Details for: SLC5A5

Gene ID: 6528

Symbol: SLC5A5

Ensembl ID: ENSG00000105641

Description: solute carrier family 5 member 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.97
    Marker Score: 1985
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170146
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.39
    Marker Score: 8845
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.04
    Marker Score: 264
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.01
    Marker Score: 2570
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 505
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.67
    Marker Score: 1277
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.64
    Marker Score: 491
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 237
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.51
    Marker Score: 146
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 474
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.49
    Marker Score: 990
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.47
    Marker Score: 125
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.46
    Marker Score: 7131
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.44
    Marker Score: 901
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.43
    Marker Score: 194
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.43
    Marker Score: 259
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.39
    Marker Score: 193
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.31
    Marker Score: 367
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.3
    Marker Score: 519
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.29
    Marker Score: 287
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.25
    Marker Score: 121
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.25
    Marker Score: 166
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.23
    Marker Score: 222
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.23
    Marker Score: 121
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.22
    Marker Score: 276
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.21
    Marker Score: 65
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.2
    Marker Score: 125
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.19
    Marker Score: 57
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.19
    Marker Score: 532
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.18
    Marker Score: 125
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.17
    Marker Score: 54
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.16
    Marker Score: 56
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.16
    Marker Score: 86
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.16
    Marker Score: 97
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.16
    Marker Score: 222
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.16
    Marker Score: 92
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.16
    Marker Score: 1347.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.16
    Marker Score: 70
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.14
    Marker Score: 124
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.14
    Marker Score: 49
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.14
    Marker Score: 55
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.13
    Marker Score: 121
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.13
    Marker Score: 122
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.13
    Marker Score: 146
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.13
    Marker Score: 38
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.13
    Marker Score: 168
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.13
    Marker Score: 54
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.13
    Marker Score: 62
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.12
    Marker Score: 108
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.11
    Marker Score: 319
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.11
    Marker Score: 55
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.11
    Marker Score: 1418
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.1
    Marker Score: 68
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.1
    Marker Score: 153
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.1
    Marker Score: 276
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.1
    Marker Score: 47
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.1
    Marker Score: 33
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.09
    Marker Score: 70
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.09
    Marker Score: 74
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.09
    Marker Score: 4709
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.09
    Marker Score: 51
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.09
    Marker Score: 518
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.08
    Marker Score: 92
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.08
    Marker Score: 142
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.08
    Marker Score: 192
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.08
    Marker Score: 245
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.08
    Marker Score: 45
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.08
    Marker Score: 49.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.07
    Marker Score: 311
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.07
    Marker Score: 165
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.07
    Marker Score: 116
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.07
    Marker Score: 129
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.07
    Marker Score: 242
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.07
    Marker Score: 84
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.07
    Marker Score: 65
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.07
    Marker Score: 41
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.07
    Marker Score: 46
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.06
    Marker Score: 32

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Other Information

**Key characteristics:** * SLC5A5 is a sodium/iodide cotransporter, which means that it actively transports sodium and iodide ions across a lipid bilayer. * It is expressed in high levels in the heart, skeletal muscle, and central nervous system. * It is also expressed in lower levels in the kidneys, liver, and pancreas. * Mutations in the SLC5A5 gene have been linked to several human diseases, including thyroid dyshormonogenesis 1 (tdh1). **Pathways and functions:** * SLC5A5 is involved in a variety of cellular processes, including: * Thyroid hormone transport * Sodium-dependent potassium pump regulation * Calcium transport * Fluid and electrolyte balance * Immune response **Clinical significance:** * Mutations in the SLC5A5 gene have been linked to several human diseases, including: * Thyroid dyshormonogenesis 1 (tdh1) * Congenital hypothyroidism * Addison's disease * Diabetes insipidus * Hypokalemia **Additional notes:** * SLC5A5 is a highly conserved protein, with a similar gene product found in other mammals. * The SLC5A5 gene is located on chromosome 15q21.1. * It is a single-exon gene, with a size of approximately 2.5 kb.

Genular Protein ID: 1706231399

Symbol: SC5A5_HUMAN

Name: Sodium/iodide cotransporter

UniProtKB Accession Codes:

Q92911 O43702 Q2M335 Q9NYB6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 10 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 6 Ensembl 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 5 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8806637

Title: Cloning of the human sodium iodide symporter.

PubMed ID: 8806637

DOI: 10.1006/bbrc.1996.1358

PubMed ID: 9329364

Title: Increased expression of the Na+/I- symporter in cultured human thyroid cells exposed to thyrotropin and in Graves' thyroid tissue.

PubMed ID: 9329364

DOI: 10.1210/jcem.82.10.4269

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20797386

Title: Characterisation of the purified human sodium/iodide symporter reveals that the protein is mainly present in a dimeric form and permits the detailed study of a native C-terminal fragment.

PubMed ID: 20797386

DOI: 10.1016/j.bbamem.2010.08.013

PubMed ID: 12488351

Title: Anion selectivity by the sodium iodide symporter.

PubMed ID: 12488351

DOI: 10.1210/en.2002-220744

PubMed ID: 18372236

Title: Comparison of expressed human and mouse sodium/iodide symporters reveals differences in transport properties and subcellular localization.

PubMed ID: 18372236

DOI: 10.1677/joe-07-0455

PubMed ID: 18708479

Title: Histidine residue at position 226 is critical for iodide uptake activity of human sodium/iodide symporter.

PubMed ID: 18708479

DOI: 10.1677/joe-08-0249

PubMed ID: 31310151

Title: Dimerization of the Sodium/Iodide Symporter.

PubMed ID: 31310151

DOI: 10.1089/thy.2019.0034

PubMed ID: 32084174

Title: Inter-species variation in monovalent anion substrate selectivity and inhibitor sensitivity in the sodium iodide symporter (NIS).

PubMed ID: 32084174

DOI: 10.1371/journal.pone.0229085

PubMed ID: 9171822

Title: Congenital hypothyroidism caused by a mutation in the Na(+)/I(-) symporter.

PubMed ID: 9171822

DOI: 10.1038/ng0697-124

PubMed ID: 9745458

Title: Novel, missense and loss-of-function mutations in the sodium/iodide symporter gene causing iodide transport defect in three Japanese patients.

PubMed ID: 9745458

DOI: 10.1210/jcem.83.9.5245

PubMed ID: 9486973

Title: Congenital hypothyroidism due to mutations in the sodium/iodide symporter: identification of a nonsense mutation producing a downstream cryptic 3' splice site.

PubMed ID: 9486973

DOI: 10.1172/jci1504

PubMed ID: 10487695

Title: A novel mutation in the sodium/iodide symporter gene in the largest family with iodide transport defect.

PubMed ID: 10487695

DOI: 10.1210/jcem.84.9.5971

Sequence Information:

  • Length: 643
  • Mass: 68666
  • Checksum: 02D361A27B2FDA43
  • Sequence:
    • MEAVETGERP TFGAWDYGVF ALMLLVSTGI GLWVGLARGG QRSAEDFFTG GRRLAALPVG 
LSLSASFMSA VQVLGVPSEA YRYGLKFLWM CLGQLLNSVL TALLFMPVFY RLGLTSTYEY 
LEMRFSRAVR LCGTLQYIVA TMLYTGIVIY APALILNQVT GLDIWASLLS TGIICTFYTA 
VGGMKAVVWT DVFQVVVMLS GFWVVLARGV MLVGGPRQVL TLAQNHSRIN LMDFNPDPRS 
RYTFWTFVVG GTLVWLSMYG VNQAQVQRYV ACRTEKQAKL ALLINQVGLF LIVSSAACCG 
IVMFVFYTDC DPLLLGRISA PDQYMPLLVL DIFEDLPGVP GLFLACAYSG TLSTASTSIN 
AMAAVTVEDL IKPRLRSLAP RKLVIISKGL SLIYGSACLT VAALSSLLGG GVLQGSFTVM 
GVISGPLLGA FILGMFLPAC NTPGVLAGLG AGLALSLWVA LGATLYPPSE QTMRVLPSSA 
ARCVALSVNA SGLLDPALLP ANDSSRAPSS GMDASRPALA DSFYAISYLY YGALGTLTTV 
LCGALISCLT GPTKRSTLAP GLLWWDLARQ TASVAPKEEV AILDDNLVKG PEELPTGNKK 
PPGFLPTNED RLFFLGQKEL EGAGSWTPCV GHDGGRDQQE TNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.