H2BC14 | ENSG00000273703 | NCBI 8342

Details for: H2BC14

Gene ID: 8342

Symbol: H2BC14

Ensembl ID: ENSG00000273703

Description: H2B clustered histone 14

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
E3 ubiquitin ligases ubiquitinate target proteins
(R-HSA-8866654)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Protein ubiquitination
(R-HSA-8852135)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Ub-specific processing proteases
(R-HSA-5689880)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.4120
Cell Significance Index: 5.9000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3703
Cell Significance Index: 23.8900
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.3604
Cell Significance Index: 5.0000
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.3191
Cell Significance Index: 6.6200
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.3167
Cell Significance Index: 1.8000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2985
Cell Significance Index: 17.9200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2464
Cell Significance Index: 46.9000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2370
Cell Significance Index: 27.9500
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2338
Cell Significance Index: 25.4300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2187
Cell Significance Index: 6.3000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1487
Cell Significance Index: 24.1800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1472
Cell Significance Index: 6.6700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1436
Cell Significance Index: 3.1100
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.1412
Cell Significance Index: 1.2000
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.1390
Cell Significance Index: 1.0800
Cell Name: thymocyte (CL0000893)
Fold Change: 0.1322
Cell Significance Index: 1.6700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1210
Cell Significance Index: 11.9700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0840
Cell Significance Index: 2.6900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0821
Cell Significance Index: 5.6800
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0600
Cell Significance Index: 2.1100
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.0577
Cell Significance Index: 0.8100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0544
Cell Significance Index: 1.4600
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.0489
Cell Significance Index: 1.2200
Cell Name: macroglial cell (CL0000126)
Fold Change: 0.0458
Cell Significance Index: 0.5300
Cell Name: salivary gland cell (CL0009005)
Fold Change: 0.0451
Cell Significance Index: 0.5600
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0422
Cell Significance Index: 1.1100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0278
Cell Significance Index: 25.1200
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0272
Cell Significance Index: 0.4100
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.0258
Cell Significance Index: 0.6600
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.0258
Cell Significance Index: 0.2800
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.0251
Cell Significance Index: 0.3600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0229
Cell Significance Index: 1.1900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0193
Cell Significance Index: 0.4100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.0147
Cell Significance Index: 0.9000
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.0135
Cell Significance Index: 0.0800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0024
Cell Significance Index: 1.0400
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0020
Cell Significance Index: 0.0500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.0007
Cell Significance Index: 0.0100
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.0005
Cell Significance Index: 0.0100
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0005
Cell Significance Index: -0.2800
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0016
Cell Significance Index: -0.0700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0026
Cell Significance Index: -1.9500
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0029
Cell Significance Index: -0.5700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0031
Cell Significance Index: -1.9500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0034
Cell Significance Index: -0.6100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0042
Cell Significance Index: -1.4900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0043
Cell Significance Index: -1.9300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0076
Cell Significance Index: -1.5300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0078
Cell Significance Index: -1.0700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0103
Cell Significance Index: -0.5800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0106
Cell Significance Index: -1.0800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0120
Cell Significance Index: -1.4700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0134
Cell Significance Index: -1.9500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0171
Cell Significance Index: -0.9000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0180
Cell Significance Index: -0.8400
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.0235
Cell Significance Index: -0.3300
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.0253
Cell Significance Index: -0.2500
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0267
Cell Significance Index: -0.5200
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.0317
Cell Significance Index: -0.4100
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0320
Cell Significance Index: -0.8000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0370
Cell Significance Index: -0.6200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0370
Cell Significance Index: -1.7400
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0380
Cell Significance Index: -0.4300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0392
Cell Significance Index: -1.0900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0411
Cell Significance Index: -1.3500
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0413
Cell Significance Index: -0.6000
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0421
Cell Significance Index: -1.0200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0446
Cell Significance Index: -1.1900
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0453
Cell Significance Index: -0.5800
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0483
Cell Significance Index: -0.5000
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0489
Cell Significance Index: -0.6400
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0490
Cell Significance Index: -1.8000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0517
Cell Significance Index: -1.8000
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0521
Cell Significance Index: -1.6600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0533
Cell Significance Index: -1.5700
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0538
Cell Significance Index: -1.3700
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.0555
Cell Significance Index: -0.7900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0569
Cell Significance Index: -1.5500
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0576
Cell Significance Index: -0.7300
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -0.0605
Cell Significance Index: -0.4400
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0611
Cell Significance Index: -0.7900
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0611
Cell Significance Index: -2.1400
Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.0615
Cell Significance Index: -0.8500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.0654
Cell Significance Index: -0.9800
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0673
Cell Significance Index: -1.3400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0694
Cell Significance Index: -1.9900
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.0700
Cell Significance Index: -1.0200
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0704
Cell Significance Index: -1.1400
Cell Name: myoblast (CL0000056)
Fold Change: -0.0723
Cell Significance Index: -0.7100
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.0730
Cell Significance Index: -0.7600
Cell Name: peg cell (CL4033014)
Fold Change: -0.0736
Cell Significance Index: -1.7000
Cell Name: tendon cell (CL0000388)
Fold Change: -0.0743
Cell Significance Index: -1.0100
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.0753
Cell Significance Index: -0.7600
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0754
Cell Significance Index: -1.6300
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0766
Cell Significance Index: -1.9100
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0796
Cell Significance Index: -1.6900
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: -0.0801
Cell Significance Index: -0.7000
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0813
Cell Significance Index: -1.7800
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0817
Cell Significance Index: -1.6400
Cell Name: paneth cell (CL0000510)
Fold Change: -0.0826
Cell Significance Index: -0.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** The H2BC14 gene is a histone gene that codes for a protein with a molecular weight of approximately 14 kDa. The protein is a member of the histone H2B family, which is characterized by its ability to bind to DNA and regulate chromatin structure. The H2BC14 protein has a unique structure, with a central histone domain and a C-terminal tail that interacts with other proteins. The gene is highly conserved across species, suggesting its importance in fundamental cellular processes. **Pathways and Functions** The H2BC14 gene is involved in various cellular pathways, including: 1. **DNA Repair**: H2BC14 is involved in the repair of DNA double-strand breaks, particularly through the homology-directed repair (HDR) pathway. 2. **DNA Replication**: H2BC14 is required for the assembly of the pre-replicative complex and the maintenance of chromatin structure during DNA replication. 3. **Transcription**: H2BC14 is involved in the regulation of gene expression, particularly in the transcription of RNA polymerase II-dependent genes. 4. **Chromatin Modification**: H2BC14 is a target for various chromatin-modifying enzymes, including histone acetyltransferases and histone deacetylases. 5. **Cell Cycle Regulation**: H2BC14 is involved in the regulation of the cell cycle, particularly in the G2/M checkpoint. **Clinical Significance** The H2BC14 gene has been implicated in various diseases, including: 1. **Cancer**: Alterations in H2BC14 expression have been observed in various types of cancer, including colon cancer and leukemia. 2. **Neurodegenerative Diseases**: H2BC14 has been implicated in the regulation of gene expression in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Immune System Disorders**: H2BC14 has been shown to play a role in the regulation of the immune system, particularly in the development and function of immune cells. 4. **Epigenetic Disorders**: H2BC14 has been implicated in the regulation of epigenetic marks, particularly in the context of cancer and other diseases. In conclusion, the H2BC14 gene is a critical regulator of chromatin structure and gene expression, with implications for various cellular processes, including DNA repair, replication, and transcription. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its role in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Histone H2B type 1-M

Genular Protein ID: 1785865322

Symbol: H2B1M_HUMAN

Name: Histone H2B type 1-M

UniProtKB Accession Codes:

Q99879 Q6NWQ3

Database IDs:

Citations:

PubMed ID: 9439656

Title: The human histone gene cluster at the D6S105 locus.

PubMed ID: 9439656

DOI: 10.1007/s004390050630

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12757711

Title: Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.

PubMed ID: 12757711

DOI: 10.1016/s0092-8674(03)00355-6

PubMed ID: 16307923

Title: Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.

PubMed ID: 16307923

DOI: 10.1016/j.molcel.2005.09.025

PubMed ID: 16283522

Title: Inhibition of core histones acetylation by carcinogenic nickel(II).

PubMed ID: 16283522

DOI: 10.1007/s11010-005-8285-1

PubMed ID: 16713563

Title: Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.

PubMed ID: 16713563

DOI: 10.1016/j.cell.2006.04.029

PubMed ID: 16457587

Title: Gene-specific characterization of human histone H2B by electron capture dissociation.

PubMed ID: 16457587

DOI: 10.1021/pr050268v

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21925322

Title: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

PubMed ID: 21925322

DOI: 10.1016/j.cell.2011.08.008

PubMed ID: 21726816

Title: The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation.

PubMed ID: 21726816

DOI: 10.1016/j.molcel.2011.05.015

PubMed ID: 22389435

Title: Lysine succinylation and lysine malonylation in histones.

PubMed ID: 22389435

DOI: 10.1074/mcp.m111.015875

PubMed ID: 23824326

Title: USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing.

PubMed ID: 23824326

DOI: 10.1101/gad.211037.112

PubMed ID: 24681537

Title: Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

PubMed ID: 24681537

DOI: 10.1038/nchembio.1497

PubMed ID: 27105113

Title: Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters.

PubMed ID: 27105113

DOI: 10.1016/j.molcel.2016.03.014

PubMed ID: 27105115

Title: Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation.

PubMed ID: 27105115

DOI: 10.1016/j.molcel.2016.03.036

PubMed ID: 27723750

Title: Serine is a new target residue for endogenous ADP-ribosylation on histones.

PubMed ID: 27723750

DOI: 10.1038/nchembio.2180

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 27530147

Title: PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2).

PubMed ID: 27530147

DOI: 10.1038/ncomms12404

PubMed ID: 31542297

Title: Glutarylation of histone H4 lysine 91 regulates chromatin dynamics.

PubMed ID: 31542297

DOI: 10.1016/j.molcel.2019.08.018

PubMed ID: 31645732

Title: Metabolic regulation of gene expression by histone lactylation.

PubMed ID: 31645732

DOI: 10.1038/s41586-019-1678-1

PubMed ID: 34874266

Title: Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.

PubMed ID: 34874266

DOI: 10.7554/elife.71502

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 126
Mass: 13989
Checksum: EB394C60B42C202A
Sequence:

MPEPVKSAPV PKKGSKKAIN KAQKKDGKKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM 
GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT 
KYTSSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: H2BC14

Associated with

Cells (max top 100)

Other Information

The human histone gene cluster at the D6S105 locus. PubMed ID: 9439656

The human and mouse replication-dependent histone genes. PubMed ID: 12408966

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. PubMed ID: 12757711

Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. PubMed ID: 16307923

Inhibition of core histones acetylation by carcinogenic nickel(II). PubMed ID: 16283522

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. PubMed ID: 16713563

Gene-specific characterization of human histone H2B by electron capture dissociation. PubMed ID: 16457587

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. PubMed ID: 21925322

The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. PubMed ID: 21726816

Lysine succinylation and lysine malonylation in histones. PubMed ID: 22389435

USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. PubMed ID: 23824326

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark. PubMed ID: 24681537

Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters. PubMed ID: 27105113

Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation. PubMed ID: 27105115

Serine is a new target residue for endogenous ADP-ribosylation on histones. PubMed ID: 27723750

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2). PubMed ID: 27530147

Glutarylation of histone H4 lysine 91 regulates chromatin dynamics. PubMed ID: 31542297

Metabolic regulation of gene expression by histone lactylation. PubMed ID: 31645732

Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling. PubMed ID: 34874266

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974