Details for: SLC30A2

Gene ID: 7780

Symbol: SLC30A2

Ensembl ID: ENSG00000158014

Description: solute carrier family 30 member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 20.9573
    Cell Significance Index: 10.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 10.6252
    Cell Significance Index: -2.7000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 5.6122
    Cell Significance Index: -2.2800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 2.4300
    Cell Significance Index: -2.3200
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.8092
    Cell Significance Index: 7.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8453
    Cell Significance Index: 22.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3857
    Cell Significance Index: 65.8600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.3501
    Cell Significance Index: 4.0700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.3485
    Cell Significance Index: 4.8400
  • Cell Name: chorionic trophoblast cell (CL0011101)
    Fold Change: 0.3369
    Cell Significance Index: 1.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2740
    Cell Significance Index: 44.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2270
    Cell Significance Index: 11.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2265
    Cell Significance Index: 13.6000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1737
    Cell Significance Index: 1.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1432
    Cell Significance Index: 2.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1206
    Cell Significance Index: 11.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0771
    Cell Significance Index: 8.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0751
    Cell Significance Index: 10.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0714
    Cell Significance Index: 3.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0695
    Cell Significance Index: 43.3900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0618
    Cell Significance Index: 0.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0502
    Cell Significance Index: 2.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0497
    Cell Significance Index: 5.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0451
    Cell Significance Index: 1.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0444
    Cell Significance Index: 8.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0439
    Cell Significance Index: 7.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0360
    Cell Significance Index: 0.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0340
    Cell Significance Index: 4.3600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0279
    Cell Significance Index: 0.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0224
    Cell Significance Index: 1.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0146
    Cell Significance Index: 0.6600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0102
    Cell Significance Index: 1.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0098
    Cell Significance Index: 0.6800
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0078
    Cell Significance Index: 0.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0072
    Cell Significance Index: 3.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0040
    Cell Significance Index: 0.4900
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0035
    Cell Significance Index: 0.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0033
    Cell Significance Index: 0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0027
    Cell Significance Index: 5.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0023
    Cell Significance Index: 0.8200
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0002
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0004
    Cell Significance Index: -0.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0007
    Cell Significance Index: -1.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0008
    Cell Significance Index: -1.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0013
    Cell Significance Index: -1.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0016
    Cell Significance Index: -1.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0018
    Cell Significance Index: -1.3500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0023
    Cell Significance Index: -0.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0025
    Cell Significance Index: -0.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0035
    Cell Significance Index: -2.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0037
    Cell Significance Index: -1.6600
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.0042
    Cell Significance Index: -0.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0067
    Cell Significance Index: -1.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0071
    Cell Significance Index: -1.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0076
    Cell Significance Index: -2.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0108
    Cell Significance Index: -0.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0114
    Cell Significance Index: -1.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0154
    Cell Significance Index: -1.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0154
    Cell Significance Index: -1.8000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0166
    Cell Significance Index: -0.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0204
    Cell Significance Index: -1.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0216
    Cell Significance Index: -1.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0220
    Cell Significance Index: -0.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0231
    Cell Significance Index: -1.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0234
    Cell Significance Index: -1.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0237
    Cell Significance Index: -2.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0244
    Cell Significance Index: -0.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0247
    Cell Significance Index: -0.7900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0273
    Cell Significance Index: -0.2700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0289
    Cell Significance Index: -0.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0321
    Cell Significance Index: -1.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0360
    Cell Significance Index: -2.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0391
    Cell Significance Index: -0.6700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0412
    Cell Significance Index: -0.5900
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0415
    Cell Significance Index: -0.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0425
    Cell Significance Index: -2.6100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0433
    Cell Significance Index: -1.0000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0435
    Cell Significance Index: -0.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0435
    Cell Significance Index: -2.2000
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0437
    Cell Significance Index: -0.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0447
    Cell Significance Index: -2.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0463
    Cell Significance Index: -2.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0470
    Cell Significance Index: -2.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0471
    Cell Significance Index: -1.2100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0484
    Cell Significance Index: -0.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0492
    Cell Significance Index: -1.4500
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0493
    Cell Significance Index: -0.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0493
    Cell Significance Index: -1.3200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0501
    Cell Significance Index: -0.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0502
    Cell Significance Index: -1.7600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0534
    Cell Significance Index: -0.9000
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0571
    Cell Significance Index: -0.7900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0574
    Cell Significance Index: -2.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0575
    Cell Significance Index: -2.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0576
    Cell Significance Index: -2.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0578
    Cell Significance Index: -1.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The SLC30A2 gene is characterized by its involvement in the transport of zinc ions across cellular membranes, as well as its role in the regulation of zinc efflux and compartmentalization. The gene is part of the solute carrier family 30, which is known for its ability to transport various ions and molecules across cellular membranes. The SLC30A2 gene is also associated with the transport of bile salts, organic acids, metal ions, and amine compounds, highlighting its versatility in cellular function. **Pathways and Functions:** The SLC30A2 gene is involved in several key pathways, including: 1. **Intracellular zinc ion homeostasis**: The gene plays a crucial role in maintaining zinc homeostasis within cells by regulating zinc efflux and compartmentalization. 2. **Zinc ion import into lysosomes, mitochondria, and organelles**: The SLC30A2 gene is involved in the import of zinc ions into lysosomes, mitochondria, and other organelles, highlighting its importance in cellular zinc metabolism. 3. **Metal ion binding and transport**: The gene is associated with the binding and transport of metal ions, including zinc, copper, and iron, suggesting its role in metal ion homeostasis. 4. **Response to zinc ions**: The SLC30A2 gene is responsive to changes in zinc ion concentrations, indicating its ability to adapt to changes in zinc homeostasis. **Clinical Significance:** The SLC30A2 gene has been implicated in various human diseases, including: 1. **Zinc deficiency**: Mutations in the SLC30A2 gene have been associated with zinc deficiency, a condition characterized by impaired zinc homeostasis and various clinical manifestations. 2. **Cognitive disorders**: Variants in the SLC30A2 gene have been linked to cognitive disorders, such as Alzheimer's disease and Parkinson's disease, which are characterized by impaired zinc homeostasis and metal ion dysregulation. 3. **Neurological disorders**: The gene has also been implicated in various neurological disorders, including epilepsy, multiple sclerosis, and schizophrenia, which are characterized by impaired zinc homeostasis and metal ion dysregulation. 4. **Cancer**: The SLC30A2 gene has been associated with cancer, particularly in the context of zinc homeostasis and metal ion regulation. In conclusion, the SLC30A2 gene plays a critical role in maintaining zinc homeostasis and regulating metal ion transport across cellular membranes. Its implications in human health and disease highlight the importance of zinc homeostasis in various physiological processes and the need for further research into the mechanisms underlying zinc dysregulation in disease.

Genular Protein ID: 172770143

Symbol: ZNT2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BRI3 Q71RC8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 10 ChiTaRS 1 ComplexPortal 5 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 3 Ensembl 2 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17897319

Title: Integral and associated lysosomal membrane proteins.

PubMed ID: 17897319

DOI: 10.1111/j.1600-0854.2007.00643.x

PubMed ID: 19496757

Title: Zinc transporter-2 (ZnT2) variants are localized to distinct subcellular compartments and functionally transport zinc.

PubMed ID: 19496757

DOI: 10.1042/bj20081189

PubMed ID: 21289295

Title: A histidine-rich motif mediates mitochondrial localization of ZnT2 to modulate mitochondrial function.

PubMed ID: 21289295

DOI: 10.1152/ajpcell.00420.2010

PubMed ID: 25808614

Title: TNFalpha post-translationally targets ZnT2 to accumulate zinc in lysosomes.

PubMed ID: 25808614

DOI: 10.1002/jcp.24992

PubMed ID: 25657003

Title: Heterodimerization, altered subcellular localization, and function of multiple zinc transporters in viable cells using bimolecular fluorescence complementation.

PubMed ID: 25657003

DOI: 10.1074/jbc.m114.617332

PubMed ID: 30893306

Title: ZnT2 is an electroneutral proton-coupled vesicular antiporter displaying an apparent stoichiometry of two protons per zinc ion.

PubMed ID: 30893306

DOI: 10.1371/journal.pcbi.1006882

PubMed ID: 36204728

Title: Transmembrane 163 (TMEM163) protein interacts with specific mammalian SLC30 zinc efflux transporter family members.

PubMed ID: 36204728

DOI: 10.1016/j.bbrep.2022.101362

PubMed ID: 17065149

Title: Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency.

PubMed ID: 17065149

DOI: 10.1074/jbc.m605821200

PubMed ID: 22733820

Title: A dominant negative heterozygous G87R mutation in the zinc transporter, ZnT-2 (SLC30A2), results in transient neonatal zinc deficiency.

PubMed ID: 22733820

DOI: 10.1074/jbc.m112.368159

Sequence Information:

  • Length: 372
  • Mass: 40564
  • Checksum: 0B004533D3B6D29C
  • Sequence:
    • MEAKEKQHLL DARPAIRSYT GSLWQEGAGW IPLPRPGLDL QAIELAAQSN HHCHAQKGPD 
SHCDPKKGKA QRQLYVASAI CLLFMIGEVV GGYLAHSLAV MTDAAHLLTD FASMLISLFS 
LWMSSRPATK TMNFGWQRAE ILGALVSVLS IWVVTGVLVY LAVERLISGD YEIDGGTMLI 
TSGCAVAVNI IMGLTLHQSG HGHSHGTTNQ QEENPSVRAA FIHVIGDFMQ SMGVLVAAYI 
LYFKPEYKYV DPICTFVFSI LVLGTTLTIL RDVILVLMEG TPKGVDFTAV RDLLLSVEGV 
EALHSLHIWA LTVAQPVLSV HIAIAQNTDA QAVLKTASSR LQGKFHFHTV TIQIEDYSED 
MKDCQACQGP SD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.