Details for: CHST1

Gene ID: 8534

Symbol: CHST1

Ensembl ID: ENSG00000175264

Description: carbohydrate sulfotransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.4803
    Cell Significance Index: -13.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1795
    Cell Significance Index: 236.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.7234
    Cell Significance Index: 15.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6911
    Cell Significance Index: 46.4700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.6741
    Cell Significance Index: 10.4300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6097
    Cell Significance Index: 17.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3043
    Cell Significance Index: 7.0300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.2361
    Cell Significance Index: 3.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1712
    Cell Significance Index: 118.4300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.1550
    Cell Significance Index: 3.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1528
    Cell Significance Index: 54.8000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.1201
    Cell Significance Index: 1.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1059
    Cell Significance Index: 3.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0990
    Cell Significance Index: 3.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0952
    Cell Significance Index: 5.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0929
    Cell Significance Index: 4.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0294
    Cell Significance Index: 1.8100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0209
    Cell Significance Index: 1.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0046
    Cell Significance Index: 2.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0041
    Cell Significance Index: 0.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0078
    Cell Significance Index: -14.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0127
    Cell Significance Index: -19.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0154
    Cell Significance Index: -2.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0186
    Cell Significance Index: -11.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0186
    Cell Significance Index: -10.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0234
    Cell Significance Index: -17.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0302
    Cell Significance Index: -17.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0325
    Cell Significance Index: -5.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0346
    Cell Significance Index: -1.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0356
    Cell Significance Index: -16.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0429
    Cell Significance Index: -12.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0496
    Cell Significance Index: -9.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0850
    Cell Significance Index: -17.9100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0871
    Cell Significance Index: -0.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0908
    Cell Significance Index: -11.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0991
    Cell Significance Index: -14.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1042
    Cell Significance Index: -17.8000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1081
    Cell Significance Index: -3.0200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1241
    Cell Significance Index: -3.1900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1260
    Cell Significance Index: -2.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1321
    Cell Significance Index: -2.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1336
    Cell Significance Index: -17.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1363
    Cell Significance Index: -9.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1399
    Cell Significance Index: -16.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1473
    Cell Significance Index: -15.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1476
    Cell Significance Index: -15.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1518
    Cell Significance Index: -4.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1529
    Cell Significance Index: -17.5200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1631
    Cell Significance Index: -2.8200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1950
    Cell Significance Index: -6.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2000
    Cell Significance Index: -15.3500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2026
    Cell Significance Index: -8.8100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2131
    Cell Significance Index: -5.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2226
    Cell Significance Index: -16.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2354
    Cell Significance Index: -6.1900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2649
    Cell Significance Index: -2.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2681
    Cell Significance Index: -16.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2690
    Cell Significance Index: -15.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2723
    Cell Significance Index: -3.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2986
    Cell Significance Index: -15.5100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3063
    Cell Significance Index: -7.6400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3091
    Cell Significance Index: -10.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3244
    Cell Significance Index: -15.2500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.3316
    Cell Significance Index: -4.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3378
    Cell Significance Index: -15.3100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3433
    Cell Significance Index: -3.7400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3935
    Cell Significance Index: -7.7800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3996
    Cell Significance Index: -14.6700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4037
    Cell Significance Index: -4.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4085
    Cell Significance Index: -8.5500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4147
    Cell Significance Index: -2.8100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4283
    Cell Significance Index: -4.0600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.4311
    Cell Significance Index: -7.3700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.4482
    Cell Significance Index: -5.1300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4508
    Cell Significance Index: -9.7400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4607
    Cell Significance Index: -13.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4650
    Cell Significance Index: -16.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4787
    Cell Significance Index: -10.1600
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.4985
    Cell Significance Index: -5.5000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5012
    Cell Significance Index: -10.4600
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.5055
    Cell Significance Index: -4.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5393
    Cell Significance Index: -14.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5557
    Cell Significance Index: -14.8900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5593
    Cell Significance Index: -11.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5692
    Cell Significance Index: -16.4000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.5716
    Cell Significance Index: -11.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5742
    Cell Significance Index: -16.4600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.5864
    Cell Significance Index: -7.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5864
    Cell Significance Index: -15.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5891
    Cell Significance Index: -15.7300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5895
    Cell Significance Index: -14.7000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.5930
    Cell Significance Index: -14.8100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5934
    Cell Significance Index: -7.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5995
    Cell Significance Index: -8.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6208
    Cell Significance Index: -15.8600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.6259
    Cell Significance Index: -19.8000
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.6340
    Cell Significance Index: -2.7600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.6371
    Cell Significance Index: -12.5400
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.6376
    Cell Significance Index: -7.0300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.6417
    Cell Significance Index: -16.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Catalytic Activity:** CHST1 is a sulfotransferase enzyme that catalyzes the sulfation of keratan sulfate, a type of GAG. 2. **Tissue Expression:** The gene is highly expressed in hematopoietic stem cells, neurons, cardiac endothelial cells, and other cell types, indicating its widespread role in cellular development and function. 3. **Metabolic Pathways:** CHST1 is involved in various metabolic pathways, including galactose metabolism, glycosaminoglycan metabolism, and keratan sulfate biosynthesis. 4. **Cellular Localization:** The enzyme is localized to the Golgi apparatus, where it is responsible for the sulfation of GAGs. **Pathways and Functions:** 1. **Galactose Metabolic Process:** CHST1 plays a crucial role in the galactose metabolic pathway, which is essential for the synthesis of GAGs. 2. **Glycosaminoglycan Metabolism:** The enzyme is involved in the biosynthesis and degradation of GAGs, which are negatively charged polysaccharides that play critical roles in cell signaling and inflammation. 3. **Keratan Sulfate Biosynthesis:** CHST1 is responsible for the sulfation of keratan sulfate, a type of GAG that is involved in cell-cell interactions and tissue development. 4. **Inflammatory Response:** The enzyme's involvement in the inflammatory response pathway suggests its role in regulating immune cell function and tissue homeostasis. 5. **Protein Binding:** CHST1 can bind to various proteins, including keratan sulfate-binding proteins, which may regulate GAG function and cellular signaling. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations in the CHST1 gene have been associated with immunodeficiency disorders, such as cartilage-hair hypoplasia syndrome, which highlights the gene's importance in immune function. 2. **Cancer:** Aberrant expression of CHST1 has been linked to cancer development and progression, suggesting its role in tumor growth and metastasis. 3. **Neurological Disorders:** The gene's involvement in neuronal development and function makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular Disease:** CHST1's role in endothelial cell function and vascular development makes it a potential therapeutic target for cardiovascular disease. In conclusion, the CHST1 gene plays a critical role in glycosaminoglycan metabolism, inflammation, and immune function. Its widespread expression in various cell types and its association with multiple metabolic pathways highlight its importance in maintaining cellular homeostasis. Further research on CHST1 is necessary to elucidate its precise mechanisms of action and to explore its potential therapeutic applications in various diseases.

Genular Protein ID: 3179051292

Symbol: CHST1_HUMAN

Name: Carbohydrate sulfotransferase 1

UniProtKB Accession Codes:

O43916 D3DQP2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 2 DNASU 1 DisGeNET 1 EC 1 EMBL 8 Ensembl 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SABIO-RK 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9405439

Title: Molecular cloning and characterization of human keratan sulfate Gal-6-sulfotransferase.

PubMed ID: 9405439

DOI: 10.1074/jbc.272.51.32321

PubMed ID: 9639683

Title: Human chondroitin 6-sulfotransferase: cloning, gene structure, and chromosomal localization.

PubMed ID: 9639683

DOI: 10.1016/s0925-4439(98)00028-3

PubMed ID: 10049591

Title: CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization.

PubMed ID: 10049591

DOI: 10.1006/geno.1998.5653

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10642612

Title: Sulfation of sialyl N-acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal-6-sulfotransferase.

PubMed ID: 10642612

DOI: 10.1093/glycob/10.2.203

PubMed ID: 10330415

Title: Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin.

PubMed ID: 10330415

DOI: 10.1083/jcb.145.4.899

PubMed ID: 11310842

Title: CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin.

PubMed ID: 11310842

PubMed ID: 17690104

Title: Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans.

PubMed ID: 17690104

DOI: 10.1074/jbc.m703695200

Sequence Information:

  • Length: 411
  • Mass: 46715
  • Checksum: F07D0A23B6338A09
  • Sequence:
    • MQCSWKAVLL LALASIAIQY TAIRTFTAKS FHTCPGLAEA GLAERLCEES PTFAYNLSRK 
THILILATTR SGSSFVGQLF NQHLDVFYLF EPLYHVQNTL IPRFTQGKSP ADRRVMLGAS 
RDLLRSLYDC DLYFLENYIK PPPVNHTTDR IFRRGASRVL CSRPVCDPPG PADLVLEEGD 
CVRKCGLLNL TVAAEACRER SHVAIKTVRV PEVNDLRALV EDPRLNLKVI QLVRDPRGIL 
ASRSETFRDT YRLWRLWYGT GRKPYNLDVT QLTTVCEDFS NSVSTGLMRP PWLKGKYMLV 
RYEDLARNPM KKTEEIYGFL GIPLDSHVAR WIQNNTRGDP TLGKHKYGTV RNSAATAEKW 
RFRLSYDIVA FAQNACQQVL AQLGYKIAAS EEELKNPSVS LVEERDFRPF S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.