Details for: SYT4

Gene ID: 6860

Symbol: SYT4

Ensembl ID: ENSG00000132872

Description: synaptotagmin 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.8683
    Cell Significance Index: 237.1700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 3.3771
    Cell Significance Index: 26.0300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 2.8492
    Cell Significance Index: 29.6800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 2.4345
    Cell Significance Index: 41.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.3148
    Cell Significance Index: 50.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4694
    Cell Significance Index: 66.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4369
    Cell Significance Index: 288.2400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.2654
    Cell Significance Index: 36.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1771
    Cell Significance Index: 37.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.0607
    Cell Significance Index: 55.6900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.8351
    Cell Significance Index: 12.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7909
    Cell Significance Index: 53.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6007
    Cell Significance Index: 215.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5849
    Cell Significance Index: 528.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5838
    Cell Significance Index: 57.7600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.4985
    Cell Significance Index: 6.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4021
    Cell Significance Index: 278.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3321
    Cell Significance Index: 20.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3021
    Cell Significance Index: 49.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2075
    Cell Significance Index: 22.5800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.2041
    Cell Significance Index: 1.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1212
    Cell Significance Index: 6.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0850
    Cell Significance Index: 16.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0529
    Cell Significance Index: 2.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0098
    Cell Significance Index: 7.2700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0073
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0098
    Cell Significance Index: -6.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0100
    Cell Significance Index: -0.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0153
    Cell Significance Index: -0.9200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0156
    Cell Significance Index: -29.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0159
    Cell Significance Index: -0.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0194
    Cell Significance Index: -10.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0211
    Cell Significance Index: -4.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0307
    Cell Significance Index: -0.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0309
    Cell Significance Index: -1.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0482
    Cell Significance Index: -30.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0545
    Cell Significance Index: -29.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0688
    Cell Significance Index: -31.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0816
    Cell Significance Index: -23.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0858
    Cell Significance Index: -14.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1508
    Cell Significance Index: -29.9300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1539
    Cell Significance Index: -3.6900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1689
    Cell Significance Index: -1.9700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1784
    Cell Significance Index: -2.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1974
    Cell Significance Index: -12.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2078
    Cell Significance Index: -30.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2173
    Cell Significance Index: -29.8400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2286
    Cell Significance Index: -26.0900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2451
    Cell Significance Index: -3.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2700
    Cell Significance Index: -30.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2876
    Cell Significance Index: -29.9500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2912
    Cell Significance Index: -2.7600
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.3294
    Cell Significance Index: -3.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3520
    Cell Significance Index: -11.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3531
    Cell Significance Index: -7.5200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3785
    Cell Significance Index: -4.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4013
    Cell Significance Index: -13.1400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4572
    Cell Significance Index: -9.0400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.4736
    Cell Significance Index: -5.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5087
    Cell Significance Index: -17.8200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5145
    Cell Significance Index: -10.9200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5461
    Cell Significance Index: -5.9500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5582
    Cell Significance Index: -11.5800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5758
    Cell Significance Index: -11.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5894
    Cell Significance Index: -30.7000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6357
    Cell Significance Index: -13.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6562
    Cell Significance Index: -30.8400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.6703
    Cell Significance Index: -8.4600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.7377
    Cell Significance Index: -10.7100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.7757
    Cell Significance Index: -16.1900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7761
    Cell Significance Index: -19.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7925
    Cell Significance Index: -41.1700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.8143
    Cell Significance Index: -10.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8628
    Cell Significance Index: -40.2300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.9427
    Cell Significance Index: -20.1500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.9533
    Cell Significance Index: -11.5600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.9643
    Cell Significance Index: -30.5000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9897
    Cell Significance Index: -21.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9993
    Cell Significance Index: -26.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0158
    Cell Significance Index: -26.7100
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -1.0349
    Cell Significance Index: -10.6400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0380
    Cell Significance Index: -30.5800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.0436
    Cell Significance Index: -20.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.0731
    Cell Significance Index: -29.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0733
    Cell Significance Index: -28.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0755
    Cell Significance Index: -30.8300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -1.1043
    Cell Significance Index: -14.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.1303
    Cell Significance Index: -30.1800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.1791
    Cell Significance Index: -16.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.1858
    Cell Significance Index: -24.8200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.1958
    Cell Significance Index: -29.8200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.1959
    Cell Significance Index: -29.8700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -1.2022
    Cell Significance Index: -13.1500
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -1.2308
    Cell Significance Index: -13.5800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.2369
    Cell Significance Index: -29.9600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.2472
    Cell Significance Index: -24.8700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.2481
    Cell Significance Index: -31.8000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.2832
    Cell Significance Index: -26.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.3085
    Cell Significance Index: -32.7100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.3240
    Cell Significance Index: -30.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SYT4 is a calcium-binding protein that is highly expressed in the nervous system, particularly in neurons and glial cells. It is a member of the synaptotagmin family, which is characterized by its ability to bind to calcium ions and phospholipids. The protein has a unique structure, consisting of four transmembrane domains and a cytoplasmic domain that interacts with SNARE proteins and other regulatory molecules. SYT4 has been shown to regulate various cellular processes, including calcium-dependent exocytosis, dendrite extension, and synaptic vesicle fusion. **Pathways and Functions** SYT4 is involved in several key pathways that regulate synaptic transmission and neurotransmitter release. These include: 1. **Calcium-dependent phospholipid binding**: SYT4 binds to calcium ions and phospholipids in the synaptic vesicle membrane, triggering the fusion of vesicles with the plasma membrane and the release of neurotransmitters. 2. **Calcium ion-regulated exocytosis of neurotransmitter**: SYT4 regulates the release of neurotransmitters by binding to calcium ions and phospholipids, which triggers the fusion of synaptic vesicles with the plasma membrane. 3. **Dendrite extension**: SYT4 regulates dendrite extension by promoting the growth of new dendritic branches and the formation of synapses. 4. **Synaptic vesicle fusion**: SYT4 regulates the fusion of synaptic vesicles with the plasma membrane, which is essential for neurotransmitter release. **Clinical Significance** Dysregulation of SYT4 has been implicated in various neurological disorders, including: 1. **Neurodegenerative diseases**: SYT4 has been shown to play a role in the regulation of synaptic transmission and neurotransmitter release, which is impaired in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. 2. **Mental health disorders**: SYT4 has been implicated in the regulation of synaptic transmission and neurotransmitter release, which is disrupted in mental health disorders such as depression and anxiety. 3. **Cognitive impairment**: SYT4 has been shown to play a role in the regulation of synaptic transmission and neurotransmitter release, which is impaired in cognitive impairment disorders such as attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). In conclusion, SYT4 is a critical gene that regulates synaptic transmission and neurotransmitter release. Its dysregulation has been implicated in various neurological disorders, highlighting the importance of this gene in maintaining normal brain function.

Genular Protein ID: 1985896365

Symbol: SYT4_HUMAN

Name: Synaptotagmin-4

UniProtKB Accession Codes:

Q9H2B2 B4DEU3 Q9P2K4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 40 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10938284

Title: The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity.

PubMed ID: 10938284

DOI: 10.1074/jbc.m005801200

PubMed ID: 10718198

Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10718198

DOI: 10.1093/dnares/7.1.65

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23999003

Title: SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation.

PubMed ID: 23999003

DOI: 10.1016/j.jdermsci.2013.07.010

Sequence Information:

  • Length: 425
  • Mass: 47958
  • Checksum: DA3D4CB175CB528D
  • Sequence:
    • MAPITTSREE FDEIPTVVGI FSAFGLVFTV SLFAWICCQR KSSKSNKTPP YKFVHVLKGV 
DIYPENLNSK KKFGADDKNE VKNKPAVPKN SLHLDLEKRD LNGNFPKTNL KPGSPSDLEN 
ATPKLFLEGE KESVSPESLK SSTSLTSEEK QEKLGTLFFS LEYNFERKAF VVNIKEARGL 
PAMDEQSMTS DPYIKMTILP EKKHKVKTRV LRKTLDPAFD ETFTFYGIPY TQIQELALHF 
TILSFDRFSR DDIIGEVLIP LSGIELSEGK MLMNREIIKR NVRKSSGRGE LLISLCYQST 
TNTLTVVVLK ARHLPKSDVS GLSDPYVKVN LYHAKKRISK KKTHVKKCTP NAVFNELFVF 
DIPCEGLEDI SVEFLVLDSE RGSRNEVIGQ LVLGAAAEGT GGEHWKEICD YPRRQIAKWH 
VLCDG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.