Details for: SNTB2

Gene ID: 6645

Symbol: SNTB2

Ensembl ID: ENSG00000168807

Description: syntrophin beta 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 242.3089
    Cell Significance Index: -37.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 149.3830
    Cell Significance Index: -37.8900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 85.0626
    Cell Significance Index: -40.1600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 79.4571
    Cell Significance Index: -32.2800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.3443
    Cell Significance Index: -32.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.7554
    Cell Significance Index: -37.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.1553
    Cell Significance Index: -37.9200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.4739
    Cell Significance Index: -32.1700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.5969
    Cell Significance Index: -37.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.5453
    Cell Significance Index: 510.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.1195
    Cell Significance Index: 133.5900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.8472
    Cell Significance Index: 22.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.5598
    Cell Significance Index: 81.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.5258
    Cell Significance Index: 29.7800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.3906
    Cell Significance Index: 18.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.2174
    Cell Significance Index: 13.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9932
    Cell Significance Index: 896.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9482
    Cell Significance Index: 26.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9232
    Cell Significance Index: 34.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7819
    Cell Significance Index: 34.5900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.7782
    Cell Significance Index: 39.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7672
    Cell Significance Index: 94.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7238
    Cell Significance Index: 99.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6988
    Cell Significance Index: 19.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6946
    Cell Significance Index: 125.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6746
    Cell Significance Index: 73.3800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6520
    Cell Significance Index: 39.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6259
    Cell Significance Index: 101.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6052
    Cell Significance Index: 217.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5641
    Cell Significance Index: 111.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5562
    Cell Significance Index: 384.6900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.5237
    Cell Significance Index: 9.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3641
    Cell Significance Index: 198.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3071
    Cell Significance Index: 4.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2663
    Cell Significance Index: 34.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2600
    Cell Significance Index: 7.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2593
    Cell Significance Index: 14.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2456
    Cell Significance Index: 5.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1952
    Cell Significance Index: 37.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1808
    Cell Significance Index: 79.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1096
    Cell Significance Index: 4.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0968
    Cell Significance Index: 182.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0700
    Cell Significance Index: 95.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0693
    Cell Significance Index: 3.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0423
    Cell Significance Index: 4.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0332
    Cell Significance Index: 15.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0293
    Cell Significance Index: 18.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0265
    Cell Significance Index: 0.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0185
    Cell Significance Index: 28.5200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0180
    Cell Significance Index: 0.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0105
    Cell Significance Index: 19.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0095
    Cell Significance Index: 1.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0034
    Cell Significance Index: 0.2400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0061
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0170
    Cell Significance Index: -10.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0190
    Cell Significance Index: -14.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0210
    Cell Significance Index: -3.0500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0279
    Cell Significance Index: -0.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0327
    Cell Significance Index: -23.9600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0366
    Cell Significance Index: -0.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0371
    Cell Significance Index: -28.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0474
    Cell Significance Index: -26.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0547
    Cell Significance Index: -0.9100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0735
    Cell Significance Index: -1.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0977
    Cell Significance Index: -20.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1229
    Cell Significance Index: -12.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1315
    Cell Significance Index: -37.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1355
    Cell Significance Index: -15.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1605
    Cell Significance Index: -12.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1709
    Cell Significance Index: -20.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1725
    Cell Significance Index: -19.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1898
    Cell Significance Index: -8.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1968
    Cell Significance Index: -25.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2000
    Cell Significance Index: -5.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2246
    Cell Significance Index: -16.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2502
    Cell Significance Index: -11.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2637
    Cell Significance Index: -27.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2716
    Cell Significance Index: -5.7900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3070
    Cell Significance Index: -35.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3188
    Cell Significance Index: -10.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3390
    Cell Significance Index: -21.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3786
    Cell Significance Index: -10.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3896
    Cell Significance Index: -10.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4081
    Cell Significance Index: -32.3200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4103
    Cell Significance Index: -9.4800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4127
    Cell Significance Index: -3.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4327
    Cell Significance Index: -26.5300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4411
    Cell Significance Index: -14.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5696
    Cell Significance Index: -18.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5701
    Cell Significance Index: -29.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6191
    Cell Significance Index: -16.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6266
    Cell Significance Index: -13.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6374
    Cell Significance Index: -22.3300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6968
    Cell Significance Index: -4.2100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7133
    Cell Significance Index: -15.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7189
    Cell Significance Index: -24.9800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.7403
    Cell Significance Index: -12.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7516
    Cell Significance Index: -19.3200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7738
    Cell Significance Index: -15.3000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.7992
    Cell Significance Index: -16.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Role:** SNTB2 forms a homodimeric complex with dystrophin, providing a scaffold for the assembly of the DAGC. 2. **Cell Adhesion:** SNTB2 interacts with dystrophin and other DAGC proteins to mediate cell adhesion and maintain the integrity of muscle cells. 3. **Cytoskeletal Organization:** SNTB2 regulates the organization and dynamics of the cytoskeleton, particularly in muscle cells. 4. **Signaling:** SNTB2 modulates signaling pathways, including the regulation of calcium influx and the activation of downstream signaling molecules. 5. **Expression:** SNTB2 is widely expressed in various cell types, including photoreceptor cells, neurons, and fibroblasts. **Pathways and Functions:** 1. **Actin Binding:** SNTB2 interacts with actin-binding proteins, regulating the dynamics of the cytoskeleton. 2. **Calmodulin Binding:** SNTB2 binds to calmodulin, modulating calcium-dependent signaling pathways. 3. **Dystrophin-Associated Glycoprotein Complex:** SNTB2 forms a complex with dystrophin, other DAGC proteins, and associated molecules, maintaining muscle cell integrity. 4. **Focal Adhesion:** SNTB2 regulates the formation and maintenance of focal adhesions, essential for cell adhesion and migration. 5. **Golgi Apparatus and Endoplasmic Reticulum:** SNTB2 interacts with proteins involved in protein transport and modification, highlighting its role in protein processing and secretion. **Clinical Significance:** 1. **Muscle Disorders:** Alterations in SNTB2 expression have been implicated in various muscle disorders, including muscular dystrophy and myopathy. 2. **Neurological Disorders:** SNTB2 has been linked to neurological disorders, such as epilepsy and autism spectrum disorder, where disruptions in synaptic function and plasticity are observed. 3. **Cancer:** SNTB2 has been implicated in cancer progression, where its role in cell adhesion and signaling is exploited by cancer cells to promote metastasis and tumor growth. 4. **Eye Diseases:** SNTB2 expression has been observed in eye diseases, such as retinitis pigmentosa, where photoreceptor cell function is impaired. In conclusion, SNTB2 is a critical component of the DAGC, playing a pivotal role in maintaining muscle cell integrity, regulating cell adhesion, and modulating signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying SNTB2 function and its clinical significance.

Genular Protein ID: 2414525668

Symbol: SNTB2_HUMAN

Name: Beta-2-syntrophin

UniProtKB Accession Codes:

Q13425 Q9BY09

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8576247

Title: The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives.

PubMed ID: 8576247

DOI: 10.1074/jbc.271.5.2724

PubMed ID: 11043403

Title: The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cells.

PubMed ID: 11043403

DOI: 10.1078/0171-9335-00095

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10725395

Title: The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.

PubMed ID: 10725395

DOI: 10.1073/pnas.97.7.3596

PubMed ID: 11483505

Title: Dephosphorylation of beta2-syntrophin and Ca2+/mu-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion.

PubMed ID: 11483505

DOI: 10.1093/emboj/20.15.4013

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24234652

Title: LRP4 third beta-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated MuSK signaling in a position-specific manner.

PubMed ID: 24234652

DOI: 10.1093/hmg/ddt578

Sequence Information:

  • Length: 540
  • Mass: 57950
  • Checksum: 53A9F3340DC024ED
  • Sequence:
    • MRVAAATAAA GAGPAMAVWT RATKAGLVEL LLRERWVRVV AELSGESLSL TGDAAAAELE 
PALGPAAAAF NGLPNGGGAG DSLPGSPSRG LGPPSPPAPP RGPAGEAGAS PPVRRVRVVK 
QEAGGLGISI KGGRENRMPI LISKIFPGLA ADQSRALRLG DAILSVNGTD LRQATHDQAV 
QALKRAGKEV LLEVKFIREV TPYIKKPSLV SDLPWEGAAP QSPSFSGSED SGSPKHQNST 
KDRKIIPLKM CFAARNLSMP DLENRLIELH SPDSRNTLIL RCKDTATAHS WFVAIHTNIM 
ALLPQVLAEL NAMLGATSTA GGSKEVKHIA WLAEQAKLDG GRQQWRPVLM AVTEKDLLLY 
DCMPWTRDAW ASPCHSYPLV ATRLVHSGSG CRSPSLGSDL TFATRTGSRQ GIEMHLFRVE 
THRDLSSWTR ILVQGCHAAA ELIKEVSLGC MLNGQEVRLT IHYENGFTIS RENGGSSSIL 
YRYPFERLKM SADDGIRNLY LDFGGPEGEL TMDLHSCPKP IVFVLHTFLS AKVTRMGLLV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.