Details for: SLC16A2

Gene ID: 6567

Symbol: SLC16A2

Ensembl ID: ENSG00000147100

Description: solute carrier family 16 member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.6323
    Cell Significance Index: -18.9300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.0732
    Cell Significance Index: -18.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.5723
    Cell Significance Index: -19.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.8631
    Cell Significance Index: -19.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.4121
    Cell Significance Index: 32.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.8160
    Cell Significance Index: 58.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.5012
    Cell Significance Index: 40.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8281
    Cell Significance Index: 37.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8121
    Cell Significance Index: 45.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8106
    Cell Significance Index: 290.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7509
    Cell Significance Index: 50.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6702
    Cell Significance Index: 25.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6579
    Cell Significance Index: 29.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6423
    Cell Significance Index: 128.8400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5660
    Cell Significance Index: 13.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5548
    Cell Significance Index: 34.1000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5207
    Cell Significance Index: 360.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3646
    Cell Significance Index: 69.3900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3550
    Cell Significance Index: 10.1300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3407
    Cell Significance Index: 8.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3351
    Cell Significance Index: 33.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3223
    Cell Significance Index: 291.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3159
    Cell Significance Index: 62.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2986
    Cell Significance Index: 6.4700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2797
    Cell Significance Index: 6.1300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2161
    Cell Significance Index: 4.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1841
    Cell Significance Index: 29.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1829
    Cell Significance Index: 19.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1661
    Cell Significance Index: 9.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1113
    Cell Significance Index: 15.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0467
    Cell Significance Index: 1.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0444
    Cell Significance Index: 3.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0229
    Cell Significance Index: 43.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0175
    Cell Significance Index: 11.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0174
    Cell Significance Index: 7.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0140
    Cell Significance Index: 1.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0119
    Cell Significance Index: 0.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0078
    Cell Significance Index: 12.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0036
    Cell Significance Index: 0.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0009
    Cell Significance Index: 1.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0026
    Cell Significance Index: -1.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0047
    Cell Significance Index: -0.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0049
    Cell Significance Index: -0.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0059
    Cell Significance Index: -0.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0069
    Cell Significance Index: -5.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0087
    Cell Significance Index: -11.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0089
    Cell Significance Index: -1.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0105
    Cell Significance Index: -6.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0129
    Cell Significance Index: -9.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0144
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0151
    Cell Significance Index: -2.5800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0158
    Cell Significance Index: -0.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0215
    Cell Significance Index: -12.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0250
    Cell Significance Index: -0.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0269
    Cell Significance Index: -20.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0324
    Cell Significance Index: -17.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0486
    Cell Significance Index: -5.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0549
    Cell Significance Index: -11.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0560
    Cell Significance Index: -16.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0638
    Cell Significance Index: -11.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0955
    Cell Significance Index: -11.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1044
    Cell Significance Index: -11.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1090
    Cell Significance Index: -12.8500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1118
    Cell Significance Index: -12.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1333
    Cell Significance Index: -17.2200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1374
    Cell Significance Index: -2.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1389
    Cell Significance Index: -8.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1495
    Cell Significance Index: -11.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1640
    Cell Significance Index: -17.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1686
    Cell Significance Index: -17.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1774
    Cell Significance Index: -12.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1798
    Cell Significance Index: -11.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1810
    Cell Significance Index: -4.5300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1823
    Cell Significance Index: -3.0700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1955
    Cell Significance Index: -3.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2136
    Cell Significance Index: -5.9700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2233
    Cell Significance Index: -4.7400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2333
    Cell Significance Index: -4.8400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2419
    Cell Significance Index: -7.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2486
    Cell Significance Index: -19.6900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2591
    Cell Significance Index: -3.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2638
    Cell Significance Index: -12.4000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2834
    Cell Significance Index: -4.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2988
    Cell Significance Index: -5.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3186
    Cell Significance Index: -8.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3235
    Cell Significance Index: -6.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3377
    Cell Significance Index: -17.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3389
    Cell Significance Index: -10.8000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3432
    Cell Significance Index: -6.8900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3616
    Cell Significance Index: -9.0200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3822
    Cell Significance Index: -13.3900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3914
    Cell Significance Index: -7.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3931
    Cell Significance Index: -20.4200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3981
    Cell Significance Index: -7.7700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4058
    Cell Significance Index: -5.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4096
    Cell Significance Index: -11.1500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4185
    Cell Significance Index: -6.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4238
    Cell Significance Index: -8.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4344
    Cell Significance Index: -15.1000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.4438
    Cell Significance Index: -7.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transporter Function:** The MOT8 protein is a type of monocarboxylate transporter, which facilitates the transport of monocarboxylate molecules, such as amino acids, across the plasma membrane. 2. **Specificity:** The MOT8 protein has a broad substrate specificity, allowing it to transport various amino acids, including glycine, glutamate, and aspartate. 3. **Regulatory Mechanisms:** The SLC16A2 gene is involved in negative regulation of neural precursor cell proliferation, suggesting that it may play a role in modulating neural development and function. 4. **Cellular Expression:** The SLC16A2 gene is expressed in various cell types, including colon goblet cells, enterocytes, and neurons, indicating its widespread importance in maintaining cellular homeostasis. **Pathways and Functions:** 1. **Amino Acid Metabolism:** The MOT8 protein is involved in the transport of amino acids across the plasma membrane, which is essential for maintaining amino acid homeostasis and regulating various physiological processes, including protein synthesis and degradation. 2. **Thyroid Hormone Generation:** The SLC16A2 gene is also involved in the transport of thyroid hormones across the plasma membrane, which is critical for regulating thyroid hormone levels and maintaining thyroid function. 3. **Blood-Brain Barrier Transport:** The MOT8 protein is expressed in the blood-brain barrier, where it plays a role in regulating the transport of small molecules, including amino acids and thyroid hormones, across this barrier. 4. **Neurotransmitter Regulation:** The SLC16A2 gene is involved in the regulation of neural precursor cell proliferation, suggesting that it may also play a role in modulating neurotransmitter release and synaptic function. **Clinical Significance:** 1. **Thyroid Function Disorders:** Mutations in the SLC16A2 gene have been associated with thyroid function disorders, including hypothyroidism and goiter. 2. **Neurological Disorders:** The SLC16A2 gene is also involved in the regulation of neural development and function, suggesting that it may play a role in the development of neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Cancer:** The MOT8 protein has been implicated in the regulation of cancer cell proliferation and migration, suggesting that it may play a role in the development and progression of various cancers. 4. **Nutritional Deficiencies:** The SLC16A2 gene is involved in the transport of amino acids across the plasma membrane, which is essential for maintaining amino acid homeostasis and regulating various physiological processes. Mutations in the SLC16A2 gene may contribute to nutritional deficiencies, including amino acid deficiencies. In conclusion, the SLC16A2 gene plays a critical role in regulating amino acid and thyroid hormone transport across the plasma membrane. Its involvement in various physiological processes, including amino acid metabolism, thyroid hormone generation, and neural development, highlights its importance in maintaining cellular homeostasis and regulating various physiological processes. Further research is needed to fully understand the functional significance of the SLC16A2 gene and its role in various diseases.

Genular Protein ID: 1547335428

Symbol: MOT8_HUMAN

Name: Monocarboxylate transporter 8

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7981683

Title: A novel transmembrane transporter encoded by the XPCT gene in Xq13.2.

PubMed ID: 7981683

DOI: 10.1093/hmg/3.7.1133

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 16887882

Title: Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism.

PubMed ID: 16887882

DOI: 10.1210/me.2005-0256

PubMed ID: 18687783

Title: Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier.

PubMed ID: 18687783

DOI: 10.1210/en.2008-0378

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19797118

Title: Evidence for a homodimeric structure of human monocarboxylate transporter 8.

PubMed ID: 19797118

DOI: 10.1210/en.2009-0699

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23610131

Title: Importance of His192 in the human thyroid hormone transporter MCT8 for substrate recognition.

PubMed ID: 23610131

DOI: 10.1210/en.2012-2225

PubMed ID: 14661163

Title: A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene.

PubMed ID: 14661163

DOI: 10.1086/380999

PubMed ID: 18398436

Title: MCT8 mutation analysis and identification of the first female with Allan-Herndon-Dudley syndrome due to loss of MCT8 expression.

PubMed ID: 18398436

DOI: 10.1038/ejhg.2008.66

PubMed ID: 18337592

Title: Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10.

PubMed ID: 18337592

DOI: 10.1210/me.2007-0112

PubMed ID: 20628049

Title: Essential molecular determinants for thyroid hormone transport and first structural implications for monocarboxylate transporter 8.

PubMed ID: 20628049

DOI: 10.1074/jbc.m110.129577

PubMed ID: 32143555

Title: Spatiotemporal changes of cerebral monocarboxylate transporter 8 expression.

PubMed ID: 32143555

DOI: 10.1089/thy.2019.0544

PubMed ID: 15488219

Title: Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation.

PubMed ID: 15488219

DOI: 10.1016/s0140-6736(04)17226-7

PubMed ID: 15889350

Title: Allan-Herndon-Dudley syndrome and the monocarboxylate transporter 8 (MCT8) gene.

PubMed ID: 15889350

DOI: 10.1086/431313

PubMed ID: 18636565

Title: Novel pathogenic mechanism suggested by ex vivo analysis of MCT8 (SLC16A2) mutations.

PubMed ID: 18636565

DOI: 10.1002/humu.20808

PubMed ID: 23550058

Title: Mutations in MCT8 in patients with Allan-Herndon-Dudley-syndrome affecting its cellular distribution.

PubMed ID: 23550058

DOI: 10.1210/me.2012-1356

PubMed ID: 25380603

Title: Myelination delay and Allan-Herndon-Dudley syndrome caused by a novel mutation in the SLC16A2 gene.

PubMed ID: 25380603

DOI: 10.1177/0883073814555189

PubMed ID: 26426690

Title: Further insights into the Allan-Herndon-Dudley syndrome: clinical and functional characterization of a novel MCT8 mutation.

PubMed ID: 26426690

DOI: 10.1371/journal.pone.0139343

PubMed ID: 25527620

Title: Modulation of monocarboxylate transporter 8 oligomerization by specific pathogenic mutations.

PubMed ID: 25527620

DOI: 10.1530/jme-14-0272

PubMed ID: 27805744

Title: Clinical and Molecular Characteristics of SLC16A2 (MCT8) Mutations in Three Families with the Allan-Herndon-Dudley Syndrome.

PubMed ID: 27805744

DOI: 10.1002/humu.23140

PubMed ID: 28526555

Title: Modeling psychomotor retardation using iPSCs from MCT8-deficient patients indicates a prominent role for the blood-brain barrier.

PubMed ID: 28526555

DOI: 10.1016/j.stem.2017.04.002

PubMed ID: 31436139

Title: In Vitro Characterization of Human, Mouse, and Zebrafish MCT8 Orthologues.

PubMed ID: 31436139

DOI: 10.1089/thy.2019.0009

Sequence Information:

  • Length: 539
  • Mass: 59511
  • Checksum: E4DB873D59FA4DD6
  • Sequence:
  • MALQSQASEE AKGPWQEADQ EQQEPVGSPE PESEPEPEPE PEPVPVPPPE PQPEPQPLPD 
    PAPLPELEFE SERVHEPEPT PTVETRGTAR GFQPPEGGFG WVVVFAATWC NGSIFGIHNS 
    VGILYSMLLE EEKEKNRQVE FQAAWVGALA MGMIFFCSPI VSIFTDRLGC RITATAGAAV 
    AFIGLHTSSF TSSLSLRYFT YGILFGCGCS FAFQPSLVIL GHYFQRRLGL ANGVVSAGSS 
    IFSMSFPFLI RMLGDKIKLA QTFQVLSTFM FVLMLLSLTY RPLLPSSQDT PSKRGVRTLH 
    QRFLAQLRKY FNMRVFRQRT YRIWAFGIAA AALGYFVPYV HLMKYVEEEF SEIKETWVLL 
    VCIGATSGLG RLVSGHISDS IPGLKKIYLQ VLSFLLLGLM SMMIPLCRDF GGLIVVCLFL 
    GLCDGFFITI MAPIAFELVG PMQASQAIGY LLGMMALPMI AGPPIAGLLR NCFGDYHVAF 
    YFAGVPPIIG AVILFFVPLM HQRMFKKEQR DSSKDKMLAP DPDPNGELLP GSPNPEEPI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.