H3C3 | ENSG00000287080 | NCBI 8352

Details for: H3C3

Gene ID: 8352

Symbol: H3C3

Ensembl ID: ENSG00000287080

Description: H3 clustered histone 3

Associated with

Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes klk2 and klk3
(R-HSA-5625886)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Condensation of prophase chromosomes
(R-HSA-2299718)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective pyroptosis
(R-HSA-9710421)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna methylation
(R-HSA-5334118)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
(R-HSA-9851695)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hcmv late events
(R-HSA-9610379)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interleukin-7 signaling
(R-HSA-1266695)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
(R-HSA-9841922)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Oxidative stress induced senescence
(R-HSA-2559580)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)
Cadherin binding
(GO:0045296)
Chromatin organization
(GO:0006325)
Dna binding
(GO:0003677)
Gene expression
(GO:0010467)
Nucleosome assembly
(GO:0006334)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Structural constituent of chromatin
(GO:0030527)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 15.0124
Cell Significance Index: 480.8300
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 2.5429
Cell Significance Index: 52.7500
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 2.0846
Cell Significance Index: 50.5000
Cell Name: promonocyte (CL0000559)
Fold Change: 2.0322
Cell Significance Index: 21.7100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.8549
Cell Significance Index: 84.0800
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.5518
Cell Significance Index: 18.3400
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.5308
Cell Significance Index: 17.3300
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.7182
Cell Significance Index: 15.3000
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.5052
Cell Significance Index: 7.0900
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.4104
Cell Significance Index: 4.2700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3360
Cell Significance Index: 20.1700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2564
Cell Significance Index: 27.8900
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.1874
Cell Significance Index: 1.0700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1672
Cell Significance Index: 27.2000
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.1147
Cell Significance Index: 1.1100
Cell Name: enterocyte (CL0000584)
Fold Change: 0.0919
Cell Significance Index: 0.5700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0816
Cell Significance Index: 2.3500
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0756
Cell Significance Index: 1.1400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0746
Cell Significance Index: 5.1600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0745
Cell Significance Index: 14.1700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0703
Cell Significance Index: 6.9500
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.0497
Cell Significance Index: 0.6300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0320
Cell Significance Index: 0.8600
Cell Name: granulocyte (CL0000094)
Fold Change: 0.0174
Cell Significance Index: 0.2100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0083
Cell Significance Index: 1.4900
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.0061
Cell Significance Index: 0.0600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0036
Cell Significance Index: 0.0900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0005
Cell Significance Index: 0.0100
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.0000
Cell Significance Index: 0.0000
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0018
Cell Significance Index: -0.2300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0019
Cell Significance Index: -3.6000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0026
Cell Significance Index: -0.0900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0044
Cell Significance Index: -0.1200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0052
Cell Significance Index: -3.7900
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0053
Cell Significance Index: -0.3000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0059
Cell Significance Index: -3.7400
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.0081
Cell Significance Index: -0.0800
Cell Name: lung macrophage (CL1001603)
Fold Change: -0.0098
Cell Significance Index: -0.1100
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0123
Cell Significance Index: -0.1700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0139
Cell Significance Index: -2.7900
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0157
Cell Significance Index: -0.2700
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -0.0165
Cell Significance Index: -0.1200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0167
Cell Significance Index: -2.2900
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0179
Cell Significance Index: -0.3500
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0209
Cell Significance Index: -0.5200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0215
Cell Significance Index: -2.6400
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.0242
Cell Significance Index: -0.2500
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: -0.0244
Cell Significance Index: -0.1500
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: -0.0246
Cell Significance Index: -0.2500
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.0255
Cell Significance Index: -0.2800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0259
Cell Significance Index: -3.7700
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.0279
Cell Significance Index: -0.3100
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: -0.0322
Cell Significance Index: -0.3700
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: -0.0323
Cell Significance Index: -0.3400
Cell Name: secretory cell (CL0000151)
Fold Change: -0.0357
Cell Significance Index: -0.2500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0386
Cell Significance Index: -1.3400
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.0433
Cell Significance Index: -0.4400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0468
Cell Significance Index: -2.2000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0479
Cell Significance Index: -3.7900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0486
Cell Significance Index: -1.5900
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0516
Cell Significance Index: -0.7600
Cell Name: myofibroblast cell (CL0000186)
Fold Change: -0.0587
Cell Significance Index: -0.6200
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -0.0590
Cell Significance Index: -0.4200
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0592
Cell Significance Index: -0.6500
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0619
Cell Significance Index: -2.1700
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.0627
Cell Significance Index: -0.7500
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.0653
Cell Significance Index: -0.7300
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0657
Cell Significance Index: -0.8500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0698
Cell Significance Index: -2.0000
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.0704
Cell Significance Index: -0.7100
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0719
Cell Significance Index: -2.2900
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0723
Cell Significance Index: -1.4300
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: -0.0731
Cell Significance Index: -0.6900
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0734
Cell Significance Index: -0.9600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0754
Cell Significance Index: -2.2200
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0797
Cell Significance Index: -2.0300
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0798
Cell Significance Index: -1.9900
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.0828
Cell Significance Index: -1.0000
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.0837
Cell Significance Index: -0.5200
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: -0.0855
Cell Significance Index: -0.7400
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.0893
Cell Significance Index: -0.7500
Cell Name: paneth cell (CL0000510)
Fold Change: -0.0933
Cell Significance Index: -0.9700
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.0967
Cell Significance Index: -1.4100
Cell Name: goblet cell (CL0000160)
Fold Change: -0.0978
Cell Significance Index: -0.8900
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: -0.0998
Cell Significance Index: -1.0600
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.1000
Cell Significance Index: -1.3600
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.1033
Cell Significance Index: -2.0600
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: -0.1056
Cell Significance Index: -0.9600
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.1075
Cell Significance Index: -1.5400
Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.1086
Cell Significance Index: -1.3700
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.1097
Cell Significance Index: -2.1600
Cell Name: brain vascular cell (CL4023072)
Fold Change: -0.1129
Cell Significance Index: -1.2900
Cell Name: erythroblast (CL0000765)
Fold Change: -0.1174
Cell Significance Index: -1.4000
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: -0.1218
Cell Significance Index: -1.0900
Cell Name: medial ganglionic eminence derived GABAergic cortical interneuron (CL4023069)
Fold Change: -0.1228
Cell Significance Index: -1.1600
Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.1250
Cell Significance Index: -1.3700
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -0.1257
Cell Significance Index: -1.0800
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1357
Cell Significance Index: -2.8800
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.1365
Cell Significance Index: -1.3100
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.1377
Cell Significance Index: -1.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** The H3C3 gene is a type of histone protein, which is a fundamental component of chromatin structure. Histones are responsible for packaging DNA into a compact form, allowing for efficient transcription and replication. H3C3 is a specific variant of histone 3, which is involved in the assembly of the pre-replicative complex and the origin of replication. This gene is highly expressed in various cell types, including enterocytes, plasmablasts, and intestinal epithelial cells. **Pathways and Functions** The H3C3 gene is involved in several key pathways, including: 1. **Transcriptional Regulation**: H3C3 plays a crucial role in regulating gene expression by interacting with transcription factors and RNA polymerase complexes. It is involved in the activation of androgen receptor-regulated genes and the repression of RNA polymerase I transcription. 2. **Chromatin Organization**: H3C3 is involved in the assembly of the nucleosome, which is the basic unit of chromatin structure. It also plays a role in the regulation of chromatin modifications during the maternal-to-zygotic transition. 3. **Cell Cycle Progression**: H3C3 is involved in the regulation of cell cycle progression, particularly during mitosis. It is required for the formation of condensed prophase chromosomes. 4. **Immune System**: H3C3 is expressed in immune cells, including plasmablasts and intestinal epithelial cells, where it plays a role in the regulation of cytokine signaling and immune responses. **Clinical Significance** Dysregulation of the H3C3 gene has been implicated in various diseases, including: 1. **Cancer**: Mutations in the H3C3 gene have been associated with various types of cancer, including leukemia and lymphoma. 2. **Immune System Disorders**: Dysregulation of the H3C3 gene has been implicated in immune system disorders, such as autoimmune diseases and immunodeficiency syndromes. 3. **Neurological Disorders**: H3C3 has been implicated in the regulation of neuronal development and function, and dysregulation of the gene has been associated with neurological disorders, such as Alzheimer's disease. In conclusion, the H3C3 gene plays a crucial role in various cellular processes, including transcriptional regulation, chromatin organization, and cell cycle progression. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining tissue homeostasis and preventing disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.