Details for: ZNF23

Gene ID: 7571

Symbol: ZNF23

Ensembl ID: ENSG00000167377

Description: zinc finger protein 23

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 42.4957
    Cell Significance Index: -6.6100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 26.4545
    Cell Significance Index: -6.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 15.3597
    Cell Significance Index: -6.2400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.5253
    Cell Significance Index: -6.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.3773
    Cell Significance Index: -6.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6731
    Cell Significance Index: 128.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4243
    Cell Significance Index: 25.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3258
    Cell Significance Index: 65.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3068
    Cell Significance Index: 10.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2616
    Cell Significance Index: 28.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2593
    Cell Significance Index: 16.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2309
    Cell Significance Index: 208.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2282
    Cell Significance Index: 22.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1961
    Cell Significance Index: 15.0500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1957
    Cell Significance Index: 4.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1920
    Cell Significance Index: 68.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1786
    Cell Significance Index: 10.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1571
    Cell Significance Index: 6.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1538
    Cell Significance Index: 25.0100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1504
    Cell Significance Index: 104.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1394
    Cell Significance Index: 9.6400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1312
    Cell Significance Index: 3.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1246
    Cell Significance Index: 4.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1100
    Cell Significance Index: 5.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1003
    Cell Significance Index: 18.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0978
    Cell Significance Index: 5.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0975
    Cell Significance Index: 2.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0836
    Cell Significance Index: 2.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0763
    Cell Significance Index: 3.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0697
    Cell Significance Index: 3.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0511
    Cell Significance Index: 1.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0475
    Cell Significance Index: 6.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0338
    Cell Significance Index: 4.1600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0273
    Cell Significance Index: 0.6300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0062
    Cell Significance Index: 0.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0035
    Cell Significance Index: 1.9000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0030
    Cell Significance Index: 0.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0020
    Cell Significance Index: -0.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0033
    Cell Significance Index: -6.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0046
    Cell Significance Index: -8.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0054
    Cell Significance Index: -0.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0054
    Cell Significance Index: -8.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0055
    Cell Significance Index: -7.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0058
    Cell Significance Index: -2.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0067
    Cell Significance Index: -4.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0081
    Cell Significance Index: -5.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0093
    Cell Significance Index: -5.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0101
    Cell Significance Index: -7.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0105
    Cell Significance Index: -6.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0132
    Cell Significance Index: -8.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0149
    Cell Significance Index: -6.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0197
    Cell Significance Index: -0.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0218
    Cell Significance Index: -6.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0254
    Cell Significance Index: -0.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0360
    Cell Significance Index: -2.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0374
    Cell Significance Index: -6.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0376
    Cell Significance Index: -7.9100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0388
    Cell Significance Index: -0.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0401
    Cell Significance Index: -4.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0450
    Cell Significance Index: -6.5400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0482
    Cell Significance Index: -1.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0487
    Cell Significance Index: -2.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0524
    Cell Significance Index: -5.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0545
    Cell Significance Index: -6.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0557
    Cell Significance Index: -7.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0655
    Cell Significance Index: -4.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0839
    Cell Significance Index: -4.3600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0848
    Cell Significance Index: -1.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0852
    Cell Significance Index: -6.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0870
    Cell Significance Index: -4.5700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0879
    Cell Significance Index: -1.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0910
    Cell Significance Index: -2.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0926
    Cell Significance Index: -6.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0948
    Cell Significance Index: -3.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0975
    Cell Significance Index: -4.5800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1017
    Cell Significance Index: -2.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1023
    Cell Significance Index: -6.6000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1036
    Cell Significance Index: -2.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1081
    Cell Significance Index: -3.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1135
    Cell Significance Index: -7.6300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1161
    Cell Significance Index: -1.7500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1177
    Cell Significance Index: -2.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1191
    Cell Significance Index: -3.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1219
    Cell Significance Index: -4.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1233
    Cell Significance Index: -1.4700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1314
    Cell Significance Index: -1.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1350
    Cell Significance Index: -3.5500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1368
    Cell Significance Index: -2.3700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1379
    Cell Significance Index: -1.9800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.1487
    Cell Significance Index: -0.9200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1488
    Cell Significance Index: -6.4700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1508
    Cell Significance Index: -1.8800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1519
    Cell Significance Index: -3.7900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1588
    Cell Significance Index: -3.4300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1646
    Cell Significance Index: -1.5600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1665
    Cell Significance Index: -2.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1681
    Cell Significance Index: -4.8200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1792
    Cell Significance Index: -3.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1797
    Cell Significance Index: -6.2500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1799
    Cell Significance Index: -2.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ZNF23 is a member of the zinc finger protein family, characterized by its unique DNA-binding domain composed of Cys2His2 zinc fingers. This domain enables the protein to recognize and bind to specific DNA sequences, thereby regulating gene expression. The protein's small size (approximately 390 amino acids) and high degree of conservation across species suggest its importance in fundamental cellular processes. **Pathways and Functions** ZNF23 is involved in various cellular processes, including: 1. **Gene expression regulation**: ZNF23 binds to specific DNA sequences, influencing the transcription of target genes involved in cellular development, differentiation, and function. 2. **Transcriptional regulation by RNA polymerase II**: ZNF23 interacts with RNA polymerase II to regulate the expression of genes involved in transcriptional regulation, demonstrating its role in the generic transcription pathway. 3. **Metal ion binding**: ZNF23's zinc finger domain allows it to bind to metal ions, which are essential for its DNA-binding activity. 4. **Cellular differentiation and development**: ZNF23's expression in specific cell types, such as GABAergic interneurons and intestinal epithelial cells, suggests its involvement in cellular differentiation and development. **Clinical Significance** The clinical significance of ZNF23 lies in its potential role in various diseases, including: 1. **Neurological disorders**: Alterations in ZNF23 expression or function may contribute to neurological disorders, such as epilepsy or schizophrenia, which are associated with GABAergic interneuron dysfunction. 2. **Intestinal diseases**: ZNF23's expression in intestinal epithelial cells suggests its involvement in intestinal homeostasis and disease, such as inflammatory bowel disease (IBD) or colorectal cancer. 3. **Cancer research**: ZNF23's role in regulating gene expression may contribute to cancer development and progression, highlighting its potential as a therapeutic target. In conclusion, ZNF23 is a transcription factor protein that plays a crucial role in regulating gene expression in various cell types, particularly in the brain and intestinal epithelium. Its involvement in cellular differentiation, development, and disease suggests its potential as a therapeutic target for various neurological and intestinal disorders. Further research is necessary to fully elucidate the clinical significance of ZNF23 and its role in human disease.

Genular Protein ID: 376171007

Symbol: ZNF23_HUMAN

Name: Zinc finger protein 23

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12127974

Title: Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development.

PubMed ID: 12127974

DOI: 10.1016/s0006-291x(02)00759-3

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 643
  • Mass: 73059
  • Checksum: A86682E8A75F5A45
  • Sequence:
  • MLENYGNVAS LGFPLLKPAV ISQLEGGSEL GGSSPLAAGT GLQGLQTDIQ TDNDLTKEMY 
    EGKENVSFEL QRDFSQETDF SEASLLEKQQ EVHSAGNIKK EKSNTIDGTV KDETSPVEEC 
    FFSQSSNSYQ CHTITGEQPS GCTGLGKSIS FDTKLVKHEI INSEERPFKC EELVEPFRCD 
    SQLIQHQENN TEEKPYQCSE CGKAFSINEK LIWHQRLHSG EKPFKCVECG KSFSYSSHYI 
    THQTIHSGEK PYQCKMCGKA FSVNGSLSRH QRIHTGEKPY QCKECGNGFS CSSAYITHQR 
    VHTGEKPYEC NDCGKAFNVN AKLIQHQRIH TGEKPYECNE CGKGFRCSSQ LRQHQSIHTG 
    EKPYQCKECG KGFNNNTKLI QHQRIHTGEK PYECTECGKA FSVKGKLIQH QRIHTGEKPY 
    ECNECGKAFR CNSQFRQHLR IHTGEKPYEC NECGKAFSVN GKLMRHQRIH TGEKPFECNE 
    CGRCFTSKRN LLDHHRIHTG EKPYQCKECG KAFSINAKLT RHQRIHTGEK PFKCMECEKA 
    FSCSSNYIVH QRIHTGEKPF QCKECGKAFH VNAHLIRHQR SHTGEKPFRC VECGKGFSFS 
    SDYIIHQTVH TWKKPYMCSV CGKAFRFSFQ LSQHQSVHSE GKS

Genular Protein ID: 2851040139

Symbol: B4DLS2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 585
  • Mass: 67188
  • Checksum: C54601C89A6DEE1F
  • Sequence:
  • MYEGKENVSF ELQRDFSQET DFSEASLLEK QQEVHSVGNI KKEKSNTIDG TVKDETSPVE 
    ECFFSQSSNS YQCHTITGEQ PSGCTGLGKS ISFDTKLVKH EIINSEERPF KCEELVEPFR 
    CDSQLIQHQE NNTEEKPYQC SECGKAFSIN EKLIWHQRLH SGEKPFKCVE CGKSFSYSSH 
    YITHQTIHSG EKPYQCKMCG KAFSVNGSLS RHQRIHTGEK PYQCKECGNG FSCSSAYITH 
    QRVHTGEKPY ECNDCGKAFN VNAKLIQHQR IHTGEKPYEC NECGKGFRCS SQLRQHQSIH 
    TGEKPYQCKE CGKGFNNNTK LIQHQRIHTG EKPYECTECG KAFSVKGKLI QHQRIHTGEK 
    PYECNECGKA FRCNSQFRQH LRIHTGEKPY ECNECGKAFS VNGKLMRHQR IHTGEKPFEC 
    NECGRCFTSK RNLLDHHRIH TGEKPYQCKE CGKAFSINAK LTRHQRIHTG EKPFKCMECE 
    KAFSCSSNYI VHQRIHTGEK PFQCKECGKA FHVNAHLIRH QRSHTGEKPF RCVECGKGFS 
    FSSDYIIHQT VHTWKKPYMC SVCGKAFRFS FQLSQHQSVH SEGKS

Genular Protein ID: 717155486

Symbol: B3KR55_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 643
  • Mass: 73033
  • Checksum: 1DE2ED7B395B656B
  • Sequence:
  • MLENYGNVAS LGFPLLKPAV ISQLEGGSEL GGSSPLAAGT GLQGLQTDIQ TDNDLTKEMY 
    EGKENVSFEL QRDFSQETDF SEASLLEKQQ EVHSAGNIKK EKSNTIDGTV KDETSPVEEC 
    FFSQSSNSYQ CHTITGEQPS GCTGLGKSIS FDTKLVKHEI INSEERPFKC EELVEPFRCD 
    SQLIQHQENN TEEKPYQCSE CGKAFSINEK SIWHQRLHSG EKPFKCVECG KSFSYSSHYI 
    THQTIHSGEK PYQCKMCGKA FSVNGSLSRH QRIHTGEKPY QCKECGNGFS CSSAYITHQR 
    VHTGEKPYEC NDCGKAFNVN AKLIQHQRIH TGEKPYECNE CGKGFRCSSQ LRQHQSIHTG 
    EKPYQCKECG KGFNNNTKLI QHQRIHTGEK PYECTECGKA FSVKGKLIQH QRIHTGEKPY 
    ECNECGKAFR CNSQFRQHLR IHTGEKPYEC NECGKAFSVN GKLMRHQRIH TGEKPFECNE 
    CGRCFTSKRN LLDHHRIHTG EKPYQCKECG KAFSINAKLT RHQRIHTGEK PFKCMECEKA 
    FSCSSNYIVH QRIHTGEKPF QCKECGKAFH VNAHLIRHQR SHTGEKPFRC VECGKGFSFS 
    SDYIIHQTVH TWKKPYMCSV CGKAFRFSFQ LSQHQSVHSE GKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.