H4C13 | ENSG00000275126 | NCBI 8368

Details for: H4C13

Gene ID: 8368

Symbol: H4C13

Ensembl ID: ENSG00000275126

Description: H4 clustered histone 13

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 4.2205
Cell Significance Index: 135.1800
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1.0385
Cell Significance Index: 7.5500
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.9641
Cell Significance Index: 11.9300
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.8141
Cell Significance Index: 11.8200
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.6659
Cell Significance Index: 7.9200
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.6011
Cell Significance Index: 14.5600
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.5106
Cell Significance Index: 6.4700
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.5035
Cell Significance Index: 7.2200
Cell Name: thymocyte (CL0000893)
Fold Change: 0.3902
Cell Significance Index: 4.9300
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.2502
Cell Significance Index: 5.1900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.2021
Cell Significance Index: 4.3100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1874
Cell Significance Index: 5.4000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1861
Cell Significance Index: 18.4100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1791
Cell Significance Index: 34.0900
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.1670
Cell Significance Index: 1.8100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.1531
Cell Significance Index: 4.1000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1148
Cell Significance Index: 103.6900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1055
Cell Significance Index: 11.4800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0940
Cell Significance Index: 2.0400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0743
Cell Significance Index: 8.7600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0716
Cell Significance Index: 11.6500
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0632
Cell Significance Index: 4.0800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0556
Cell Significance Index: 2.5200
Cell Name: granulocyte (CL0000094)
Fold Change: 0.0547
Cell Significance Index: 0.6600
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.0497
Cell Significance Index: 0.6900
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.0457
Cell Significance Index: 0.5900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0451
Cell Significance Index: 1.5900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0446
Cell Significance Index: 3.0900
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0285
Cell Significance Index: 1.7100
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.0221
Cell Significance Index: 0.3100
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.0218
Cell Significance Index: 0.2100
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.0217
Cell Significance Index: 0.5400
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0209
Cell Significance Index: 0.5500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.0113
Cell Significance Index: 0.1700
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.0106
Cell Significance Index: 0.0900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.0093
Cell Significance Index: 0.5700
Cell Name: salivary gland cell (CL0009005)
Fold Change: 0.0032
Cell Significance Index: 0.0400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0010
Cell Significance Index: 0.0500
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0005
Cell Significance Index: -0.0200
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.0010
Cell Significance Index: -0.0100
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0011
Cell Significance Index: -0.5900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0012
Cell Significance Index: -0.0300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0016
Cell Significance Index: -1.1800
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0029
Cell Significance Index: -0.1500
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0033
Cell Significance Index: -0.0500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0047
Cell Significance Index: -0.8400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0047
Cell Significance Index: -0.8100
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0048
Cell Significance Index: -0.9600
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0051
Cell Significance Index: -0.1300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0056
Cell Significance Index: -1.1300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0060
Cell Significance Index: -0.8300
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0086
Cell Significance Index: -0.1100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0087
Cell Significance Index: -0.2400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0093
Cell Significance Index: -1.1400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0113
Cell Significance Index: -0.6400
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0162
Cell Significance Index: -0.3400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0166
Cell Significance Index: -0.4500
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.0169
Cell Significance Index: -0.1000
Cell Name: lung resident memory CD4-positive, alpha-beta T cell (CL4033038)
Fold Change: -0.0170
Cell Significance Index: -0.1300
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0189
Cell Significance Index: -0.6200
Cell Name: sensory neuron (CL0000101)
Fold Change: -0.0194
Cell Significance Index: -0.1100
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0223
Cell Significance Index: -0.3200
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0229
Cell Significance Index: -0.2500
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: -0.0246
Cell Significance Index: -0.2200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0247
Cell Significance Index: -1.1600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0265
Cell Significance Index: -0.3000
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0270
Cell Significance Index: -0.8600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0286
Cell Significance Index: -0.3900
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0289
Cell Significance Index: -1.0600
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0310
Cell Significance Index: -0.4100
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0312
Cell Significance Index: -0.6100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0330
Cell Significance Index: -0.8800
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0336
Cell Significance Index: -0.3800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0341
Cell Significance Index: -0.5700
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0346
Cell Significance Index: -0.5600
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0353
Cell Significance Index: -0.9000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0354
Cell Significance Index: -1.2300
Cell Name: macroglial cell (CL0000126)
Fold Change: -0.0354
Cell Significance Index: -0.4100
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0359
Cell Significance Index: -0.3900
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.0386
Cell Significance Index: -0.5500
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0397
Cell Significance Index: -0.9900
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.0399
Cell Significance Index: -0.5600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0407
Cell Significance Index: -1.2000
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0416
Cell Significance Index: -0.8300
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.0432
Cell Significance Index: -0.6300
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0456
Cell Significance Index: -1.1400
Cell Name: DN4 thymocyte (CL0000808)
Fold Change: -0.0465
Cell Significance Index: -0.3500
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0475
Cell Significance Index: -0.9400
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.0479
Cell Significance Index: -0.5200
Cell Name: osteoclast (CL0000092)
Fold Change: -0.0490
Cell Significance Index: -0.5000
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.0503
Cell Significance Index: -0.9900
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0521
Cell Significance Index: -1.1400
Cell Name: erythroblast (CL0000765)
Fold Change: -0.0528
Cell Significance Index: -0.6300
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0549
Cell Significance Index: -0.7100
Cell Name: myoblast (CL0000056)
Fold Change: -0.0560
Cell Significance Index: -0.5500
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.0564
Cell Significance Index: -0.6300
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.0575
Cell Significance Index: -0.6800
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: -0.0584
Cell Significance Index: -0.6100
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.0596
Cell Significance Index: -0.6600
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.0600
Cell Significance Index: -0.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** 1. **Clusterin Family Member**: H4C13 is a member of the clusterin family of proteins, which are characterized by their ability to bind to DNA and regulate various cellular processes. 2. **DNA Repair**: H4C13 is involved in the assembly of the Orc complex at the origin of replication, which is essential for DNA replication and repair. 3. **Gene Expression Regulation**: H4C13 is implicated in the regulation of gene expression, particularly in the context of RNA polymerase I and the development of the anterior hox genes in hindbrain development during early embryogenesis. 4. **Significant Expression in Intestinal Cells**: H4C13 is significantly expressed in various intestinal cell types, including goblet cells, intestinal crypt stem cells, and transit amplifying cells. **Pathways and Functions** 1. **DNA Replication and Repair**: H4C13 is involved in the assembly of the Orc complex at the origin of replication, which is essential for DNA replication and repair. 2. **Gene Expression Regulation**: H4C13 is implicated in the regulation of gene expression, particularly in the context of RNA polymerase I and the development of the anterior hox genes in hindbrain development during early embryogenesis. 3. **Cell Cycle Regulation**: H4C13 is involved in the regulation of the cell cycle, particularly in the context of the G2/M checkpoint and the DNA damage response. 4. **Apoptosis and Senescence**: H4C13 is implicated in the regulation of apoptosis and senescence, particularly in the context of the senescence-associated secretory phenotype (SASP). **Clinical Significance** 1. **Cancer**: Aberrant expression of H4C13 has been implicated in various types of cancer, including colon cancer, where it is associated with poor prognosis and advanced disease. 2. **Neurological Disorders**: H4C13 has been implicated in the regulation of gene expression in the development of the anterior hox genes in hindbrain development during early embryogenesis, which is essential for the development of the central nervous system. 3. **Infectious Diseases**: H4C13 has been implicated in the regulation of DNA repair and replication, which is essential for the survival of cells infected with viruses such as HIV. 4. **Aging and Senescence**: H4C13 has been implicated in the regulation of apoptosis and senescence, particularly in the context of the SASP, which is associated with age-related diseases. In conclusion, H4C13 is a multifunctional gene that plays critical roles in various cellular processes, including DNA repair, gene expression regulation, and apoptosis. Its expression is significantly detected in various cell types, including intestinal cells, and its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and infectious diseases. Further studies are necessary to fully understand the mechanisms of H4C13 and its role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.