Details for: WNT5A

Gene ID: 7474

Symbol: WNT5A

Ensembl ID: ENSG00000114251

Description: Wnt family member 5A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 31.4961
    Cell Significance Index: -14.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.4749
    Cell Significance Index: 180.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.2545
    Cell Significance Index: 70.5100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 2.0584
    Cell Significance Index: 23.0100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.8390
    Cell Significance Index: 16.9400
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 1.5166
    Cell Significance Index: 9.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2506
    Cell Significance Index: 238.0000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.2153
    Cell Significance Index: 17.6500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.1481
    Cell Significance Index: 18.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9855
    Cell Significance Index: 97.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8638
    Cell Significance Index: 155.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6930
    Cell Significance Index: 625.7600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.6681
    Cell Significance Index: 5.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6452
    Cell Significance Index: 88.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6318
    Cell Significance Index: 13.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5677
    Cell Significance Index: 72.7800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5427
    Cell Significance Index: 11.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4904
    Cell Significance Index: 79.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4385
    Cell Significance Index: 47.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4270
    Cell Significance Index: 52.5100
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.3763
    Cell Significance Index: 1.8300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3607
    Cell Significance Index: 4.6200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3297
    Cell Significance Index: 180.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2905
    Cell Significance Index: 104.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2579
    Cell Significance Index: 15.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1981
    Cell Significance Index: 5.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1714
    Cell Significance Index: 7.9900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1681
    Cell Significance Index: 2.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1661
    Cell Significance Index: 11.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1507
    Cell Significance Index: 66.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0968
    Cell Significance Index: 131.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0918
    Cell Significance Index: 18.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0915
    Cell Significance Index: 18.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0730
    Cell Significance Index: 137.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0657
    Cell Significance Index: 1.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0320
    Cell Significance Index: 1.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0317
    Cell Significance Index: 48.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0270
    Cell Significance Index: 49.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0189
    Cell Significance Index: 1.3400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0130
    Cell Significance Index: 0.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0066
    Cell Significance Index: 4.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0021
    Cell Significance Index: 0.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0019
    Cell Significance Index: 0.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0031
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0033
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0060
    Cell Significance Index: -3.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0064
    Cell Significance Index: -4.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0092
    Cell Significance Index: -6.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0095
    Cell Significance Index: -6.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0124
    Cell Significance Index: -7.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0128
    Cell Significance Index: -2.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0131
    Cell Significance Index: -0.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0182
    Cell Significance Index: -13.3700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0206
    Cell Significance Index: -2.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0250
    Cell Significance Index: -7.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0300
    Cell Significance Index: -1.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0314
    Cell Significance Index: -14.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0340
    Cell Significance Index: -0.8500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0373
    Cell Significance Index: -0.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0464
    Cell Significance Index: -4.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0624
    Cell Significance Index: -2.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0666
    Cell Significance Index: -9.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0981
    Cell Significance Index: -7.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1002
    Cell Significance Index: -10.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1059
    Cell Significance Index: -6.5100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.1070
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1143
    Cell Significance Index: -13.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1153
    Cell Significance Index: -14.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1247
    Cell Significance Index: -7.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1308
    Cell Significance Index: -3.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1309
    Cell Significance Index: -8.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1311
    Cell Significance Index: -15.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1563
    Cell Significance Index: -12.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1627
    Cell Significance Index: -2.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1851
    Cell Significance Index: -14.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2034
    Cell Significance Index: -9.5600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2052
    Cell Significance Index: -1.3900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2386
    Cell Significance Index: -9.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2638
    Cell Significance Index: -7.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2649
    Cell Significance Index: -7.0900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2695
    Cell Significance Index: -5.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2762
    Cell Significance Index: -14.5000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2894
    Cell Significance Index: -2.3600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2945
    Cell Significance Index: -6.1100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3240
    Cell Significance Index: -11.3500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3247
    Cell Significance Index: -10.2700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3269
    Cell Significance Index: -9.3300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3369
    Cell Significance Index: -4.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3371
    Cell Significance Index: -14.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3430
    Cell Significance Index: -9.3400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3503
    Cell Significance Index: -12.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3515
    Cell Significance Index: -9.0400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3694
    Cell Significance Index: -5.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3726
    Cell Significance Index: -12.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3895
    Cell Significance Index: -14.7500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3898
    Cell Significance Index: -5.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3927
    Cell Significance Index: -13.6500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4076
    Cell Significance Index: -12.9800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4108
    Cell Significance Index: -17.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4240
    Cell Significance Index: -9.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** WNT5A is a secreted protein that belongs to the Wnt family of proteins, which are small, cysteine-rich proteins that play a crucial role in signaling pathways. WNT5A is characterized by its unique structure, which includes a disheveled (Dvl) binding motif and a Frizzled binding motif. This unique structure allows WNT5A to interact with multiple signaling molecules, including Frizzled receptors, Dvl proteins, and β-catenin. WNT5A is also known for its ability to regulate cell polarity and planar polarity, which are critical for tissue development and organization. **Pathways and Functions:** WNT5A's signaling pathways intersect with multiple pathways, including: 1. **Canonical Wnt/β-catenin pathway:** WNT5A can regulate the activity of the canonical Wnt/β-catenin pathway, which is involved in cell proliferation, differentiation, and survival. 2. **Non-canonical Wnt signaling pathway:** WNT5A can also regulate non-canonical Wnt signaling pathways, which are involved in cell migration, polarity, and planar polarity. 3. **BMP signaling pathway:** WNT5A can regulate the activity of the BMP (bone morphogenetic protein) signaling pathway, which is involved in cell proliferation, differentiation, and survival. 4. **FGF signaling pathway:** WNT5A can regulate the activity of the FGF (fibroblast growth factor) signaling pathway, which is involved in cell proliferation, differentiation, and survival. 5. **Calcium modulating pathway:** WNT5A can regulate the activity of the calcium modulating pathway, which is involved in cell signaling and regulation. WNT5A's functions include: 1. **Cell fate commitment:** WNT5A can regulate cell fate commitment by influencing the activity of transcription factors and signaling molecules. 2. **Proliferation and differentiation:** WNT5A can regulate cell proliferation and differentiation by influencing the activity of signaling molecules and transcription factors. 3. **Cell migration and polarity:** WNT5A can regulate cell migration and polarity by influencing the activity of signaling molecules and transcription factors. 4. **Planar polarity:** WNT5A can regulate planar polarity by influencing the activity of signaling molecules and transcription factors. **Clinical Significance:** Aberrant expression of WNT5A has been implicated in various diseases, including: 1. **Cancer:** WNT5A has been implicated in the development and progression of various cancers, including breast, lung, and colon cancer. 2. **Fibrosis:** WNT5A has been implicated in the development of fibrosis, including liver, kidney, and lung fibrosis. 3. **Inflammatory disorders:** WNT5A has been implicated in the development of inflammatory disorders, including rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. In conclusion, WNT5A is a multifaceted gene that plays a crucial role in various biological processes, including development, immunity, and disease. Its signaling pathways intersect with multiple pathways, and its functions include cell fate commitment, proliferation, migration, and differentiation. Aberrant expression of WNT5A has been implicated in various diseases, highlighting the importance of understanding its role in human health and disease.

Genular Protein ID: 4250829529

Symbol: WNT5A_HUMAN

Name: Protein Wnt-5a

UniProtKB Accession Codes:

P41221 A8K4A4 Q6P278

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 ExpressionAtlas 1 GO 100 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 12 RefSeq 9 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8288227

Title: Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21.

PubMed ID: 8288227

DOI: 10.1006/geno.1993.1463

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14610063

Title: Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements.

PubMed ID: 14610063

DOI: 10.1083/jcb.200302152

PubMed ID: 15735754

Title: Wnt-5a has tumor suppressor activity in thyroid carcinoma.

PubMed ID: 15735754

DOI: 10.1038/sj.onc.1208370

PubMed ID: 17426020

Title: The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition.

PubMed ID: 17426020

DOI: 10.1074/jbc.m700075200

PubMed ID: 26902720

Title: Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/alpha-albumin.

PubMed ID: 26902720

DOI: 10.7554/elife.11621

PubMed ID: 27214281

Title: The polycystin complex mediates Wnt/Ca(2+) signalling.

PubMed ID: 27214281

DOI: 10.1038/ncb3363

PubMed ID: 34731008

Title: Structure of the human Meckel-Gruber protein Meckelin.

PubMed ID: 34731008

DOI: 10.1126/sciadv.abj9748

PubMed ID: 19918918

Title: WNT5A mutations in patients with autosomal dominant Robinow syndrome.

PubMed ID: 19918918

DOI: 10.1002/dvdy.22156

PubMed ID: 29276006

Title: WNT signaling perturbations underlie the genetic heterogeneity of Robinow syndrome.

PubMed ID: 29276006

DOI: 10.1016/j.ajhg.2017.10.002

Sequence Information:

  • Length: 380
  • Mass: 42339
  • Checksum: 50E73AC7FE96C7B5
  • Sequence:
    • MKKSIGILSP GVALGMAGSA MSSKFFLVAL AIFFSFAQVV IEANSWWSLG MNNPVQMSEV 
YIIGAQPLCS QLAGLSQGQK KLCHLYQDHM QYIGEGAKTG IKECQYQFRH RRWNCSTVDN 
TSVFGRVMQI GSRETAFTYA VSAAGVVNAM SRACREGELS TCGCSRAARP KDLPRDWLWG 
GCGDNIDYGY RFAKEFVDAR ERERIHAKGS YESARILMNL HNNEAGRRTV YNLADVACKC 
HGVSGSCSLK TCWLQLADFR KVGDALKEKY DSAAAMRLNS RGKLVQVNSR FNSPTTQDLV 
YIDPSPDYCV RNESTGSLGT QGRLCNKTSE GMDGCELMCC GRGYDQFKTV QTERCHCKFH 
WCCYVKCKKC TEIVDQFVCK

Genular Protein ID: 548209432

Symbol: B3KQX9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KQX9

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SMART 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 291
  • Mass: 32692
  • Checksum: F14DB4987CA7BFE6
  • Sequence:
    • MQYIGEGAKT GIKECQYQFR HRRWNCSTVD NTSVFGRVMQ IGSRETAFTY AVSAAGVVNA 
MSRACRGGEL STCGCSRAAR PKDLPRDWLW GGCGDNIDYG YRFAKEFVDA RERERIHAKG 
SYESARILMN LHNNEAGRRT VYNLADVACK CHGVSGSCSL KTCWLQLADF RKVGDALKEK 
YDSAAAMRLN SRGKLVQVNS RFNSPTTQDL VYIDPSPDYC VRNESTGSLG TQGRLCNKTS 
EGMDGCELMC CGRGYDQFKT VQTERCHCKF HWCCYVKCKK CTEIVDQFVC K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.