Details for: TCEA3

Gene ID: 6920

Symbol: TCEA3

Ensembl ID: ENSG00000204219

Description: transcription elongation factor A3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 185.1552
    Cell Significance Index: -28.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 115.3982
    Cell Significance Index: -29.2700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 63.8182
    Cell Significance Index: -30.1300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 44.5589
    Cell Significance Index: -29.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.3504
    Cell Significance Index: -28.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.1395
    Cell Significance Index: -32.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.4036
    Cell Significance Index: -29.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.5131
    Cell Significance Index: 120.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 4.4086
    Cell Significance Index: 60.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.3020
    Cell Significance Index: 113.1200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.5932
    Cell Significance Index: 53.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.3008
    Cell Significance Index: 149.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.0694
    Cell Significance Index: 143.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.6366
    Cell Significance Index: 2380.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6408
    Cell Significance Index: 325.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.5669
    Cell Significance Index: 108.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4640
    Cell Significance Index: 42.1800
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.3704
    Cell Significance Index: 6.6700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.3232
    Cell Significance Index: 30.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2163
    Cell Significance Index: 63.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.1441
    Cell Significance Index: 29.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1433
    Cell Significance Index: 24.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0661
    Cell Significance Index: 105.4600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.0049
    Cell Significance Index: 24.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9677
    Cell Significance Index: 26.3400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.9000
    Cell Significance Index: 13.9300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.8758
    Cell Significance Index: 12.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.8403
    Cell Significance Index: 143.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.7418
    Cell Significance Index: 23.7600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.6960
    Cell Significance Index: 11.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6780
    Cell Significance Index: 52.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6372
    Cell Significance Index: 74.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5181
    Cell Significance Index: 12.9500
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.5130
    Cell Significance Index: 5.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4422
    Cell Significance Index: 32.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4273
    Cell Significance Index: 55.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4259
    Cell Significance Index: 46.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4258
    Cell Significance Index: 69.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3986
    Cell Significance Index: 75.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3683
    Cell Significance Index: 19.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3238
    Cell Significance Index: 41.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3195
    Cell Significance Index: 16.1500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.3142
    Cell Significance Index: 3.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2372
    Cell Significance Index: 6.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2041
    Cell Significance Index: 90.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1867
    Cell Significance Index: 22.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1659
    Cell Significance Index: 11.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1635
    Cell Significance Index: 29.4700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1451
    Cell Significance Index: 273.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1109
    Cell Significance Index: 69.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1100
    Cell Significance Index: 15.1100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0948
    Cell Significance Index: 1.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0807
    Cell Significance Index: 59.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0786
    Cell Significance Index: 54.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0633
    Cell Significance Index: 12.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0458
    Cell Significance Index: 62.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0347
    Cell Significance Index: 22.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0321
    Cell Significance Index: 24.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0309
    Cell Significance Index: 11.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0290
    Cell Significance Index: 44.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0174
    Cell Significance Index: 32.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0085
    Cell Significance Index: 3.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0052
    Cell Significance Index: -0.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0075
    Cell Significance Index: -4.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0103
    Cell Significance Index: -7.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0211
    Cell Significance Index: -1.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0309
    Cell Significance Index: -17.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0316
    Cell Significance Index: -3.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0601
    Cell Significance Index: -17.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0753
    Cell Significance Index: -15.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0834
    Cell Significance Index: -9.5600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1015
    Cell Significance Index: -1.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1403
    Cell Significance Index: -4.9300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1457
    Cell Significance Index: -2.4500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1687
    Cell Significance Index: -1.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1959
    Cell Significance Index: -20.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2157
    Cell Significance Index: -10.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2162
    Cell Significance Index: -4.2200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2177
    Cell Significance Index: -24.8500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2474
    Cell Significance Index: -4.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2543
    Cell Significance Index: -15.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2826
    Cell Significance Index: -33.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3153
    Cell Significance Index: -6.6000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3795
    Cell Significance Index: -3.5000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3904
    Cell Significance Index: -4.0400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4170
    Cell Significance Index: -8.6500
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.4585
    Cell Significance Index: -4.7300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4590
    Cell Significance Index: -5.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4848
    Cell Significance Index: -25.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4864
    Cell Significance Index: -17.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4885
    Cell Significance Index: -31.5200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4905
    Cell Significance Index: -7.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5198
    Cell Significance Index: -32.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5270
    Cell Significance Index: -29.5700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5337
    Cell Significance Index: -5.5300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5401
    Cell Significance Index: -11.5500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5466
    Cell Significance Index: -20.0700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.5520
    Cell Significance Index: -5.8700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5616
    Cell Significance Index: -11.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6095
    Cell Significance Index: -26.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TCEA3 is a highly conserved gene, with its homologs found in numerous species, including humans, rodents, and other vertebrates. The gene is primarily expressed in cells of the gastrointestinal tract, reproductive system, and nervous system. TCEA3 is a zinc-binding protein, which is essential for its function as a transcription elongation factor. The protein's structure consists of three domains: an N-terminal domain, a central domain, and a C-terminal domain, which interact with RNA polymerase II and other transcriptional regulators. **Pathways and Functions:** TCEA3 is involved in the regulation of transcription elongation by RNA polymerase II, a process that is essential for the expression of genes involved in various cellular processes, including cell growth, differentiation, and survival. The gene's primary function is to facilitate the progression of RNA polymerase II along the transcriptional DNA template, thereby regulating the expression of genes involved in cell-specific functions. TCEA3 also interacts with other transcriptional regulators, such as E2F transcription factors, to modulate the expression of genes involved in cell cycle progression and apoptosis. **Clinical Significance:** Dysregulation of TCEA3 has been implicated in various human diseases, including cancer, where it is often associated with poor prognosis and reduced survival rates. For example, elevated expression of TCEA3 has been observed in breast cancer, lung cancer, and colon cancer, suggesting its potential as a prognostic biomarker. Furthermore, TCEA3 has been shown to play a role in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it is involved in the regulation of transcriptional programs involved in neuronal survival and death. In conclusion, TCEA3 is a critical gene involved in the regulation of transcription elongation by RNA polymerase II, with significant implications for our understanding of various human diseases. Further research is needed to fully elucidate the mechanisms by which TCEA3 regulates gene expression and to explore its potential as a therapeutic target for the treatment of cancer and neurodegenerative diseases. **Significantly expressed cells:** - Intestine goblet cell - Granulosa cell - Sertoli cell - Serous secreting cell - Mucous neck cell - Pancreatic acinar cell - Ovarian surface epithelial cell - Cell of skeletal muscle - Peptic cell - Choroid plexus epithelial cell **Proteins:** - TCEA3_HUMAN (Transcription elongation factor A protein 3) - B4DUM4_HUMAN

Genular Protein ID: 120718720

Symbol: TCEA3_HUMAN

Name: Transcription elongation factor A protein 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9790746

Title: Identification of novel genes encoding transcription elongation factor TFIIS (TCEA) in vertebrates: conservation of three distinct TFIIS isoforms in frog, mouse, and human.

PubMed ID: 9790746

DOI: 10.1006/geno.1998.5449

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 348
  • Mass: 38972
  • Checksum: 3D0A046B5096753D
  • Sequence:
  • MGQEEELLRI AKKLEKMVAR KNTEGALDLL KKLHSCQMSI QLLQTTRIGV AVNGVRKHCS 
    DKEVVSLAKV LIKNWKRLLD SPGPPKGEKG EEREKAKKKE KGLECSDWKP EAGLSPPRKK 
    REDPKTRRDS VDSKSSASSS PKRPSVERSN SSKSKAESPK TPSSPLTPTF ASSMCLLAPC 
    YLTGDSVRDK CVEMLSAALK ADDDYKDYGV NCDKMASEIE DHIYQELKST DMKYRNRVRS 
    RISNLKDPRN PGLRRNVLSG AISAGLIAKM TAEEMASDEL RELRNAMTQE AIREHQMAKT 
    GGTTTDLFQC SKCKKKNCTY NQVQTRSADE PMTTFVLCNE CGNRWKFC

Genular Protein ID: 718363572

Symbol: B4DUM4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 123
  • Mass: 13678
  • Checksum: D8F5146C44960C0A
  • Sequence:
  • MSIQLLQTTR IGVAVNGVRK HCSDKEVVSL AKVLIKNWKR LLDSPGPPKG EKGEEREKAK 
    KKEKGLECSD WKPEAGLSPP RKKREDPKTR RDSVDSKSSV SWPPAISQGT LSGTSVWRCC 
    QQP

Genular Protein ID: 2592639639

Symbol: S4R3M9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 351
  • Mass: 39227
  • Checksum: B35B9218A5546B50
  • Sequence:
  • MGQEEELLRI AKKLEKMVAR KNTEGALDLL KKLHSCQMSI QLLQTTRIGV AVNGVRKHCS 
    DKEVVSLAKV LIKNWKRLLD SPGPPKGEKG EEREKAKKKE KGLECSDWKP EAGLSPPRKK 
    REDPKTRRDS VDSKSSASSS PKRPSVERSN SSKSKAESPK TPSSPLTPTF ASSMCLLAPC 
    YLTGDSVRDK CVEMLSAALK ADDDYKDYGV NCDKMASEIE DHIYQELKST DMKYRNRVRS 
    RISNLKDPRN PGLRRNVLSG AISAGLIAKM TAEEMASDEL RELRNAMTQE AIREHQMAKT 
    GGTTTDLFQC SKCKKKNCTY NQVQTRSADE PMTTFVLCNE CGNRWKMESA S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.