Details for: SLC5A5

Gene ID: 6528

Symbol: SLC5A5

Ensembl ID: ENSG00000105641

Description: solute carrier family 5 member 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 6.3869
    Cell Significance Index: -1.6200
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 5.9108
    Cell Significance Index: 32.9000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.9544
    Cell Significance Index: 20.4000
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.4296
    Cell Significance Index: 3.7800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.3673
    Cell Significance Index: 7.6600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.3614
    Cell Significance Index: 2.2300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3106
    Cell Significance Index: 2.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.2294
    Cell Significance Index: 33.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2147
    Cell Significance Index: 3.6800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.2109
    Cell Significance Index: 2.6700
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.1326
    Cell Significance Index: 0.5700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.1228
    Cell Significance Index: 1.3100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1081
    Cell Significance Index: 1.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0994
    Cell Significance Index: 11.5800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0728
    Cell Significance Index: 1.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0723
    Cell Significance Index: 13.0300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.0446
    Cell Significance Index: 0.4600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0438
    Cell Significance Index: 0.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0239
    Cell Significance Index: 0.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0150
    Cell Significance Index: 3.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0135
    Cell Significance Index: 8.5700
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.0108
    Cell Significance Index: 0.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0094
    Cell Significance Index: 1.8600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0061
    Cell Significance Index: 0.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0046
    Cell Significance Index: 0.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0033
    Cell Significance Index: 6.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0031
    Cell Significance Index: 1.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0027
    Cell Significance Index: 4.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0019
    Cell Significance Index: 2.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0005
    Cell Significance Index: 0.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0012
    Cell Significance Index: -0.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0015
    Cell Significance Index: -0.4300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0018
    Cell Significance Index: -1.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0020
    Cell Significance Index: -1.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0025
    Cell Significance Index: -1.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0028
    Cell Significance Index: -1.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0030
    Cell Significance Index: -1.6800
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0053
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0067
    Cell Significance Index: -1.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0070
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0090
    Cell Significance Index: -1.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0096
    Cell Significance Index: -0.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0107
    Cell Significance Index: -1.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0110
    Cell Significance Index: -0.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0110
    Cell Significance Index: -0.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0114
    Cell Significance Index: -0.4300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0122
    Cell Significance Index: -0.1600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0127
    Cell Significance Index: -0.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0128
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0129
    Cell Significance Index: -1.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0130
    Cell Significance Index: -1.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0130
    Cell Significance Index: -1.0000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0135
    Cell Significance Index: -0.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0140
    Cell Significance Index: -0.6600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0146
    Cell Significance Index: -0.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0147
    Cell Significance Index: -0.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0150
    Cell Significance Index: -0.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0153
    Cell Significance Index: -1.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0154
    Cell Significance Index: -1.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0164
    Cell Significance Index: -1.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0165
    Cell Significance Index: -0.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0176
    Cell Significance Index: -0.4900
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0177
    Cell Significance Index: -0.1900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0181
    Cell Significance Index: -0.2100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0183
    Cell Significance Index: -0.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0183
    Cell Significance Index: -0.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0185
    Cell Significance Index: -1.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0282
    Cell Significance Index: -1.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0295
    Cell Significance Index: -1.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0305
    Cell Significance Index: -0.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0310
    Cell Significance Index: -0.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0321
    Cell Significance Index: -1.6700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0337
    Cell Significance Index: -1.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0339
    Cell Significance Index: -0.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0351
    Cell Significance Index: -1.1500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0386
    Cell Significance Index: -0.6500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0389
    Cell Significance Index: -0.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0407
    Cell Significance Index: -1.4300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0408
    Cell Significance Index: -1.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0411
    Cell Significance Index: -1.5100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0425
    Cell Significance Index: -1.0600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0445
    Cell Significance Index: -0.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0455
    Cell Significance Index: -1.5800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0471
    Cell Significance Index: -1.4900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0482
    Cell Significance Index: -0.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0487
    Cell Significance Index: -0.9500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0493
    Cell Significance Index: -0.5100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0498
    Cell Significance Index: -1.0000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0502
    Cell Significance Index: -1.0900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0506
    Cell Significance Index: -0.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0509
    Cell Significance Index: -1.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0533
    Cell Significance Index: -1.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0550
    Cell Significance Index: -1.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0565
    Cell Significance Index: -1.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0573
    Cell Significance Index: -1.5600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0585
    Cell Significance Index: -1.2200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0589
    Cell Significance Index: -0.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0594
    Cell Significance Index: -1.7100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0595
    Cell Significance Index: -1.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transmembrane Protein**: SLC5A5 is a type II transmembrane protein, consisting of two extracellular domains and 10 transmembrane domains. 2. **Iodide Uptake**: SLC5A5 mediates the uptake of iodide into thyroid follicular cells, a critical step in thyroid hormone synthesis. 3. **Thyroid Hormone Regulation**: SLC5A5 is regulated by thyroid-stimulating hormone (TSH), with its expression and activity influenced by TSH receptor signaling pathways. 4. **Cellular Localization**: SLC5A5 is primarily expressed in thyroid follicular cells, but its expression is also detected in other cell types, including cerebral cortex GABAergic interneurons and intestinal crypt stem cells. **Pathways and Functions** 1. **Cellular Response to Thyroid Stimulating Hormone (TSH)**: SLC5A5 expression is regulated by TSH signaling pathways, which involve the activation of G-protein coupled receptors and the subsequent phosphorylation of SLC5A5. 2. **Iodide Transport**: SLC5A5 mediates the uptake of iodide into thyroid follicular cells, where it is converted into iodine, a necessary component of thyroid hormones. 3. **Thyroid Hormone Synthesis**: SLC5A5 plays a critical role in thyroid hormone synthesis, with its activity required for the production of triiodothyronine (T3) and thyroxine (T4). 4. **Regulation of Thyroid Hormone Release**: SLC5A5 also regulates the release of thyroid hormones into the bloodstream, with its activity influenced by feedback mechanisms involving TSH and thyroid hormones. **Clinical Significance** 1. **Thyroid Dyshormonogenesis 1 (TDH1)**: Defects in SLC5A5 have been linked to TDH1, a rare genetic disorder characterized by impaired thyroid hormone synthesis and hypothyroidism. 2. **Thyroid Disorders**: Abnormalities in SLC5A5 expression and function have been implicated in various thyroid disorders, including goiter, hypothyroidism, and hyperthyroidism. 3. **Cancer Treatment**: SLC5A5 has been identified as a potential target for cancer therapy, with its inhibition shown to inhibit the growth of thyroid cancer cells. 4. **Neurological Disorders**: Abnormalities in SLC5A5 expression have been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, SLC5A5 plays a critical role in thyroid hormone regulation and transport, with its defects linked to thyroid dyshormonogenesis 1 and various thyroid disorders. Further research into the mechanisms of SLC5A5 function and regulation is essential for the development of novel therapeutic strategies for thyroid disorders and cancer treatment.

Genular Protein ID: 1706231399

Symbol: SC5A5_HUMAN

Name: Sodium/iodide cotransporter

UniProtKB Accession Codes:

Q92911 O43702 Q2M335 Q9NYB6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 10 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 6 Ensembl 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 5 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8806637

Title: Cloning of the human sodium iodide symporter.

PubMed ID: 8806637

DOI: 10.1006/bbrc.1996.1358

PubMed ID: 9329364

Title: Increased expression of the Na+/I- symporter in cultured human thyroid cells exposed to thyrotropin and in Graves' thyroid tissue.

PubMed ID: 9329364

DOI: 10.1210/jcem.82.10.4269

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20797386

Title: Characterisation of the purified human sodium/iodide symporter reveals that the protein is mainly present in a dimeric form and permits the detailed study of a native C-terminal fragment.

PubMed ID: 20797386

DOI: 10.1016/j.bbamem.2010.08.013

PubMed ID: 12488351

Title: Anion selectivity by the sodium iodide symporter.

PubMed ID: 12488351

DOI: 10.1210/en.2002-220744

PubMed ID: 18372236

Title: Comparison of expressed human and mouse sodium/iodide symporters reveals differences in transport properties and subcellular localization.

PubMed ID: 18372236

DOI: 10.1677/joe-07-0455

PubMed ID: 18708479

Title: Histidine residue at position 226 is critical for iodide uptake activity of human sodium/iodide symporter.

PubMed ID: 18708479

DOI: 10.1677/joe-08-0249

PubMed ID: 31310151

Title: Dimerization of the Sodium/Iodide Symporter.

PubMed ID: 31310151

DOI: 10.1089/thy.2019.0034

PubMed ID: 32084174

Title: Inter-species variation in monovalent anion substrate selectivity and inhibitor sensitivity in the sodium iodide symporter (NIS).

PubMed ID: 32084174

DOI: 10.1371/journal.pone.0229085

PubMed ID: 9171822

Title: Congenital hypothyroidism caused by a mutation in the Na(+)/I(-) symporter.

PubMed ID: 9171822

DOI: 10.1038/ng0697-124

PubMed ID: 9745458

Title: Novel, missense and loss-of-function mutations in the sodium/iodide symporter gene causing iodide transport defect in three Japanese patients.

PubMed ID: 9745458

DOI: 10.1210/jcem.83.9.5245

PubMed ID: 9486973

Title: Congenital hypothyroidism due to mutations in the sodium/iodide symporter: identification of a nonsense mutation producing a downstream cryptic 3' splice site.

PubMed ID: 9486973

DOI: 10.1172/jci1504

PubMed ID: 10487695

Title: A novel mutation in the sodium/iodide symporter gene in the largest family with iodide transport defect.

PubMed ID: 10487695

DOI: 10.1210/jcem.84.9.5971

Sequence Information:

  • Length: 643
  • Mass: 68666
  • Checksum: 02D361A27B2FDA43
  • Sequence:
    • MEAVETGERP TFGAWDYGVF ALMLLVSTGI GLWVGLARGG QRSAEDFFTG GRRLAALPVG 
LSLSASFMSA VQVLGVPSEA YRYGLKFLWM CLGQLLNSVL TALLFMPVFY RLGLTSTYEY 
LEMRFSRAVR LCGTLQYIVA TMLYTGIVIY APALILNQVT GLDIWASLLS TGIICTFYTA 
VGGMKAVVWT DVFQVVVMLS GFWVVLARGV MLVGGPRQVL TLAQNHSRIN LMDFNPDPRS 
RYTFWTFVVG GTLVWLSMYG VNQAQVQRYV ACRTEKQAKL ALLINQVGLF LIVSSAACCG 
IVMFVFYTDC DPLLLGRISA PDQYMPLLVL DIFEDLPGVP GLFLACAYSG TLSTASTSIN 
AMAAVTVEDL IKPRLRSLAP RKLVIISKGL SLIYGSACLT VAALSSLLGG GVLQGSFTVM 
GVISGPLLGA FILGMFLPAC NTPGVLAGLG AGLALSLWVA LGATLYPPSE QTMRVLPSSA 
ARCVALSVNA SGLLDPALLP ANDSSRAPSS GMDASRPALA DSFYAISYLY YGALGTLTTV 
LCGALISCLT GPTKRSTLAP GLLWWDLARQ TASVAPKEEV AILDDNLVKG PEELPTGNKK 
PPGFLPTNED RLFFLGQKEL EGAGSWTPCV GHDGGRDQQE TNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.