Details for: ZFY

Gene ID: 7544

Symbol: ZFY

Ensembl ID: ENSG00000067646

Description: zinc finger protein Y-linked

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 100.8067
    Cell Significance Index: -15.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 61.3460
    Cell Significance Index: -15.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.2886
    Cell Significance Index: -13.9300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.6427
    Cell Significance Index: -13.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.3419
    Cell Significance Index: -16.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.7151
    Cell Significance Index: -15.3100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 4.9064
    Cell Significance Index: 80.8500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.2295
    Cell Significance Index: -16.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.7683
    Cell Significance Index: -3.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3103
    Cell Significance Index: 129.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.8414
    Cell Significance Index: 12.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8218
    Cell Significance Index: 89.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8007
    Cell Significance Index: 48.0700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7298
    Cell Significance Index: 118.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6969
    Cell Significance Index: 81.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5552
    Cell Significance Index: 111.3800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5283
    Cell Significance Index: 4.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4944
    Cell Significance Index: 37.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4487
    Cell Significance Index: 80.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3825
    Cell Significance Index: 75.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3506
    Cell Significance Index: 15.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3439
    Cell Significance Index: 123.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3321
    Cell Significance Index: 40.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3153
    Cell Significance Index: 9.0900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3096
    Cell Significance Index: 21.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3064
    Cell Significance Index: 5.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2724
    Cell Significance Index: 7.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2087
    Cell Significance Index: 14.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1735
    Cell Significance Index: 4.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1074
    Cell Significance Index: 2.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0941
    Cell Significance Index: 4.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0862
    Cell Significance Index: 3.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0715
    Cell Significance Index: 9.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0555
    Cell Significance Index: 1.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0364
    Cell Significance Index: 2.3500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0292
    Cell Significance Index: 0.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0291
    Cell Significance Index: 18.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0265
    Cell Significance Index: 3.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0194
    Cell Significance Index: 8.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0069
    Cell Significance Index: 0.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0046
    Cell Significance Index: 8.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0002
    Cell Significance Index: 0.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0005
    Cell Significance Index: -0.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0017
    Cell Significance Index: -2.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0022
    Cell Significance Index: -0.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0040
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0073
    Cell Significance Index: -5.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0150
    Cell Significance Index: -11.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0174
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0194
    Cell Significance Index: -3.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0204
    Cell Significance Index: -5.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0208
    Cell Significance Index: -15.7400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0222
    Cell Significance Index: -0.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0254
    Cell Significance Index: -14.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0299
    Cell Significance Index: -16.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0301
    Cell Significance Index: -0.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0342
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0777
    Cell Significance Index: -16.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0826
    Cell Significance Index: -1.7900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0858
    Cell Significance Index: -1.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0895
    Cell Significance Index: -9.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0972
    Cell Significance Index: -2.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0985
    Cell Significance Index: -11.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1021
    Cell Significance Index: -5.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1188
    Cell Significance Index: -16.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1262
    Cell Significance Index: -3.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1410
    Cell Significance Index: -4.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1442
    Cell Significance Index: -7.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1467
    Cell Significance Index: -15.2700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1501
    Cell Significance Index: -3.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1503
    Cell Significance Index: -4.2000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1636
    Cell Significance Index: -1.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1718
    Cell Significance Index: -10.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1741
    Cell Significance Index: -9.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1828
    Cell Significance Index: -4.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1877
    Cell Significance Index: -14.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1963
    Cell Significance Index: -12.3700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2206
    Cell Significance Index: -3.5000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2243
    Cell Significance Index: -1.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2265
    Cell Significance Index: -13.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2547
    Cell Significance Index: -8.8500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2597
    Cell Significance Index: -2.9500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2646
    Cell Significance Index: -3.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2951
    Cell Significance Index: -9.4000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2987
    Cell Significance Index: -4.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3041
    Cell Significance Index: -5.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3180
    Cell Significance Index: -10.4100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3194
    Cell Significance Index: -6.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3264
    Cell Significance Index: -15.3400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3314
    Cell Significance Index: -11.6100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3424
    Cell Significance Index: -6.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3579
    Cell Significance Index: -10.5100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3721
    Cell Significance Index: -8.0400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3766
    Cell Significance Index: -7.5600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3871
    Cell Significance Index: -14.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4057
    Cell Significance Index: -11.9500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4119
    Cell Significance Index: -10.0500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4141
    Cell Significance Index: -10.5800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4167
    Cell Significance Index: -18.1200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4217
    Cell Significance Index: -10.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger Domain**: The ZFY protein contains a highly specific zinc finger domain, which is responsible for its DNA-binding activity. This domain is composed of a Cys2His2 arrangement, allowing for precise interaction with specific DNA sequences. 2. **RNA Polymerase II Interaction**: ZFY exhibits a high degree of specificity for RNA polymerase II, a key enzyme responsible for transcribing protein-coding genes. This interaction enables ZFY to modulate transcriptional activity in a cell-type specific manner. 3. **Cellular Expression**: ZFY is expressed in a wide range of cell types, including mural cells, neurons, GABAergic interneurons, and epithelial cells. Its expression is often restricted to specific tissues, such as the cerebral cortex and intestinal epithelium. 4. **Transcriptional Regulation**: ZFY functions as a transcriptional activator, promoting the expression of specific genes in response to various cellular signals. **Pathways and Functions:** 1. **Chromatin Remodeling**: ZFY interacts with chromatin remodeling complexes, facilitating the reorganization of chromatin structure and accessibility to transcriptional machinery. 2. **RNA Polymerase II Cis-Regulatory Region Binding**: ZFY binds to specific DNA sequences within the promoter regions of target genes, recruiting RNA polymerase II and other transcriptional factors to initiate transcription. 3. **Metal Ion Binding**: ZFY's zinc finger domain is sensitive to metal ion binding, which can modulate its DNA-binding activity and transcriptional regulation. 4. **Nucleolar and Nucleoplasmic Localization**: ZFY is localized to both the nucleolus and nucleoplasm, suggesting its involvement in both transcriptional regulation and RNA processing. **Clinical Significance:** Dysregulation of ZFY expression has been implicated in various diseases, including: 1. **Neurodevelopmental Disorders**: Abnormal ZFY expression has been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Cancer**: ZFY overexpression has been observed in certain types of cancer, including colon cancer, suggesting its potential as a prognostic marker or therapeutic target. 3. **Epithelial Dysregulation**: Abnormal ZFY expression has been associated with epithelial dysregulation, leading to diseases such as inflammatory bowel disease. In conclusion, the Zinc Finger Protein Y-Linked (ZFY) gene plays a critical role in transcriptional regulation and cellular differentiation, with implications for various diseases. Further research is needed to fully elucidate the mechanisms by which ZFY regulates transcription and to explore its therapeutic potential.

Genular Protein ID: 2913196533

Symbol: ZFY_HUMAN

Name: Zinc finger Y-chromosomal protein

UniProtKB Accession Codes:

P08048 B4DVF7 Q14021 Q15558 Q1RME9 Q24JR0 Q96TF3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 8 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2511751

Title: The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues.

PubMed ID: 2511751

PubMed ID: 2308929

Title: Comparison of human ZFY and ZFX transcripts.

PubMed ID: 2308929

DOI: 10.1073/pnas.87.5.1681

PubMed ID: 10779541

Title: Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans.

PubMed ID: 10779541

DOI: 10.1093/oxfordjournals.molbev.a026359

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12815422

Title: The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.

PubMed ID: 12815422

DOI: 10.1038/nature01722

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3690661

Title: The sex-determining region of the human Y chromosome encodes a finger protein.

PubMed ID: 3690661

DOI: 10.1016/0092-8674(87)90595-2

PubMed ID: 2041734

Title: Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY.

PubMed ID: 2041734

DOI: 10.1093/nar/19.10.2579

PubMed ID: 2498838

Title: Evidence for distinguishable transcripts of the putative testis determining gene (ZFY) and mapping of homologous cDNA sequences to chromosomes X,Y and 9.

PubMed ID: 2498838

DOI: 10.1093/nar/17.8.2987

PubMed ID: 20028140

Title: Characterization of the DNA binding activity of the ZFY zinc finger domain.

PubMed ID: 20028140

DOI: 10.1021/bi9018626

PubMed ID: 1849423

Title: Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for 'jumping-linker' DNA recognition.

PubMed ID: 1849423

DOI: 10.1021/bi00228a004

PubMed ID: 1854720

Title: Alternating zinc fingers in the human male associated protein ZFY: refinement of the NMR structure of an even finger by selective deuterium labeling and implications for DNA recognition.

PubMed ID: 1854720

DOI: 10.1021/bi00243a005

PubMed ID: 15557258

Title: Solvation and the hidden thermodynamics of a zinc finger probed by nonstandard repair of a protein crevice.

PubMed ID: 15557258

DOI: 10.1110/ps.04866404

Sequence Information:

  • Length: 801
  • Mass: 90505
  • Checksum: 956B9B3DA16648FA
  • Sequence:
    • MDEDEFELQP QEPNSFFDGI GADATHMDGD QIVVEIQEAV FVSNIVDSDI TVHNFVPDDP 
DSVVIQDVVE DVVIEEDVQC SDILEEADVS ENVIIPEQVL DSDVTEEVSL PHCTVPDDVL 
ASDITSTSMS MPEHVLTSES MHVCDIGHVE HMVHDSVVEA EIITDPLTSD IVSEEVLVAD 
CAPEAVIDAS GISVDQQDND KASCEDYLMI SLDDAGKIEH DGSTGVTIDA ESEMDPCKVD 
STCPEVIKVY IFKADPGEDD LGGTVDIVES EPENDHGVEL LDQNSSIRVP REKMVYMTVN 
DSQQEDEDLN VAEIADEVYM EVIVGEEDAA VAAAAAAVHE QQIDEDEMKT FVPIAWAAAY 
GNNSDGIENR NGTASALLHI DESAGLGRLA KQKPKKKRRP DSRQYQTAII IGPDGHPLTV 
YPCMICGKKF KSRGFLKRHM KNHPEHLAKK KYHCTDCDYT TNKKISLHNH LESHKLTSKA 
EKAIECDECG KHFSHAGALF THKMVHKEKG ANKMHKCKFC EYETAEQGLL NRHLLAVHSK 
NFPHICVECG KGFRHPSELR KHMRIHTGEK PYQCQYCEYR SADSSNLKTH IKTKHSKEMP 
FKCDICLLTF SDTKEVQQHT LVHQESKTHQ CLHCDHKSSN SSDLKRHVIS VHTKDYPHKC 
EMCEKGFHRP SELKKHVAVH KGKKMHQCRH CDFKIADPFV LSRHILSVHT KDLPFRCKRC 
RKGFRQQNEL KKHMKTHSGR KVYQCEYCEY STTDASGFKR HVISIHTKDY PHRCEYCKKG 
FRRPSEKNQH IMRHHKEVGL P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.