Details for: CHST1

Gene ID: 8534

Symbol: CHST1

Ensembl ID: ENSG00000175264

Description: carbohydrate sulfotransferase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.73
    Marker Score: 912
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.44
    Marker Score: 12411
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.43
    Marker Score: 2702
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 865
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.34
    Marker Score: 12694
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7505
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.11
    Marker Score: 42000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.06
    Marker Score: 10989
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.06
    Marker Score: 4314
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1
    Marker Score: 61509
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71818
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48043
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.98
    Marker Score: 9261
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2423
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5348
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.92
    Marker Score: 19691
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.9
    Marker Score: 1389
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.87
    Marker Score: 365
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 624
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8
    Marker Score: 12466
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.77
    Marker Score: 1760
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.75
    Marker Score: 494
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.74
    Marker Score: 1046
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.7
    Marker Score: 1431.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.69
    Marker Score: 599
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.65
    Marker Score: 203
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 413
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.59
    Marker Score: 843
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.58
    Marker Score: 276
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.58
    Marker Score: 543
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 456
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.54
    Marker Score: 183
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.53
    Marker Score: 1516
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.52
    Marker Score: 312
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.49
    Marker Score: 465
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 471
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.45
    Marker Score: 253
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.44
    Marker Score: 8750
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.43
    Marker Score: 1681
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.42
    Marker Score: 710
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.42
    Marker Score: 847
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.4
    Marker Score: 373
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.37
    Marker Score: 137
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.37
    Marker Score: 445
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 369
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.36
    Marker Score: 167
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.34
    Marker Score: 578
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.33
    Marker Score: 2516
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.32
    Marker Score: 141
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.31
    Marker Score: 445
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.3
    Marker Score: 145
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.3
    Marker Score: 95
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.3
    Marker Score: 265
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.29
    Marker Score: 132
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.29
    Marker Score: 9667
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.28
    Marker Score: 150
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.28
    Marker Score: 1173
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.28
    Marker Score: 102
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.27
    Marker Score: 160
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 155
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.26
    Marker Score: 291
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.25
    Marker Score: 504
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.25
    Marker Score: 9226
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.25
    Marker Score: 520
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.24
    Marker Score: 218
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.24
    Marker Score: 564
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.23
    Marker Score: 955
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.23
    Marker Score: 79
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.22
    Marker Score: 1942
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.21
    Marker Score: 105
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.21
    Marker Score: 55
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.21
    Marker Score: 3154
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.21
    Marker Score: 120
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.2
    Marker Score: 185
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.2
    Marker Score: 83
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.2
    Marker Score: 492
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.18
    Marker Score: 194
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.18
    Marker Score: 1841
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.18
    Marker Score: 139
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.18
    Marker Score: 103
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.17
    Marker Score: 2306
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.17
    Marker Score: 315
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.17
    Marker Score: 79
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.17
    Marker Score: 794
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.17
    Marker Score: 210
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.17
    Marker Score: 98
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.16
    Marker Score: 171
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.16
    Marker Score: 227
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.16
    Marker Score: 39
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.16
    Marker Score: 86
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.16
    Marker Score: 32
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.16
    Marker Score: 259

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Other Information

**Key Characteristics:** 1. **Catalytic Activity:** CHST1 is a sulfotransferase enzyme that catalyzes the sulfation of keratan sulfate, a type of GAG. 2. **Tissue Expression:** The gene is highly expressed in hematopoietic stem cells, neurons, cardiac endothelial cells, and other cell types, indicating its widespread role in cellular development and function. 3. **Metabolic Pathways:** CHST1 is involved in various metabolic pathways, including galactose metabolism, glycosaminoglycan metabolism, and keratan sulfate biosynthesis. 4. **Cellular Localization:** The enzyme is localized to the Golgi apparatus, where it is responsible for the sulfation of GAGs. **Pathways and Functions:** 1. **Galactose Metabolic Process:** CHST1 plays a crucial role in the galactose metabolic pathway, which is essential for the synthesis of GAGs. 2. **Glycosaminoglycan Metabolism:** The enzyme is involved in the biosynthesis and degradation of GAGs, which are negatively charged polysaccharides that play critical roles in cell signaling and inflammation. 3. **Keratan Sulfate Biosynthesis:** CHST1 is responsible for the sulfation of keratan sulfate, a type of GAG that is involved in cell-cell interactions and tissue development. 4. **Inflammatory Response:** The enzyme's involvement in the inflammatory response pathway suggests its role in regulating immune cell function and tissue homeostasis. 5. **Protein Binding:** CHST1 can bind to various proteins, including keratan sulfate-binding proteins, which may regulate GAG function and cellular signaling. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations in the CHST1 gene have been associated with immunodeficiency disorders, such as cartilage-hair hypoplasia syndrome, which highlights the gene's importance in immune function. 2. **Cancer:** Aberrant expression of CHST1 has been linked to cancer development and progression, suggesting its role in tumor growth and metastasis. 3. **Neurological Disorders:** The gene's involvement in neuronal development and function makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular Disease:** CHST1's role in endothelial cell function and vascular development makes it a potential therapeutic target for cardiovascular disease. In conclusion, the CHST1 gene plays a critical role in glycosaminoglycan metabolism, inflammation, and immune function. Its widespread expression in various cell types and its association with multiple metabolic pathways highlight its importance in maintaining cellular homeostasis. Further research on CHST1 is necessary to elucidate its precise mechanisms of action and to explore its potential therapeutic applications in various diseases.

Genular Protein ID: 3179051292

Symbol: CHST1_HUMAN

Name: Carbohydrate sulfotransferase 1

UniProtKB Accession Codes:

O43916 D3DQP2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 2 DNASU 1 DisGeNET 1 EC 1 EMBL 8 Ensembl 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SABIO-RK 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9405439

Title: Molecular cloning and characterization of human keratan sulfate Gal-6-sulfotransferase.

PubMed ID: 9405439

DOI: 10.1074/jbc.272.51.32321

PubMed ID: 9639683

Title: Human chondroitin 6-sulfotransferase: cloning, gene structure, and chromosomal localization.

PubMed ID: 9639683

DOI: 10.1016/s0925-4439(98)00028-3

PubMed ID: 10049591

Title: CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization.

PubMed ID: 10049591

DOI: 10.1006/geno.1998.5653

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10642612

Title: Sulfation of sialyl N-acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal-6-sulfotransferase.

PubMed ID: 10642612

DOI: 10.1093/glycob/10.2.203

PubMed ID: 10330415

Title: Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin.

PubMed ID: 10330415

DOI: 10.1083/jcb.145.4.899

PubMed ID: 11310842

Title: CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin.

PubMed ID: 11310842

PubMed ID: 17690104

Title: Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans.

PubMed ID: 17690104

DOI: 10.1074/jbc.m703695200

Sequence Information:

  • Length: 411
  • Mass: 46715
  • Checksum: F07D0A23B6338A09
  • Sequence:
    • MQCSWKAVLL LALASIAIQY TAIRTFTAKS FHTCPGLAEA GLAERLCEES PTFAYNLSRK 
THILILATTR SGSSFVGQLF NQHLDVFYLF EPLYHVQNTL IPRFTQGKSP ADRRVMLGAS 
RDLLRSLYDC DLYFLENYIK PPPVNHTTDR IFRRGASRVL CSRPVCDPPG PADLVLEEGD 
CVRKCGLLNL TVAAEACRER SHVAIKTVRV PEVNDLRALV EDPRLNLKVI QLVRDPRGIL 
ASRSETFRDT YRLWRLWYGT GRKPYNLDVT QLTTVCEDFS NSVSTGLMRP PWLKGKYMLV 
RYEDLARNPM KKTEEIYGFL GIPLDSHVAR WIQNNTRGDP TLGKHKYGTV RNSAATAEKW 
RFRLSYDIVA FAQNACQQVL AQLGYKIAAS EEELKNPSVS LVEERDFRPF S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.