Details for: TBX15

Gene ID: 6913

Symbol: TBX15

Ensembl ID: ENSG00000092607

Description: T-box transcription factor 15

Associated with

  • Cell fate specification
    (GO:0001708)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Embryonic cranial skeleton morphogenesis
    (GO:0048701)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription repressor complex
    (GO:0090571)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 7.2972
    Cell Significance Index: 155.9800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 4.3628
    Cell Significance Index: 29.5600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 3.8230
    Cell Significance Index: 48.1400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.4415
    Cell Significance Index: 59.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.1604
    Cell Significance Index: 45.2200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.0576
    Cell Significance Index: 33.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.9854
    Cell Significance Index: 25.3300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9530
    Cell Significance Index: 23.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8850
    Cell Significance Index: 25.3700
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.5383
    Cell Significance Index: 3.1600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.5285
    Cell Significance Index: 7.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4780
    Cell Significance Index: 94.8600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3142
    Cell Significance Index: 15.8800
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.3029
    Cell Significance Index: 2.6200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.2625
    Cell Significance Index: 2.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1774
    Cell Significance Index: 20.6700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1766
    Cell Significance Index: 2.9800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1587
    Cell Significance Index: 1.7300
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.1535
    Cell Significance Index: 0.8800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1075
    Cell Significance Index: 1.9000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1034
    Cell Significance Index: 1.6400
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0988
    Cell Significance Index: 0.4300
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.0816
    Cell Significance Index: 0.5000
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.0760
    Cell Significance Index: 0.6900
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.0744
    Cell Significance Index: 0.7600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0205
    Cell Significance Index: 0.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0163
    Cell Significance Index: 1.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0059
    Cell Significance Index: 0.8600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0029
    Cell Significance Index: 2.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0028
    Cell Significance Index: 0.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0022
    Cell Significance Index: -2.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0030
    Cell Significance Index: -5.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0036
    Cell Significance Index: -5.5300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0041
    Cell Significance Index: -0.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0042
    Cell Significance Index: -2.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0052
    Cell Significance Index: -3.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0053
    Cell Significance Index: -3.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0058
    Cell Significance Index: -3.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0060
    Cell Significance Index: -4.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0063
    Cell Significance Index: -2.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0071
    Cell Significance Index: -4.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0086
    Cell Significance Index: -3.9000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0107
    Cell Significance Index: -0.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0116
    Cell Significance Index: -5.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0134
    Cell Significance Index: -2.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0139
    Cell Significance Index: -3.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0139
    Cell Significance Index: -2.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0193
    Cell Significance Index: -4.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0216
    Cell Significance Index: -2.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0244
    Cell Significance Index: -3.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0286
    Cell Significance Index: -3.5200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0294
    Cell Significance Index: -0.4400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0321
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0331
    Cell Significance Index: -3.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0338
    Cell Significance Index: -4.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0345
    Cell Significance Index: -4.0700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0366
    Cell Significance Index: -0.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0377
    Cell Significance Index: -1.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0413
    Cell Significance Index: -4.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0426
    Cell Significance Index: -2.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0429
    Cell Significance Index: -3.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0469
    Cell Significance Index: -3.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0493
    Cell Significance Index: -3.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0504
    Cell Significance Index: -2.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0623
    Cell Significance Index: -1.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0644
    Cell Significance Index: -2.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0688
    Cell Significance Index: -4.2300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0744
    Cell Significance Index: -0.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0756
    Cell Significance Index: -4.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0817
    Cell Significance Index: -5.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0855
    Cell Significance Index: -4.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0941
    Cell Significance Index: -2.6300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0944
    Cell Significance Index: -0.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0950
    Cell Significance Index: -2.0800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0968
    Cell Significance Index: -3.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1099
    Cell Significance Index: -3.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1100
    Cell Significance Index: -3.6000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1118
    Cell Significance Index: -0.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1167
    Cell Significance Index: -5.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1199
    Cell Significance Index: -3.8200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1247
    Cell Significance Index: -3.1100
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.1256
    Cell Significance Index: -0.7900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1291
    Cell Significance Index: -1.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1324
    Cell Significance Index: -3.9000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1328
    Cell Significance Index: -3.7900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1348
    Cell Significance Index: -2.3100
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.1433
    Cell Significance Index: -1.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1439
    Cell Significance Index: -3.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1468
    Cell Significance Index: -3.9200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1483
    Cell Significance Index: -3.7000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1516
    Cell Significance Index: -2.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1523
    Cell Significance Index: -5.3500
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1530
    Cell Significance Index: -2.0400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1573
    Cell Significance Index: -3.2000
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1577
    Cell Significance Index: -2.3600
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.1582
    Cell Significance Index: -1.6700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1591
    Cell Significance Index: -5.8400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1608
    Cell Significance Index: -2.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1639
    Cell Significance Index: -4.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TBX15 is a transcription factor that belongs to the T-box family of proteins, which are essential for the regulation of cell fate decisions during development. TBX15 exhibits a unique combination of transcriptional activation and repression activities, allowing it to fine-tune gene expression in response to various stimuli. Its ability to bind to specific DNA sequences and interact with RNA polymerase II makes it a potent regulator of transcriptional programs. **Pathways and Functions:** TBX15 is involved in several critical pathways, including: 1. **Cell Fate Specification:** TBX15 regulates the differentiation of immune cells, such as conventional dendritic cells and granulocyte-monocyte progenitor cells, ensuring proper immune cell development and function. 2. **Chromatin and DNA-binding:** TBX15 interacts with chromatin to regulate gene expression, and its ability to bind to specific DNA sequences allows it to modulate transcriptional programs. 3. **RNA Polymerase II-specific:** TBX15 regulates transcription by interacting with RNA polymerase II, a key enzyme responsible for transcribing genes into RNA. 4. **Embryonic Cranial Skeleton Morphogenesis:** TBX15 plays a role in the development of the embryonic cranial skeleton, highlighting its importance in tissue development and patterning. **Clinical Significance:** Dysregulation of TBX15 has been implicated in several autoimmune and inflammatory disorders, including: 1. **Autoimmune Diseases:** TBX15 has been shown to play a critical role in the development of autoimmune diseases, such as rheumatoid arthritis and lupus, by regulating immune cell function and tissue homeostasis. 2. **Inflammatory Disorders:** TBX15 has been implicated in the pathogenesis of inflammatory disorders, such as atherosclerosis and inflammatory bowel disease, by regulating the expression of pro-inflammatory genes. 3. **Cancer:** TBX15 has been shown to play a role in cancer development and progression, particularly in the context of immune evasion and tumor microenvironment regulation. In conclusion, TBX15 is a critical T-box transcription factor that plays a pivotal role in regulating immune cell development, function, and tissue homeostasis. Its dysregulation has been implicated in several autoimmune and inflammatory disorders, highlighting the importance of further research into the mechanisms underlying TBX15 function and its role in human disease.

Genular Protein ID: 1124808869

Symbol: TBX15_HUMAN

Name: T-box transcription factor TBX15

UniProtKB Accession Codes:

Q96SF7 Q08E76 Q5JT54 Q5T9S7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19068278

Title: TBX15 mutations cause craniofacial dysmorphism, hypoplasia of scapula and pelvis, and short stature in Cousin syndrome.

PubMed ID: 19068278

DOI: 10.1016/j.ajhg.2008.10.011

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 602
  • Mass: 65757
  • Checksum: 95CF3C1CDF089085
  • Sequence:
    • MSERRRSAVA LSSRAHAFSV EALIGSNKKR KLRDWEEKGL DLSMEALSPA GPLGDTEDAA 
AHGLEPHPDS EQSTGSDSEV LTERTSCSFS THTDLASGAA GPVPAAMSSM EEIQVELQCA 
DLWKRFHDIG TEMIITKAGR RMFPAMRVKI TGLDPHQQYY IAMDIVPVDN KRYRYVYHSS 
KWMVAGNADS PVPPRVYIHP DSLASGDTWM RQVVSFDKLK LTNNELDDQG HIILHSMHKY 
QPRVHVIRKD FSSDLSPTKP VPVGDGVKTF NFPETVFTTV TAYQNQQITR LKIDRNPFAK 
GFRDSGRNRT GLEAIMETYA FWRPPVRTLT FEDFTTMQKQ QGGSTGTSPT TSSTGTPSPS 
ASSHLLSPSC SPPTFHLAPN TFNVGCRESQ LCNLNLSDYP PCARSNMAAL QSYPGLSDSG 
YNRLQSGTTS ATQPSETFMP QRTPSLISGI PTPPSLPGNS KMEAYGGQLG SFPTSQFQYV 
MQAGNAASSS SSPHMFGGSH MQQSSYNAFS LHNPYNLYGY NFPTSPRLAA SPEKLSASQS 
TLLCSSPSNG AFGERQYLPS GMEHSMHMIS PSPNNQQATN TCDGRQYGAV PGSSSQMSVH 
MV

Genular Protein ID: 634609623

Symbol: Q8N8P2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N8P2

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 PharmGKB 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 287
  • Mass: 30592
  • Checksum: 7BB39CBC7AC579D6
  • Sequence:
    • METYAFWRPP VRTLTFEDFT TMQKQQGGST GTSPTTSSTG TPSPSASSHL LSPSCSPPTF 
HLAPNTFNVG CRESQLCNLN LSDYPPCARS NMAALQSYPG LSDSGYNRLQ SGTTSATQPS 
ETFMPQRTPS LISGIPTPPS LPGNSKMEAY GGQLGSFPTS QFQYVMQAGN AASSSSSPHM 
FGGSHMQQSS YNAFSLHNPY NLYGYNFPTS PRLAASPEKL SASQSTLLCS SPSNGAFGER 
QYLPSGMEHS MHMISPSPNN QQATNTCDGR QYGAVPGSSS QMSVHMV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.