Details for: FOXN1

Gene ID: 8456

Symbol: FOXN1

Ensembl ID: ENSG00000109101

Description: forkhead box N1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 3.94
    Marker Score: 2185
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 2.57
    Marker Score: 3686
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.49
    Marker Score: 4295
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.87
    Marker Score: 6923
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.32
    Marker Score: 958
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 861
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.24
    Marker Score: 1177
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 492
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7689
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4821
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.09
    Marker Score: 1222
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.03
    Marker Score: 473.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 514
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.99
    Marker Score: 581
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 467
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.98
    Marker Score: 2035
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 378
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5336
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 330
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 497
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.82
    Marker Score: 1344
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.68
    Marker Score: 434.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.65
    Marker Score: 1324
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 514
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.64
    Marker Score: 1021.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.58
    Marker Score: 1105
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.47
    Marker Score: 245
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.45
    Marker Score: 346
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.43
    Marker Score: 433.5
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.42
    Marker Score: 354
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.39
    Marker Score: 354
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.39
    Marker Score: 125
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.39
    Marker Score: 126
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.38
    Marker Score: 6020
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.36
    Marker Score: 403
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.34
    Marker Score: 805
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.34
    Marker Score: 380
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.33
    Marker Score: 319
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.32
    Marker Score: 255
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.32
    Marker Score: 2497
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.29
    Marker Score: 172
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.28
    Marker Score: 182.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.24
    Marker Score: 2098
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.23
    Marker Score: 96
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.23
    Marker Score: 157
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.21
    Marker Score: 77
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.21
    Marker Score: 98
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.2
    Marker Score: 255
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.17
    Marker Score: 1281
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.17
    Marker Score: 195
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.16
    Marker Score: 41
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.16
    Marker Score: 89
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.12
    Marker Score: 55
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.12
    Marker Score: 80
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.11
    Marker Score: 36
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.1
    Marker Score: 129
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.1
    Marker Score: 271
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.08
    Marker Score: 207
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.08
    Marker Score: 88
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.07
    Marker Score: 108
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.07
    Marker Score: 45
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.07
    Marker Score: 91
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.06
    Marker Score: 829
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.05
    Marker Score: 14.5
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.05
    Marker Score: 11
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.05
    Marker Score: 53.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.05
    Marker Score: 91
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.05
    Marker Score: 11
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.05
    Marker Score: 272
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.04
    Marker Score: 82
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.04
    Marker Score: 48
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.04
    Marker Score: 65
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.04
    Marker Score: 58
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.04
    Marker Score: 32

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Other Information

**Key Characteristics:** 1. **Transcriptional regulation:** FOXN1 belongs to the forkhead box (FOX) family of transcription factors, which are known for their role in regulating gene expression. FOXN1 specifically binds to the promoter regions of target genes, influencing their transcription. 2. **Cell type specificity:** FOXN1 expression is highly restricted to specific cell types, including cortical thymic epithelial cells, T cells, and epithelial cells of the skin and gut. 3. **Thymic development:** FOXN1 is critical for thymocyte development and selection, ensuring the proper maturation of T cells. 4. **Epithelial homeostasis:** FOXN1 regulates the differentiation and maintenance of epithelial cells, including those in the skin, gut, and thymus. **Pathways and Functions:** 1. **Thymocyte development:** FOXN1 regulates the expression of genes involved in thymocyte development, including those involved in the Notch signaling pathway. 2. **Epithelial cell differentiation:** FOXN1 promotes the differentiation of epithelial cells into specific cell types, such as keratinocytes and goblet cells. 3. **Cell migration and proliferation:** FOXN1 influences the migration and proliferation of cells, including thymocytes and epithelial cells. 4. **Chromatin remodeling:** FOXN1 interacts with chromatin remodeling complexes to regulate gene expression. **Clinical Significance:** Dysregulation of FOXN1 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases:** Mutations in FOXC1, the gene encoding FOXN1, have been associated with autoimmune diseases, such as autoimmune thyroid disease and type 1 diabetes. 2. **Immunodeficiency:** FOXN1 mutations have been linked to immunodeficiency disorders, including severe combined immunodeficiency (SCID). 3. **Cancer:** FOXN1 has been implicated in the development and progression of certain cancers, including lymphoma and leukemia. In conclusion, FOXN1 is a critical transcription factor that regulates the development and maintenance of the immune system. Its dysregulation has significant clinical implications, highlighting the need for further research into the molecular mechanisms underlying FOXN1-mediated immune responses.

Genular Protein ID: 1102969575

Symbol: FOXN1_HUMAN

Name: Forkhead box protein N1

UniProtKB Accession Codes:

O15353 B2R9Q7 O15352

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9321431

Title: Characterization of mouse and human nude genes.

PubMed ID: 9321431

DOI: 10.1007/s002510050312

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10206641

Title: Exposing the human nude phenotype.

PubMed ID: 10206641

DOI: 10.1038/18997

PubMed ID: 21507891

Title: FOXN1 mutation abrogates prenatal T-cell development in humans.

PubMed ID: 21507891

DOI: 10.1136/jmg.2011.089532

PubMed ID: 25173801

Title: A novel mutation in FOXN1 resulting in SCID: a case report and literature review.

PubMed ID: 25173801

DOI: 10.1016/j.clim.2014.08.005

PubMed ID: 23874334

Title: FOXN1: a master regulator gene of thymic epithelial development program.

PubMed ID: 23874334

DOI: 10.3389/fimmu.2013.00187

PubMed ID: 24432845

Title: FOXN1 in organ development and human diseases.

PubMed ID: 24432845

DOI: 10.3109/08830185.2013.870171

PubMed ID: 20978268

Title: First use of thymus transplantation therapy for FOXN1 deficiency (nude/SCID): a report of 2 cases.

PubMed ID: 20978268

DOI: 10.1182/blood-2010-06-292490

PubMed ID: 28636882

Title: FOXN1 Italian founder mutation in Indian family: Implications in prenatal diagnosis.

PubMed ID: 28636882

DOI: 10.1016/j.gene.2017.06.033

PubMed ID: 31447097

Title: Heterozygous FOXN1 variants cause low TRECs and severe T cell lymphopenia, revealing a crucial role of FOXN1 in supporting early thymopoiesis.

PubMed ID: 31447097

DOI: 10.1016/j.ajhg.2019.07.014

PubMed ID: 31566583

Title: FOXN1 compound heterozygous mutations cause selective thymic hypoplasia in humans.

PubMed ID: 31566583

DOI: 10.1172/jci127565

Sequence Information:

  • Length: 648
  • Mass: 68925
  • Checksum: F32F4C95627E60DE
  • Sequence:
    • MVSLPPPQSD VTLPGPTRLE GERQGDLMQA PGLPGSPAPQ SKHAGFSCSS FVSDGPPERT 
PSLPPHSPRI ASPGPEQVQG HCPAGPGPGP FRLSPSDKYP GFGFEEAAAS SPGRFLKGSH 
APFHPYKRPF HEDVFPEAET TLALKGHSFK TPGPLEAFEE IPVDVAEAEA FLPGFSAEAW 
CNGLPYPSQE HGPQVLGSEV KVKPPVLESG AGMFCYQPPL QHMYCSSQPP FHQYSPGGGS 
YPIPYLGSSH YQYQRMAPQA STDGHQPLFP KPIYSYSILI FMALKNSKTG SLPVSEIYNF 
MTEHFPYFKT APDGWKNSVR HNLSLNKCFE KVENKSGSSS RKGCLWALNP AKIDKMQEEL 
QKWKRKDPIA VRKSMAKPEE LDSLIGDKRE KLGSPLLGCP PPGLSGSGPI RPLAPPAGLS 
PPLHSLHPAP GPIPGKNPLQ DLLMGHTPSC YGQTYLHLSP GLAPPGPPQP LFPQPDGHLE 
LRAQPGTPQD SPLPAHTPPS HSAKLLAEPS PARTMHDTLL PDGDLGTDLD AINPSLTDFD 
FQGNLWEQLK DDSLALDPLV LVTSSPTSSS MPPPQPPPHC FPPGPCLTET GSGAGDLAAP 
GSGGSGALGD LHLTTLYSAF MELEPTPPTA PAGPSVYLSP SSKPVALA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.