Details for: SLC15A2

Gene ID: 6565

Symbol: SLC15A2

Ensembl ID: ENSG00000163406

Description: solute carrier family 15 member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 82.4519
    Cell Significance Index: -12.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 48.2567
    Cell Significance Index: -12.2400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.5947
    Cell Significance Index: -11.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.4221
    Cell Significance Index: -12.8500
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.8259
    Cell Significance Index: 29.1500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 1.8114
    Cell Significance Index: 25.3300
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.2675
    Cell Significance Index: 7.8200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9176
    Cell Significance Index: 21.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5905
    Cell Significance Index: 118.4500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.4436
    Cell Significance Index: 7.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4422
    Cell Significance Index: 22.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4172
    Cell Significance Index: 19.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3408
    Cell Significance Index: 64.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2630
    Cell Significance Index: 26.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2607
    Cell Significance Index: 93.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2466
    Cell Significance Index: 156.6400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2415
    Cell Significance Index: 3.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2059
    Cell Significance Index: 379.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2007
    Cell Significance Index: 181.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1882
    Cell Significance Index: 8.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1555
    Cell Significance Index: 11.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1463
    Cell Significance Index: 225.2200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1391
    Cell Significance Index: 1.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1385
    Cell Significance Index: 8.9400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1304
    Cell Significance Index: 3.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1241
    Cell Significance Index: 14.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1201
    Cell Significance Index: 19.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0995
    Cell Significance Index: 187.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0612
    Cell Significance Index: 7.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0589
    Cell Significance Index: 10.6300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0412
    Cell Significance Index: 0.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0398
    Cell Significance Index: 4.3300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0391
    Cell Significance Index: 0.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0343
    Cell Significance Index: 4.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0278
    Cell Significance Index: 5.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0261
    Cell Significance Index: 11.8500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0198
    Cell Significance Index: 0.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0095
    Cell Significance Index: 6.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0023
    Cell Significance Index: 0.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0009
    Cell Significance Index: 1.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0022
    Cell Significance Index: -1.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0023
    Cell Significance Index: -1.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0032
    Cell Significance Index: -0.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0064
    Cell Significance Index: -0.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0078
    Cell Significance Index: -0.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0083
    Cell Significance Index: -4.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0186
    Cell Significance Index: -13.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0237
    Cell Significance Index: -14.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0242
    Cell Significance Index: -0.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0248
    Cell Significance Index: -13.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0347
    Cell Significance Index: -2.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0352
    Cell Significance Index: -15.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0383
    Cell Significance Index: -11.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0445
    Cell Significance Index: -1.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0475
    Cell Significance Index: -8.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0489
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0534
    Cell Significance Index: -6.1200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0585
    Cell Significance Index: -0.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0618
    Cell Significance Index: -3.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0656
    Cell Significance Index: -4.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0697
    Cell Significance Index: -14.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0712
    Cell Significance Index: -9.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0740
    Cell Significance Index: -4.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0787
    Cell Significance Index: -3.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0827
    Cell Significance Index: -11.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0851
    Cell Significance Index: -5.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0870
    Cell Significance Index: -2.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0915
    Cell Significance Index: -9.3500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0979
    Cell Significance Index: -1.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1018
    Cell Significance Index: -13.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1080
    Cell Significance Index: -11.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1104
    Cell Significance Index: -4.1800
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.1199
    Cell Significance Index: -1.2000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1239
    Cell Significance Index: -2.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1241
    Cell Significance Index: -1.8700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1249
    Cell Significance Index: -2.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1316
    Cell Significance Index: -6.1900
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.1355
    Cell Significance Index: -1.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1399
    Cell Significance Index: -11.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1516
    Cell Significance Index: -11.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1561
    Cell Significance Index: -9.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1721
    Cell Significance Index: -3.6700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1736
    Cell Significance Index: -1.0900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1883
    Cell Significance Index: -9.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1900
    Cell Significance Index: -6.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1926
    Cell Significance Index: -6.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1956
    Cell Significance Index: -5.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2116
    Cell Significance Index: -11.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2117
    Cell Significance Index: -6.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2190
    Cell Significance Index: -5.6300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2305
    Cell Significance Index: -8.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2363
    Cell Significance Index: -16.7100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2441
    Cell Significance Index: -5.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2449
    Cell Significance Index: -6.5400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.2466
    Cell Significance Index: -1.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2715
    Cell Significance Index: -9.5100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2733
    Cell Significance Index: -8.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2770
    Cell Significance Index: -7.4100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2791
    Cell Significance Index: -6.0300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3235
    Cell Significance Index: -8.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Dipeptide Transporter:** SLC15A2 is a dipeptide transporter that facilitates the transport of dipeptides across cell membranes, playing a crucial role in the regulation of amino acid levels and the immune response. 2. **Proton/Oligopeptide Cotransporters:** SLC15A2 also functions as a proton/oligopeptide cotransporter, transporting protons and oligopeptides across membranes, which is essential for maintaining cellular pH and regulating the transport of essential amino acids. 3. **Xenobiotic Detoxification:** SLC15A2 has been shown to play a role in xenobiotic detoxification by transmembrane export across the plasma membrane, contributing to the removal of toxic substances from cells. 4. **Antibacterial Innate Immune Response:** SLC15A2 has been implicated in the regulation of the antibacterial innate immune response, suggesting its potential role in modulating the immune response to bacterial infections. **Pathways and Functions:** 1. **Antibacterial Innate Immune Response:** SLC15A2 interacts with pattern recognition receptors (PRRs) to regulate the activation of the innate immune response to bacterial infections. 2. **Dipeptide Transport:** SLC15A2 facilitates the transport of dipeptides across cell membranes, regulating amino acid levels and immune function. 3. **Proton/Oligopeptide Cotransport:** SLC15A2 transports protons and oligopeptides across membranes, maintaining cellular pH and regulating the transport of essential amino acids. 4. **Xenobiotic Detoxification:** SLC15A2 contributes to the removal of toxic substances from cells through transmembrane export. 5. **Regulation of Nucleotide-Binding Domain, Leucine-Rich Repeat Containing Receptor Signaling Pathway:** SLC15A2 interacts with the nucleotide-binding domain, leucine-rich repeat containing receptor signaling pathway, regulating immune function and cellular homeostasis. **Clinical Significance:** 1. **Immune Dysfunction:** Alterations in SLC15A2 expression or function may contribute to immune dysfunction and increased susceptibility to infections. 2. **Neurological Disorders:** SLC15A2's role in xenobiotic detoxification and its interaction with the nucleotide-binding domain, leucine-rich repeat containing receptor signaling pathway may be relevant to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** SLC15A2's involvement in xenobiotic detoxification and its expression in cancer cells may make it a potential target for cancer therapy. 4. **Respiratory Diseases:** SLC15A2's role in dipeptide transport and its expression in respiratory epithelial cells may contribute to the development of respiratory diseases, such as cystic fibrosis. In conclusion, SLC15A2 is a multifaceted gene that plays a crucial role in various cellular processes, including the immune response, transport of dipeptides and oligopeptides, and xenobiotic detoxification. Its clinical significance highlights the importance of further research into the function and regulation of SLC15A2 in maintaining cellular homeostasis and immune function.

Genular Protein ID: 1047592371

Symbol: S15A2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q16348 A8K1A5 B4E2A7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 41 DrugCentral 1 EMBL 5 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 16 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7756356

Title: Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney.

PubMed ID: 7756356

DOI: 10.1016/0005-2736(95)80036-f

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 16434549

Title: Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters.

PubMed ID: 16434549

DOI: 10.1124/dmd.105.006791

PubMed ID: 18367661

Title: Molecular mechanism of dipeptide and drug transport by the human renal H+/oligopeptide cotransporter hPEPT2.

PubMed ID: 18367661

DOI: 10.1152/ajprenal.00030.2008

PubMed ID: 20406817

Title: Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters.

PubMed ID: 20406817

DOI: 10.1074/jbc.m110.115584

PubMed ID: 31073693

Title: The proton-coupled oligopeptide transporters PEPT2, PHT1 and PHT2 mediate the uptake of carnosine in glioblastoma cells.

PubMed ID: 31073693

DOI: 10.1007/s00726-019-02739-w

Sequence Information:

  • Length: 729
  • Mass: 81783
  • Checksum: 0169DC150BD35BC3
  • Sequence:
    • MNPFQKNESK ETLFSPVSIE EVPPRPPSPP KKPSPTICGS NYPLSIAFIV VNEFCERFSY 
YGMKAVLILY FLYFLHWNED TSTSIYHAFS SLCYFTPILG AAIADSWLGK FKTIIYLSLV 
YVLGHVIKSL GALPILGGQV VHTVLSLIGL SLIALGTGGI KPCVAAFGGD QFEEKHAEER 
TRYFSVFYLS INAGSLISTF ITPMLRGDVQ CFGEDCYALA FGVPGLLMVI ALVVFAMGSK 
IYNKPPPEGN IVAQVFKCIW FAISNRFKNR SGDIPKRQHW LDWAAEKYPK QLIMDVKALT 
RVLFLYIPLP MFWALLDQQG SRWTLQAIRM NRNLGFFVLQ PDQMQVLNPL LVLIFIPLFD 
FVIYRLVSKC GINFSSLRKM AVGMILACLA FAVAAAVEIK INEMAPAQPG PQEVFLQVLN 
LADDEVKVTV VGNENNSLLI ESIKSFQKTP HYSKLHLKTK SQDFHFHLKY HNLSLYTEHS 
VQEKNWYSLV IREDGNSISS MMVKDTESRT TNGMTTVRFV NTLHKDVNIS LSTDTSLNVG 
EDYGVSAYRT VQRGEYPAVH CRTEDKNFSL NLGLLDFGAA YLFVITNNTN QGLQAWKIED 
IPANKMSIAW QLPQYALVTA GEVMFSVTGL EFSYSQAPSS MKSVLQAAWL LTIAVGNIIV 
LVVAQFSGLV QWAEFILFSC LLLVICLIFS IMGYYYVPVK TEDMRGPADK HIPHIQGNMI 
KLETKKTKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.