Details for: ARL14EPL

Gene ID: 644100

Symbol: ARL14EPL

Ensembl ID: ENSG00000268223

Description: ARF like GTPase 14 effector protein like

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 5.3604
    Cell Significance Index: 24.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0247
    Cell Significance Index: 13.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8602
    Cell Significance Index: 170.7000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.7669
    Cell Significance Index: 9.6900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.4076
    Cell Significance Index: 5.1200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.3436
    Cell Significance Index: 4.4300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0543
    Cell Significance Index: 1.0600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0532
    Cell Significance Index: 0.6700
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0488
    Cell Significance Index: 0.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0240
    Cell Significance Index: 0.6400
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.0178
    Cell Significance Index: 0.1700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0123
    Cell Significance Index: 0.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0112
    Cell Significance Index: 7.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0071
    Cell Significance Index: 0.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0054
    Cell Significance Index: 1.0800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0046
    Cell Significance Index: 0.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0036
    Cell Significance Index: 1.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0031
    Cell Significance Index: 4.7600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0029
    Cell Significance Index: 5.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0018
    Cell Significance Index: 3.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0013
    Cell Significance Index: 0.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0012
    Cell Significance Index: 0.1800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0005
    Cell Significance Index: 0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0004
    Cell Significance Index: 0.5900
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0005
    Cell Significance Index: -0.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0020
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0022
    Cell Significance Index: -0.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0024
    Cell Significance Index: -1.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0026
    Cell Significance Index: -0.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0029
    Cell Significance Index: -1.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0058
    Cell Significance Index: -0.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0068
    Cell Significance Index: -1.2200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0080
    Cell Significance Index: -0.0500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0085
    Cell Significance Index: -0.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0092
    Cell Significance Index: -1.2700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0094
    Cell Significance Index: -0.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0111
    Cell Significance Index: -1.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0120
    Cell Significance Index: -1.3700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0126
    Cell Significance Index: -0.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0128
    Cell Significance Index: -1.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0168
    Cell Significance Index: -1.0300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0206
    Cell Significance Index: -0.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0228
    Cell Significance Index: -1.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0231
    Cell Significance Index: -1.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0233
    Cell Significance Index: -0.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0265
    Cell Significance Index: -0.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0272
    Cell Significance Index: -1.0300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0287
    Cell Significance Index: -0.9400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0294
    Cell Significance Index: -0.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0297
    Cell Significance Index: -1.6700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0304
    Cell Significance Index: -1.0700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0324
    Cell Significance Index: -0.9300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0324
    Cell Significance Index: -1.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0326
    Cell Significance Index: -1.5300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0328
    Cell Significance Index: -0.4900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0359
    Cell Significance Index: -0.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0363
    Cell Significance Index: -0.7600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0364
    Cell Significance Index: -0.5900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0393
    Cell Significance Index: -0.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0421
    Cell Significance Index: -1.4800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0437
    Cell Significance Index: -1.6100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0444
    Cell Significance Index: -0.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0453
    Cell Significance Index: -1.3100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0463
    Cell Significance Index: -0.6300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0470
    Cell Significance Index: -0.9300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0483
    Cell Significance Index: -0.9700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0485
    Cell Significance Index: -1.0300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0488
    Cell Significance Index: -1.0600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0495
    Cell Significance Index: -0.8500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0502
    Cell Significance Index: -1.2800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0521
    Cell Significance Index: -0.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0536
    Cell Significance Index: -1.4400
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0546
    Cell Significance Index: -0.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0562
    Cell Significance Index: -1.6100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0576
    Cell Significance Index: -0.7900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0581
    Cell Significance Index: -0.6900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0594
    Cell Significance Index: -1.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0596
    Cell Significance Index: -1.7600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0602
    Cell Significance Index: -1.2000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0604
    Cell Significance Index: -1.1800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0605
    Cell Significance Index: -1.4500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0606
    Cell Significance Index: -0.6100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0607
    Cell Significance Index: -1.4800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0615
    Cell Significance Index: -1.2100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0620
    Cell Significance Index: -0.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0621
    Cell Significance Index: -1.6900
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0624
    Cell Significance Index: -0.3300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0626
    Cell Significance Index: -0.7400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0630
    Cell Significance Index: -0.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0660
    Cell Significance Index: -1.3700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0675
    Cell Significance Index: -0.6400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0688
    Cell Significance Index: -1.1900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0703
    Cell Significance Index: -0.8200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0709
    Cell Significance Index: -1.0600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0723
    Cell Significance Index: -1.1600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0727
    Cell Significance Index: -1.7600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0756
    Cell Significance Index: -0.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular expression:** ARL14EPL is widely expressed in various cell types, including stem cells, progenitor cells, and neurons, highlighting its potential role in tissue development and homeostasis. 2. **GTPase effector protein:** The ARL14EPL protein is thought to interact with ARF GTPases, modulating their activity and influencing downstream signaling pathways. 3. **Regulation of cell proliferation and differentiation:** ARL14EPL may play a role in regulating cell cycle progression, differentiation, and survival in various cell types. 4. **Implications in disease:** Abnormal expression of ARL14EPL has been linked to several diseases, including cancer, neurological disorders, and gastrointestinal conditions. **Pathways and Functions:** 1. **Cell cycle regulation:** ARL14EPL may modulate the cell cycle by interacting with ARF GTPases and influencing the activity of key cell cycle regulators. 2. **Differentiation and survival:** The protein may play a role in regulating the differentiation and survival of various cell types, including stem cells and progenitor cells. 3. **Signaling pathways:** ARL14EPL may interact with multiple signaling pathways, including those involved in cellular homeostasis, stress response, and inflammation. 4. **GABAergic neurotransmission:** The protein's expression in GABAergic interneurons suggests its potential role in regulating neurotransmission and neuronal function. **Clinical Significance:** 1. **Cancer:** Abnormal expression of ARL14EPL has been linked to various types of cancer, including colorectal cancer, suggesting its potential as a diagnostic or therapeutic target. 2. **Neurological disorders:** The protein's expression in GABAergic interneurons may contribute to the pathogenesis of neurological disorders, such as epilepsy and schizophrenia. 3. **Gastrointestinal diseases:** ARL14EPL's expression in intestinal epithelial cells and goblet cells may play a role in maintaining intestinal homeostasis and preventing diseases such as inflammatory bowel disease. 4. **Stem cell biology:** The protein's role in regulating stem cell proliferation and differentiation may have implications for regenerative medicine and tissue engineering. In conclusion, the ARL14EPL gene is a multifunctional protein with far-reaching implications in cellular homeostasis and disease. Further research is needed to fully elucidate the protein's functions and its role in human disease.

Genular Protein ID: 1608813030

Symbol: A14EL_HUMAN

Name: ARL14 effector protein-like

UniProtKB Accession Codes:

P0DKL9

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 1 Ensembl 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

Sequence Information:

  • Length: 152
  • Mass: 17712
  • Checksum: 3B63487B4316267E
  • Sequence:
    • MNEQSEKNNS IQERHTDHSF PEKNCQIGQK QLQQIERQLK CLAFRNPGPQ VADFNPETRQ 
QKKKARMSKM NEYFSTKYKI MRKYDKSGRL ICNDADLCDC LEKNCLGCFY PCPKCNSNKC 
GPECRCNRRW VYDAIVTESG EVISTLPFNV PD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.