Details for: ZNF23

Gene ID: 7571

Symbol: ZNF23

Ensembl ID: ENSG00000167377

Description: zinc finger protein 23

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71819
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5317
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 366
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.89
    Marker Score: 605
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.87
    Marker Score: 1764
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.81
    Marker Score: 1536
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.79
    Marker Score: 12303
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1255
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 702
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 570
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2977
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.69
    Marker Score: 1201
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.62
    Marker Score: 959
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.61
    Marker Score: 5261
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.59
    Marker Score: 5582.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.58
    Marker Score: 35396
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 340
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.52
    Marker Score: 314
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.51
    Marker Score: 412
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.51
    Marker Score: 4752
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.48
    Marker Score: 1002
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.46
    Marker Score: 16882
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.45
    Marker Score: 1728
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.43
    Marker Score: 212
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.43
    Marker Score: 204
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.42
    Marker Score: 8440
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.41
    Marker Score: 15620
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.39
    Marker Score: 490
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.37
    Marker Score: 7875
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.37
    Marker Score: 384.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.36
    Marker Score: 105
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.36
    Marker Score: 328.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.35
    Marker Score: 5298
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.35
    Marker Score: 1438
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.35
    Marker Score: 2652
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.33
    Marker Score: 176
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.33
    Marker Score: 470
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.32
    Marker Score: 1313
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.31
    Marker Score: 210
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.31
    Marker Score: 128
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.3
    Marker Score: 122
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.3
    Marker Score: 88
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.29
    Marker Score: 122
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.29
    Marker Score: 92
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.29
    Marker Score: 111
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.29
    Marker Score: 78
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.28
    Marker Score: 251
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.27
    Marker Score: 645
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.27
    Marker Score: 760
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.25
    Marker Score: 167
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.25
    Marker Score: 111
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.24
    Marker Score: 208
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.24
    Marker Score: 75
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.24
    Marker Score: 277
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.23
    Marker Score: 73
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.22
    Marker Score: 379
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.22
    Marker Score: 59
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.22
    Marker Score: 139
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.22
    Marker Score: 55
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.22
    Marker Score: 170
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.22
    Marker Score: 164
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 71
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.2
    Marker Score: 65
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.2
    Marker Score: 479
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.19
    Marker Score: 222
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.19
    Marker Score: 80
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.19
    Marker Score: 49
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.18
    Marker Score: 133
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.18
    Marker Score: 120
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.18
    Marker Score: 71
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.18
    Marker Score: 452.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.18
    Marker Score: 67
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.18
    Marker Score: 80.5
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.18
    Marker Score: 1538
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.17
    Marker Score: 135
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.17
    Marker Score: 82
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.17
    Marker Score: 457
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.17
    Marker Score: 73
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.16
    Marker Score: 56
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.16
    Marker Score: 95
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.16
    Marker Score: 157
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.16
    Marker Score: 540
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.15
    Marker Score: 103
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.15
    Marker Score: 77
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.15
    Marker Score: 127
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.15
    Marker Score: 149
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.15
    Marker Score: 32

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Other Information

**Key Characteristics** ZNF23 is a member of the zinc finger protein family, characterized by its unique DNA-binding domain composed of Cys2His2 zinc fingers. This domain enables the protein to recognize and bind to specific DNA sequences, thereby regulating gene expression. The protein's small size (approximately 390 amino acids) and high degree of conservation across species suggest its importance in fundamental cellular processes. **Pathways and Functions** ZNF23 is involved in various cellular processes, including: 1. **Gene expression regulation**: ZNF23 binds to specific DNA sequences, influencing the transcription of target genes involved in cellular development, differentiation, and function. 2. **Transcriptional regulation by RNA polymerase II**: ZNF23 interacts with RNA polymerase II to regulate the expression of genes involved in transcriptional regulation, demonstrating its role in the generic transcription pathway. 3. **Metal ion binding**: ZNF23's zinc finger domain allows it to bind to metal ions, which are essential for its DNA-binding activity. 4. **Cellular differentiation and development**: ZNF23's expression in specific cell types, such as GABAergic interneurons and intestinal epithelial cells, suggests its involvement in cellular differentiation and development. **Clinical Significance** The clinical significance of ZNF23 lies in its potential role in various diseases, including: 1. **Neurological disorders**: Alterations in ZNF23 expression or function may contribute to neurological disorders, such as epilepsy or schizophrenia, which are associated with GABAergic interneuron dysfunction. 2. **Intestinal diseases**: ZNF23's expression in intestinal epithelial cells suggests its involvement in intestinal homeostasis and disease, such as inflammatory bowel disease (IBD) or colorectal cancer. 3. **Cancer research**: ZNF23's role in regulating gene expression may contribute to cancer development and progression, highlighting its potential as a therapeutic target. In conclusion, ZNF23 is a transcription factor protein that plays a crucial role in regulating gene expression in various cell types, particularly in the brain and intestinal epithelium. Its involvement in cellular differentiation, development, and disease suggests its potential as a therapeutic target for various neurological and intestinal disorders. Further research is necessary to fully elucidate the clinical significance of ZNF23 and its role in human disease.

Genular Protein ID: 376171007

Symbol: ZNF23_HUMAN

Name: Zinc finger protein 23

UniProtKB Accession Codes:

P17027 Q8NDP5 Q96IT3 Q9UG42

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12127974

Title: Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development.

PubMed ID: 12127974

DOI: 10.1016/s0006-291x(02)00759-3

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 643
  • Mass: 73059
  • Checksum: A86682E8A75F5A45
  • Sequence:
    • MLENYGNVAS LGFPLLKPAV ISQLEGGSEL GGSSPLAAGT GLQGLQTDIQ TDNDLTKEMY 
EGKENVSFEL QRDFSQETDF SEASLLEKQQ EVHSAGNIKK EKSNTIDGTV KDETSPVEEC 
FFSQSSNSYQ CHTITGEQPS GCTGLGKSIS FDTKLVKHEI INSEERPFKC EELVEPFRCD 
SQLIQHQENN TEEKPYQCSE CGKAFSINEK LIWHQRLHSG EKPFKCVECG KSFSYSSHYI 
THQTIHSGEK PYQCKMCGKA FSVNGSLSRH QRIHTGEKPY QCKECGNGFS CSSAYITHQR 
VHTGEKPYEC NDCGKAFNVN AKLIQHQRIH TGEKPYECNE CGKGFRCSSQ LRQHQSIHTG 
EKPYQCKECG KGFNNNTKLI QHQRIHTGEK PYECTECGKA FSVKGKLIQH QRIHTGEKPY 
ECNECGKAFR CNSQFRQHLR IHTGEKPYEC NECGKAFSVN GKLMRHQRIH TGEKPFECNE 
CGRCFTSKRN LLDHHRIHTG EKPYQCKECG KAFSINAKLT RHQRIHTGEK PFKCMECEKA 
FSCSSNYIVH QRIHTGEKPF QCKECGKAFH VNAHLIRHQR SHTGEKPFRC VECGKGFSFS 
SDYIIHQTVH TWKKPYMCSV CGKAFRFSFQ LSQHQSVHSE GKS

Genular Protein ID: 717155486

Symbol: B3KR55_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KR55

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 643
  • Mass: 73033
  • Checksum: 1DE2ED7B395B656B
  • Sequence:
    • MLENYGNVAS LGFPLLKPAV ISQLEGGSEL GGSSPLAAGT GLQGLQTDIQ TDNDLTKEMY 
EGKENVSFEL QRDFSQETDF SEASLLEKQQ EVHSAGNIKK EKSNTIDGTV KDETSPVEEC 
FFSQSSNSYQ CHTITGEQPS GCTGLGKSIS FDTKLVKHEI INSEERPFKC EELVEPFRCD 
SQLIQHQENN TEEKPYQCSE CGKAFSINEK SIWHQRLHSG EKPFKCVECG KSFSYSSHYI 
THQTIHSGEK PYQCKMCGKA FSVNGSLSRH QRIHTGEKPY QCKECGNGFS CSSAYITHQR 
VHTGEKPYEC NDCGKAFNVN AKLIQHQRIH TGEKPYECNE CGKGFRCSSQ LRQHQSIHTG 
EKPYQCKECG KGFNNNTKLI QHQRIHTGEK PYECTECGKA FSVKGKLIQH QRIHTGEKPY 
ECNECGKAFR CNSQFRQHLR IHTGEKPYEC NECGKAFSVN GKLMRHQRIH TGEKPFECNE 
CGRCFTSKRN LLDHHRIHTG EKPYQCKECG KAFSINAKLT RHQRIHTGEK PFKCMECEKA 
FSCSSNYIVH QRIHTGEKPF QCKECGKAFH VNAHLIRHQR SHTGEKPFRC VECGKGFSFS 
SDYIIHQTVH TWKKPYMCSV CGKAFRFSFQ LSQHQSVHSE GKS

Genular Protein ID: 2851040139

Symbol: B4DLS2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DLS2

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 Gene3D 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 585
  • Mass: 67188
  • Checksum: C54601C89A6DEE1F
  • Sequence:
    • MYEGKENVSF ELQRDFSQET DFSEASLLEK QQEVHSVGNI KKEKSNTIDG TVKDETSPVE 
ECFFSQSSNS YQCHTITGEQ PSGCTGLGKS ISFDTKLVKH EIINSEERPF KCEELVEPFR 
CDSQLIQHQE NNTEEKPYQC SECGKAFSIN EKLIWHQRLH SGEKPFKCVE CGKSFSYSSH 
YITHQTIHSG EKPYQCKMCG KAFSVNGSLS RHQRIHTGEK PYQCKECGNG FSCSSAYITH 
QRVHTGEKPY ECNDCGKAFN VNAKLIQHQR IHTGEKPYEC NECGKGFRCS SQLRQHQSIH 
TGEKPYQCKE CGKGFNNNTK LIQHQRIHTG EKPYECTECG KAFSVKGKLI QHQRIHTGEK 
PYECNECGKA FRCNSQFRQH LRIHTGEKPY ECNECGKAFS VNGKLMRHQR IHTGEKPFEC 
NECGRCFTSK RNLLDHHRIH TGEKPYQCKE CGKAFSINAK LTRHQRIHTG EKPFKCMECE 
KAFSCSSNYI VHQRIHTGEK PFQCKECGKA FHVNAHLIRH QRSHTGEKPF RCVECGKGFS 
FSSDYIIHQT VHTWKKPYMC SVCGKAFRFS FQLSQHQSVH SEGKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.