Details for: GPR68

Gene ID: 8111

Symbol: GPR68

Ensembl ID: ENSG00000119714

Description: G protein-coupled receptor 68

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 36.3881
    Cell Significance Index: -5.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.5906
    Cell Significance Index: -5.6600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.1612
    Cell Significance Index: -4.7300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.3336
    Cell Significance Index: 15.1500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.1135
    Cell Significance Index: -3.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.5975
    Cell Significance Index: 36.6400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.5786
    Cell Significance Index: 1.5500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3813
    Cell Significance Index: 8.3500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.2637
    Cell Significance Index: 2.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2606
    Cell Significance Index: 11.8100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.2533
    Cell Significance Index: 3.6300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2401
    Cell Significance Index: 7.0500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2258
    Cell Significance Index: 3.9900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1749
    Cell Significance Index: 2.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1737
    Cell Significance Index: 34.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1718
    Cell Significance Index: 4.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1589
    Cell Significance Index: 45.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1256
    Cell Significance Index: 113.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1004
    Cell Significance Index: 19.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0969
    Cell Significance Index: 9.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0762
    Cell Significance Index: 1.0400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.0724
    Cell Significance Index: 0.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0585
    Cell Significance Index: 9.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0435
    Cell Significance Index: 3.3400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0429
    Cell Significance Index: 29.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0319
    Cell Significance Index: 1.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0311
    Cell Significance Index: 0.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0301
    Cell Significance Index: 1.1400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.0292
    Cell Significance Index: 0.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0154
    Cell Significance Index: 0.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0151
    Cell Significance Index: 2.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0074
    Cell Significance Index: 14.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0035
    Cell Significance Index: 5.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0019
    Cell Significance Index: 3.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0008
    Cell Significance Index: 0.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0005
    Cell Significance Index: 0.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0011
    Cell Significance Index: -1.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0020
    Cell Significance Index: -0.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0027
    Cell Significance Index: -2.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0029
    Cell Significance Index: -1.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0033
    Cell Significance Index: -2.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0038
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0073
    Cell Significance Index: -5.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0079
    Cell Significance Index: -5.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0084
    Cell Significance Index: -4.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0087
    Cell Significance Index: -4.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0106
    Cell Significance Index: -4.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0107
    Cell Significance Index: -6.7000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0123
    Cell Significance Index: -0.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0165
    Cell Significance Index: -2.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0262
    Cell Significance Index: -2.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0265
    Cell Significance Index: -1.7800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0265
    Cell Significance Index: -0.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0289
    Cell Significance Index: -3.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0291
    Cell Significance Index: -6.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0330
    Cell Significance Index: -5.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0351
    Cell Significance Index: -1.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0360
    Cell Significance Index: -4.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0367
    Cell Significance Index: -0.9800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0373
    Cell Significance Index: -1.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0374
    Cell Significance Index: -5.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0450
    Cell Significance Index: -5.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0460
    Cell Significance Index: -3.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0462
    Cell Significance Index: -5.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0488
    Cell Significance Index: -5.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0539
    Cell Significance Index: -5.6100
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0543
    Cell Significance Index: -0.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0560
    Cell Significance Index: -3.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0573
    Cell Significance Index: -5.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0598
    Cell Significance Index: -4.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0618
    Cell Significance Index: -2.8800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0664
    Cell Significance Index: -0.9800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0678
    Cell Significance Index: -0.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0704
    Cell Significance Index: -5.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0754
    Cell Significance Index: -3.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0757
    Cell Significance Index: -2.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0814
    Cell Significance Index: -4.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0846
    Cell Significance Index: -5.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0850
    Cell Significance Index: -2.4500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0916
    Cell Significance Index: -0.9500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0974
    Cell Significance Index: -4.9200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1092
    Cell Significance Index: -0.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1125
    Cell Significance Index: -3.9400
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.1166
    Cell Significance Index: -1.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1203
    Cell Significance Index: -3.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: -0.1232
    Cell Significance Index: 0.3300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1238
    Cell Significance Index: -1.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1302
    Cell Significance Index: -2.8200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1313
    Cell Significance Index: -4.8200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1363
    Cell Significance Index: -2.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1376
    Cell Significance Index: -2.9200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1435
    Cell Significance Index: -1.3600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1461
    Cell Significance Index: -3.5400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1474
    Cell Significance Index: -6.0400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1482
    Cell Significance Index: -4.2300
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1500
    Cell Significance Index: -2.0400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1527
    Cell Significance Index: -3.0200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1532
    Cell Significance Index: -3.3100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1533
    Cell Significance Index: -3.7400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1628
    Cell Significance Index: -4.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** GPR68 is expressed in enterocytes of the large and small intestine, kidney proximal convoluted tubule epithelial cells, cardiac endothelial cells, and other cell types associated with immune and metabolic processes. 2. **G-Protein Coupled Receptor (GPCR) Family:** GPR68 belongs to the rhodopsin-like receptor subfamily, characterized by its seven transmembrane domains and G-protein coupling mechanism. 3. **Signaling Pathways:** GPR68 is involved in various signaling pathways, including Gαq signaling events, GPCR downstream signaling, and GPCR ligand binding, which regulate inflammatory responses, insulin secretion, and osteoclast development. 4. **Positive and Negative Regulation:** GPR68 exhibits both positive and negative regulatory roles in insulin secretion, osteoclast development, and monocyte differentiation, highlighting its complex and context-dependent function. **Pathways and Functions:** 1. **Inflammatory Response:** GPR68 modulates inflammatory responses by interacting with Gαq signaling events, leading to the activation of immune cells and the production of pro-inflammatory cytokines. 2. **Insulin Secretion:** GPR68 plays a crucial role in regulating insulin secretion in response to glucose stimuli, primarily through its positive regulation of insulin secretion. 3. **Osteoclast Development:** GPR68 promotes osteoclast development and activation, contributing to bone remodeling and calcium homeostasis. 4. **Monocyte Differentiation:** GPR68 influences monocyte differentiation, differentiation, and function, highlighting its significance in immune cell development and regulation. 5. **Cellular Response to pH:** GPR68 is involved in the cellular response to pH changes, which is essential for maintaining cellular homeostasis and function. **Clinical Significance:** 1. **Immunological Disorders:** GPR68's role in modulating inflammatory responses and immune cell development makes it a potential target for the treatment of immunological disorders, such as autoimmune diseases and inflammatory bowel disease. 2. **Metabolic Disorders:** GPR68's involvement in insulin secretion and glucose homeostasis suggests its potential role in the pathogenesis of metabolic disorders, such as type 2 diabetes. 3. **Cancer:** GPR68's expression in ovarian cancer cells and its potential role in cancer progression highlight the need for further investigation into its clinical significance in cancer research. 4. **Cardiovascular Diseases:** GPR68's expression in cardiac endothelial cells and its potential role in cardiovascular disease suggest its potential as a therapeutic target for cardiovascular diseases. In conclusion, GPR68 is a multifunctional GPCR that plays a critical role in regulating various physiological and pathological processes, including inflammatory responses, insulin secretion, osteoclast development, and monocyte differentiation. Further investigation into its signaling pathways and clinical significance is necessary to fully elucidate its role in human health and disease.

Genular Protein ID: 1971131050

Symbol: OGR1_HUMAN

Name: Ovarian cancer G-protein coupled receptor 1

UniProtKB Accession Codes:

Q15743 Q13334 Q4VBB4 Q6IX34

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 3 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 11 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7498459

Title: Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue.

PubMed ID: 7498459

DOI: 10.1016/0014-5793(95)01196-l

PubMed ID: 8661159

Title: Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14.

PubMed ID: 8661159

DOI: 10.1006/geno.1996.0377

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10806476

Title: Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1.

PubMed ID: 10806476

DOI: 10.1038/35010529

PubMed ID: 16508674

Title:

PubMed ID: 16508674

DOI: 10.1038/ncb1377

PubMed ID: 12955148

Title: Proton-sensing G-protein-coupled receptors.

PubMed ID: 12955148

DOI: 10.1038/nature01905

PubMed ID: 27693231

Title: Mutations in the pH-sensing G-protein-coupled receptor GPR68 cause amelogenesis imperfecta.

PubMed ID: 27693231

DOI: 10.1016/j.ajhg.2016.08.020

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

  • Length: 365
  • Mass: 41077
  • Checksum: 05919AFD5B842CCD
  • Sequence:
    • MGNITADNSS MSCTIDHTIH QTLAPVVYVT VLVVGFPANC LSLYFGYLQI KARNELGVYL 
CNLTVADLFY ICSLPFWLQY VLQHDNWSHG DLSCQVCGIL LYENIYISVG FLCCISVDRY 
LAVAHPFRFH QFRTLKAAVG VSVVIWAKEL LTSIYFLMHE EVIEDENQHR VCFEHYPIQA 
WQRAINYYRF LVGFLFPICL LLASYQGILR AVRRSHGTQK SRKDQIQRLV LSTVVIFLAC 
FLPYHVLLLV RSVWEASCDF AKGVFNAYHF SLLLTSFNCV ADPVLYCFVS ETTHRDLARL 
RGACLAFLTC SRTGRAREAY PLGAPEASGK SGAQGEEPEL LTKLHPAFQT PNSPGSGGFP 
TGRLA

Genular Protein ID: 1921992799

Symbol: A1A5B2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A1A5B2

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 350
  • Mass: 39538
  • Checksum: B79E15B456B91000
  • Sequence:
    • MRSVAPSGPK MGNITADNSS MSCTIDHTIH QTLAPVVYVT VLVVGFPANC LSLYFGYLQI 
KARNELGVYL CNLTVADLFY ICSLPFWLQY VLQHDNWSHG DLSCQVCGIL LYENIYISVG 
FLCCISVDRY LAVAHPFRFH QFRTLKAAVG VSVVIWAKEL LTSIYFLMHE EVIEDENQHR 
VCFEHYPIQA WQRAINYYRF LVGFLFPICL LLASYQGILR AVRRSHGTQK SRKDQIQRLV 
LSTVVIFLAC FLPYHVLLLV RSVWEASCDF AKGVFNAYHF SLLLTSFNCV ADPVLYCFVS 
ETTHRDLARL RGACLAFLTC SRTGRAREAY PLGAPEASGK SGAQGEEPII

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.