Gene TLR4 - ENSG00000136869 | NCBI Gene ID: 7099

Details for: TLR4

Gene ID: 7099

Symbol: TLR4

Ensembl ID: ENSG00000136869

Description: toll like receptor 4

Associated with

Activation of irf3, irf7 mediated by tbk1, ikbke
(R-HSA-936964)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apoptosis
(R-HSA-109581)
Caspase activation via death receptors in the presence of ligand
(R-HSA-140534)
Caspase activation via extrinsic apoptotic signalling pathway
(R-HSA-5357769)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Disease
(R-HSA-1643685)
Diseases associated with the tlr signaling cascade
(R-HSA-5602358)
Diseases of immune system
(R-HSA-5260271)
Er-phagosome pathway
(R-HSA-1236974)
Heme signaling
(R-HSA-9707616)
Ikk complex recruitment mediated by rip1
(R-HSA-937041)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Irak2 mediated activation of tak1 complex upon tlr7/8 or 9 stimulation
(R-HSA-975163)
Irak4 deficiency (tlr2/4)
(R-HSA-5603041)
Myd88 deficiency (tlr2/4)
(R-HSA-5602498)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Programmed cell death
(R-HSA-5357801)
Regulation of tlr by endogenous ligand
(R-HSA-5686938)
Respiratory syncytial virus (rsv) attachment and entry
(R-HSA-9820960)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rsv-host interactions
(R-HSA-9833110)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Traf6-mediated induction of tak1 complex within tlr4 complex
(R-HSA-937072)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Trif-mediated programmed cell death
(R-HSA-2562578)
Viral infection pathways
(R-HSA-9824446)
Amyloid-beta binding
(GO:0001540)
Astrocyte development
(GO:0014002)
B cell proliferation involved in immune response
(GO:0002322)
Detection of fungus
(GO:0016046)
Detection of lipopolysaccharide
(GO:0032497)
Gene expression
(GO:0010467)
I-kappab phosphorylation
(GO:0007252)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Jnk cascade
(GO:0007254)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Lipopolysaccharide binding
(GO:0001530)
Lipopolysaccharide immune receptor activity
(GO:0001875)
Microglia differentiation
(GO:0014004)
Myd88-dependent toll-like receptor signaling pathway
(GO:0002755)
Nad+ nucleotidase, cyclic adp-ribose generating
(GO:0061809)
Nadp+ nucleosidase activity
(GO:0050135)
Negative regulation of interleukin-6 production
(GO:0032715)
Negative regulation of interleukin-17 production
(GO:0032700)
Negative regulation of interleukin-23 production
(GO:0032707)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Negative regulation of type ii interferon production
(GO:0032689)
Nitric oxide biosynthetic process
(GO:0006809)
Nitric oxide production involved in inflammatory response
(GO:0002537)
Phagocytosis
(GO:0006909)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interferon-alpha production
(GO:0032727)
Positive regulation of interferon-beta production
(GO:0032728)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of interleukin-1 production
(GO:0032732)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of platelet activation
(GO:0010572)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of type ii interferon production
(GO:0032729)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Regulation of dendritic cell cytokine production
(GO:0002730)
Response to lipopolysaccharide
(GO:0032496)
Signaling receptor activity
(GO:0038023)
Signaling receptor binding
(GO:0005102)
Toll-like receptor signaling pathway
(GO:0002224)
Transmembrane signaling receptor activity
(GO:0004888)
Wound healing involved in inflammatory response
(GO:0002246)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.09
Marker Score: 44558
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.96
Marker Score: 1384
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.65
Marker Score: 1650
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.45
Marker Score: 2954
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.41
Marker Score: 574
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.31
Marker Score: 73293
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.25
Marker Score: 845
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.23
Marker Score: 1411
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4801
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.11
Marker Score: 28388.5
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.1
Marker Score: 1330
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.07
Marker Score: 2079
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251792
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.02
Marker Score: 561
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71809
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48034
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30406
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 501
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 455
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.94
Marker Score: 2329.5
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5302
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.93
Marker Score: 385
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 367
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2735
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.91
Marker Score: 5534
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 320
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5291
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.86
Marker Score: 2077
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.82
Marker Score: 492.5
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.81
Marker Score: 338
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 595
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1255
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.77
Marker Score: 1451
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 389
Cell Name: brush cell (CL0002204)
Fold Change: 0.75
Marker Score: 680
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.69
Marker Score: 2851
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: endocardial cell (CL0002350)
Fold Change: 0.67
Marker Score: 376
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.66
Marker Score: 207
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.66
Marker Score: 159
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.65
Marker Score: 946
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.63
Marker Score: 1017
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.61
Marker Score: 9532
Cell Name: blood cell (CL0000081)
Fold Change: 0.61
Marker Score: 7078
Cell Name: macrophage (CL0000235)
Fold Change: 0.6
Marker Score: 669
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.6
Marker Score: 587
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 0.59
Marker Score: 138
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.58
Marker Score: 4898
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.58
Marker Score: 370
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.56
Marker Score: 822
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.54
Marker Score: 322
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.51
Marker Score: 461
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.51
Marker Score: 122
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.51
Marker Score: 333
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.5
Marker Score: 288
Cell Name: keratocyte (CL0002363)
Fold Change: 0.5
Marker Score: 114
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.5
Marker Score: 171
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.49
Marker Score: 107.5
Cell Name: vasa recta ascending limb cell (CL1001131)
Fold Change: 0.49
Marker Score: 129
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 0.49
Marker Score: 1238
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.46
Marker Score: 167
Cell Name: microglial cell (CL0000129)
Fold Change: 0.45
Marker Score: 827
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.44
Marker Score: 93
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.43
Marker Score: 1119
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.43
Marker Score: 387
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.43
Marker Score: 4803.5
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.42
Marker Score: 260
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.42
Marker Score: 423
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.39
Marker Score: 423
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.39
Marker Score: 187
Cell Name: neutrophil (CL0000775)
Fold Change: 0.39
Marker Score: 235
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.38
Marker Score: 124
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.38
Marker Score: 441
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.38
Marker Score: 578
Cell Name: glomerular endothelial cell (CL0002188)
Fold Change: 0.36
Marker Score: 92
Cell Name: monocyte (CL0000576)
Fold Change: 0.36
Marker Score: 471
Cell Name: promonocyte (CL0000559)
Fold Change: 0.36
Marker Score: 229
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.35
Marker Score: 154
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.34
Marker Score: 686
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.34
Marker Score: 248.5
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.32
Marker Score: 84
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 0.31
Marker Score: 73
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.31
Marker Score: 525
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.3
Marker Score: 142
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.3
Marker Score: 148
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.3
Marker Score: 229
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.3
Marker Score: 146
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.29
Marker Score: 93
Cell Name: decidual cell (CL2000002)
Fold Change: 0.29
Marker Score: 1246
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.29
Marker Score: 71
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 0.28
Marker Score: 243
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.28
Marker Score: 349
Cell Name: stromal cell (CL0000499)
Fold Change: 0.28
Marker Score: 329
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 0.28
Marker Score: 143
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.28
Marker Score: 277
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.27
Marker Score: 274
Cell Name: leukocyte (CL0000738)
Fold Change: 0.27
Marker Score: 157
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.27
Marker Score: 84

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**Key Characteristics** TLR4 is characterized by its ability to recognize LPS and initiate a signaling cascade that leads to the activation of the innate immune response. Some key characteristics of TLR4 include: * **LPS recognition**: TLR4 recognizes LPS, a major component of the outer membrane of Gram-negative bacteria. * **Signaling cascade**: TLR4 triggers a signaling cascade that leads to the activation of downstream transcription factors, including NF-κB and IRFs. * **Pro-inflammatory cytokine production**: TLR4 leads to the production of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6. * **Expression on immune cells**: TLR4 is expressed on various immune cells, including macrophages, dendritic cells, and epithelial cells. **Pathways and Functions** TLR4 is involved in various signaling pathways and functions, including: * **Activation of NF-κB**: TLR4 activates NF-κB, a transcription factor that regulates the expression of genes involved in inflammation and immune responses. * **Activation of IRFs**: TLR4 activates IRFs, transcription factors that regulate the expression of genes involved in innate immunity and inflammation. * **Production of pro-inflammatory cytokines**: TLR4 leads to the production of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6. * **Recognition of PAMPs**: TLR4 recognizes various PAMPs, including LPS, and triggers an immune response. **Clinical Significance** TLR4 plays a critical role in the defense against bacterial infections and inflammatory responses. Some clinical implications of TLR4 include: * **Infectious diseases**: TLR4 is involved in the recognition of bacterial infections, including pneumonia, sepsis, and tuberculosis. * **Inflammatory disorders**: TLR4 is involved in the pathogenesis of inflammatory disorders, including rheumatoid arthritis, atherosclerosis, and inflammatory bowel disease. * **Cancer**: TLR4 is involved in the recognition of tumor-associated antigens and the activation of immune responses against cancer. * **Neurological disorders**: TLR4 is involved in the recognition of neuroinflammatory mediators and the activation of immune responses in neurological disorders, including multiple sclerosis and Alzheimer's disease. In conclusion, TLR4 is a crucial component of the innate immune system, involved in the recognition of PAMPs and the activation of immune responses. Its dysregulation has been implicated in various clinical conditions, including infectious diseases, inflammatory disorders, and cancer. Further research is needed to fully understand the role of TLR4 in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Toll-like receptor 4

Genular Protein ID: 2856655026

Symbol: TLR4_HUMAN

Name: Toll-like receptor 4

UniProtKB Accession Codes:

O00206 A8K1Y8 A9XLP9 A9XLQ0 A9XLQ1 B4E194 D1CS52 D1CS53 Q5VZI8 Q5VZI9 Q9UK78 Q9UM57

Database IDs:

Citations:

PubMed ID: 9237759

Title: A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.

PubMed ID: 9237759

DOI: 10.1038/41131

PubMed ID: 9435236

Title: A family of human receptors structurally related to Drosophila Toll.

PubMed ID: 9435236

DOI: 10.1073/pnas.95.2.588

PubMed ID: 11104518

Title: Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4).

PubMed ID: 11104518

DOI: 10.1186/gb-2000-1-1-research002

PubMed ID: 10835634

Title: TLR4 mutations are associated with endotoxin hyporesponsiveness in humans.

PubMed ID: 10835634

DOI: 10.1038/76048

PubMed ID: 18810425

Title: Natural selection in the TLR-related genes in the course of primate evolution.

PubMed ID: 18810425

DOI: 10.1007/s00251-008-0332-0

PubMed ID: 19924287

Title: The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes.

PubMed ID: 19924287

DOI: 10.1371/journal.pone.0007803

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 11081518

Title: Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.

PubMed ID: 11081518

DOI: 10.1038/35040600

PubMed ID: 11274165

Title: Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2.

PubMed ID: 11274165

DOI: 10.1074/jbc.m009164200

PubMed ID: 11706042

Title: MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor.

PubMed ID: 11706042

DOI: 10.1074/jbc.m109910200

PubMed ID: 14519765

Title: TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta.

PubMed ID: 14519765

DOI: 10.1074/jbc.m305820200

PubMed ID: 14517278

Title: LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.

PubMed ID: 14517278

DOI: 10.1084/jem.20031023

PubMed ID: 15265881

Title: Regulation of IFN regulatory factor-7 and IFN-alpha production by enveloped virus and lipopolysaccharide in human plasmacytoid dendritic cells.

PubMed ID: 15265881

DOI: 10.4049/jimmunol.173.3.1535

PubMed ID: 15356101

Title: Direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B.

PubMed ID: 15356101

DOI: 10.4049/jimmunol.173.6.3589

PubMed ID: 15809303

Title: Mycobacterium tuberculosis heat shock proteins use diverse Toll-like receptor pathways to activate pro-inflammatory signals.

PubMed ID: 15809303

DOI: 10.1074/jbc.m411379200

PubMed ID: 16622205

Title: The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through Toll-like receptors 2 and 4 in human monocytes.

PubMed ID: 16622205

DOI: 10.1128/iai.74.5.2686-2696.2006

PubMed ID: 17292937

Title: Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway.

PubMed ID: 17292937

DOI: 10.1016/j.virol.2006.12.032

PubMed ID: 17098818

Title: Effects of TREM-1 activation in human neutrophils: activation of signaling pathways, recruitment into lipid rafts and association with TLR4.

PubMed ID: 17098818

DOI: 10.1093/intimm/dxl119

PubMed ID: 17478729

Title: Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity.

PubMed ID: 17478729

DOI: 10.1161/circresaha.106.142851

PubMed ID: 20865800

Title: Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone.

PubMed ID: 20865800

DOI: 10.1038/ncomms1070

PubMed ID: 21393102

Title: TREM-1 interaction with the LPS/TLR4 receptor complex.

PubMed ID: 21393102

DOI: 10.1684/ecn.2011.0274

PubMed ID: 20037584

Title: CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.

PubMed ID: 20037584

DOI: 10.1038/ni.1836

PubMed ID: 19846529

Title: Interaction between Ebola virus glycoprotein and host toll-like receptor 4 leads to induction of proinflammatory cytokines and SOCS1.

PubMed ID: 19846529

DOI: 10.1128/jvi.01462-09

PubMed ID: 20711192

Title: Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel.

PubMed ID: 20711192

DOI: 10.1038/ni.1919

PubMed ID: 21602844

Title: MLK4 has negative effect on TLR4 signaling.

PubMed ID: 21602844

DOI: 10.1038/cmi.2011.15

PubMed ID: 23880187

Title: CD14 and TLR4 mediate cytokine release promoted by electronegative LDL in monocytes.

PubMed ID: 23880187

DOI: 10.1016/j.atherosclerosis.2013.05.011

PubMed ID: 23569230

Title: Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli.

PubMed ID: 23569230

DOI: 10.1073/pnas.1215770110

PubMed ID: 24265315

Title: Mechanism of bacterial interference with TLR4 signaling by Brucella Toll/interleukin-1 receptor domain-containing protein TcpB.

PubMed ID: 24265315

DOI: 10.1074/jbc.m113.523274

PubMed ID: 25736436

Title: WDFY1 mediates TLR3/4 signaling by recruiting TRIF.

PubMed ID: 25736436

DOI: 10.15252/embr.201439637

PubMed ID: 27022195

Title: Raftlin controls lipopolysaccharide-induced TLR4 internalization and TICAM-1 signaling in a cell type-specific manner.

PubMed ID: 27022195

DOI: 10.4049/jimmunol.1501734

PubMed ID: 29038465

Title: NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury.

PubMed ID: 29038465

DOI: 10.1038/s41467-017-00930-9

PubMed ID: 28334607

Title: The SARM1 Toll/Interleukin-1 receptor domain possesses intrinsic NAD+ cleavage activity that promotes pathological axonal degeneration.

PubMed ID: 28334607

DOI: 10.1016/j.neuron.2017.02.022

PubMed ID: 30573680

Title: TRAF3-interacting JNK-activating modulator promotes inflammation by stimulating translocation of Toll-like receptor 4 to lipid rafts.

PubMed ID: 30573680

DOI: 10.1074/jbc.ra118.003137

PubMed ID: 32894580

Title: Mycoplasma pneumoniae lipids license TLR-4 for activation of NLRP3 inflammasome and autophagy to evoke a proinflammatory response.

PubMed ID: 32894580

DOI: 10.1111/cei.13510

PubMed ID: 36232715

Title: PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively via the TLR4/MyD88/NF-kappaB Signaling Pathway.

PubMed ID: 36232715

DOI: 10.3390/ijms231911414

PubMed ID: 17803912

Title: Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran.

PubMed ID: 17803912

DOI: 10.1016/j.cell.2007.08.002

PubMed ID: 19252480

Title: The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex.

PubMed ID: 19252480

DOI: 10.1038/nature07830

PubMed ID: 22363519

Title: Structure-based rational design of a Toll-like receptor 4 (TLR4) decoy receptor with high binding affinity for a target protein.

PubMed ID: 22363519

DOI: 10.1371/journal.pone.0030929

PubMed ID: 11514453

Title: Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans.

PubMed ID: 11514453

DOI: 10.1093/genetics/158.4.1657

PubMed ID: 15829498

Title: Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration.

PubMed ID: 15829498

DOI: 10.1093/hmg/ddi154

PubMed ID: 25787250

Title: Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.

PubMed ID: 25787250

DOI: 10.1073/pnas.1503696112

Sequence Information:

Length: 839
Mass: 95680
Checksum: 92C48F55821133E8
Sequence:

MMSASRLAGT LIPAMAFLSC VRPESWEPCV EVVPNITYQC MELNFYKIPD NLPFSTKNLD 
LSFNPLRHLG SYSFFSFPEL QVLDLSRCEI QTIEDGAYQS LSHLSTLILT GNPIQSLALG 
AFSGLSSLQK LVAVETNLAS LENFPIGHLK TLKELNVAHN LIQSFKLPEY FSNLTNLEHL 
DLSSNKIQSI YCTDLRVLHQ MPLLNLSLDL SLNPMNFIQP GAFKEIRLHK LTLRNNFDSL 
NVMKTCIQGL AGLEVHRLVL GEFRNEGNLE KFDKSALEGL CNLTIEEFRL AYLDYYLDDI 
IDLFNCLTNV SSFSLVSVTI ERVKDFSYNF GWQHLELVNC KFGQFPTLKL KSLKRLTFTS 
NKGGNAFSEV DLPSLEFLDL SRNGLSFKGC CSQSDFGTTS LKYLDLSFNG VITMSSNFLG 
LEQLEHLDFQ HSNLKQMSEF SVFLSLRNLI YLDISHTHTR VAFNGIFNGL SSLEVLKMAG 
NSFQENFLPD IFTELRNLTF LDLSQCQLEQ LSPTAFNSLS SLQVLNMSHN NFFSLDTFPY 
KCLNSLQVLD YSLNHIMTSK KQELQHFPSS LAFLNLTQND FACTCEHQSF LQWIKDQRQL 
LVEVERMECA TPSDKQGMPV LSLNITCQMN KTIIGVSVLS VLVVSVVAVL VYKFYFHLML 
LAGCIKYGRG ENIYDAFVIY SSQDEDWVRN ELVKNLEEGV PPFQLCLHYR DFIPGVAIAA 
NIIHEGFHKS RKVIVVVSQH FIQSRWCIFE YEIAQTWQFL SSRAGIIFIV LQKVEKTLLR 
QQVELYRLLS RNTYLEWEDS VLGRHIFWRR LRKALLDGKS WNPEGTVGTG CNWQEATSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: TLR4

Associated with

Cells (max top 100)

Other Information

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. PubMed ID: 9237759

A family of human receptors structurally related to Drosophila Toll. PubMed ID: 9435236

Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4). PubMed ID: 11104518

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. PubMed ID: 10835634

Natural selection in the TLR-related genes in the course of primate evolution. PubMed ID: 18810425

The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes. PubMed ID: 19924287

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. PubMed ID: 11081518

Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2. PubMed ID: 11274165

MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor. PubMed ID: 11706042

TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta. PubMed ID: 14519765

LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. PubMed ID: 14517278

Regulation of IFN regulatory factor-7 and IFN-alpha production by enveloped virus and lipopolysaccharide in human plasmacytoid dendritic cells. PubMed ID: 15265881

Direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B. PubMed ID: 15356101

Mycobacterium tuberculosis heat shock proteins use diverse Toll-like receptor pathways to activate pro-inflammatory signals. PubMed ID: 15809303

The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through Toll-like receptors 2 and 4 in human monocytes. PubMed ID: 16622205

Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. PubMed ID: 17292937

Effects of TREM-1 activation in human neutrophils: activation of signaling pathways, recruitment into lipid rafts and association with TLR4. PubMed ID: 17098818

Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. PubMed ID: 17478729

Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone. PubMed ID: 20865800

TREM-1 interaction with the LPS/TLR4 receptor complex. PubMed ID: 21393102

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. PubMed ID: 20037584

Interaction between Ebola virus glycoprotein and host toll-like receptor 4 leads to induction of proinflammatory cytokines and SOCS1. PubMed ID: 19846529

Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel. PubMed ID: 20711192

MLK4 has negative effect on TLR4 signaling. PubMed ID: 21602844

CD14 and TLR4 mediate cytokine release promoted by electronegative LDL in monocytes. PubMed ID: 23880187

Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli. PubMed ID: 23569230

Mechanism of bacterial interference with TLR4 signaling by Brucella Toll/interleukin-1 receptor domain-containing protein TcpB. PubMed ID: 24265315

WDFY1 mediates TLR3/4 signaling by recruiting TRIF. PubMed ID: 25736436

Raftlin controls lipopolysaccharide-induced TLR4 internalization and TICAM-1 signaling in a cell type-specific manner. PubMed ID: 27022195

NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury. PubMed ID: 29038465

The SARM1 Toll/Interleukin-1 receptor domain possesses intrinsic NAD+ cleavage activity that promotes pathological axonal degeneration. PubMed ID: 28334607

TRAF3-interacting JNK-activating modulator promotes inflammation by stimulating translocation of Toll-like receptor 4 to lipid rafts. PubMed ID: 30573680

Mycoplasma pneumoniae lipids license TLR-4 for activation of NLRP3 inflammasome and autophagy to evoke a proinflammatory response. PubMed ID: 32894580

PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively via the TLR4/MyD88/NF-kappaB Signaling Pathway. PubMed ID: 36232715

Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. PubMed ID: 17803912

The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. PubMed ID: 19252480

Structure-based rational design of a Toll-like receptor 4 (TLR4) decoy receptor with high binding affinity for a target protein. PubMed ID: 22363519

Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans. PubMed ID: 11514453

Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration. PubMed ID: 15829498

Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas. PubMed ID: 25787250