Details for: VGF

Gene ID: 7425

Symbol: VGF

Ensembl ID: ENSG00000128564

Description: VGF nerve growth factor inducible

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 19.5197
    Cell Significance Index: -7.9300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.2253
    Cell Significance Index: -8.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.0630
    Cell Significance Index: 187.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.3069
    Cell Significance Index: 68.6200
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.0391
    Cell Significance Index: 11.8300
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.8255
    Cell Significance Index: 9.3800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6823
    Cell Significance Index: 14.9400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.5877
    Cell Significance Index: 7.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5540
    Cell Significance Index: 54.8100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5411
    Cell Significance Index: 15.4400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.4943
    Cell Significance Index: 56.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4780
    Cell Significance Index: 431.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3915
    Cell Significance Index: 78.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3710
    Cell Significance Index: 22.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3643
    Cell Significance Index: 39.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3451
    Cell Significance Index: 65.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3008
    Cell Significance Index: 48.9300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.2707
    Cell Significance Index: 3.5100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2483
    Cell Significance Index: 3.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2281
    Cell Significance Index: 14.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2259
    Cell Significance Index: 10.2400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1710
    Cell Significance Index: 11.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1650
    Cell Significance Index: 4.7600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0726
    Cell Significance Index: 1.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0669
    Cell Significance Index: 7.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0592
    Cell Significance Index: 21.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0353
    Cell Significance Index: 19.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0273
    Cell Significance Index: 0.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0218
    Cell Significance Index: 2.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0156
    Cell Significance Index: 1.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0099
    Cell Significance Index: 0.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0092
    Cell Significance Index: 6.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0055
    Cell Significance Index: 1.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0013
    Cell Significance Index: 0.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0042
    Cell Significance Index: -2.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0047
    Cell Significance Index: -2.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0081
    Cell Significance Index: -5.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0117
    Cell Significance Index: -0.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0118
    Cell Significance Index: -8.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0129
    Cell Significance Index: -0.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0165
    Cell Significance Index: -7.2800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0189
    Cell Significance Index: -0.3800
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: -0.0210
    Cell Significance Index: -0.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0244
    Cell Significance Index: -0.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0249
    Cell Significance Index: -7.1600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0253
    Cell Significance Index: -0.5000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0292
    Cell Significance Index: -0.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0318
    Cell Significance Index: -0.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0330
    Cell Significance Index: -1.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0343
    Cell Significance Index: -6.1900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0343
    Cell Significance Index: -0.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0355
    Cell Significance Index: -16.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0377
    Cell Significance Index: -0.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0399
    Cell Significance Index: -7.9100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0451
    Cell Significance Index: -0.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0484
    Cell Significance Index: -5.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0516
    Cell Significance Index: -2.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0517
    Cell Significance Index: -5.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0531
    Cell Significance Index: -0.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0561
    Cell Significance Index: -7.7100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0565
    Cell Significance Index: -1.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0619
    Cell Significance Index: -0.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0707
    Cell Significance Index: -9.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0717
    Cell Significance Index: -1.9200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0759
    Cell Significance Index: -8.9500
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.1031
    Cell Significance Index: -1.1500
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.1033
    Cell Significance Index: -1.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1067
    Cell Significance Index: -8.4500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1103
    Cell Significance Index: -1.4700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1172
    Cell Significance Index: -1.3500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1279
    Cell Significance Index: -2.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1287
    Cell Significance Index: -9.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1317
    Cell Significance Index: -7.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1387
    Cell Significance Index: -4.5400
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -0.1399
    Cell Significance Index: -1.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1410
    Cell Significance Index: -4.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1469
    Cell Significance Index: -7.6500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1495
    Cell Significance Index: -4.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1518
    Cell Significance Index: -7.1400
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.1543
    Cell Significance Index: -1.4300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1648
    Cell Significance Index: -4.1100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1720
    Cell Significance Index: -1.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1806
    Cell Significance Index: -5.0500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1879
    Cell Significance Index: -4.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1941
    Cell Significance Index: -9.0500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2072
    Cell Significance Index: -1.7100
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.2175
    Cell Significance Index: -2.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2180
    Cell Significance Index: -5.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2184
    Cell Significance Index: -7.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2311
    Cell Significance Index: -6.2900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2501
    Cell Significance Index: -3.8700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2535
    Cell Significance Index: -3.8200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2572
    Cell Significance Index: -9.4400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2803
    Cell Significance Index: -6.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2872
    Cell Significance Index: -8.4600
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.2930
    Cell Significance Index: -3.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2990
    Cell Significance Index: -8.7800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2998
    Cell Significance Index: -5.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3039
    Cell Significance Index: -7.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Neurosecretory protein:** VGF is a neurosecretory protein that is induced by nerve growth factor (NGF), a key regulator of neuronal development and survival. 2. **Wide tissue expression:** VGF is expressed in various tissues, including the nervous system, pancreas, intestine, and immune cells. 3. **Multiple signaling pathways:** VGF is involved in multiple signaling pathways, including those related to carbohydrate and glucose homeostasis, insulin secretion, neuronal synaptic plasticity, and response to dietary excess and insulin. 4. **Regulation of IGF transport:** VGF has been shown to regulate the transport and uptake of IGF by IGFBPs, which is essential for IGF signaling. **Pathways and Functions:** 1. **Carbohydrate homeostasis:** VGF has been implicated in the regulation of carbohydrate homeostasis, including the modulation of glucose and insulin signaling pathways. 2. **Glucose homeostasis:** VGF has been shown to regulate glucose homeostasis by modulating the activity of enzymes involved in glucose metabolism. 3. **Insulin secretion:** VGF has been implicated in the regulation of insulin secretion from pancreatic beta cells. 4. **Neuronal synaptic plasticity:** VGF has been shown to modulate synaptic plasticity and neuronal signaling, including the regulation of neurotransmitter release and synaptic transmission. 5. **Response to dietary excess:** VGF has been implicated in the regulation of response to dietary excess, including the modulation of insulin and glucose signaling pathways. 6. **Regulation of IGF transport:** VGF has been shown to regulate the transport and uptake of IGF by IGFBPs, which is essential for IGF signaling. 7. **Neuroprotection:** VGF has been implicated in neuroprotection, including the modulation of neuronal survival and apoptosis. **Clinical Significance:** 1. **Diabetes:** VGF has been implicated in the regulation of insulin secretion and glucose homeostasis, making it a potential therapeutic target for the treatment of diabetes. 2. **Neurodegenerative diseases:** VGF has been implicated in the regulation of neuronal synaptic plasticity and neuronal survival, making it a potential therapeutic target for the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. 3. **Cancer:** VGF has been implicated in the regulation of insulin-like growth factor (IGF) signaling, which is involved in cancer development and progression. 4. **Inflammation:** VGF has been implicated in the regulation of immune responses, including the modulation of inflammation. In conclusion, VGF nerve growth factor inducible is a gene that plays a crucial role in various physiological and pathological processes, including carbohydrate homeostasis, glucose homeostasis, insulin secretion, neuronal synaptic plasticity, and response to dietary excess and insulin. Further research is needed to fully elucidate the mechanisms by which VGF regulates these processes and to explore its potential therapeutic applications.

Genular Protein ID: 4002616462

Symbol: VGF_HUMAN

Name: Neurosecretory protein VGF

UniProtKB Accession Codes:

O15240 Q9UDW8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 25 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 4 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9344675

Title: Cloning, structural organization analysis and chromosomal assignment of the human gene for neurosecretory protein VGF.

PubMed ID: 9344675

DOI: 10.1006/geno.1997.4945

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23250050

Title: Large-scale identification of endogenous secretory peptides using electron transfer dissociation mass spectrometry.

PubMed ID: 23250050

DOI: 10.1074/mcp.m112.017400

PubMed ID: 19194657

Title: Neuroendocrine regulatory peptide-1 and -2: novel bioactive peptides processed from VGF.

PubMed ID: 19194657

DOI: 10.1007/s00018-009-8796-0

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 28934328

Title: The human VGF-derived bioactive peptide TLQP-21 binds heat shock 71 kDa protein 8 (HSPA8)on the surface of SH-SY5Y cells.

PubMed ID: 28934328

DOI: 10.1371/journal.pone.0185176

Sequence Information:

  • Length: 615
  • Mass: 67258
  • Checksum: 198097C5622AC087
  • Sequence:
    • MKALRLSASA LFCLLLINGL GAAPPGRPEA QPPPLSSEHK EPVAGDAVPG PKDGSAPEVR 
GARNSEPQDE GELFQGVDPR ALAAVLLQAL DRPASPPAPS GSQQGPEEEA AEALLTETVR 
SQTHSLPAPE SPEPAAPPRP QTPENGPEAS DPSEELEALA SLLQELRDFS PSSAKRQQET 
AAAETETRTH TLTRVNLESP GPERVWRASW GEFQARVPER APLPPPAPSQ FQARMPDSGP 
LPETHKFGEG VSSPKTHLGE ALAPLSKAYQ GVAAPFPKAR RPESALLGGS EAGERLLQQG 
LAQVEAGRRQ AEATRQAAAQ EERLADLASD LLLQYLLQGG ARQRGLGGRG LQEAAEERES 
AREEEEAEQE RRGGEERVGE EDEEAAEAEA EAEEAERARQ NALLFAEEED GEAGAEDKRS 
QEETPGHRRK EAEGTEEGGE EEDDEEMDPQ TIDSLIELST KLHLPADDVV SIIEEVEEKR 
KRKKNAPPEP VPPPRAAPAP THVRSPQPPP PAPAPARDEL PDWNEVLPPW DREEDEVYPP 
GPYHPFPNYI RPRTLQPPSA LRRRHYHHAL PPSRHYPGRE AQARRAQEEA EAEERRLQEQ 
EELENYIEHV LLRRP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.