Details for: NPFF

Gene ID: 8620

Symbol: NPFF

Ensembl ID: ENSG00000139574

Description: neuropeptide FF-amide peptide precursor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.8224
    Cell Significance Index: 6.2100
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.3202
    Cell Significance Index: 3.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2487
    Cell Significance Index: 7.9700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2126
    Cell Significance Index: 4.4100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.1965
    Cell Significance Index: 2.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1253
    Cell Significance Index: 20.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1104
    Cell Significance Index: 6.6300
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.0911
    Cell Significance Index: 0.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0727
    Cell Significance Index: 2.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0587
    Cell Significance Index: 11.7900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0489
    Cell Significance Index: 0.7000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0470
    Cell Significance Index: 0.6600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0430
    Cell Significance Index: 0.9200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0418
    Cell Significance Index: 0.6000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0344
    Cell Significance Index: 0.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0257
    Cell Significance Index: 9.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0252
    Cell Significance Index: 2.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0219
    Cell Significance Index: 2.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0211
    Cell Significance Index: 0.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0205
    Cell Significance Index: 2.0300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0184
    Cell Significance Index: 0.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0145
    Cell Significance Index: 2.6100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0106
    Cell Significance Index: 0.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0078
    Cell Significance Index: 0.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0064
    Cell Significance Index: 0.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0020
    Cell Significance Index: 0.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0014
    Cell Significance Index: -0.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0020
    Cell Significance Index: -1.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0031
    Cell Significance Index: -2.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0047
    Cell Significance Index: -2.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0048
    Cell Significance Index: -0.9200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0054
    Cell Significance Index: -0.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0057
    Cell Significance Index: -0.6300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0121
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0123
    Cell Significance Index: -2.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0124
    Cell Significance Index: -1.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0135
    Cell Significance Index: -1.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0143
    Cell Significance Index: -0.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0150
    Cell Significance Index: -1.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0204
    Cell Significance Index: -0.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0212
    Cell Significance Index: -0.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0219
    Cell Significance Index: -1.2300
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0236
    Cell Significance Index: -0.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0295
    Cell Significance Index: -0.8500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0358
    Cell Significance Index: -0.5400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0359
    Cell Significance Index: -0.3400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0372
    Cell Significance Index: -0.9300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0389
    Cell Significance Index: -0.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0391
    Cell Significance Index: -1.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0392
    Cell Significance Index: -1.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0409
    Cell Significance Index: -1.3400
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0430
    Cell Significance Index: -0.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0468
    Cell Significance Index: -1.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0482
    Cell Significance Index: -0.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0504
    Cell Significance Index: -1.9100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0537
    Cell Significance Index: -0.6000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0561
    Cell Significance Index: -1.1900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0563
    Cell Significance Index: -1.1300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0584
    Cell Significance Index: -1.3500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0592
    Cell Significance Index: -1.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0607
    Cell Significance Index: -1.6200
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0611
    Cell Significance Index: -0.6200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0629
    Cell Significance Index: -1.5700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0708
    Cell Significance Index: -1.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0716
    Cell Significance Index: -1.9500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0733
    Cell Significance Index: -0.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0740
    Cell Significance Index: -1.9800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0740
    Cell Significance Index: -1.0600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0767
    Cell Significance Index: -1.6400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0792
    Cell Significance Index: -1.9000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0811
    Cell Significance Index: -0.6200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0828
    Cell Significance Index: -1.6300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0834
    Cell Significance Index: -1.2000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0848
    Cell Significance Index: -1.7700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0860
    Cell Significance Index: -1.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0894
    Cell Significance Index: -2.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0904
    Cell Significance Index: -2.2600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0977
    Cell Significance Index: -0.5900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0979
    Cell Significance Index: -1.9200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0979
    Cell Significance Index: -1.2800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0990
    Cell Significance Index: -2.5300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1001
    Cell Significance Index: -2.5500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1005
    Cell Significance Index: -4.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1021
    Cell Significance Index: -3.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1035
    Cell Significance Index: -2.6600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1050
    Cell Significance Index: -1.3300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1062
    Cell Significance Index: -1.2600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1078
    Cell Significance Index: -2.1500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1129
    Cell Significance Index: -1.2300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1157
    Cell Significance Index: -1.5600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1167
    Cell Significance Index: -1.8900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1168
    Cell Significance Index: -1.4100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1172
    Cell Significance Index: -1.2600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1201
    Cell Significance Index: -2.9100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1203
    Cell Significance Index: -1.2900
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1217
    Cell Significance Index: -1.8200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1220
    Cell Significance Index: -2.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1242
    Cell Significance Index: -2.6000
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.1257
    Cell Significance Index: -1.3300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1260
    Cell Significance Index: -1.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Neuropeptide Signaling:** NPFF is a neuropeptide hormone that plays a crucial role in modulating immune responses through its interaction with specific receptors. 2. **Precursor Protein:** The NPFF precursor protein is a multifunctional molecule that gives rise to multiple neuropeptides, including NPFF, which are involved in various physiological processes. 3. **Significant Expression:** NPFF is significantly expressed in various cell types, including enterocytes, colon goblet cells, and granulocyte monocyte progenitor cells, highlighting its importance in immune homeostasis. 4. **Receptor Binding:** NPFF binds to specific receptors, including orexin receptors, which are involved in regulating energy homeostasis and immune responses. **Pathways and Functions:** 1. **Neuroendocrine Signaling:** NPFF modulates immune responses through its interaction with orexin receptors, which are involved in regulating energy homeostasis and immune responses. 2. **G-Protein Coupled Receptor (GPCR) Signaling:** NPFF binds to GPCRs, which activate downstream signaling pathways involved in regulating immune responses. 3. **Neurotransmitter Release:** NPFF is involved in regulating neurotransmitter release, including the release of neuropeptides involved in immune responses. 4. **Inflammation Regulation:** NPFF has anti-inflammatory properties, regulating the expression of pro-inflammatory genes and modulating immune responses. **Clinical Significance:** The NPFF gene has significant implications for various immune-related disorders, including: 1. **Inflammatory Bowel Disease (IBD):** NPFF has been shown to have anti-inflammatory properties, suggesting its potential as a therapeutic target for IBD. 2. **Autoimmune Diseases:** NPFF's role in regulating immune responses makes it a potential target for developing therapies for autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological Disorders:** NPFF's involvement in neurotransmitter release and neuroendocrine signaling makes it a potential target for developing therapies for neurological disorders, such as Parkinson's disease and Alzheimer's disease. In conclusion, the NPFF gene plays a critical role in regulating immune responses and maintaining immune homeostasis. Further research is needed to fully elucidate the mechanisms underlying NPFF's immunological significance and to explore its potential as a therapeutic target for various immune-related disorders.

Genular Protein ID: 1086732368

Symbol: NPFF_HUMAN

Name: Pro-FMRFamide-related neuropeptide FF

UniProtKB Accession Codes:

O15130 Q3SXL4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9224703

Title: A human gene encoding morphine modulating peptides related to NPFF and FMRFamide.

PubMed ID: 9224703

DOI: 10.1016/s0014-5793(97)00557-7

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11587714

Title: Selective modulation of heteromeric ASIC proton-gated channels by neuropeptide FF.

PubMed ID: 11587714

DOI: 10.1016/s0028-3908(01)00107-1

Sequence Information:

  • Length: 113
  • Mass: 12440
  • Checksum: 1E9D4ED2A69238E3
  • Sequence:
    • MDSRQAAALL VLLLLIDGGC AEGPGGQQED QLSAEEDSEP LPPQDAQTSG SLLHYLLQAM 
ERPGRSQAFL FQPQRFGRNT QGSWRNEWLS PRAGEGLNSQ FWSLAAPQRF GKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.