Details for: TBCD

Gene ID: 6904

Symbol: TBCD

Ensembl ID: ENSG00000141556

Description: tubulin folding cofactor D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 250.2005
    Cell Significance Index: -38.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 159.6730
    Cell Significance Index: -40.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 89.7648
    Cell Significance Index: -42.3800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 89.5745
    Cell Significance Index: -36.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 83.1370
    Cell Significance Index: -33.7800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 77.2573
    Cell Significance Index: -39.7400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.4598
    Cell Significance Index: -33.8600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.5454
    Cell Significance Index: -41.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.4338
    Cell Significance Index: -38.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.2552
    Cell Significance Index: -32.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.6157
    Cell Significance Index: -41.8900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.4621
    Cell Significance Index: -18.5200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 4.2857
    Cell Significance Index: 61.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0412
    Cell Significance Index: 409.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.6841
    Cell Significance Index: 74.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.5692
    Cell Significance Index: 59.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5071
    Cell Significance Index: 299.0800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.3547
    Cell Significance Index: 936.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3380
    Cell Significance Index: 132.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3296
    Cell Significance Index: 476.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3132
    Cell Significance Index: 36.7000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.8837
    Cell Significance Index: 18.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7631
    Cell Significance Index: 35.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7374
    Cell Significance Index: 41.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7000
    Cell Significance Index: 113.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6849
    Cell Significance Index: 47.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6460
    Cell Significance Index: 41.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6153
    Cell Significance Index: 66.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5568
    Cell Significance Index: 42.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4363
    Cell Significance Index: 393.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3379
    Cell Significance Index: 184.5100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3265
    Cell Significance Index: 19.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3168
    Cell Significance Index: 7.9200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2493
    Cell Significance Index: 469.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2039
    Cell Significance Index: 10.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2015
    Cell Significance Index: 24.7800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1870
    Cell Significance Index: 2.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1853
    Cell Significance Index: 117.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1831
    Cell Significance Index: 83.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1778
    Cell Significance Index: 32.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1666
    Cell Significance Index: 8.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1269
    Cell Significance Index: 5.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1207
    Cell Significance Index: 185.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1168
    Cell Significance Index: 3.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1017
    Cell Significance Index: 187.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0957
    Cell Significance Index: 2.4600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0811
    Cell Significance Index: 1.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0573
    Cell Significance Index: 77.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0403
    Cell Significance Index: 17.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0029
    Cell Significance Index: 0.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0033
    Cell Significance Index: -0.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0066
    Cell Significance Index: -0.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0153
    Cell Significance Index: -2.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0176
    Cell Significance Index: -0.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0337
    Cell Significance Index: -25.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0415
    Cell Significance Index: -30.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0420
    Cell Significance Index: -0.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0486
    Cell Significance Index: -36.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0502
    Cell Significance Index: -1.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0584
    Cell Significance Index: -9.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0672
    Cell Significance Index: -37.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0774
    Cell Significance Index: -48.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0904
    Cell Significance Index: -1.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1228
    Cell Significance Index: -35.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1247
    Cell Significance Index: -16.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1271
    Cell Significance Index: -2.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1464
    Cell Significance Index: -17.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1493
    Cell Significance Index: -15.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1542
    Cell Significance Index: -18.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1711
    Cell Significance Index: -4.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1760
    Cell Significance Index: -8.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2155
    Cell Significance Index: -45.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2462
    Cell Significance Index: -6.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2488
    Cell Significance Index: -25.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2920
    Cell Significance Index: -21.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2969
    Cell Significance Index: -34.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3585
    Cell Significance Index: -7.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3605
    Cell Significance Index: -18.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4040
    Cell Significance Index: -28.5800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4205
    Cell Significance Index: -8.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4552
    Cell Significance Index: -36.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4624
    Cell Significance Index: -28.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4644
    Cell Significance Index: -14.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4969
    Cell Significance Index: -31.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4980
    Cell Significance Index: -15.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5415
    Cell Significance Index: -17.7300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5663
    Cell Significance Index: -8.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5796
    Cell Significance Index: -30.4300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.5896
    Cell Significance Index: -7.8700
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.5899
    Cell Significance Index: -6.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6017
    Cell Significance Index: -20.9100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6191
    Cell Significance Index: -12.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6728
    Cell Significance Index: -9.1800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7106
    Cell Significance Index: -14.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7109
    Cell Significance Index: -24.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7250
    Cell Significance Index: -19.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7355
    Cell Significance Index: -12.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7363
    Cell Significance Index: -19.3600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7609
    Cell Significance Index: -18.9800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7627
    Cell Significance Index: -11.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TBCD is a protein that shares structural homology with other tubulin-specific chaperones, such as TBC1D1 and TBC1D2. Its primary function is to facilitate the folding of tubulin subunits into their native conformation, thereby regulating microtubule assembly and dynamics. This process is essential for maintaining the cytoskeletal structure and function, which in turn, influences various cellular processes, including cell migration, division, and differentiation. One of the most striking aspects of TBCD is its ability to interact with other proteins, such as beta-tubulin, and regulate microtubule polymerization. This interaction is mediated by a conserved GTPase-activating protein (GAP) domain, which enables TBCD to modulate the activity of GTP-binding proteins, such as RAB11 and RAB21. These proteins play critical roles in regulating membrane trafficking, vesicle transport, and protein secretion. **Pathways and Functions:** TBCD is implicated in several key pathways that regulate cellular processes, including: 1. **Microtubule organization and dynamics**: TBCD regulates microtubule assembly and disassembly by modulating the activity of GTP-binding proteins, such as RAB11 and RAB21. 2. **Cell morphology and adhesion**: TBCD influences cell morphology by regulating microtubule dynamics, which in turn, affects cell shape, adhesion, and migration. 3. **Protein folding and degradation**: TBCD interacts with chaperones, such as Hsp90, to regulate protein folding and degradation, which is essential for maintaining protein homeostasis. 4. **Endocytosis and exocytosis**: TBCD regulates membrane trafficking by modulating the activity of GTP-binding proteins, such as RAB11 and RAB21. **Clinical Significance:** Dysregulation of TBCD has been implicated in various diseases, including: 1. **Neurological disorders**: TBCD has been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, where microtubule dysfunction is a hallmark. 2. **Cancer**: TBCD has been implicated in cancer progression, where dysregulation of microtubule dynamics and protein folding can contribute to tumorigenesis and metastasis. 3. **Neurodevelopmental disorders**: TBCD has been linked to neurodevelopmental disorders, such as autism spectrum disorder, where microtubule dysfunction and protein folding abnormalities are thought to contribute to cognitive and behavioral deficits. In conclusion, TBCD is a multifunctional protein that plays a critical role in regulating microtubule dynamics, protein folding, and cell morphology. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the mechanisms underlying TBCD's function and its role in maintaining cellular homeostasis. Further research is needed to elucidate the complex relationships between TBCD and other proteins, as well as its role in various physiological and pathological contexts.

Genular Protein ID: 4104590708

Symbol: TBCD_HUMAN

Name: Tubulin-specific chaperone D

UniProtKB Accession Codes:

Q9BTW9 O95458 Q7L8K1 Q8IXP6 Q8NAX0 Q8WYH4 Q96E74 Q9UF82 Q9UG46 Q9Y2J3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11110777

Title: Shear stress-dependent regulation of the human beta-tubulin folding cofactor D gene.

PubMed ID: 11110777

DOI: 10.1161/01.res.87.12.1188

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10722852

Title: Tubulin folding cofactor D is a microtubule destabilizing protein.

PubMed ID: 10722852

DOI: 10.1016/s0014-5793(00)01293-x

PubMed ID: 10831612

Title: ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin.

PubMed ID: 10831612

DOI: 10.1083/jcb.149.5.1087

PubMed ID: 11847227

Title: Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C.

PubMed ID: 11847227

DOI: 10.1074/jbc.m200128200

PubMed ID: 20740604

Title: Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity.

PubMed ID: 20740604

DOI: 10.1002/cm.20480

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 27666374

Title: Biallelic TBCD mutations cause early-onset neurodegenerative encephalopathy.

PubMed ID: 27666374

DOI: 10.1016/j.ajhg.2016.08.005

PubMed ID: 27666370

Title: Biallelic mutations in TBCD, encoding the tubulin folding cofactor D, perturb microtubule dynamics and cause early-onset encephalopathy.

PubMed ID: 27666370

DOI: 10.1016/j.ajhg.2016.08.003

PubMed ID: 28158450

Title: Infantile neurodegenerative disorder associated with mutations in TBCD, an essential gene in the tubulin heterodimer assembly pathway.

PubMed ID: 28158450

DOI: 10.1093/hmg/ddw292

PubMed ID: 27807845

Title: Microcephaly, intractable seizures and developmental delay caused by biallelic variants in TBCD: further delineation of a new chaperone-mediated tubulinopathy.

PubMed ID: 27807845

DOI: 10.1111/cge.12914

Sequence Information:

  • Length: 1192
  • Mass: 132600
  • Checksum: C46BE2048A5FEBC2
  • Sequence:
    • MALSDEPAAG GPEEEAEDET LAFGAALEAF GESAETRALL GRLREVHGGG AEREVALERF 
RVIMDKYQEQ PHLLDPHLEW MMNLLLDIVQ DQTSPASLVH LAFKFLYIIT KVRGYKTFLR 
LFPHEVADVE PVLDLVTIQN PKDHEAWETR YMLLLWLSVT CLIPFDFSRL DGNLLTQPGQ 
ARMSIMDRIL QIAESYLIVS DKARDAAAVL VSRFITRPDV KQSKMAEFLD WSLCNLARSS 
FQTMQGVITM DGTLQALAQI FKHGKREDCL PYAATVLRCL DGCRLPESNQ TLLRKLGVKL 
VQRLGLTFLK PKVAAWRYQR GCRSLAANLQ LLTQGQSEQK PLILTEDDDE DDDVPEGVER 
VIEQLLVGLK DKDTVVRWSA AKGIGRMAGR LPRALADDVV GSVLDCFSFQ ETDKAWHGGC 
LALAELGRRG LLLPSRLVDV VAVILKALTY DEKRGACSVG TNVRDAACYV CWAFARAYEP 
QELKPFVTAI SSALVIAAVF DRDINCRRAA SAAFQENVGR QGTFPHGIDI LTTADYFAVG 
NRSNCFLVIS VFIAGFPEYT QPMIDHLVTM KISHWDGVIR ELAARALHNL AQQAPEFSAT 
QVFPRLLSMT LSPDLHMRHG SILACAEVAY ALYKLAAQEN RPVTDHLDEQ AVQGLKQIHQ 
QLYDRQLYRG LGGQLMRQAV CVLIEKLSLS KMPFRGDTVI DGWQWLINDT LRHLHLISSH 
SRQQMKDAAV SALAALCSEY YMKEPGEADP AIQEELITQY LAELRNPEEM TRCGFSLALG 
ALPGFLLKGR LQQVLTGLRA VTHTSPEDVS FAESRRDGLK AIARICQTVG VKAGAPDEAV 
CGENVSQIYC ALLGCMDDYT TDSRGDVGTW VRKAAMTSLM DLTLLLARSQ PELIEAHTCE 
RIMCCVAQQA SEKIDRFRAH AASVFLTLLH FDSPPIPHVP HRGELEKLFP RSDVASVNWS 
APSQAFPRIT QLLGLPTYRY HVLLGLVVSL GGLTESTIRH STQSLFEYMK GIQSDPQALG 
SFSGTLLQIF EDNLLNERVS VPLLKTLDHV LTHGCFDIFT TEEDHPFAVK LLALCKKEIK 
NSKDIQKLLS GIAVFCEMVQ FPGDVRRQAL LQLCLLLCHR FPLIRKTTAS QVYETLLTYS 
DVVGADVLDE VVTVLSDTAW DAELAVVREQ RNRLCDLLGV PRPQLVPQPG AC

Genular Protein ID: 3589288611

Symbol: A0A804HI02_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A804HI02

Database IDs:

ARBA 2 AlphaFoldDB 1 Bgee 1 CTD 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 1073
  • Mass: 119092
  • Checksum: 318A9F7EDD50EC64
  • Sequence:
    • MALSDEPAAG GPEEEAEDET LAFGAALEAF GESAETRALL GRLREVHGGG AEREVALERF 
RVIMDKYQEQ PHLLDPHLEW MMNLLLDIVQ DQTSPASLVH LAFKFLYIIT KVRGYKTFLR 
LFPHEVADVE PVLDLVTIQN PKDHEAWETR YMLLLWLSVT CLIPFDFSRL DGNLLTQPGQ 
ARMSIMDRIL QIAESYLIVS DKARDAAAVL VSRFITRPDV KQSKMAEFLD WSLCNLARSS 
FQTMQGVITM DGTLQALAQI FKHGKREDCL PYAATVLRCL DGCRLPESNQ TLLRKLGVKL 
VQRLGLTFLK PKVAAWRYQR GCRSLAANLQ LLTQGQSEQK PLILTEDDDE DDDVPEGVER 
VIEQLLVGLK DKDTVVRWSA AKGIGRMAGR LPRALADDVV GSVLDCFSFQ ETDKAWHGGC 
LALAELGRRG LLLPSRLVDV VAVILKALTY DEKRGACSVG TNVRDAACYV CWAFARAYEP 
QELKPFVTAI SSALVIAAVF DRDINCRRAA SAAFQENVGR QGTFPHGIDI LTTADYFAVG 
NRSNCFLVIR GLGGQLMRQA VCVLIEKLSL SKMPFRGDTV IDGWQWLIND TLRHLHLISS 
HSRQQMKDAA VSALAALCSE YYMKEPGEAD PAIQEELITQ YLAELRNPEE MTRCGFSLAL 
GALPGFLLKG RLQQVLTGLR AVTHTSPEDV SFAESRRDGL KAIARICQTV GVKAGAPDEA 
VCGENVSQIY CALLGCMDDY TTDSRGDVGT WVRKAAMTSL MDLTLLLARS QPELIEAHTC 
ERIMCCVAQQ ASEKIDRFRA HAASVFLTLL HFDSPPIPHV PHRGELEKLF PRSDVASVNW 
SAPSQAFPRI TQLLGLPTYR YHVLLGLVVS LGGLTESTIR HSTQSLFEYM KGIQSDPQAL 
GSFSGTLLQI FEDNLLNERV SVPLLKTLDH VLTHGCFDIF TTEEDHPFAV KLLALCKKEI 
KNSKDIQKLL SGIAVFCEMV QFPGDVRRQA LLQLCLLLCH RFPLIRKTTA SQVYETLLTY 
SDVVGADVLD EVVTVLSDTA WDAELAVVRE QRNRLCDLLG VPRPQLVPQP GAC

Genular Protein ID: 599559592

Symbol: A0A804HJU6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A804HJU6

Database IDs:

ARBA 2 Bgee 1 CTD 1 DisGeNET 1 EMBL 5 Ensembl 3 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 4 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 630
  • Mass: 70091
  • Checksum: 50332751560B8C2D
  • Sequence:
    • MIDHLVTMKI SHWDGVIREL AARALHNLAQ QAPEFSATQV FPRLLSMTLS PDLHMRHGSI 
LACAEVAYAL YKLAAQENRP VTDHLDEQAV QGLKQIHQQL YDRQLYRGLG GQLMRQAVCV 
LIEKLSLSKM PFRGDTVIDG WQWLINDTLR HLHLISSHSR QQMKDAAVSA LAALCSEYYM 
KEPGEADPAI QEELITQYLA ELRNPEEMTR CGFSLALGAL PGFLLKGRLQ QVLTGLRAVT 
HTSPEDVSFA ESRRDGLKAI ARICQTVGVK AGAPDEAVCG ENVSQIYCAL LGCMDDYTTD 
SRGDVGTWVR KAAMTSLMDL TLLLARSQPE LIEAHTCERI MCCVAQQASE KIDRFRAHAA 
SVFLTLLHFD SPPIPHVPHR GELEKLFPRS DVASVNWSAP SQAFPRITQL LGLPTYRYHV 
LLGLVVSLGG LTESTIRHST QSLFEYMKGI QSDPQALGSF SGTLLQIFED NLLNERVSVP 
LLKTLDHVLT HGCFDIFTTE EDHPFAVKLL ALCKKEIKNS KDIQKLLSGI AVFCEMVQFP 
GDVRRQALLQ LCLLLCHRFP LIRKTTASQV YETLLTYSDV VGADVLDEVV TVLSDTAWDA 
ELAVVREQRN RLCDLLGVPR PQLVPQPGAC

Genular Protein ID: 3369776194

Symbol: A0A804HIN6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A804HIN6

Database IDs:

ARBA 2 AlphaFoldDB 1 Bgee 1 CTD 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 1129
  • Mass: 125962
  • Checksum: 38C07A57E54B90C0
  • Sequence:
    • MDKYQEQPHL LDPHLEWMMN LLLDIVQDQT SPASLVHLAF KFLYIITKVR GYKTFLRLFP 
HEVADVEPVL DLVTIQNPKD HEAWETRYML LLWLSVTCLI PFDFSRLDGN LLTQPGQARM 
SIMDRILQIA ESYLIVSDKA RDAAAVLVSR FITRPDVKQS KMAEFLDWSL CNLARSSFQT 
MQGVITMDGT LQALAQIFKH GKREDCLPYA ATVLRCLDGC RLPESNQTLL RKLGVKLVQR 
LGLTFLKPKV AAWRYQRGCR SLAANLQLLT QGQSEQKPLI LTEDDDEDDD VPEGVERVIE 
QLLVGLKDKD TVVRWSAAKG IGRMAGRLPR ALADDVVGSV LDCFSFQETD KAWHGGCLAL 
AELGRRGLLL PSRLVDVVAV ILKALTYDEK RGACSVGTNV RDAACYVCWA FARAYEPQEL 
KPFVTAISSA LVIAAVFDRD INCRRAASAA FQENVGRQGT FPHGIDILTT ADYFAVGNRS 
NCFLVISVFI AGFPEYTQPM IDHLVTMKIS HWDGVIRELA ARALHNLAQQ APEFSATQVF 
PRLLSMTLSP DLHMRHGSIL ACAEVAYALY KLAAQENRPV TDHLDEQAVQ GLKQIHQQLY 
DRQLYRGLGG QLMRQAVCVL IEKLSLSKMP FRGDTVIDGW QWLINDTLRH LHLISSHSRQ 
QMKDAAVSAL AALCSEYYMK EPGEADPAIQ EELITQYLAE LRNPEEMTRC GFSLALGALP 
GFLLKGRLQQ VLTGLRAVTH TSPEDVSFAE SRRDGLKAIA RICQTVGVKA GAPDEAVCGE 
NVSQIYCALL GCMDDYTTDS RGDVGTWVRK AAMTSLMDLT LLLARSQPEL IEAHTCERIM 
CCVAQQASEK IDRFRAHAAS VFLTLLHFDS PPIPHVPHRG ELEKLFPRSD VASVNWSAPS 
QAFPRITQLL GLPTYRYHVL LGLVVSLGGL TESTIRHSTQ SLFEYMKGIQ SDPQALGSFS 
GTLLQIFEDN LLNERVSVPL LKTLDHVLTH GCFDIFTTEE DHPFAVKLLA LCKKEIKNSK 
DIQKLLSGIA VFCEMVQFPG DVRRQALLQL CLLLCHRFPL IRKTTASQVY ETLLTYSDVV 
GADVLDEVVT VLSDTAWDAE LAVVREQRNR LCDLLGVPRP QLVPQPGAC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.