Details for: TCF20
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 213.5070
Cell Significance Index: -33.2100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 133.4551
Cell Significance Index: -33.8500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 69.0942
Cell Significance Index: -28.0700 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 62.8323
Cell Significance Index: -32.3200 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 29.4530
Cell Significance Index: -28.1200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 27.6774
Cell Significance Index: -34.1300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 12.7106
Cell Significance Index: -34.0500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.4446
Cell Significance Index: -32.0800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.8824
Cell Significance Index: -19.4400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.7100
Cell Significance Index: -34.3700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.8673
Cell Significance Index: 80.1300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.3644
Cell Significance Index: 848.0800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.2040
Cell Significance Index: 30.0700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.1269
Cell Significance Index: 94.0800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.1192
Cell Significance Index: 420.5600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.9892
Cell Significance Index: 399.0400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.9793
Cell Significance Index: 74.9500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.4991
Cell Significance Index: 84.1200 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.3353
Cell Significance Index: 923.5700 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.2755
Cell Significance Index: 27.9300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.1877
Cell Significance Index: 1072.3700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8765
Cell Significance Index: 95.3400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.8393
Cell Significance Index: 20.9800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8094
Cell Significance Index: 131.6400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7962
Cell Significance Index: 47.8000 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.6209
Cell Significance Index: 9.1700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5643
Cell Significance Index: 16.2600 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.4454
Cell Significance Index: 5.5300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3742
Cell Significance Index: 67.4500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3639
Cell Significance Index: 16.5000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3573
Cell Significance Index: 27.4200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3505
Cell Significance Index: 43.1000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.3452
Cell Significance Index: 17.9800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.2670
Cell Significance Index: 166.7500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2562
Cell Significance Index: 113.2900 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.2451
Cell Significance Index: 12.3900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1982
Cell Significance Index: 37.7100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1537
Cell Significance Index: 15.2000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1399
Cell Significance Index: 76.4200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1205
Cell Significance Index: 226.9200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1176
Cell Significance Index: 8.1400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1164
Cell Significance Index: 2.0000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0950
Cell Significance Index: 43.1000 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.0926
Cell Significance Index: 1.5600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0925
Cell Significance Index: 58.7500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0847
Cell Significance Index: 4.4000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0666
Cell Significance Index: 90.6200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0647
Cell Significance Index: 4.0800 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 0.0486
Cell Significance Index: 0.4900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0472
Cell Significance Index: 1.6600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0464
Cell Significance Index: 71.4200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0448
Cell Significance Index: 82.6200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0149
Cell Significance Index: 2.5400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0016
Cell Significance Index: -0.0400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0229
Cell Significance Index: -16.9700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0269
Cell Significance Index: -3.7000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0281
Cell Significance Index: -4.0900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0310
Cell Significance Index: -22.7000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0383
Cell Significance Index: -28.9800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0478
Cell Significance Index: -26.9400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0757
Cell Significance Index: -2.0200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0764
Cell Significance Index: -3.5600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0897
Cell Significance Index: -1.9100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0909
Cell Significance Index: -19.1600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1159
Cell Significance Index: -33.3600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1278
Cell Significance Index: -9.0400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1316
Cell Significance Index: -15.3400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1323
Cell Significance Index: -6.2200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1427
Cell Significance Index: -14.5800 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1511
Cell Significance Index: -19.3700 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1524
Cell Significance Index: -19.6900 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.1537
Cell Significance Index: -3.0400 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1620
Cell Significance Index: -2.3200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1657
Cell Significance Index: -19.5400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1808
Cell Significance Index: -20.7100 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2095
Cell Significance Index: -4.3500 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2498
Cell Significance Index: -8.1800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2512
Cell Significance Index: -26.1600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2699
Cell Significance Index: -30.8100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2790
Cell Significance Index: -20.7900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2894
Cell Significance Index: -7.7600 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2995
Cell Significance Index: -9.5400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3329
Cell Significance Index: -21.4800 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.3434
Cell Significance Index: -7.3400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3486
Cell Significance Index: -8.9600 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.3515
Cell Significance Index: -6.8600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3677
Cell Significance Index: -29.1300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.3854
Cell Significance Index: -10.4900 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3934
Cell Significance Index: -8.3500 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4248
Cell Significance Index: -22.3100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4366
Cell Significance Index: -26.7700 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.4443
Cell Significance Index: -8.9200 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.4471
Cell Significance Index: -9.6600 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.4585
Cell Significance Index: -4.0700 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -0.5050
Cell Significance Index: -5.2600 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.5126
Cell Significance Index: -6.1100 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.5480
Cell Significance Index: -13.6700 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5715
Cell Significance Index: -20.0200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5736
Cell Significance Index: -18.3700 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.5853
Cell Significance Index: -8.8200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 635648954
Symbol: TCF20_HUMAN
Name: Transcription factor 20
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10995766
Title: The nuclear factor SPBP contains different functional domains and stimulates the activity of various transcriptional activators.
PubMed ID: 10995766
PubMed ID: 10591208
PubMed ID: 9179496
Title: Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins.
PubMed ID: 9179496
PubMed ID: 9730594
Title: Assignment of AR1, transcription factor 20 (TCF20), to human chromosome 22q13.3 with somatic cell hybrids and in situ hybridization.
PubMed ID: 9730594
DOI: 10.1159/000015021
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25114211
Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
PubMed ID: 25114211
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 25228304
Title: De novo and rare inherited mutations implicate the transcriptional coregulator TCF20/SPBP in autism spectrum disorder.
PubMed ID: 25228304
PubMed ID: 27436265
Title: De novo nonsense and frameshift variants of TCF20 in individuals with intellectual disability and postnatal overgrowth.
PubMed ID: 27436265
DOI: 10.1038/ejhg.2016.90
PubMed ID: 30819258
Title: De novo and inherited TCF20 pathogenic variants are associated with intellectual disability, dysmorphic features, hypotonia, and neurological impairments with similarities to Smith-Magenis syndrome.
PubMed ID: 30819258
PubMed ID: 30739909
Title: Variants in TCF20 in neurodevelopmental disability: description of 27 new patients and review of literature.
PubMed ID: 30739909
Sequence Information:
- Length: 1960
- Mass: 211771
- Checksum: D3E34B1FAA6ED06F
- Sequence:
MQSFREQSSY HGNQQSYPQE VHGSSRLEEF SPRQAQMFQN FGGTGGSSGS SGSGSGGGRR GAAAAAAAMA SETSGHQGYQ GFRKEAGDFY YMAGNKDPVT TGTPQPPQRR PSGPVQSYGP PQGSSFGNQY GSEGHVGQFQ AQHSGLGGVS HYQQDYTGPF SPGSAQYQQQ ASSQQQQQQV QQLRQQLYQS HQPLPQATGQ PASSSSHLQP MQRPSTLPSS AAGYQLRVGQ FGQHYQSSAS SSSSSSFPSP QRFSQSGQSY DGSYNVNAGS QYEGHNVGSN AQAYGTQSNY SYQPQSMKNF EQAKIPQGTQ QGQQQQQPQQ QQHPSQHVMQ YTNAATKLPL QSQVGQYNQP EVPVRSPMQF HQNFSPISNP SPAASVVQSP SCSSTPSPLM QTGENLQCGQ GSVPMGSRNR ILQLMPQLSP TPSMMPSPNS HAAGFKGFGL EGVPEKRLTD PGLSSLSALS TQVANLPNTV QHMLLSDALT PQKKTSKRPS SSKKADSCTN SEGSSQPEEQ LKSPMAESLD GGCSSSSEDQ GERVRQLSGQ STSSDTTYKG GASEKAGSSP AQGAQNEPPR LNASPAAREE ATSPGAKDMP LSSDGNPKVN EKTVGVIVSR EAMTGRVEKP GGQDKGSQED DPAATQRPPS NGGAKETSHA SLPQPEPPGG GGSKGNKNGD NNSNHNGEGN GQSGHSAAGP GFTSRTEPSK SPGSLRYSYK DSFGSAVPRN VSGFPQYPTG QEKGDFTGHG ERKGRNEKFP SLLQEVLQGY HHHPDRRYSR STQEHQGMAG SLEGTTRPNV LVSQTNELAS RGLLNKSIGS LLENPHWGPW ERKSSSTAPE MKQINLTDYP IPRKFEIEPQ SSAHEPGGSL SERRSVICDI SPLRQIVRDP GAHSLGHMSA DTRIGRNDRL NPTLSQSVIL PGGLVSMETK LKSQSGQIKE EDFEQSKSQA SFNNKKSGDH CHPPSIKHES YRGNASPGAA THDSLSDYGP QDSRPTPMRR VPGRVGGREG MRGRSPSQYH DFAEKLKMSP GRSRGPGGDP HHMNPHMTFS ERANRSSLHT PFSPNSETLA SAYHANTRAH AYGDPNAGLN SQLHYKRQMY QQQPEEYKDW SSGSAQGVIA AAQHRQEGPR KSPRQQQFLD RVRSPLKNDK DGMMYGPPVG TYHDPSAQEA GRCLMSSDGL PNKGMELKHG SQKLQESCWD LSRQTSPAKS SGPPGMSSQK RYGPPHETDG HGLAEATQSS KPGSVMLRLP GQEDHSSQNP LIMRRRVRSF ISPIPSKRQS QDVKNSSTED KGRLLHSSKE GADKAFNSYA HLSHSQDIKS IPKRDSSKDL PSPDSRNCPA VTLTSPAKTK ILPPRKGRGL KLEAIVQKIT SPNIRRSASS NSAEAGGDTV TLDDILSLKS GPPEGGSVAV QDADIEKRKG EVASDLVSPA NQELHVEKPL PRSSEEWRGS VDDKVKTETH AETVTAGKEP PGAMTSTTSQ KPGSNQGRPD GSLGGTAPLI FPDSKNVPPV GILAPEANPK AEEKENDTVT ISPKQEGFPP KGYFPSGKKK GRPIGSVNKQ KKQQQPPPPP PQPPQIPEGS ADGEPKPKKQ RQRRERRKPG AQPRKRKTKQ AVPIVEPQEP EIKLKYATQP LDKTDAKNKS FYPYIHVVNK CELGAVCTII NAEEEEQTKL VRGRKGQRSL TPPPSSTESK ALPASSFMLQ GPVVTESSVM GHLVCCLCGK WASYRNMGDL FGPFYPQDYA ATLPKNPPPK RATEMQSKVK VRHKSASNGS KTDTEEEEEQ QQQQKEQRSL AAHPRFKRRH RSEDCGGGPR SLSRGLPCKK AATEGSSEKT VLDSKPSVPT TSEGGPELEL QIPELPLDSN EFWVHEGCIL WANGIYLVCG RLYGLQEALE IAREMKCSHC QEAGATLGCY NKGCSFRYHY PCAIDADCLL HEENFSVRCP KHKPPLPCPL PPLQNKTAKG SLSTEQSERG
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.