Details for: PPFIA1
Gene ID: 8500
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PPFIA1
Ensembl ID: ENSG00000131626
Description: PTPRF interacting protein alpha 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 15rCSI 36.46%PRS 27.77
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CSI 12.94rCSI 19.76%PRS 52.36
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CSI 12.03rCSI 43.27%PRS 27.52
-
CSI 10.94rCSI 18.37%PRS 28.58
-
CSI 9.24rCSI 22.07%PRS 54.08
-
CSI 8.1rCSI 11.26%PRS 43
-
CSI 7.64rCSI 17.41%PRS 42.16
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CSI 7.63rCSI 23.85%PRS 29.73
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CSI 7.57rCSI 5.28%PRS 45.17
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CSI 7.24rCSI 16.16%PRS 49.89
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CSI 7.2rCSI 11.06%PRS 45.74
-
CSI 6.58rCSI 14.75%PRS 29.24
-
CSI 6.35rCSI 4.94%PRS 60.18
-
CSI 6.04rCSI 8.61%PRS 46.15
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CSI 5.96rCSI 7.68%PRS 29.49
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CSI 5.95rCSI 19.92%PRS 32.57
-
CSI 5.81rCSI 4.72%PRS 44.26
-
CSI 5.59rCSI 14.14%PRS 51.65
-
CSI 5.35rCSI 6.66%PRS 54.84
-
CSI 4.94rCSI 7.24%PRS 43.17
-
CSI 4.82rCSI 6.19%PRS 41.61
-
CSI 4.75rCSI 10.86%PRS 42.91
-
CSI 4.71rCSI 7.59%PRS 52.35
-
CSI 4.55rCSI 7.24%PRS 36.95
-
CSI 4.54rCSI 9.01%PRS 42.99
-
CSI 4.44rCSI 26.17%PRS 29.95
-
CSI 4.43rCSI 14.17%PRS 40.54
-
CSI 4.3rCSI 5.19%PRS 51.07
-
CSI 3.88rCSI 11.03%PRS 43.57
-
CSI 3.8rCSI 4.07%PRS 41.46
-
CSI 3.7rCSI 5.68%PRS 50.29
-
CSI 3.6rCSI 13.6%PRS 29.54
-
CSI 3.46rCSI 5.23%PRS 45.41
-
CSI 3.46rCSI 4.44%PRS 39.33
-
CSI 3.43rCSI 5.47%PRS 37.65
-
CSI 3.42rCSI 13.29%PRS 52.35
-
CSI 3.39rCSI 4.07%PRS 41.64
-
CSI 3.25rCSI 4.44%PRS 48.23
-
CSI 3.21rCSI 14.27%PRS 42.22
-
CSI 3.08rCSI 4.21%PRS 46.04
-
CSI 3.07rCSI 4.7%PRS 59.73
-
CSI 3.05rCSI 2.26%PRS 37.46
-
CSI 2.93rCSI 2.37%PRS 54.57
-
CSI 2.93rCSI 70.08%PRS 28.08
-
CSI 2.9rCSI 7.65%PRS 50.88
-
CSI 2.88rCSI 69.5%PRS 28.96
-
CSI 2.78rCSI 3.39%PRS 51.05
-
CSI 2.76rCSI 2.82%PRS 62.1
-
CSI 2.74rCSI 15.82%PRS 45.73
-
CSI 2.72rCSI 10.95%PRS 42.11
-
CSI 2.71rCSI 6.46%PRS 45.79
-
CSI 2.7rCSI 12.95%PRS 42.01
-
CSI 2.65rCSI 7.02%PRS 56.84
-
CSI 2.61rCSI 3.32%PRS 48.64
-
CSI 2.6rCSI 4.25%PRS 34.63
-
CSI 2.59rCSI 3.22%PRS 27.14
-
CSI 2.58rCSI 3.8%PRS 39.78
-
CSI 2.55rCSI 3.49%PRS 40.18
-
CSI 2.52rCSI 3.37%PRS 51.69
-
CSI 2.46rCSI 2.56%PRS 44.17
-
CSI 2.46rCSI 2.32%PRS 44.47
-
CSI 2.44rCSI 5.57%PRS 37.33
-
CSI 2.39rCSI 4.08%PRS 69.45
-
CSI 2.38rCSI 3.38%PRS 40.6
-
CSI 2.37rCSI 2.75%PRS 54.32
-
CSI 2.37rCSI 1.96%PRS 44.43
-
CSI 2.35rCSI 2.26%PRS 44.03
-
CSI 2.35rCSI 20.68%PRS 32.74
-
CSI 2.33rCSI 9.92%PRS 41.13
-
CSI 2.32rCSI 6.89%PRS 55.2
-
CSI 2.32rCSI 2.02%PRS 52.63
-
CSI 2.3rCSI 2.14%PRS 43.37
-
CSI 2.28rCSI 1.73%PRS 55.52
-
CSI 2.22rCSI 4.23%PRS 60.24
-
CSI 2.19rCSI 9.62%PRS 37.34
-
CSI 2.17rCSI 5.77%PRS 36.32
-
CSI 2.16rCSI 8.45%PRS 21.55
-
CSI 2.16rCSI 1.55%PRS 56.23
-
CSI 2.16rCSI 2.68%PRS 46.14
-
CSI 2.14rCSI 15.76%PRS 32.08
-
CSI 2.14rCSI 8%PRS 36.92
-
CSI 2.13rCSI 5.4%PRS 34.5
-
CSI 2.12rCSI 4.26%PRS 33.88
-
CSI 2.1rCSI 4.35%PRS 41.49
-
CSI 2.09rCSI 1.66%PRS 31.84
-
CSI 2.07rCSI 2.43%PRS 47.22
-
CSI 2.07rCSI 2.03%PRS 45.7
-
CSI 2.02rCSI 3.28%PRS 42.09
-
CSI 2.01rCSI 10.29%PRS 47.16
-
CSI 2rCSI 1.84%PRS 44.44
-
CSI 1.99rCSI 2.33%PRS 58.92
-
CSI 1.98rCSI 1.39%PRS 66.04
-
CSI 1.97rCSI 2.91%PRS 48.33
-
CSI 1.93rCSI 1.86%PRS 34.56
-
CSI 1.92rCSI 2.77%PRS 53.49
-
CSI 1.91rCSI 5.63%PRS 42.45
-
CSI 1.88rCSI 3.02%PRS 30.64
-
CSI 1.87rCSI 2.16%PRS 38.08
-
CSI 1.85rCSI 2.29%PRS 39.51
-
CSI 1.84rCSI 2.91%PRS 44.42
-
CSI 0.3rCSI 3.9%PRS 69.2%
-
CSI 0.3rCSI 2.7%PRS 31.6%
-
CSI 0.4rCSI 1.4%PRS 56.4%
-
CSI 0.4rCSI 2.0%PRS 43.5%
-
CSI 0.5rCSI 1.0%PRS 63.2%
-
CSI 0.5rCSI 2.1%PRS 62.7%
-
CSI 0.5rCSI 2.7%PRS 54.4%
-
CSI 0.5rCSI 10.3%PRS 37.8%
-
CSI 0.5rCSI 2.7%PRS 58.3%
-
CSI 0.5rCSI 1.6%PRS 60.7%
-
CSI 0.6rCSI 2.0%PRS 58.9%
-
CSI 0.6rCSI 1.7%PRS 35.4%
-
CSI 0.7rCSI 1.2%PRS 52.0%
-
CSI 0.7rCSI 2.0%PRS 61.3%
-
CSI 0.7rCSI 2.1%PRS 46.0%
-
CSI 0.7rCSI 15.0%PRS 36.8%
-
CSI 0.8rCSI 1.2%PRS 34.7%
-
CSI 0.8rCSI 2.5%PRS 32.9%
-
CSI 0.8rCSI 2.0%PRS 43.5%
-
CSI 0.8rCSI 2.6%PRS 42.9%
-
CSI 0.8rCSI 3.3%PRS 55.3%
-
CSI 0.8rCSI 3.7%PRS 65.9%
-
CSI 0.8rCSI 2.0%PRS 41.6%
-
CSI 0.8rCSI 2.3%PRS 58.0%
-
CSI 0.8rCSI 1.3%PRS 53.9%
-
CSI 0.8rCSI 2.0%PRS 53.6%
-
CSI 0.9rCSI 12.1%PRS 36.5%
-
CSI 0.9rCSI 1.3%PRS 40.4%
-
CSI 0.9rCSI 1.5%PRS 42.0%
-
CSI 0.9rCSI 1.1%PRS 62.8%
-
CSI 0.9rCSI 3.1%PRS 35.7%
-
CSI 0.9rCSI 2.0%PRS 34.2%
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CSI 1.0rCSI 2.1%PRS 32.5%
-
CSI 1.0rCSI 1.9%PRS 45.4%
-
CSI 1.0rCSI 2.2%PRS 58.0%
-
CSI 1.0rCSI 5.8%PRS 30.5%
-
CSI 1.0rCSI 1.6%PRS 53.5%
-
CSI 1.0rCSI 2.8%PRS 52.3%
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CSI 1.1rCSI 2.4%PRS 40.8%
-
CSI 1.1rCSI 2.9%PRS 36.8%
-
CSI 1.1rCSI 1.4%PRS 48.2%
-
CSI 1.1rCSI 5.6%PRS 55.1%
-
CSI 1.1rCSI 2.1%PRS 37.2%
-
CSI 1.2rCSI 2.1%PRS 37.3%
-
CSI 1.2rCSI 1.9%PRS 49.0%
-
CSI 1.2rCSI 2.6%PRS 53.5%
-
CSI 1.2rCSI 1.8%PRS 44.1%
-
CSI 1.2rCSI 3.4%PRS 44.0%
-
CSI 1.2rCSI 3.9%PRS 45.7%
-
CSI 1.2rCSI 2.2%PRS 41.9%
-
CSI 1.2rCSI 7.5%PRS 36.4%
-
CSI 1.2rCSI 2.1%PRS 34.7%
-
CSI 1.2rCSI 9.3%PRS 63.7%
-
CSI 1.2rCSI 3.0%PRS 39.8%
-
CSI 1.2rCSI 3.4%PRS 40.4%
-
CSI 1.3rCSI 1.7%PRS 45.0%
-
CSI 1.3rCSI 2.0%PRS 47.2%
-
CSI 1.3rCSI 2.6%PRS 38.4%
-
CSI 1.3rCSI 1.2%PRS 58.4%
-
CSI 1.3rCSI 3.3%PRS 39.8%
-
CSI 1.3rCSI 2.4%PRS 53.6%
-
CSI 1.3rCSI 2.4%PRS 66.8%
-
CSI 1.3rCSI 1.9%PRS 46.4%
-
CSI 1.4rCSI 3.5%PRS 51.8%
-
CSI 1.4rCSI 4.3%PRS 32.0%
-
CSI 1.4rCSI 1.3%PRS 50.7%
-
CSI 1.4rCSI 3.3%PRS 49.3%
-
CSI 1.4rCSI 1.7%PRS 28.6%
-
CSI 1.4rCSI 1.1%PRS 44.0%
-
CSI 1.4rCSI 1.4%PRS 38.0%
-
CSI 1.4rCSI 1.5%PRS 49.2%
-
CSI 1.4rCSI 15.2%PRS 45.0%
-
CSI 1.4rCSI 4.6%PRS 51.1%
-
CSI 1.5rCSI 2.6%PRS 27.6%
-
CSI 1.5rCSI 3.8%PRS 42.6%
-
CSI 1.5rCSI 2.2%PRS 54.5%
-
CSI 1.5rCSI 1.2%PRS 42.0%
-
CSI 1.5rCSI 2.1%PRS 35.3%
-
CSI 1.5rCSI 3.3%PRS 47.5%
-
CSI 1.5rCSI 1.6%PRS 40.9%
-
CSI 1.5rCSI 3.6%PRS 33.5%
-
CSI 1.5rCSI 1.3%PRS 47.1%
-
CSI 1.5rCSI 4.9%PRS 46.4%
-
CSI 1.5rCSI 2.3%PRS 48.1%
-
CSI 1.5rCSI 3.0%PRS 69.3%
-
CSI 1.5rCSI 4.0%PRS 48.8%
-
CSI 1.5rCSI 2.9%PRS 33.8%
-
CSI 1.5rCSI 3.3%PRS 58.5%
-
CSI 1.5rCSI 3.7%PRS 59.3%
-
CSI 1.6rCSI 1.4%PRS 40.2%
-
CSI 1.6rCSI 2.3%PRS 50.8%
-
CSI 1.6rCSI 6.1%PRS 37.4%
-
CSI 1.6rCSI 6.3%PRS 63.7%
-
CSI 1.6rCSI 1.4%PRS 42.6%
-
CSI 1.6rCSI 2.4%PRS 60.8%
-
CSI 1.6rCSI 4.2%PRS 46.5%
-
CSI 1.7rCSI 1.9%PRS 34.1%
-
CSI 1.7rCSI 4.0%PRS 61.2%
-
CSI 1.7rCSI 2.4%PRS 59.6%
-
CSI 1.7rCSI 1.5%PRS 33.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1075004719
Symbol: LIPA1_HUMAN
Name: Liprin-alpha-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7796809
Title: The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions.
PubMed ID: 7796809
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8524829
Title: The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1.
PubMed ID: 8524829
PubMed ID: 9624153
Title: Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.
PubMed ID: 9624153
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 24120883
Title: CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor.
PubMed ID: 24120883
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 27410476
Title: Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions.
PubMed ID: 27410476
DOI: 10.7554/elife.18124
Sequence Information:
- Length: 1202
- Mass: 135779
- Checksum: C8CF7C20B298BFB1
- Sequence:
MMCEVMPTIS EAEGPPGGGG GHGSGSPSQP DADSHFEQLM VSMLEERDRL LDTLRETQET LALTQGKLHE VGHERDSLQR QLNTALPQEF AALTKELNVC REQLLEREEE IAELKAERNN TRLLLEHLEC LVSRHERSLR MTVVKRQAQS PAGVSSEVEV LKALKSLFEH HKALDEKVRE RLRVALERCS LLEEELGATH KELMILKEQN NQKKTLTDGV LDINHEQENT PSTSGKRSSD GSLSHEEDLA KVIELQEIIS KQSREQSQMK ERLASLSSHV TELEEDLDTA RKDLIKSEEM NTKLQRDVRE AMAQKEDMEE RITTLEKRYL AAQREATSVH DLNDKLENEI ANKDSMHRQT EDKNRQLQER LELAEQKLQQ TLRKAETLPE VEAELAQRVA ALSKAEERHG NIEERLRQME AQLEEKNQEL QRARQREKMN EEHNKRLSDT VDKLLSESNE RLQLHLKERM AALEDKNSLL REVESAKKQL EETQHDKDQL VLNIEALRAE LDHMRLRGAS LHHGRPHLGS VPDFRFPMAD GHTDSYSTSA VLRRPQKGRL AALRDEPSKV QTLNEQDWER AQQASVLANV AQAFESDADV SDGEDDRDTL LSSVDLLSPS GQADAHTLAM MLQEQLDAIN KEIRLIQEEK ENTEQRAEEI ESRVGSGSLD NLGRFRSMSS IPPYPASSLA SSSPPGSGRS TPRRIPHSPA REVDRLGVMT LLPPSREEVR DDKTTIKCET SPPSSPRALR LDRLHKGALH TVSHEDIRDI RNSTGSQDGP VSNPSSSNSS QDSLHKAPKK KGIKSSIGRL FGKKEKGRPG QTGKEALGQA GVSETDNSSQ DALGLSKLGG QAEKNRKLQK KHELLEEARR QGLPFAQWDG PTVVVWLELW VGMPAWYVAA CRANVKSGAI MSALSDTEIQ REIGISNPLH RLKLRLAIQE IMSLTSPSAP PTSRTTLAYG DMNHEWIGNE WLPSLGLPQY RSYFMECLVD ARMLDHLTKK DLRGQLKMVD SFHRNSFQCG IMCLRRLNYD RKELERKREE SQSEIKDVLV WSNDRVIRWI LSIGLKEYAN NLIESGVHGA LLALDETFDF SALALLLQIP TQNTQARAVL EREFNNLLVM GTDRRFDEDD DKSFRRAPSW RKKFRPKDIR GLAAGSAETL PANFRVTSSM SSPSMQPKKM QMDGNVSGTQ RLDSATVRTY SC
Genular Protein ID: 2676400756
Symbol: B3KVS8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 241
- Mass: 27886
- Checksum: B189E9B11A2B9BAC
- Sequence:
MNHEWIGNEW LPSLGLPQYR SYFMECLVDA RMLDHLTKKD LRGQLKMVDS FHRNSFQCGI MCLRRLNYDR KELERKREES QSEIKDVLVW SNDRVIRWIL SIGLKEYANN LIESGVHGAL LALDETFDFS ALALLLQIPT QNTQARAVLE REFNNLLVMG TDRRFDEDDD KSFRRAPSWR KKFRPKDIRG LAAGSAETLP ANFRVTSSMS SPSMQPKKMQ MDGNVSGTQR LDSATVRTYS C