Details for: ABHD16A

Gene ID: 7920

Symbol: ABHD16A

Ensembl ID: ENSG00000204427

Description: abhydrolase domain containing 16A, phospholipase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 78.3052
    Cell Significance Index: -12.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 49.9914
    Cell Significance Index: -12.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.2764
    Cell Significance Index: -12.3000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 28.5389
    Cell Significance Index: -14.6800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.2077
    Cell Significance Index: -12.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.1220
    Cell Significance Index: -12.4800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.6106
    Cell Significance Index: -15.0300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2412
    Cell Significance Index: -12.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4119
    Cell Significance Index: 84.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0133
    Cell Significance Index: 52.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9725
    Cell Significance Index: 8.9600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8813
    Cell Significance Index: 20.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7596
    Cell Significance Index: 82.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6454
    Cell Significance Index: 17.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6313
    Cell Significance Index: 18.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5946
    Cell Significance Index: 411.2800
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.5185
    Cell Significance Index: 3.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5066
    Cell Significance Index: 101.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4837
    Cell Significance Index: 47.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4829
    Cell Significance Index: 12.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4745
    Cell Significance Index: 85.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4348
    Cell Significance Index: 392.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3942
    Cell Significance Index: 27.2600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.3593
    Cell Significance Index: 7.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3396
    Cell Significance Index: 41.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2938
    Cell Significance Index: 37.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2838
    Cell Significance Index: 46.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2682
    Cell Significance Index: 96.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1844
    Cell Significance Index: 4.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1793
    Cell Significance Index: 21.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1723
    Cell Significance Index: 9.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1713
    Cell Significance Index: 5.0300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1540
    Cell Significance Index: 2.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1427
    Cell Significance Index: 4.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1375
    Cell Significance Index: 6.2300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1342
    Cell Significance Index: 15.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1239
    Cell Significance Index: 5.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0963
    Cell Significance Index: 4.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0879
    Cell Significance Index: 3.3300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0856
    Cell Significance Index: 1.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0791
    Cell Significance Index: 2.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0438
    Cell Significance Index: 8.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0356
    Cell Significance Index: 2.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0129
    Cell Significance Index: 0.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0009
    Cell Significance Index: 0.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0040
    Cell Significance Index: -2.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0049
    Cell Significance Index: -0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0064
    Cell Significance Index: -12.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0073
    Cell Significance Index: -3.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0074
    Cell Significance Index: -13.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0082
    Cell Significance Index: -1.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0090
    Cell Significance Index: -6.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0091
    Cell Significance Index: -14.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0106
    Cell Significance Index: -14.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0130
    Cell Significance Index: -7.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0178
    Cell Significance Index: -13.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0180
    Cell Significance Index: -13.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0209
    Cell Significance Index: -13.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0239
    Cell Significance Index: -4.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0268
    Cell Significance Index: -5.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0270
    Cell Significance Index: -0.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0286
    Cell Significance Index: -12.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0461
    Cell Significance Index: -13.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0499
    Cell Significance Index: -5.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0503
    Cell Significance Index: -5.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0563
    Cell Significance Index: -3.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0622
    Cell Significance Index: -1.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0624
    Cell Significance Index: -12.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0667
    Cell Significance Index: -6.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0704
    Cell Significance Index: -1.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0801
    Cell Significance Index: -1.4800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0809
    Cell Significance Index: -0.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0887
    Cell Significance Index: -12.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0930
    Cell Significance Index: -2.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1015
    Cell Significance Index: -13.1100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1140
    Cell Significance Index: -1.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1249
    Cell Significance Index: -13.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1398
    Cell Significance Index: -9.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1540
    Cell Significance Index: -7.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1553
    Cell Significance Index: -7.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1563
    Cell Significance Index: -11.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1688
    Cell Significance Index: -8.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1760
    Cell Significance Index: -10.7900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1774
    Cell Significance Index: -5.6500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1778
    Cell Significance Index: -5.8200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1781
    Cell Significance Index: -11.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1781
    Cell Significance Index: -3.7800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1943
    Cell Significance Index: -1.2200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1963
    Cell Significance Index: -2.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2045
    Cell Significance Index: -4.2800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2185
    Cell Significance Index: -4.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2207
    Cell Significance Index: -11.5900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2251
    Cell Significance Index: -4.5200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2275
    Cell Significance Index: -7.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2325
    Cell Significance Index: -8.0800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2387
    Cell Significance Index: -4.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2448
    Cell Significance Index: -6.8400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.2644
    Cell Significance Index: -1.7200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2690
    Cell Significance Index: -6.7100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2741
    Cell Significance Index: -5.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Phospholipase activity:** ABHD16A exhibits lysophospholipase and acylglycerol lipase activities, which enable it to hydrolyze membrane-bound lipids, such as phosphatidylserine and monoacylglycerols. 2. **Cellular localization:** ABHD16A is predominantly expressed in immune cells, including germ cells, myeloid dendritic cells, and monocytes, suggesting its role in immune cell function and development. 3. **Tissue specificity:** ABHD16A is significantly expressed in various tissues, including the respiratory epithelium, intestinal epithelium, and oogonial cells, indicating its involvement in multiple physiological processes. 4. **Protein binding:** ABHD16A interacts with various proteins, including CD14 and CD16, which may modulate its activity and regulate immune responses. **Pathways and Functions:** 1. **Acylglycerol lipase activity:** ABHD16A's acylglycerol lipase activity is involved in the degradation of monoacylglycerols, which can regulate lipid metabolism and influence cellular signaling pathways. 2. **Lysophospholipase activity:** ABHD16A's lysophospholipase activity is implicated in the regulation of membrane-bound lipids, including phosphatidylserine, which can modulate cellular signaling and immune responses. 3. **Prostaglandin catabolic process:** ABHD16A's phospholipase activity is involved in the degradation of prostaglandins, which can regulate inflammation and immune responses. 4. **Protein binding:** ABHD16A's interaction with proteins, such as CD14 and CD16, can modulate its activity and regulate immune responses. **Clinical Significance:** 1. **Immune system dysregulation:** Dysregulation of ABHD16A's phospholipase activity has been implicated in various immune-related disorders, including atherosclerosis, inflammatory bowel disease, and cancer. 2. **Cancer development:** ABHD16A's involvement in lipid metabolism and cellular signaling pathways suggests its potential role in cancer development and progression. 3. **Neurological disorders:** ABHD16A's phospholipase activity has been implicated in the regulation of membrane-bound lipids, which can influence neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases:** ABHD16A's interaction with CD14 and CD16 suggests its potential role in regulating immune responses to infectious diseases. In conclusion, ABHD16A is a multifunctional enzyme that plays a critical role in the immune system, influencing lipid metabolism, cellular signaling pathways, and immune responses. Further research is necessary to elucidate the mechanisms underlying ABHD16A's functions and to explore its potential therapeutic applications in various diseases.

Genular Protein ID: 2157025923

Symbol: ABHGA_HUMAN

Name: Protein G5

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25290914

Title: Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A).

PubMed ID: 25290914

DOI: 10.1371/journal.pone.0109869

PubMed ID: 34587489

Title: ABHD16A deficiency causes a complicated form of hereditary spastic paraplegia associated with intellectual disability and cerebral anomalies.

PubMed ID: 34587489

DOI: 10.1016/j.ajhg.2021.09.005

PubMed ID: 34489854

Title: Pathogenic variants in ABHD16A cause a novel psychomotor developmental disorder with spastic paraplegia.

PubMed ID: 34489854

DOI: 10.3389/fneur.2021.720201

PubMed ID: 34866177

Title: A homozygous ABHD16A variant causes a complex hereditary spastic paraplegia with developmental delay, absent speech, and characteristic face.

PubMed ID: 34866177

DOI: 10.1111/cge.14097

Sequence Information:

  • Length: 558
  • Mass: 63243
  • Checksum: BC46EDA0725D44EA
  • Sequence:
  • MAKLLSCVLG PRLYKIYRER DSERAPASVP ETPTAVTAPH SSSWDTYYQP RALEKHADSI 
    LALASVFWSI SYYSSPFAFF YLYRKGYLSL SKVVPFSHYA GTLLLLLAGV ACLRGIGRWT 
    NPQYRQFITI LEATHRNQSS ENKRQLANYN FDFRSWPVDF HWEEPSSRKE SRGGPSRRGV 
    ALLRPEPLHR GTADTLLNRV KKLPCQITSY LVAHTLGRRM LYPGSVYLLQ KALMPVLLQG 
    QARLVEECNG RRAKLLACDG NEIDTMFVDR RGTAEPQGQK LVICCEGNAG FYEVGCVSTP 
    LEAGYSVLGW NHPGFAGSTG VPFPQNEANA MDVVVQFAIH RLGFQPQDII IYAWSIGGFT 
    ATWAAMSYPD VSAMILDASF DDLVPLALKV MPDSWRGLVT RTVRQHLNLN NAEQLCRYQG 
    PVLLIRRTKD EIITTTVPED IMSNRGNDLL LKLLQHRYPR VMAEEGLRVV RQWLEASSQL 
    EEASIYSRWE VEEDWCLSVL RSYQAEHGPD FPWSVGEDMS ADGRRQLALF LARKHLHNFE 
    ATHCTPLPAQ NFQMPWHL

Genular Protein ID: 1774007003

Symbol: B3KNX9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 339
  • Mass: 38193
  • Checksum: EC0CDCF7BC485797
  • Sequence:
  • MLYPGSVYLL QKALMPVLLQ GQARLVEECN GRRAKLLACD GNEIDTMFVD RRGTAEPQGQ 
    KLVICCEGNA GFYEVGCVST PLEAGYSVLG WNHPGFAGST GVPFPQNEAN AMDVVVQFAI 
    HRLGFQPQDI IIYAWSIGGF TATWAAMSYP DVSAMILDAS FDDLVPLALK VMPDSWRGLV 
    TRTVRQHLNL NNAEQLCRYQ GPVLLIRRTK DEIITTTVPE DIMSNRGNDL LLKLLQHRYP 
    RVMAEEGLRV VRQWLEASSQ LEEASIYSRW EVEEDWCLSV LRSYQAEHGP DFPWSVGEDM 
    SADGRRQLAL FLARKHLHNF EATHCTPLPA QNFQMPWHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.