Gene H4C13 - ENSG00000275126 | NCBI Gene ID: 8368

Details for: H4C13

Gene ID: 8368

Symbol: H4C13

Ensembl ID: ENSG00000275126

Description: H4 clustered histone 13

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Cleavage of the damaged purine
(R-HSA-110331)
Cleavage of the damaged pyrimidine
(R-HSA-110329)
Condensation of prophase chromosomes
(R-HSA-2299718)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation of gene expression
(R-HSA-212165)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recognition and association of dna glycosylase with site containing an affected purine
(R-HSA-110330)
Recognition and association of dna glycosylase with site containing an affected pyrimidine
(R-HSA-110328)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.62
Marker Score: 1175
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 859
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7693
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.05
Marker Score: 800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 511
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 464
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.95
Marker Score: 435
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5336
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2743
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 327
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5291
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.84
Marker Score: 335
Cell Name: mast cell (CL0000097)
Fold Change: 0.78
Marker Score: 455
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1269
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 711
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 464
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.69
Marker Score: 521
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2858
Cell Name: thymocyte (CL0000893)
Fold Change: 0.63
Marker Score: 657
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.6
Marker Score: 969
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.6
Marker Score: 477
Cell Name: neutrophil (CL0000775)
Fold Change: 0.57
Marker Score: 346
Cell Name: fibroblast (CL0000057)
Fold Change: 0.44
Marker Score: 426
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 372
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.33
Marker Score: 215.5
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.29
Marker Score: 280
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.27
Marker Score: 245
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.26
Marker Score: 109
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.25
Marker Score: 79
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.24
Marker Score: 332
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.23
Marker Score: 636
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.22
Marker Score: 121
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.21
Marker Score: 69
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.2
Marker Score: 112
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.17
Marker Score: 452
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.16
Marker Score: 320
Cell Name: stromal cell (CL0000499)
Fold Change: 0.15
Marker Score: 180
Cell Name: promonocyte (CL0000559)
Fold Change: 0.15
Marker Score: 94
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.14
Marker Score: 97
Cell Name: plasma cell (CL0000786)
Fold Change: 0.13
Marker Score: 149
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.13
Marker Score: 33
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.13
Marker Score: 126
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.12
Marker Score: 31
Cell Name: plasmablast (CL0000980)
Fold Change: 0.11
Marker Score: 148
Cell Name: late pro-B cell (CL0002048)
Fold Change: 0.11
Marker Score: 131
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.11
Marker Score: 323
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.1
Marker Score: 42
Cell Name: pericyte (CL0000669)
Fold Change: 0.1
Marker Score: 61
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.1
Marker Score: 43
Cell Name: germ cell (CL0000586)
Fold Change: 0.1
Marker Score: 179
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.09
Marker Score: 68
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.09
Marker Score: 54
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.09
Marker Score: 114
Cell Name: granulocyte (CL0000094)
Fold Change: 0.09
Marker Score: 39
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.08
Marker Score: 81
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.08
Marker Score: 773
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.08
Marker Score: 91
Cell Name: B cell (CL0000236)
Fold Change: 0.07
Marker Score: 69
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.07
Marker Score: 35
Cell Name: supporting cell (CL0000630)
Fold Change: 0.07
Marker Score: 132
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.07
Marker Score: 22
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.07
Marker Score: 99
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.07
Marker Score: 142
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.07
Marker Score: 15
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.07
Marker Score: 135
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.06
Marker Score: 110
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.06
Marker Score: 34
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.06
Marker Score: 15
Cell Name: Unknown (CL0000003)
Fold Change: 0.06
Marker Score: 192
Cell Name: centrocyte (CL0009111)
Fold Change: 0.06
Marker Score: 14
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.06
Marker Score: 14
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.06
Marker Score: 29
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.05
Marker Score: 27
Cell Name: lung neuroendocrine cell (CL1000223)
Fold Change: 0.05
Marker Score: 15
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.05
Marker Score: 15
Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
Fold Change: 0.05
Marker Score: 14
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.05
Marker Score: 27
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.05
Marker Score: 52
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 0.05
Marker Score: 36
Cell Name: Unknown (CL0000548)
Fold Change: 0.05
Marker Score: 36
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.05
Marker Score: 134
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.05
Marker Score: 70
Cell Name: Unknown (CL0002371)
Fold Change: 0.05
Marker Score: 51
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.05
Marker Score: 13
Cell Name: neural cell (CL0002319)
Fold Change: 0.05
Marker Score: 22
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.05
Marker Score: 239
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.05
Marker Score: 12
Cell Name: leukocyte (CL0000738)
Fold Change: 0.05
Marker Score: 26
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.05
Marker Score: 45
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.04
Marker Score: 14
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.04
Marker Score: 28
Cell Name: T cell (CL0000084)
Fold Change: 0.04
Marker Score: 75
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.04
Marker Score: 15
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.04
Marker Score: 21
Cell Name: basophil mast progenitor cell (CL0002028)
Fold Change: 0.04
Marker Score: 13

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Other Information

Description

**Key Characteristics** 1. **Clusterin Family Member**: H4C13 is a member of the clusterin family of proteins, which are characterized by their ability to bind to DNA and regulate various cellular processes. 2. **DNA Repair**: H4C13 is involved in the assembly of the Orc complex at the origin of replication, which is essential for DNA replication and repair. 3. **Gene Expression Regulation**: H4C13 is implicated in the regulation of gene expression, particularly in the context of RNA polymerase I and the development of the anterior hox genes in hindbrain development during early embryogenesis. 4. **Significant Expression in Intestinal Cells**: H4C13 is significantly expressed in various intestinal cell types, including goblet cells, intestinal crypt stem cells, and transit amplifying cells. **Pathways and Functions** 1. **DNA Replication and Repair**: H4C13 is involved in the assembly of the Orc complex at the origin of replication, which is essential for DNA replication and repair. 2. **Gene Expression Regulation**: H4C13 is implicated in the regulation of gene expression, particularly in the context of RNA polymerase I and the development of the anterior hox genes in hindbrain development during early embryogenesis. 3. **Cell Cycle Regulation**: H4C13 is involved in the regulation of the cell cycle, particularly in the context of the G2/M checkpoint and the DNA damage response. 4. **Apoptosis and Senescence**: H4C13 is implicated in the regulation of apoptosis and senescence, particularly in the context of the senescence-associated secretory phenotype (SASP). **Clinical Significance** 1. **Cancer**: Aberrant expression of H4C13 has been implicated in various types of cancer, including colon cancer, where it is associated with poor prognosis and advanced disease. 2. **Neurological Disorders**: H4C13 has been implicated in the regulation of gene expression in the development of the anterior hox genes in hindbrain development during early embryogenesis, which is essential for the development of the central nervous system. 3. **Infectious Diseases**: H4C13 has been implicated in the regulation of DNA repair and replication, which is essential for the survival of cells infected with viruses such as HIV. 4. **Aging and Senescence**: H4C13 has been implicated in the regulation of apoptosis and senescence, particularly in the context of the SASP, which is associated with age-related diseases. In conclusion, H4C13 is a multifunctional gene that plays critical roles in various cellular processes, including DNA repair, gene expression regulation, and apoptosis. Its expression is significantly detected in various cell types, including intestinal cells, and its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and infectious diseases. Further studies are necessary to fully understand the mechanisms of H4C13 and its role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.