Details for: CYP4F2

Gene ID: 8529

Symbol: CYP4F2

Ensembl ID: ENSG00000186115

Description: cytochrome P450 family 4 subfamily F member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 6.0321
    Cell Significance Index: -1.5300
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 2.3001
    Cell Significance Index: 2.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.1220
    Cell Significance Index: 61.1400
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.9610
    Cell Significance Index: 14.8700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.2997
    Cell Significance Index: 21.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1673
    Cell Significance Index: 25.2900
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.9894
    Cell Significance Index: 2.6100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9541
    Cell Significance Index: 57.2800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5495
    Cell Significance Index: 59.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5009
    Cell Significance Index: 452.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3907
    Cell Significance Index: 38.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3686
    Cell Significance Index: 25.4900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3390
    Cell Significance Index: 5.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2957
    Cell Significance Index: 10.3900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.2634
    Cell Significance Index: 3.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2539
    Cell Significance Index: 13.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2535
    Cell Significance Index: 41.2300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.2419
    Cell Significance Index: 3.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2224
    Cell Significance Index: 42.3200
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.1853
    Cell Significance Index: 1.1500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.1781
    Cell Significance Index: 4.3200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1755
    Cell Significance Index: 2.5900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1355
    Cell Significance Index: 1.9400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1184
    Cell Significance Index: 2.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1046
    Cell Significance Index: 4.7400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0937
    Cell Significance Index: 0.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0707
    Cell Significance Index: 14.0300
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.0558
    Cell Significance Index: 0.2100
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.0356
    Cell Significance Index: 0.2100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.0178
    Cell Significance Index: 0.1800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0163
    Cell Significance Index: 0.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0113
    Cell Significance Index: 0.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0103
    Cell Significance Index: 0.6300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0085
    Cell Significance Index: 0.0700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0032
    Cell Significance Index: 0.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0024
    Cell Significance Index: 1.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0002
    Cell Significance Index: 0.0300
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0011
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0011
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0015
    Cell Significance Index: -0.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0016
    Cell Significance Index: -0.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0024
    Cell Significance Index: -1.1000
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.0028
    Cell Significance Index: -0.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0028
    Cell Significance Index: -1.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0035
    Cell Significance Index: -2.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0035
    Cell Significance Index: -1.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0043
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0061
    Cell Significance Index: -1.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0072
    Cell Significance Index: -0.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0081
    Cell Significance Index: -0.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0095
    Cell Significance Index: -1.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0122
    Cell Significance Index: -0.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0147
    Cell Significance Index: -0.7400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0150
    Cell Significance Index: -0.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0184
    Cell Significance Index: -2.6800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0204
    Cell Significance Index: -0.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0211
    Cell Significance Index: -1.4200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0214
    Cell Significance Index: -0.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0229
    Cell Significance Index: -2.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0240
    Cell Significance Index: -0.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0242
    Cell Significance Index: -0.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0252
    Cell Significance Index: -2.0000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0273
    Cell Significance Index: -0.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0287
    Cell Significance Index: -0.7700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0289
    Cell Significance Index: -1.0600
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0290
    Cell Significance Index: -0.3500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0301
    Cell Significance Index: -0.3300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0303
    Cell Significance Index: -0.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0307
    Cell Significance Index: -1.8900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0308
    Cell Significance Index: -0.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0309
    Cell Significance Index: -0.8400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0332
    Cell Significance Index: -0.4600
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.0336
    Cell Significance Index: -0.2800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0360
    Cell Significance Index: -0.9000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0367
    Cell Significance Index: -0.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0373
    Cell Significance Index: -0.7800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0404
    Cell Significance Index: -0.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0440
    Cell Significance Index: -1.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0449
    Cell Significance Index: -1.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0456
    Cell Significance Index: -2.5600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0477
    Cell Significance Index: -0.9900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0479
    Cell Significance Index: -1.2800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0479
    Cell Significance Index: -0.6600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0480
    Cell Significance Index: -1.5700
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0488
    Cell Significance Index: -0.6500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0493
    Cell Significance Index: -0.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0502
    Cell Significance Index: -1.9000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0513
    Cell Significance Index: -0.5400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0527
    Cell Significance Index: -0.9000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0527
    Cell Significance Index: -0.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0532
    Cell Significance Index: -1.4200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0537
    Cell Significance Index: -0.3500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0549
    Cell Significance Index: -1.4000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0562
    Cell Significance Index: -1.9700
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0563
    Cell Significance Index: -0.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0563
    Cell Significance Index: -1.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Expression**: The CYP4F2 gene is widely expressed in various tissues, including the liver, kidney, and vascular endothelium. 2. **Substrate specificity**: The CYP4F2 enzyme is specific for the omega-hydroxylation of arachidonic acid and other long-chain fatty acids. 3. **Metabolic pathways**: The CYP4F2 enzyme is involved in the metabolism of arachidonic acid, the synthesis of leukotrienes and eoxins, and the regulation of blood pressure. 4. **Regulatory mechanisms**: The CYP4F2 gene is regulated by various transcription factors, including Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), which is involved in the antioxidant response. **Pathways and Functions** The CYP4F2 enzyme is involved in several key pathways, including: 1. **Arachidonic acid metabolism**: The CYP4F2 enzyme is responsible for the omega-hydroxylation of arachidonic acid, which is a critical step in the production of leukotrienes and eoxins. 2. **Leukotriene synthesis**: The CYP4F2 enzyme is involved in the synthesis of leukotrienes, which are pro-inflammatory mediators that play a key role in various diseases, including asthma and cardiovascular disease. 3. **Eoxin synthesis**: The CYP4F2 enzyme is also involved in the synthesis of eoxins, which are anti-inflammatory mediators that have been implicated in the regulation of blood pressure. 4. **Blood pressure regulation**: The CYP4F2 enzyme is involved in the regulation of blood pressure through the synthesis of eoxins, which have vasodilatory effects. **Clinical Significance** Mutations in the CYP4F2 gene have been associated with various diseases, including: 1. **Hypertension**: Mutations in the CYP4F2 gene have been linked to an increased risk of hypertension, particularly in individuals with a family history of the disease. 2. **Kidney disease**: The CYP4F2 enzyme is involved in the metabolism of arachidonic acid, which is essential for the production of eoxins that have anti-inflammatory effects. Mutations in the CYP4F2 gene have been associated with an increased risk of kidney disease. 3. **Asthma**: The CYP4F2 enzyme is involved in the synthesis of leukotrienes, which are pro-inflammatory mediators that play a key role in the pathogenesis of asthma. 4. **Cardiovascular disease**: The CYP4F2 enzyme is involved in the synthesis of eoxins, which have vasodilatory effects and may help to regulate blood pressure. In conclusion, the CYP4F2 gene plays a critical role in various biological processes, including the metabolism of arachidonic acid, the synthesis of leukotrienes and eoxins, and the regulation of blood pressure. Mutations in the CYP4F2 gene have been associated with various diseases, including hypertension, kidney disease, asthma, and cardiovascular disease.

Genular Protein ID: 940303908

Symbol: CP4F2_HUMAN

Name: CYPIVF2

UniProtKB Accession Codes:

P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 100 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 EC 5 EMBL 14 Ensembl 1 ExpressionAtlas 1 GO 38 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 Rhea 100 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8026587

Title: Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liver.

PubMed ID: 8026587

DOI: 10.1016/0014-5793(94)00587-7

PubMed ID: 10492403

Title: Expression and molecular cloning of human liver leukotriene B4 omega-hydroxylase (CYP4F2) gene.

PubMed ID: 10492403

DOI: 10.1089/104454999315006

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10860554

Title: Promoter activity and regulation of the CYP4F2 leukotriene B4 omega hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells.

PubMed ID: 10860554

DOI: 10.1006/abbi.2000.1836

PubMed ID: 9799565

Title: Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4.

PubMed ID: 9799565

DOI: 10.1006/abbi.1998.0880

PubMed ID: 10833273

Title: Characterization of human liver leukotriene B(4) omega-hydroxylase P450 (CYP4F2).

PubMed ID: 10833273

DOI: 10.1093/oxfordjournals.jbchem.a022696

PubMed ID: 10660572

Title: Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of CYP4F2 and CYP4A11.

PubMed ID: 10660572

DOI: 10.1074/jbc.275.6.4118

PubMed ID: 11997390

Title: Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status.

PubMed ID: 11997390

DOI: 10.1074/jbc.m201466200

PubMed ID: 15145985

Title: Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides.

PubMed ID: 15145985

DOI: 10.1194/jlr.m300463-jlr200

PubMed ID: 16547005

Title: Omega-oxidation of very long-chain fatty acids in human liver microsomes. Implications for X-linked adrenoleukodystrophy.

PubMed ID: 16547005

DOI: 10.1074/jbc.m513481200

PubMed ID: 17341693

Title: Functional polymorphism in human CYP4F2 decreases 20-HETE production.

PubMed ID: 17341693

DOI: 10.1152/physiolgenomics.00003.2007

PubMed ID: 18182499

Title: Characterization of the human omega-oxidation pathway for omega-hydroxy-very-long-chain fatty acids.

PubMed ID: 18182499

DOI: 10.1096/fj.07-099150

PubMed ID: 18574070

Title: The V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressure.

PubMed ID: 18574070

DOI: 10.1161/hypertensionaha.108.114199

PubMed ID: 18065749

Title: Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.

PubMed ID: 18065749

DOI: 10.1194/jlr.m700450-jlr200

PubMed ID: 18577768

Title: Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.

PubMed ID: 18577768

DOI: 10.1194/jlr.m800199-jlr200

PubMed ID: 20861217

Title: Common variants of cytochrome P450 4F2 exhibit altered vitamin E-{omega}-hydroxylase specific activity.

PubMed ID: 20861217

DOI: 10.3945/jn.110.128579

PubMed ID: 24138531

Title: Cytochrome P450-dependent catabolism of vitamin K: omega-hydroxylation catalyzed by human CYP4F2 and CYP4F11.

PubMed ID: 24138531

DOI: 10.1021/bi401208m

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 18250228

Title: CYP4F2 genetic variant alters required warfarin dose.

PubMed ID: 18250228

DOI: 10.1182/blood-2007-11-122010

PubMed ID: 19270263

Title: Pharmacogenetic relevance of CYP4F2 V433M polymorphism on acenocoumarol therapy.

PubMed ID: 19270263

DOI: 10.1182/blood-2008-09-176222

PubMed ID: 19297519

Title: CYP4F2 is a vitamin K1 oxidase: An explanation for altered warfarin dose in carriers of the V433M variant.

PubMed ID: 19297519

DOI: 10.1124/mol.109.054833

PubMed ID: 19207028

Title: CYP4F2 genetic variant (rs2108622) significantly contributes to warfarin dosing variability in the Italian population.

PubMed ID: 19207028

DOI: 10.2217/14622416.10.2.261

PubMed ID: 20555338

Title: Worldwide allele frequency distribution of four polymorphisms associated with warfarin dose requirements.

PubMed ID: 20555338

DOI: 10.1038/jhg.2010.73

PubMed ID: 23132553

Title: Impact of the CYP4F2 p.V433M polymorphism on coumarin dose requirement: systematic review and meta-analysis.

PubMed ID: 23132553

DOI: 10.1038/clpt.2012.184

Sequence Information:

  • Length: 520
  • Mass: 59853
  • Checksum: 1791F9E6EECB59B5
  • Sequence:
    • MSQLSLSWLG LWPVAASPWL LLLLVGASWL LAHVLAWTYA FYDNCRRLRC FPQPPRRNWF 
WGHQGMVNPT EEGMRVLTQL VATYPQGFKV WMGPISPLLS LCHPDIIRSV INASAAIAPK 
DKFFYSFLEP WLGDGLLLSA GDKWSRHRRM LTPAFHFNIL KPYMKIFNES VNIMHAKWQL 
LASEGSACLD MFEHISLMTL DSLQKCVFSF DSHCQEKPSE YIAAILELSA LVSKRHHEIL 
LHIDFLYYLT PDGQRFRRAC RLVHDFTDAV IQERRRTLPS QGVDDFLQAK AKSKTLDFID 
VLLLSKDEDG KKLSDEDIRA EADTFMFEGH DTTASGLSWV LYHLAKHPEY QERCRQEVQE 
LLKDREPKEI EWDDLAHLPF LTMCMKESLR LHPPVPVISR HVTQDIVLPD GRVIPKGIIC 
LISVFGTHHN PAVWPDPEVY DPFRFDPENI KERSPLAFIP FSAGPRNCIG QTFAMAEMKV 
VLALTLLRFR VLPDHTEPRR KPELVLRAEG GLWLRVEPLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.