Details for: SLC16A2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 74.6323
Cell Significance Index: -18.9300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 19.0732
Cell Significance Index: -18.2100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 15.5723
Cell Significance Index: -19.2000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.8631
Cell Significance Index: -19.1900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.4121
Cell Significance Index: 32.9100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.8160
Cell Significance Index: 58.1700 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.5012
Cell Significance Index: 40.2300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.8281
Cell Significance Index: 37.5400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.8121
Cell Significance Index: 45.5700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.8106
Cell Significance Index: 290.7600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.7509
Cell Significance Index: 50.4900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.6702
Cell Significance Index: 25.3800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.6579
Cell Significance Index: 29.1000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.6423
Cell Significance Index: 128.8400 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.5660
Cell Significance Index: 13.7100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.5548
Cell Significance Index: 34.1000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5207
Cell Significance Index: 360.1600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3646
Cell Significance Index: 69.3900 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.3550
Cell Significance Index: 10.1300 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.3407
Cell Significance Index: 8.1700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3351
Cell Significance Index: 33.1500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3223
Cell Significance Index: 291.0600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3159
Cell Significance Index: 62.7000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2986
Cell Significance Index: 6.4700 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.2797
Cell Significance Index: 6.1300 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.2161
Cell Significance Index: 4.6200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1841
Cell Significance Index: 29.9500 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1829
Cell Significance Index: 19.9000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1661
Cell Significance Index: 9.9700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1113
Cell Significance Index: 15.2800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0467
Cell Significance Index: 1.6400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0444
Cell Significance Index: 3.0700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0229
Cell Significance Index: 43.1200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0175
Cell Significance Index: 11.1300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0174
Cell Significance Index: 7.7000 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0140
Cell Significance Index: 1.7900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0119
Cell Significance Index: 0.9200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0078
Cell Significance Index: 12.0100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0036
Cell Significance Index: 0.1900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0009
Cell Significance Index: 1.7500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0026
Cell Significance Index: -1.1900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0047
Cell Significance Index: -0.2900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0049
Cell Significance Index: -0.1300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0059
Cell Significance Index: -0.1300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0069
Cell Significance Index: -5.0600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0087
Cell Significance Index: -11.8000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0089
Cell Significance Index: -1.3000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0105
Cell Significance Index: -6.5700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0129
Cell Significance Index: -9.5600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0144
Cell Significance Index: -0.6700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0151
Cell Significance Index: -2.5800 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.0158
Cell Significance Index: -0.2500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0215
Cell Significance Index: -12.1100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0250
Cell Significance Index: -0.7200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0269
Cell Significance Index: -20.4000 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0324
Cell Significance Index: -17.7000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0486
Cell Significance Index: -5.9800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0549
Cell Significance Index: -11.5700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0560
Cell Significance Index: -16.1200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0638
Cell Significance Index: -11.5100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0955
Cell Significance Index: -11.1300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1044
Cell Significance Index: -11.9700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1090
Cell Significance Index: -12.8500 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1118
Cell Significance Index: -12.7600 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1333
Cell Significance Index: -17.2200 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1374
Cell Significance Index: -2.0700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1389
Cell Significance Index: -8.9600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1495
Cell Significance Index: -11.1400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1640
Cell Significance Index: -17.0800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1686
Cell Significance Index: -17.2200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1774
Cell Significance Index: -12.5500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1798
Cell Significance Index: -11.3300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1810
Cell Significance Index: -4.5300 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.1823
Cell Significance Index: -3.0700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1955
Cell Significance Index: -3.3500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2136
Cell Significance Index: -5.9700 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2233
Cell Significance Index: -4.7400 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2333
Cell Significance Index: -4.8400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2419
Cell Significance Index: -7.9200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2486
Cell Significance Index: -19.6900 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.2591
Cell Significance Index: -3.7100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2638
Cell Significance Index: -12.4000 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.2834
Cell Significance Index: -4.6700 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2988
Cell Significance Index: -5.0000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3186
Cell Significance Index: -8.1900 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.3235
Cell Significance Index: -6.9900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3377
Cell Significance Index: -17.7300 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3389
Cell Significance Index: -10.8000 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.3432
Cell Significance Index: -6.8900 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.3616
Cell Significance Index: -9.0200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3822
Cell Significance Index: -13.3900 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.3914
Cell Significance Index: -7.7400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3931
Cell Significance Index: -20.4200 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.3981
Cell Significance Index: -7.7700 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.4058
Cell Significance Index: -5.9900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.4096
Cell Significance Index: -11.1500 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.4185
Cell Significance Index: -6.0100 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.4238
Cell Significance Index: -8.8700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4344
Cell Significance Index: -15.1000 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.4438
Cell Significance Index: -7.1200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1547335428
Symbol: MOT8_HUMAN
Name: Monocarboxylate transporter 8
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7981683
Title: A novel transmembrane transporter encoded by the XPCT gene in Xq13.2.
PubMed ID: 7981683
DOI: 10.1093/hmg/3.7.1133
PubMed ID: 15772651
PubMed ID: 16887882
Title: Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism.
PubMed ID: 16887882
DOI: 10.1210/me.2005-0256
PubMed ID: 18687783
Title: Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier.
PubMed ID: 18687783
DOI: 10.1210/en.2008-0378
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19797118
Title: Evidence for a homodimeric structure of human monocarboxylate transporter 8.
PubMed ID: 19797118
DOI: 10.1210/en.2009-0699
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 23610131
Title: Importance of His192 in the human thyroid hormone transporter MCT8 for substrate recognition.
PubMed ID: 23610131
DOI: 10.1210/en.2012-2225
PubMed ID: 14661163
Title: A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene.
PubMed ID: 14661163
DOI: 10.1086/380999
PubMed ID: 18398436
Title: MCT8 mutation analysis and identification of the first female with Allan-Herndon-Dudley syndrome due to loss of MCT8 expression.
PubMed ID: 18398436
DOI: 10.1038/ejhg.2008.66
PubMed ID: 18337592
Title: Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10.
PubMed ID: 18337592
DOI: 10.1210/me.2007-0112
PubMed ID: 20628049
Title: Essential molecular determinants for thyroid hormone transport and first structural implications for monocarboxylate transporter 8.
PubMed ID: 20628049
PubMed ID: 32143555
Title: Spatiotemporal changes of cerebral monocarboxylate transporter 8 expression.
PubMed ID: 32143555
PubMed ID: 15488219
Title: Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation.
PubMed ID: 15488219
PubMed ID: 15889350
Title: Allan-Herndon-Dudley syndrome and the monocarboxylate transporter 8 (MCT8) gene.
PubMed ID: 15889350
DOI: 10.1086/431313
PubMed ID: 18636565
Title: Novel pathogenic mechanism suggested by ex vivo analysis of MCT8 (SLC16A2) mutations.
PubMed ID: 18636565
DOI: 10.1002/humu.20808
PubMed ID: 23550058
Title: Mutations in MCT8 in patients with Allan-Herndon-Dudley-syndrome affecting its cellular distribution.
PubMed ID: 23550058
DOI: 10.1210/me.2012-1356
PubMed ID: 25380603
Title: Myelination delay and Allan-Herndon-Dudley syndrome caused by a novel mutation in the SLC16A2 gene.
PubMed ID: 25380603
PubMed ID: 26426690
Title: Further insights into the Allan-Herndon-Dudley syndrome: clinical and functional characterization of a novel MCT8 mutation.
PubMed ID: 26426690
PubMed ID: 25527620
Title: Modulation of monocarboxylate transporter 8 oligomerization by specific pathogenic mutations.
PubMed ID: 25527620
DOI: 10.1530/jme-14-0272
PubMed ID: 27805744
Title: Clinical and Molecular Characteristics of SLC16A2 (MCT8) Mutations in Three Families with the Allan-Herndon-Dudley Syndrome.
PubMed ID: 27805744
DOI: 10.1002/humu.23140
PubMed ID: 28526555
Title: Modeling psychomotor retardation using iPSCs from MCT8-deficient patients indicates a prominent role for the blood-brain barrier.
PubMed ID: 28526555
PubMed ID: 31436139
Title: In Vitro Characterization of Human, Mouse, and Zebrafish MCT8 Orthologues.
PubMed ID: 31436139
Sequence Information:
- Length: 539
- Mass: 59511
- Checksum: E4DB873D59FA4DD6
- Sequence:
MALQSQASEE AKGPWQEADQ EQQEPVGSPE PESEPEPEPE PEPVPVPPPE PQPEPQPLPD PAPLPELEFE SERVHEPEPT PTVETRGTAR GFQPPEGGFG WVVVFAATWC NGSIFGIHNS VGILYSMLLE EEKEKNRQVE FQAAWVGALA MGMIFFCSPI VSIFTDRLGC RITATAGAAV AFIGLHTSSF TSSLSLRYFT YGILFGCGCS FAFQPSLVIL GHYFQRRLGL ANGVVSAGSS IFSMSFPFLI RMLGDKIKLA QTFQVLSTFM FVLMLLSLTY RPLLPSSQDT PSKRGVRTLH QRFLAQLRKY FNMRVFRQRT YRIWAFGIAA AALGYFVPYV HLMKYVEEEF SEIKETWVLL VCIGATSGLG RLVSGHISDS IPGLKKIYLQ VLSFLLLGLM SMMIPLCRDF GGLIVVCLFL GLCDGFFITI MAPIAFELVG PMQASQAIGY LLGMMALPMI AGPPIAGLLR NCFGDYHVAF YFAGVPPIIG AVILFFVPLM HQRMFKKEQR DSSKDKMLAP DPDPNGELLP GSPNPEEPI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.