Details for: SLC16A2

Gene ID: 6567

Symbol: SLC16A2

Ensembl ID: ENSG00000147100

Description: solute carrier family 16 member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1156
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168878
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.44
    Marker Score: 1434.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.29
    Marker Score: 12163
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.27
    Marker Score: 4904
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.25
    Marker Score: 617
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.25
    Marker Score: 10700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.19
    Marker Score: 17760
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4793.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.07
    Marker Score: 39557
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.07
    Marker Score: 1650
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.06
    Marker Score: 4317
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.05
    Marker Score: 18677
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.04
    Marker Score: 658
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 786
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.02
    Marker Score: 2084
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71798.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48022.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.99
    Marker Score: 591.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.98
    Marker Score: 7540
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.95
    Marker Score: 14892
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.95
    Marker Score: 531
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.93
    Marker Score: 19879
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5240
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.92
    Marker Score: 8716
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.9
    Marker Score: 34288
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.9
    Marker Score: 9248
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.89
    Marker Score: 676
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.87
    Marker Score: 17363
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.87
    Marker Score: 400
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.86
    Marker Score: 2020
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.82
    Marker Score: 4953
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.78
    Marker Score: 3243
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.77
    Marker Score: 3316
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 303
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 690
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.73
    Marker Score: 484
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.7
    Marker Score: 800.5
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.69
    Marker Score: 23399
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.69
    Marker Score: 4451
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.67
    Marker Score: 41147
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.67
    Marker Score: 701
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.66
    Marker Score: 396
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.63
    Marker Score: 1233.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.62
    Marker Score: 296.5
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.62
    Marker Score: 211
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.57
    Marker Score: 1852
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.55
    Marker Score: 2943
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 145
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.54
    Marker Score: 2480
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.53
    Marker Score: 642
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.53
    Marker Score: 1424
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.53
    Marker Score: 362
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.53
    Marker Score: 1382
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.53
    Marker Score: 165
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.52
    Marker Score: 1007
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.52
    Marker Score: 428
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.51
    Marker Score: 446
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5
    Marker Score: 192
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.5
    Marker Score: 373.5
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.48
    Marker Score: 281
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.48
    Marker Score: 1060
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.45
    Marker Score: 695
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.45
    Marker Score: 552
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.43
    Marker Score: 413
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.43
    Marker Score: 364
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.42
    Marker Score: 188
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.42
    Marker Score: 140
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.41
    Marker Score: 1727
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.41
    Marker Score: 277
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.4
    Marker Score: 1249
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.39
    Marker Score: 229
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.38
    Marker Score: 112
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.38
    Marker Score: 87.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.37
    Marker Score: 96
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.37
    Marker Score: 204
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.36
    Marker Score: 372
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.36
    Marker Score: 149
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.36
    Marker Score: 418
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.35
    Marker Score: 148
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.35
    Marker Score: 377
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.35
    Marker Score: 223
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.35
    Marker Score: 369
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.35
    Marker Score: 121
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.34
    Marker Score: 974
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.34
    Marker Score: 143
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.34
    Marker Score: 328
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.34
    Marker Score: 164

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Other Information

**Key Characteristics:** 1. **Transporter Function:** The MOT8 protein is a type of monocarboxylate transporter, which facilitates the transport of monocarboxylate molecules, such as amino acids, across the plasma membrane. 2. **Specificity:** The MOT8 protein has a broad substrate specificity, allowing it to transport various amino acids, including glycine, glutamate, and aspartate. 3. **Regulatory Mechanisms:** The SLC16A2 gene is involved in negative regulation of neural precursor cell proliferation, suggesting that it may play a role in modulating neural development and function. 4. **Cellular Expression:** The SLC16A2 gene is expressed in various cell types, including colon goblet cells, enterocytes, and neurons, indicating its widespread importance in maintaining cellular homeostasis. **Pathways and Functions:** 1. **Amino Acid Metabolism:** The MOT8 protein is involved in the transport of amino acids across the plasma membrane, which is essential for maintaining amino acid homeostasis and regulating various physiological processes, including protein synthesis and degradation. 2. **Thyroid Hormone Generation:** The SLC16A2 gene is also involved in the transport of thyroid hormones across the plasma membrane, which is critical for regulating thyroid hormone levels and maintaining thyroid function. 3. **Blood-Brain Barrier Transport:** The MOT8 protein is expressed in the blood-brain barrier, where it plays a role in regulating the transport of small molecules, including amino acids and thyroid hormones, across this barrier. 4. **Neurotransmitter Regulation:** The SLC16A2 gene is involved in the regulation of neural precursor cell proliferation, suggesting that it may also play a role in modulating neurotransmitter release and synaptic function. **Clinical Significance:** 1. **Thyroid Function Disorders:** Mutations in the SLC16A2 gene have been associated with thyroid function disorders, including hypothyroidism and goiter. 2. **Neurological Disorders:** The SLC16A2 gene is also involved in the regulation of neural development and function, suggesting that it may play a role in the development of neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Cancer:** The MOT8 protein has been implicated in the regulation of cancer cell proliferation and migration, suggesting that it may play a role in the development and progression of various cancers. 4. **Nutritional Deficiencies:** The SLC16A2 gene is involved in the transport of amino acids across the plasma membrane, which is essential for maintaining amino acid homeostasis and regulating various physiological processes. Mutations in the SLC16A2 gene may contribute to nutritional deficiencies, including amino acid deficiencies. In conclusion, the SLC16A2 gene plays a critical role in regulating amino acid and thyroid hormone transport across the plasma membrane. Its involvement in various physiological processes, including amino acid metabolism, thyroid hormone generation, and neural development, highlights its importance in maintaining cellular homeostasis and regulating various physiological processes. Further research is needed to fully understand the functional significance of the SLC16A2 gene and its role in various diseases.

Genular Protein ID: 1547335428

Symbol: MOT8_HUMAN

Name: Monocarboxylate transporter 8

UniProtKB Accession Codes:

P36021 Q7Z797

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 EMBL 10 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 12 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7981683

Title: A novel transmembrane transporter encoded by the XPCT gene in Xq13.2.

PubMed ID: 7981683

DOI: 10.1093/hmg/3.7.1133

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 16887882

Title: Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism.

PubMed ID: 16887882

DOI: 10.1210/me.2005-0256

PubMed ID: 18687783

Title: Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier.

PubMed ID: 18687783

DOI: 10.1210/en.2008-0378

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19797118

Title: Evidence for a homodimeric structure of human monocarboxylate transporter 8.

PubMed ID: 19797118

DOI: 10.1210/en.2009-0699

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23610131

Title: Importance of His192 in the human thyroid hormone transporter MCT8 for substrate recognition.

PubMed ID: 23610131

DOI: 10.1210/en.2012-2225

PubMed ID: 14661163

Title: A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene.

PubMed ID: 14661163

DOI: 10.1086/380999

PubMed ID: 18398436

Title: MCT8 mutation analysis and identification of the first female with Allan-Herndon-Dudley syndrome due to loss of MCT8 expression.

PubMed ID: 18398436

DOI: 10.1038/ejhg.2008.66

PubMed ID: 18337592

Title: Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10.

PubMed ID: 18337592

DOI: 10.1210/me.2007-0112

PubMed ID: 20628049

Title: Essential molecular determinants for thyroid hormone transport and first structural implications for monocarboxylate transporter 8.

PubMed ID: 20628049

DOI: 10.1074/jbc.m110.129577

PubMed ID: 32143555

Title: Spatiotemporal changes of cerebral monocarboxylate transporter 8 expression.

PubMed ID: 32143555

DOI: 10.1089/thy.2019.0544

PubMed ID: 15488219

Title: Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation.

PubMed ID: 15488219

DOI: 10.1016/s0140-6736(04)17226-7

PubMed ID: 15889350

Title: Allan-Herndon-Dudley syndrome and the monocarboxylate transporter 8 (MCT8) gene.

PubMed ID: 15889350

DOI: 10.1086/431313

PubMed ID: 18636565

Title: Novel pathogenic mechanism suggested by ex vivo analysis of MCT8 (SLC16A2) mutations.

PubMed ID: 18636565

DOI: 10.1002/humu.20808

PubMed ID: 23550058

Title: Mutations in MCT8 in patients with Allan-Herndon-Dudley-syndrome affecting its cellular distribution.

PubMed ID: 23550058

DOI: 10.1210/me.2012-1356

PubMed ID: 25380603

Title: Myelination delay and Allan-Herndon-Dudley syndrome caused by a novel mutation in the SLC16A2 gene.

PubMed ID: 25380603

DOI: 10.1177/0883073814555189

PubMed ID: 26426690

Title: Further insights into the Allan-Herndon-Dudley syndrome: clinical and functional characterization of a novel MCT8 mutation.

PubMed ID: 26426690

DOI: 10.1371/journal.pone.0139343

PubMed ID: 25527620

Title: Modulation of monocarboxylate transporter 8 oligomerization by specific pathogenic mutations.

PubMed ID: 25527620

DOI: 10.1530/jme-14-0272

PubMed ID: 27805744

Title: Clinical and Molecular Characteristics of SLC16A2 (MCT8) Mutations in Three Families with the Allan-Herndon-Dudley Syndrome.

PubMed ID: 27805744

DOI: 10.1002/humu.23140

PubMed ID: 28526555

Title: Modeling psychomotor retardation using iPSCs from MCT8-deficient patients indicates a prominent role for the blood-brain barrier.

PubMed ID: 28526555

DOI: 10.1016/j.stem.2017.04.002

PubMed ID: 31436139

Title: In Vitro Characterization of Human, Mouse, and Zebrafish MCT8 Orthologues.

PubMed ID: 31436139

DOI: 10.1089/thy.2019.0009

Sequence Information:

  • Length: 539
  • Mass: 59511
  • Checksum: E4DB873D59FA4DD6
  • Sequence:
    • MALQSQASEE AKGPWQEADQ EQQEPVGSPE PESEPEPEPE PEPVPVPPPE PQPEPQPLPD 
PAPLPELEFE SERVHEPEPT PTVETRGTAR GFQPPEGGFG WVVVFAATWC NGSIFGIHNS 
VGILYSMLLE EEKEKNRQVE FQAAWVGALA MGMIFFCSPI VSIFTDRLGC RITATAGAAV 
AFIGLHTSSF TSSLSLRYFT YGILFGCGCS FAFQPSLVIL GHYFQRRLGL ANGVVSAGSS 
IFSMSFPFLI RMLGDKIKLA QTFQVLSTFM FVLMLLSLTY RPLLPSSQDT PSKRGVRTLH 
QRFLAQLRKY FNMRVFRQRT YRIWAFGIAA AALGYFVPYV HLMKYVEEEF SEIKETWVLL 
VCIGATSGLG RLVSGHISDS IPGLKKIYLQ VLSFLLLGLM SMMIPLCRDF GGLIVVCLFL 
GLCDGFFITI MAPIAFELVG PMQASQAIGY LLGMMALPMI AGPPIAGLLR NCFGDYHVAF 
YFAGVPPIIG AVILFFVPLM HQRMFKKEQR DSSKDKMLAP DPDPNGELLP GSPNPEEPI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.