Details for: SLC1A1

Gene ID: 6505

Symbol: SLC1A1

Ensembl ID: ENSG00000106688

Description: solute carrier family 1 member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 55.1621
    Cell Significance Index: -22.4100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.4618
    Cell Significance Index: -22.4000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.6534
    Cell Significance Index: -25.8600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.8390
    Cell Significance Index: -19.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.0824
    Cell Significance Index: 586.6000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.0220
    Cell Significance Index: 34.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.8439
    Cell Significance Index: 40.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7645
    Cell Significance Index: 353.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5373
    Cell Significance Index: 152.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.4603
    Cell Significance Index: 98.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4361
    Cell Significance Index: 515.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.3162
    Cell Significance Index: 58.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.2401
    Cell Significance Index: 46.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.2157
    Cell Significance Index: 74.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1257
    Cell Significance Index: 67.5800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.0239
    Cell Significance Index: 15.4300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0108
    Cell Significance Index: 109.9400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.9847
    Cell Significance Index: 28.1000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.9052
    Cell Significance Index: 21.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8476
    Cell Significance Index: 137.8600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7984
    Cell Significance Index: 552.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7561
    Cell Significance Index: 16.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6719
    Cell Significance Index: 606.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6068
    Cell Significance Index: 41.9700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5214
    Cell Significance Index: 12.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.4463
    Cell Significance Index: 64.8800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3873
    Cell Significance Index: 5.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3739
    Cell Significance Index: 204.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3040
    Cell Significance Index: 7.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1458
    Cell Significance Index: 16.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0995
    Cell Significance Index: 2.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0720
    Cell Significance Index: 3.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0547
    Cell Significance Index: 1.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0430
    Cell Significance Index: 1.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0381
    Cell Significance Index: 24.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0381
    Cell Significance Index: 7.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0363
    Cell Significance Index: 67.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0233
    Cell Significance Index: 35.9100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0097
    Cell Significance Index: 0.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0023
    Cell Significance Index: -3.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0029
    Cell Significance Index: -5.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0063
    Cell Significance Index: -1.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0101
    Cell Significance Index: -1.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0107
    Cell Significance Index: -7.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0131
    Cell Significance Index: -8.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0146
    Cell Significance Index: -6.6300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0169
    Cell Significance Index: -0.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0212
    Cell Significance Index: -11.9600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0224
    Cell Significance Index: -0.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0232
    Cell Significance Index: -16.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0292
    Cell Significance Index: -3.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0320
    Cell Significance Index: -24.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0390
    Cell Significance Index: -17.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0691
    Cell Significance Index: -11.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0699
    Cell Significance Index: -20.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0709
    Cell Significance Index: -14.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0791
    Cell Significance Index: -10.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0957
    Cell Significance Index: -11.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1693
    Cell Significance Index: -10.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1729
    Cell Significance Index: -8.9800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1789
    Cell Significance Index: -2.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1798
    Cell Significance Index: -18.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1884
    Cell Significance Index: -24.3400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1933
    Cell Significance Index: -3.8800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1975
    Cell Significance Index: -22.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2212
    Cell Significance Index: -23.0300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2217
    Cell Significance Index: -7.2600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2245
    Cell Significance Index: -4.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2355
    Cell Significance Index: -7.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2477
    Cell Significance Index: -19.0100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2513
    Cell Significance Index: -5.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2780
    Cell Significance Index: -12.9600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2836
    Cell Significance Index: -6.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2892
    Cell Significance Index: -22.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2894
    Cell Significance Index: -16.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3030
    Cell Significance Index: -21.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3181
    Cell Significance Index: -23.7100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3257
    Cell Significance Index: -4.0400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3425
    Cell Significance Index: -4.9100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.3514
    Cell Significance Index: -3.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3696
    Cell Significance Index: -10.3300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3874
    Cell Significance Index: -13.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4003
    Cell Significance Index: -25.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4042
    Cell Significance Index: -21.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4275
    Cell Significance Index: -22.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4345
    Cell Significance Index: -13.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4400
    Cell Significance Index: -20.6800
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.4559
    Cell Significance Index: -3.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4626
    Cell Significance Index: -11.5400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4810
    Cell Significance Index: -5.2400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5088
    Cell Significance Index: -10.6200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.5211
    Cell Significance Index: -22.6600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.5255
    Cell Significance Index: -7.0100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5707
    Cell Significance Index: -5.4100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5712
    Cell Significance Index: -20.9700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.5784
    Cell Significance Index: -11.3900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.5845
    Cell Significance Index: -6.2100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.6169
    Cell Significance Index: -5.8700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6488
    Cell Significance Index: -8.0900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.6605
    Cell Significance Index: -20.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The SLC1A1 gene is a member of the solute carrier family 1 (SLC1) and is primarily expressed in the central nervous system (CNS), particularly in neurons and glial cells. The EAAT1 protein is a high-affinity glutamate transporter that facilitates the uptake of glutamate and aspartate across the plasma membrane. This transporter is essential for regulating glutamate levels, which is critical for neuronal function and synaptic transmission. **Pathways and Functions** The SLC1A1 gene is involved in various cellular processes, including: 1. **Glutamate homeostasis**: EAAT1 regulates glutamate levels by removing excess glutamate from the synaptic cleft, thereby modulating neurotransmitter release and synaptic transmission. 2. **Neurotransmitter release cycle**: EAAT1 plays a crucial role in the regulation of neurotransmitter release by controlling the availability of glutamate and aspartate. 3. **Synaptic transmission**: EAAT1 modulates synaptic transmission by regulating the uptake of glutamate and aspartate, which affects the strength and plasticity of synaptic connections. 4. **Neuroprotection**: EAAT1 has been shown to have neuroprotective effects by removing excess glutamate from the synaptic cleft, thereby reducing excitotoxicity and neurodegeneration. 5. **Blood-brain barrier maintenance**: EAAT1 is also involved in maintaining the blood-brain barrier by regulating the transport of glutamate and other small molecules across the barrier. **Clinical Significance** Mutations in the SLC1A1 gene have been implicated in various neurological disorders, including: 1. **Schizophrenia**: Defective EAAT1 has been linked to schizophrenia, a complex psychiatric disorder characterized by cognitive, emotional, and behavioral abnormalities. 2. **Dicarboxylic aminoaciduria**: Mutations in the SLC1A1 gene have also been associated with dicarboxylic aminoaciduria, a rare genetic disorder characterized by the accumulation of dicarboxylic amino acids in the urine. 3. **Neurodevelopmental disorders**: EAAT1 has also been implicated in neurodevelopmental disorders, such as autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD). In conclusion, the SLC1A1 gene plays a critical role in regulating glutamate homeostasis, neurotransmitter release, and synaptic transmission. Mutations in this gene have been implicated in various neurological disorders, highlighting the importance of EAAT1 in maintaining neuronal function and synaptic plasticity. As an expert immunologist, I emphasize the need for further research to elucidate the mechanisms underlying EAAT1 dysfunction and its role in neurological disorders.

Genular Protein ID: 1816760557

Symbol: EAA3_HUMAN

Name: Excitatory amino-acid carrier 1

UniProtKB Accession Codes:

P43005 O75587 Q5VZ24 Q8N199 Q9UEW2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 31 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 18 EMDB 14 Ensembl 1 ExpressionAtlas 1 GO 97 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 3 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7859077

Title: Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain.

PubMed ID: 7859077

DOI: 10.1016/0006-8993(94)90819-2

PubMed ID: 7914198

Title: The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport.

PubMed ID: 7914198

DOI: 10.1016/s0021-9258(17)32035-5

PubMed ID: 7521911

Title: Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex.

PubMed ID: 7521911

DOI: 10.1523/jneurosci.14-09-05559.1994

PubMed ID: 11317217

Title: Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder.

PubMed ID: 11317217

DOI: 10.1038/sj.mp.4000806

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8857541

Title: Flux coupling in a neuronal glutamate transporter.

PubMed ID: 8857541

DOI: 10.1038/383634a0

PubMed ID: 26690923

Title: Caveolin-1 Sensitivity of Excitatory Amino Acid Transporters EAAT1, EAAT2, EAAT3, and EAAT4.

PubMed ID: 26690923

DOI: 10.1007/s00232-015-9863-0

PubMed ID: 33658209

Title: Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport.

PubMed ID: 33658209

DOI: 10.1126/sciadv.abf5814

PubMed ID: 21982423

Title: Copy number variants for schizophrenia and related psychotic disorders in Oceanic Palau: risk and transmission in extended pedigrees.

PubMed ID: 21982423

DOI: 10.1016/j.biopsych.2011.08.009

PubMed ID: 23341099

Title: Deletion at the SLC1A1 glutamate transporter gene co-segregates with schizophrenia and bipolar schizoaffective disorder in a 5-generation family.

PubMed ID: 23341099

DOI: 10.1002/ajmg.b.32125

PubMed ID: 21123949

Title: Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria.

PubMed ID: 21123949

DOI: 10.1172/jci44474

Sequence Information:

  • Length: 524
  • Mass: 57100
  • Checksum: FC6244ADC9EA228F
  • Sequence:
    • MGKPARKGCE WKRFLKNNWV LLSTVAAVVL GITTGVLVRE HSNLSTLEKF YFAFPGEILM 
RMLKLIILPL IISSMITGVA ALDSNVSGKI GLRAVVYYFC TTLIAVILGI VLVVSIKPGV 
TQKVGEIART GSTPEVSTVD AMLDLIRNMF PENLVQACFQ QYKTKREEVK PPSDPEMNMT 
EESFTAVMTT AISKNKTKEY KIVGMYSDGI NVLGLIVFCL VFGLVIGKMG EKGQILVDFF 
NALSDATMKI VQIIMCYMPL GILFLIAGKI IEVEDWEIFR KLGLYMATVL TGLAIHSIVI 
LPLIYFIVVR KNPFRFAMGM AQALLTALMI SSSSATLPVT FRCAEENNQV DKRITRFVLP 
VGATINMDGT ALYEAVAAVF IAQLNDLDLG IGQIITISIT ATSASIGAAG VPQAGLVTMV 
IVLSAVGLPA EDVTLIIAVD WLLDRFRTMV NVLGDAFGTG IVEKLSKKEL EQMDVSSEVN 
IVNPFALEST ILDNEDSDTK KSYVNGGFAV DKSDTISFTQ TSQF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.