: CCL3_HUMAN

Name: C-C motif chemokine 3

UniProtKB Accession Codes:

P10147

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 63 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 3086300

Title: A cDNA clone used to study mRNA inducible in human tonsillar lymphocytes by a tumor promoter.

PubMed ID: 3086300

DOI: 10.1093/oxfordjournals.jbchem.a135549

PubMed ID: 2521882

Title: Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors.

PubMed ID: 2521882

PubMed ID: 2271120

Title: Three human homologs of a murine gene encoding an inhibitor of stem cell proliferation.

PubMed ID: 2271120

DOI: 10.1089/dna.1990.9.589

PubMed ID: 1694014

Title: Structures of human genes coding for cytokine LD78 and their expression.

PubMed ID: 1694014

DOI: 10.1128/mcb.10.7.3646-3658.1990

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8541527

Title: BB-10010: an active variant of human macrophage inflammatory protein-1 alpha with improved pharmaceutical properties.

PubMed ID: 8541527

PubMed ID: 8525373

Title: Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells.

PubMed ID: 8525373

DOI: 10.1126/science.270.5243.1811

PubMed ID: 7537510

Title: Identification of MIP-1 alpha/LD78 as a monocyte chemoattractant released by the HTLV-I-transformed cell line MT4.

PubMed ID: 7537510

DOI: 10.1089/aid.1995.11.155

PubMed ID: 9092555

Title: Identification of a glycosaminoglycan-binding site in chemokine macrophage inflammatory protein-1alpha.

PubMed ID: 9092555

DOI: 10.1074/jbc.272.15.10103

PubMed ID: 12070155

Title: Natural truncation of the chemokine MIP-1beta/CCL4 affects receptor specificity but not anti-HIV-1 activity.

PubMed ID: 12070155

DOI: 10.1074/jbc.m203077200

PubMed ID: 12401480

Title: Macrophage inflammatory protein-1.

PubMed ID: 12401480

DOI: 10.1016/s1359-6101(02)00045-x

PubMed ID: 15905581

Title: Proteolytic activation of alternative CCR1 ligands in inflammation.

PubMed ID: 15905581

DOI: 10.4049/jimmunol.174.11.7341

PubMed ID: 10347159

Title: Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants.

PubMed ID: 10347159

DOI: 10.1074/jbc.274.23.16077

PubMed ID: 20041127

Title: Structural basis of chemokine sequestration by a tick chemokine binding protein: the crystal structure of the complex between Evasin-1 and CCL3.

PubMed ID: 20041127

DOI: 10.1371/journal.pone.0008514

Sequence Information:

  • Length: 92
  • Mass: 10085
  • Checksum: 517865D5D6776CA8
  • Sequence:
    • MQVSTAALAV LLCTMALCNQ FSASLAADTP TACCFSYTSR QIPQNFIADY FETSSQCSKP 
GVIFLTKRSR QVCADPSEEW VQKYVSDLEL SA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.