Details for: SST

Gene ID: 6750

Symbol: SST

Ensembl ID: ENSG00000157005

Description: somatostatin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 10.6199
    Cell Significance Index: 1212.2500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.4584
    Cell Significance Index: -19.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.1044
    Cell Significance Index: 67.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8484
    Cell Significance Index: 463.3100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7931
    Cell Significance Index: 716.0900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.5760
    Cell Significance Index: 11.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3707
    Cell Significance Index: 13.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3598
    Cell Significance Index: 8.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2779
    Cell Significance Index: 45.2000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2321
    Cell Significance Index: 3.8300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2302
    Cell Significance Index: 25.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1415
    Cell Significance Index: 3.7200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1371
    Cell Significance Index: 94.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0758
    Cell Significance Index: 14.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0647
    Cell Significance Index: 6.4000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0542
    Cell Significance Index: 1.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0484
    Cell Significance Index: 8.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0352
    Cell Significance Index: 12.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0349
    Cell Significance Index: 7.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0260
    Cell Significance Index: 1.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0239
    Cell Significance Index: 14.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0018
    Cell Significance Index: 1.3200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0018
    Cell Significance Index: 0.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0065
    Cell Significance Index: -0.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0117
    Cell Significance Index: -22.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0131
    Cell Significance Index: -7.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0263
    Cell Significance Index: -1.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0279
    Cell Significance Index: -20.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0291
    Cell Significance Index: -5.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0322
    Cell Significance Index: -20.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0332
    Cell Significance Index: -3.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0401
    Cell Significance Index: -7.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0430
    Cell Significance Index: -1.9500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0597
    Cell Significance Index: -0.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0641
    Cell Significance Index: -18.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0726
    Cell Significance Index: -13.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0812
    Cell Significance Index: -2.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1137
    Cell Significance Index: -13.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1186
    Cell Significance Index: -2.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1384
    Cell Significance Index: -17.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1403
    Cell Significance Index: -20.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1440
    Cell Significance Index: -3.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1557
    Cell Significance Index: -3.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1646
    Cell Significance Index: -22.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1911
    Cell Significance Index: -6.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2308
    Cell Significance Index: -29.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2367
    Cell Significance Index: -14.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2809
    Cell Significance Index: -18.8900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3264
    Cell Significance Index: -5.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3360
    Cell Significance Index: -21.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3813
    Cell Significance Index: -19.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3947
    Cell Significance Index: -22.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4006
    Cell Significance Index: -29.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4493
    Cell Significance Index: -23.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4973
    Cell Significance Index: -10.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4976
    Cell Significance Index: -22.0100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.5012
    Cell Significance Index: -6.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5053
    Cell Significance Index: -17.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5158
    Cell Significance Index: -14.0400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.5463
    Cell Significance Index: -7.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5778
    Cell Significance Index: -21.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5875
    Cell Significance Index: -20.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5965
    Cell Significance Index: -19.5300
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.6066
    Cell Significance Index: -5.6200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6315
    Cell Significance Index: -16.9200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6327
    Cell Significance Index: -20.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6351
    Cell Significance Index: -29.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6491
    Cell Significance Index: -33.7200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.6573
    Cell Significance Index: -9.3400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6794
    Cell Significance Index: -20.0100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6826
    Cell Significance Index: -19.4800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6982
    Cell Significance Index: -25.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7000
    Cell Significance Index: -18.7300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7174
    Cell Significance Index: -15.5000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7336
    Cell Significance Index: -15.5700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7380
    Cell Significance Index: -7.6400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.7744
    Cell Significance Index: -19.3100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.7816
    Cell Significance Index: -20.8700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.7903
    Cell Significance Index: -13.5100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7932
    Cell Significance Index: -16.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7986
    Cell Significance Index: -13.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8064
    Cell Significance Index: -16.8800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.8176
    Cell Significance Index: -16.4200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.8200
    Cell Significance Index: -16.1400
  • Cell Name: sst chodl GABAergic cortical interneuron (CL4023121)
    Fold Change: -0.8240
    Cell Significance Index: -5.7800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.8242
    Cell Significance Index: -20.5600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.8423
    Cell Significance Index: -12.6900
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.8575
    Cell Significance Index: -9.3600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.8702
    Cell Significance Index: -22.1700
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.8718
    Cell Significance Index: -9.6300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.8902
    Cell Significance Index: -10.3900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.9060
    Cell Significance Index: -18.9100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.9391
    Cell Significance Index: -11.8500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.9478
    Cell Significance Index: -15.3500
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.9711
    Cell Significance Index: -11.2400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.9738
    Cell Significance Index: -19.8200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.9906
    Cell Significance Index: -13.5900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.9959
    Cell Significance Index: -19.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0249
    Cell Significance Index: -29.3800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -1.0366
    Cell Significance Index: -15.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The SST gene is a single-copy gene that encodes a 14-amino acid peptide hormone, somatostatin. It is primarily expressed in the endocrine system, with high levels found in the pancreas, hypothalamus, and gastrointestinal tract. The SST gene has been identified in various cell types, including double-negative thymocytes, endocrine cells, pancreatic stellate cells, and enterocytes. The SST protein, also known as SMS_HUMAN, is a G-protein-coupled receptor antagonist that regulates various cellular processes, including cell proliferation, differentiation, and apoptosis. **Pathways and Functions:** The SST gene is involved in several key pathways, including: 1. **Cell-cell signaling:** SST regulates cell-cell interactions by inhibiting the release of various hormones and neurotransmitters, such as insulin, growth hormone, and acetylcholine. 2. **G-protein-coupled receptor signaling pathway:** SST interacts with G-protein-coupled receptors, modulating their activity and influencing downstream signaling pathways. 3. **Hormone activity:** SST regulates the release of hormones, such as insulin, growth hormone, and thyroid-stimulating hormone, by inhibiting their release from endocrine cells. 4. **Neurotransmission:** SST modulates neurotransmission by regulating the release of neurotransmitters, such as acetylcholine and serotonin, in the central nervous system. The SST gene has several functions, including: 1. **Inhibition of cell proliferation:** SST inhibits cell proliferation by regulating the expression of genes involved in cell cycle progression. 2. **Regulation of apoptosis:** SST modulates apoptosis by regulating the expression of pro-apoptotic and anti-apoptotic genes. 3. **Modulation of immune responses:** SST regulates immune responses by modulating the activity of immune cells, such as T cells and B cells. **Clinical Significance:** Dysregulation of the SST gene has been implicated in various immunological disorders, including: 1. **Autoimmune diseases:** Alterations in SST expression have been linked to autoimmune diseases, such as type 1 diabetes and multiple sclerosis. 2. **Cancer:** SST has been shown to inhibit tumor growth and metastasis in various cancer types, including breast and colon cancer. 3. **Neurological disorders:** SST has been implicated in neurological disorders, such as Parkinson's disease and Alzheimer's disease, where alterations in SST expression have been linked to disease progression. In conclusion, the SST gene plays a crucial role in regulating various physiological processes, including cell proliferation, differentiation, and neurotransmission. Its dysregulation has been implicated in various immunological disorders, highlighting the importance of further research into the SST gene and its role in human health and disease. **Recommendations:** 1. Further research is needed to fully understand the mechanisms by which the SST gene regulates various physiological processes. 2. The SST gene should be investigated as a potential therapeutic target for autoimmune diseases, cancer, and neurological disorders. 3. The SST gene should be studied in the context of other immunological genes to identify potential interactions and regulatory mechanisms. By understanding the SST gene and its role in immunological disorders, we can develop new therapeutic strategies to treat these diseases and improve human health.

Genular Protein ID: 3341283067

Symbol: SMS_HUMAN

Name: Somatostatin

UniProtKB Accession Codes:

P61278 B2R5G3 P01166

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 7 Ensembl 1 EvolutionaryTrace 1 GO 23 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 6126875

Title: Human somatostatin I: sequence of the cDNA.

PubMed ID: 6126875

DOI: 10.1073/pnas.79.15.4575

PubMed ID: 6142531

Title: Sequence of the human somatostatin I gene.

PubMed ID: 6142531

DOI: 10.1126/science.6142531

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29615476

Title: Neuronostatin exerts actions on pituitary that are unique from its sibling peptide somatostatin.

PubMed ID: 29615476

DOI: 10.1530/joe-18-0135

Sequence Information:

  • Length: 116
  • Mass: 12736
  • Checksum: AB49BB89DC9DD8DA
  • Sequence:
    • MLSCRLQCAL AALSIVLALG CVTGAPSDPR LRQFLQKSLA AAAGKQELAK YFLAELLSEP 
NQTENDALEP EDLSQAAEQD EMRLELQRSA NSNPAMAPRE RKAGCKNFFW KTFTSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.