Details for: ZNF212

Gene ID: 7988

Symbol: ZNF212

Ensembl ID: ENSG00000170260

Description: zinc finger protein 212

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 67.4402
    Cell Significance Index: -10.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 41.1996
    Cell Significance Index: -10.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.9460
    Cell Significance Index: -11.0300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.6695
    Cell Significance Index: -9.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.8307
    Cell Significance Index: -11.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.7278
    Cell Significance Index: -5.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7724
    Cell Significance Index: 697.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6663
    Cell Significance Index: 17.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6186
    Cell Significance Index: 8.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5254
    Cell Significance Index: 31.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4951
    Cell Significance Index: 80.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3624
    Cell Significance Index: 35.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3458
    Cell Significance Index: 68.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3287
    Cell Significance Index: 9.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3035
    Cell Significance Index: 20.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2735
    Cell Significance Index: 54.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2702
    Cell Significance Index: 15.1700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2512
    Cell Significance Index: 4.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2314
    Cell Significance Index: 12.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2293
    Cell Significance Index: 41.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2288
    Cell Significance Index: 43.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2231
    Cell Significance Index: 26.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2122
    Cell Significance Index: 9.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2109
    Cell Significance Index: 4.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2025
    Cell Significance Index: 5.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1992
    Cell Significance Index: 5.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1924
    Cell Significance Index: 4.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1912
    Cell Significance Index: 55.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1726
    Cell Significance Index: 10.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1309
    Cell Significance Index: 10.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1103
    Cell Significance Index: 39.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1047
    Cell Significance Index: 72.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0906
    Cell Significance Index: 11.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0840
    Cell Significance Index: 2.1600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0731
    Cell Significance Index: 2.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0723
    Cell Significance Index: 9.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0553
    Cell Significance Index: 30.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0533
    Cell Significance Index: 23.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0455
    Cell Significance Index: 2.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0331
    Cell Significance Index: 0.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0299
    Cell Significance Index: 0.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0194
    Cell Significance Index: 0.6800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0178
    Cell Significance Index: 0.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0171
    Cell Significance Index: 2.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0100
    Cell Significance Index: 1.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0092
    Cell Significance Index: 1.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0067
    Cell Significance Index: 0.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0012
    Cell Significance Index: 0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0050
    Cell Significance Index: -3.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0056
    Cell Significance Index: -10.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0071
    Cell Significance Index: -10.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0078
    Cell Significance Index: -10.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0086
    Cell Significance Index: -3.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0105
    Cell Significance Index: -7.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0117
    Cell Significance Index: -8.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0121
    Cell Significance Index: -8.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0167
    Cell Significance Index: -0.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0175
    Cell Significance Index: -9.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0200
    Cell Significance Index: -2.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0200
    Cell Significance Index: -12.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0216
    Cell Significance Index: -3.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0324
    Cell Significance Index: -0.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0341
    Cell Significance Index: -3.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0345
    Cell Significance Index: -2.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0466
    Cell Significance Index: -3.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0550
    Cell Significance Index: -1.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0566
    Cell Significance Index: -2.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0578
    Cell Significance Index: -3.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0604
    Cell Significance Index: -4.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0612
    Cell Significance Index: -12.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0614
    Cell Significance Index: -1.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0615
    Cell Significance Index: -3.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0635
    Cell Significance Index: -1.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0757
    Cell Significance Index: -3.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0835
    Cell Significance Index: -5.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0993
    Cell Significance Index: -2.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1014
    Cell Significance Index: -3.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1058
    Cell Significance Index: -11.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1123
    Cell Significance Index: -2.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1155
    Cell Significance Index: -1.9800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1231
    Cell Significance Index: -9.7500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1356
    Cell Significance Index: -1.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1365
    Cell Significance Index: -3.6500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1518
    Cell Significance Index: -1.2900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1657
    Cell Significance Index: -2.3300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1838
    Cell Significance Index: -2.7700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2020
    Cell Significance Index: -1.8600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2114
    Cell Significance Index: -3.0300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2142
    Cell Significance Index: -2.8900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2198
    Cell Significance Index: -2.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2275
    Cell Significance Index: -7.9700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2276
    Cell Significance Index: -7.2500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2330
    Cell Significance Index: -3.4400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2346
    Cell Significance Index: -7.6800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2397
    Cell Significance Index: -7.0400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2415
    Cell Significance Index: -2.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2573
    Cell Significance Index: -7.5800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2599
    Cell Significance Index: -9.5400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2616
    Cell Significance Index: -4.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcriptional Regulator**: ZNF212 acts as a transcriptional regulator, influencing the expression of target genes through its ability to bind to specific DNA sequences. 2. **Zinc Finger Domain**: The gene encodes a zinc finger protein, a conserved domain involved in DNA binding and recognition. 3. **Cell Type Specificity**: ZNF212 is highly expressed in specific cell types, such as those found in the nervous system and the intestinal epithelium. 4. **Dendrite Development**: ZNF212 is involved in the regulation of dendrite development, a critical process in neuronal maturation and function. **Pathways and Functions** 1. **Dendrite Development**: ZNF212 regulates dendrite development by modulating the expression of genes involved in neuronal maturation and function. 2. **Gene Expression Regulation**: ZNF212 acts as a transcriptional regulator, influencing the expression of target genes involved in various cellular processes. 3. **Response to Environmental Stimuli**: ZNF212 is involved in the response to environmental stimuli, such as alcohol, through its regulation of gene expression. 4. **Neuromuscular Process**: ZNF212 is involved in the regulation of neuromuscular processes, including balance and walking behavior. **Clinical Significance** 1. **Neurological Disorders**: Alterations in ZNF212 expression have been linked to various neurological disorders, including autism spectrum disorder and schizophrenia. 2. **Cancer**: ZNF212 has been implicated in the development and progression of certain types of cancer, including colon cancer. 3. **Neurodevelopmental Disorders**: ZNF212 is involved in the regulation of neuronal development and function, making it a potential target for the treatment of neurodevelopmental disorders. 4. **Intestinal Diseases**: ZNF212 is expressed in intestinal epithelial cells and has been implicated in the regulation of intestinal homeostasis, making it a potential target for the treatment of intestinal diseases. In conclusion, ZNF212 is a critical transcription factor involved in various cellular processes, including dendrite development, gene expression regulation, and response to environmental stimuli. Its dysregulation has been linked to various neurological and intestinal disorders, highlighting the need for further research into the mechanisms of ZNF212 and its potential therapeutic applications.

Genular Protein ID: 3150064833

Symbol: ZN212_HUMAN

Name: Zinc finger protein 212

UniProtKB Accession Codes:

Q9UDV6 B2RCF4 Q13396 Q8N664

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9169157

Title: Molecular cloning and mapping of a novel human KRAB domain-containing C2H2-type zinc finger to chromosome 7q36.1.

PubMed ID: 9169157

DOI: 10.1006/geno.1997.4678

PubMed ID: 7633419

Title: Rapid isolation and characterization of 118 novel C2H2-type zinc finger cDNAs expressed in human brain.

PubMed ID: 7633419

DOI: 10.1093/hmg/4.4.685

Sequence Information:

  • Length: 495
  • Mass: 55447
  • Checksum: AF0F7EEC8A482F8A
  • Sequence:
    • MAESAPARHR RKRRSTPLTS STLPSQATEK SSYFQTTEIS LWTVVAAIQA VEKKMESQAA 
RLQSLEGRTG TAEKKLADCE KMAVEFGNQL EGKWAVLGTL LQEYGLLQRR LENVENLLRN 
RNFWILRLPP GSKGEAPKVS RSLENDGVCF TEQEWENLED WQKELYRNVM ESNYETLVSL 
KVLGQTEGEA ELGTEMLGDL EEEGPGGAHP AGGVMIKQEL QYTQEGPADL PGEFSCIAEE 
QAFLSPEQTE LWGGQGSSVL LETGPGDSTL EEPVGSRVPS SSRTVGCPKQ KSHRQVQLDQ 
ECGQGLKLKK DTSRPYECSE CEITFRYKQQ LATHLRSHSG WGSCTPEEPE ESLRPRPRLK 
PQTKKAKLHQ CDVCLRSFSC KVSLVTHQRC HLQEGPSAGQ HVQERFSPNS LVALPGHIPW 
RKSRSSLICG YCGKSFSHPS DLVRHQRIHT GERPYSCTEC EKSFVQKQHL LQHQKIHQRE 
RGGLALEPGR PNGLL

Genular Protein ID: 3807224378

Symbol: B3KQE6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KQE6

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 495
  • Mass: 55433
  • Checksum: 28130F2B965BE1E6
  • Sequence:
    • MADSAPARHR RKRRSTPLTS STLPSQATEK SSYFQTTEIS LWTVVAAIQA VEKKMESQAA 
RLQSLEGRTG TAEKKLADCE KMAVEFGNQL EGKWAVLGTL LQEYGLLQRR LENVENLLRN 
RNFWILRLPP GSKGEAPKVS RSLENDGVCF TEQEWENLED WQKELYRNVM ESNYETLVSL 
KVLGQTEGEA ELGTEMLGDL EEEGPGGAHP AGGVMIKQEL QYTQEGPADL PGEFSCIAEE 
QAFLSPEQTE LWGGQGSSVL LETGPGDSTL EEPVGSRVPS SSRTVGCPKQ KSHRQVQLDQ 
ECGQGLKLKK DTSRPYECSE CEITFRYKQQ LATHLRSHSG WGSCTPEEPE ESLRPRPRLK 
PQTKKAKLHQ CDVCLRSFSC KVSLVTHQRC HLQEGPSAGQ HVQERFSPNS LVALPGHIPW 
RKSRSSLICG YCGKSFSHPS DLVRHQRIHT GERPYSCTEC EKSFVQKQHL LQHQKIHQRE 
RGGLALEPGR PNGLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.