Details for: XRCC2

Gene ID: 7516

Symbol: XRCC2

Ensembl ID: ENSG00000196584

Description: X-ray repair cross complementing 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 40.3098
    Cell Significance Index: -6.2700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 29.2537
    Cell Significance Index: -7.4200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 18.5843
    Cell Significance Index: -7.5500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.5128
    Cell Significance Index: -8.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7253
    Cell Significance Index: 40.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7054
    Cell Significance Index: 69.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4726
    Cell Significance Index: 93.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4578
    Cell Significance Index: 74.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4138
    Cell Significance Index: 14.5400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4025
    Cell Significance Index: 8.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3836
    Cell Significance Index: 41.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3500
    Cell Significance Index: 21.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2494
    Cell Significance Index: 6.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2209
    Cell Significance Index: 5.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2034
    Cell Significance Index: 5.8600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1982
    Cell Significance Index: 137.0900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1874
    Cell Significance Index: 2.6300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1729
    Cell Significance Index: 1.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1477
    Cell Significance Index: 9.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1199
    Cell Significance Index: 24.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0951
    Cell Significance Index: 51.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0842
    Cell Significance Index: 2.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0832
    Cell Significance Index: 75.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0729
    Cell Significance Index: 8.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0697
    Cell Significance Index: 8.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0379
    Cell Significance Index: 16.7600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0337
    Cell Significance Index: 1.1700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0327
    Cell Significance Index: 0.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0311
    Cell Significance Index: 1.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0277
    Cell Significance Index: 9.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0158
    Cell Significance Index: 0.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0108
    Cell Significance Index: 1.3800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0074
    Cell Significance Index: 0.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0067
    Cell Significance Index: 0.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0053
    Cell Significance Index: 0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0035
    Cell Significance Index: 6.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0026
    Cell Significance Index: 0.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0016
    Cell Significance Index: 2.9000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0009
    Cell Significance Index: 1.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0030
    Cell Significance Index: -1.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0033
    Cell Significance Index: -4.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0066
    Cell Significance Index: -0.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0076
    Cell Significance Index: -1.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0109
    Cell Significance Index: -8.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0138
    Cell Significance Index: -6.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0141
    Cell Significance Index: -0.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0148
    Cell Significance Index: -11.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0159
    Cell Significance Index: -1.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0161
    Cell Significance Index: -11.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0168
    Cell Significance Index: -0.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0173
    Cell Significance Index: -2.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0198
    Cell Significance Index: -3.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0198
    Cell Significance Index: -1.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0205
    Cell Significance Index: -11.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0209
    Cell Significance Index: -6.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0268
    Cell Significance Index: -3.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0289
    Cell Significance Index: -2.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0296
    Cell Significance Index: -1.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0406
    Cell Significance Index: -0.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0559
    Cell Significance Index: -6.4100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0565
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0575
    Cell Significance Index: -12.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0625
    Cell Significance Index: -10.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0708
    Cell Significance Index: -9.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0737
    Cell Significance Index: -5.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0741
    Cell Significance Index: -7.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0745
    Cell Significance Index: -7.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0836
    Cell Significance Index: -3.9000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0879
    Cell Significance Index: -0.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1043
    Cell Significance Index: -6.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1065
    Cell Significance Index: -6.5300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1159
    Cell Significance Index: -2.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1178
    Cell Significance Index: -7.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1185
    Cell Significance Index: -6.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1198
    Cell Significance Index: -6.2900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1228
    Cell Significance Index: -3.2900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1270
    Cell Significance Index: -3.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1338
    Cell Significance Index: -9.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1393
    Cell Significance Index: -4.4600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1468
    Cell Significance Index: -2.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1546
    Cell Significance Index: -6.8400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1612
    Cell Significance Index: -4.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1630
    Cell Significance Index: -7.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1772
    Cell Significance Index: -6.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1776
    Cell Significance Index: -6.2200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1796
    Cell Significance Index: -2.0400
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.1871
    Cell Significance Index: -1.3500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1980
    Cell Significance Index: -2.8400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1999
    Cell Significance Index: -6.3700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2013
    Cell Significance Index: -6.5900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2022
    Cell Significance Index: -1.2000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2067
    Cell Significance Index: -2.1400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2142
    Cell Significance Index: -3.5300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2203
    Cell Significance Index: -3.3200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2268
    Cell Significance Index: -3.0600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2327
    Cell Significance Index: -3.6000
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.2388
    Cell Significance Index: -2.2100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2407
    Cell Significance Index: -2.7300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2449
    Cell Significance Index: -6.1100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2461
    Cell Significance Index: -3.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Function**: XRCC2 is a DNA repair protein that participates in the HRR pathway, which is responsible for repairing DSBs in DNA. 2. **Expression**: XRCC2 is highly expressed in various cell types, including neural progenitor cells, cardiac endothelial cells, and intestinal epithelial cells. 3. **Interactions**: XRCC2 interacts with other proteins, such as BRCA2, PALB2, and RAD51, to facilitate HRR. 4. **Pathway involvement**: XRCC2 is involved in the HRR pathway, which is responsible for repairing DSBs in DNA. **Pathways and Functions** 1. **Homologous Recombination Repair (HRR) pathway**: XRCC2 participates in the HRR pathway, which is responsible for repairing DSBs in DNA. The HRR pathway involves the recognition of DSBs by proteins such as BRCA2 and PALB2, followed by the recruitment of repair proteins, including XRCC2, to the repair site. 2. **DNA double-strand break repair**: XRCC2 is involved in the repair of DSBs in DNA, which is essential for maintaining genome stability. 3. **Genome stability**: XRCC2 plays a crucial role in maintaining genome stability by repairing DSBs and preventing mutations that can lead to cancer. 4. **Cell cycle regulation**: XRCC2 is involved in the regulation of the cell cycle, particularly in the G2/M phase, where it participates in the repair of DSBs. **Clinical Significance** 1. **Cancer**: XRCC2 dysregulation has been implicated in several types of cancer, including breast, ovarian, and colon cancer. 2. **Neurodegenerative disorders**: XRCC2 has been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, where it plays a role in maintaining genome stability. 3. **Developmental abnormalities**: XRCC2 dysregulation has been implicated in developmental abnormalities, such as embryonic development and somitogenesis. 4. **Radiation sensitivity**: XRCC2 is involved in the response to ionizing radiation, and its dysregulation can lead to increased sensitivity to radiation. In conclusion, XRCC2 is a crucial gene involved in the repair of DNA double-strand breaks through the HRR pathway. Its dysregulation has been implicated in several diseases, including cancer, neurodegenerative disorders, and developmental abnormalities. Further research is needed to fully understand the role of XRCC2 in maintaining genome stability and its clinical significance.

Genular Protein ID: 3386830233

Symbol: XRCC2_HUMAN

Name: DNA repair protein XRCC2

UniProtKB Accession Codes:

O43543 B2R925

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 4 Ensembl 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 9 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9660962

Title: XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages.

PubMed ID: 9660962

DOI: 10.1016/s1097-2765(00)80078-7

PubMed ID: 9126486

Title: The XRCC2 DNA repair gene: identification of a positional candidate.

PubMed ID: 9126486

DOI: 10.1006/geno.1997.4636

PubMed ID: 9628903

Title: The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family.

PubMed ID: 9628903

DOI: 10.1093/nar/26.13.3084

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11751635

Title: Identification and purification of two distinct complexes containing the five RAD51 paralogs.

PubMed ID: 11751635

DOI: 10.1101/gad.947001

PubMed ID: 11744692

Title: RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51.

PubMed ID: 11744692

DOI: 10.1074/jbc.m108306200

PubMed ID: 11834724

Title: Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex.

PubMed ID: 11834724

DOI: 10.1074/jbc.m105719200

PubMed ID: 11842112

Title: Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells.

PubMed ID: 11842112

DOI: 10.1093/nar/30.4.1001

PubMed ID: 11842113

Title: Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells.

PubMed ID: 11842113

DOI: 10.1093/nar/30.4.1009

PubMed ID: 14704354

Title: Domain mapping of the Rad51 paralog protein complexes.

PubMed ID: 14704354

DOI: 10.1093/nar/gkg925

PubMed ID: 21276791

Title: Homologous recombination proteins are associated with centrosomes and are required for mitotic stability.

PubMed ID: 21276791

DOI: 10.1016/j.yexcr.2011.01.021

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23149936

Title: Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway.

PubMed ID: 23149936

DOI: 10.1128/mcb.00465-12

PubMed ID: 20207730

Title: Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy.

PubMed ID: 20207730

DOI: 10.1074/jbc.m109.074286

PubMed ID: 22464251

Title: Rare mutations in XRCC2 increase the risk of breast cancer.

PubMed ID: 22464251

DOI: 10.1016/j.ajhg.2012.02.027

PubMed ID: 22232082

Title: Exome sequencing reveals a novel Fanconi group defined by XRCC2 mutation.

PubMed ID: 22232082

DOI: 10.1136/jmedgenet-2011-100585

PubMed ID: 23054243

Title: Rare variants in XRCC2 as breast cancer susceptibility alleles.

PubMed ID: 23054243

DOI: 10.1136/jmedgenet-2012-101191

PubMed ID: 27233470

Title: Functional analysis of missense variants in the putative breast cancer susceptibility gene XRCC2.

PubMed ID: 27233470

DOI: 10.1002/humu.23019

PubMed ID: 30042186

Title: XRCC2 mutation causes meiotic arrest, azoospermia and infertility.

PubMed ID: 30042186

DOI: 10.1136/jmedgenet-2017-105145

PubMed ID: 30489636

Title: XRCC2 mutation causes premature ovarian insufficiency as well as non-obstructive azoospermia in humans.

PubMed ID: 30489636

DOI: 10.1111/cge.13475

PubMed ID: 30237576

Title: Autozygome and high throughput confirmation of disease genes candidacy.

PubMed ID: 30237576

DOI: 10.1038/s41436-018-0138-x

Sequence Information:

  • Length: 280
  • Mass: 31956
  • Checksum: 5656277E74C06074
  • Sequence:
    • MCSAFHRAES GTELLARLEG RSSLKEIEPN LFADEDSPVH GDILEFHGPE GTGKTEMLYH 
LTARCILPKS EGGLEVEVLF IDTDYHFDML RLVTILEHRL SQSSEEIIKY CLGRFFLVYC 
SSSTHLLLTL YSLESMFCSH PSLCLLILDS LSAFYWIDRV NGGESVNLQE STLRKCSQCL 
EKLVNDYRLV LFATTQTIMQ KASSSSEEPS HASRRLCDVD IDYRPYLCKA WQQLVKHRMF 
FSKQDDSQSS NQFSLVSRCL KSNSLKKHFF IIGESGVEFC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.