Details for: RTCA

Gene ID: 8634

Symbol: RTCA

Ensembl ID: ENSG00000137996

Description: RNA 3'-terminal phosphate cyclase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 170.6899
    Cell Significance Index: -26.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 112.9144
    Cell Significance Index: -28.6400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 79.6218
    Cell Significance Index: -32.8000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 66.6942
    Cell Significance Index: -27.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 60.5772
    Cell Significance Index: -31.1600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.5888
    Cell Significance Index: -27.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.9806
    Cell Significance Index: -30.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.2255
    Cell Significance Index: -22.0400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.1557
    Cell Significance Index: -25.0500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.1119
    Cell Significance Index: -32.0100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.8211
    Cell Significance Index: -12.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2428
    Cell Significance Index: 135.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0935
    Cell Significance Index: 987.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7114
    Cell Significance Index: 142.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7029
    Cell Significance Index: 9.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6651
    Cell Significance Index: 34.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5286
    Cell Significance Index: 52.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5286
    Cell Significance Index: 14.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4828
    Cell Significance Index: 31.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4488
    Cell Significance Index: 245.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4485
    Cell Significance Index: 89.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4179
    Cell Significance Index: 11.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3871
    Cell Significance Index: 26.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3847
    Cell Significance Index: 137.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3763
    Cell Significance Index: 44.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3748
    Cell Significance Index: 8.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3647
    Cell Significance Index: 65.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3262
    Cell Significance Index: 15.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3095
    Cell Significance Index: 42.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2880
    Cell Significance Index: 18.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2824
    Cell Significance Index: 48.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2746
    Cell Significance Index: 12.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2633
    Cell Significance Index: 32.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2209
    Cell Significance Index: 16.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2166
    Cell Significance Index: 9.8200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.2072
    Cell Significance Index: 1.6900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2050
    Cell Significance Index: 6.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1865
    Cell Significance Index: 82.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1827
    Cell Significance Index: 34.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1605
    Cell Significance Index: 111.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1044
    Cell Significance Index: 13.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0726
    Cell Significance Index: 1.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0665
    Cell Significance Index: 8.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0503
    Cell Significance Index: 2.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0488
    Cell Significance Index: 3.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0412
    Cell Significance Index: 2.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0372
    Cell Significance Index: 69.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0250
    Cell Significance Index: 0.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0225
    Cell Significance Index: 30.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0113
    Cell Significance Index: 0.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0111
    Cell Significance Index: 20.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0106
    Cell Significance Index: 16.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0098
    Cell Significance Index: 0.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0037
    Cell Significance Index: 2.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0009
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0079
    Cell Significance Index: -5.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0099
    Cell Significance Index: -6.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0132
    Cell Significance Index: -9.9600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0134
    Cell Significance Index: -0.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0167
    Cell Significance Index: -12.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0322
    Cell Significance Index: -18.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0371
    Cell Significance Index: -3.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0396
    Cell Significance Index: -5.7600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0567
    Cell Significance Index: -0.8500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0631
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0756
    Cell Significance Index: -15.9300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0875
    Cell Significance Index: -1.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0880
    Cell Significance Index: -10.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0902
    Cell Significance Index: -25.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0924
    Cell Significance Index: -10.5900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1029
    Cell Significance Index: -1.7200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1086
    Cell Significance Index: -1.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1140
    Cell Significance Index: -3.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1550
    Cell Significance Index: -10.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1716
    Cell Significance Index: -3.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1743
    Cell Significance Index: -4.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1789
    Cell Significance Index: -9.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2214
    Cell Significance Index: -7.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2217
    Cell Significance Index: -5.9300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2641
    Cell Significance Index: -30.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2734
    Cell Significance Index: -28.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2793
    Cell Significance Index: -12.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3001
    Cell Significance Index: -23.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3373
    Cell Significance Index: -8.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3718
    Cell Significance Index: -14.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3823
    Cell Significance Index: -10.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3950
    Cell Significance Index: -7.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4409
    Cell Significance Index: -27.0300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4415
    Cell Significance Index: -8.1600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4633
    Cell Significance Index: -6.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4932
    Cell Significance Index: -12.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5613
    Cell Significance Index: -14.0300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5690
    Cell Significance Index: -5.8900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5734
    Cell Significance Index: -12.5600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5813
    Cell Significance Index: -13.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5831
    Cell Significance Index: -19.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5976
    Cell Significance Index: -17.1300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6101
    Cell Significance Index: -19.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6191
    Cell Significance Index: -13.1400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6342
    Cell Significance Index: -15.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA Processing:** RTCA is responsible for the removal of the 3'-terminal phosphate group from RNA molecules, which is a crucial step in RNA processing. This process is essential for the maturation of RNA molecules and their subsequent translation into proteins. 2. **Cell Type Specificity:** RTCA is significantly expressed in various cell types, including oogonial cells, Hofbauer cells, placental villous trophoblasts, and immune cells such as plasmablasts. This suggests that RTCA plays a specific role in the development, function, and regulation of these cell types. 3. **Enzymatic Activity:** RTCA has been shown to possess RNA-3'-phosphate cyclase activity, which involves the catalytic removal of the 3'-terminal phosphate group from RNA molecules. 4. **Regulatory Functions:** RTCA has been implicated in negative regulation of optical nerve axon regeneration, suggesting that this enzyme may play a role in the regulation of neural development and function. **Pathways and Functions:** 1. **RNA Processing:** RTCA is involved in the removal of the 3'-terminal phosphate group from RNA molecules, which is essential for RNA processing. 2. **Negative Regulation of Optical Nerve Axon Regeneration:** RTCA has been shown to negatively regulate optical nerve axon regeneration, suggesting that this enzyme may play a role in the regulation of neural development and function. 3. **Nucleoplasm and Nucleus:** RTCA is involved in the regulation of nucleoplasm and nucleus, which are critical components of the cell nucleus. 4. **RNA Binding and RNA Processing:** RTCA has been shown to bind to RNA molecules and regulate their processing. 5. **ATP Binding:** RTCA has been shown to possess ATP-binding activity, which is essential for its enzymatic function. **Clinical Significance:** The RTCA gene has been identified as significantly expressed in various cell types, including immune cells such as plasmablasts. This suggests that RTCA may play a role in the regulation of immune responses and the development of immune-related diseases. Furthermore, the RTCA gene has been implicated in negative regulation of optical nerve axon regeneration, which suggests that this enzyme may play a role in the regulation of neural development and function. In conclusion, the RTCA gene is a crucial regulator of RNA processing and immune regulation. Further studies are needed to fully elucidate the functions of RTCA and its role in various biological processes.

Genular Protein ID: 488907669

Symbol: RTCA_HUMAN

Name: RNA 3'-terminal phosphate cyclase

UniProtKB Accession Codes:

O00442 Q5VVL5 Q5VVL6 Q96E99

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 11 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 Rhea 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9184239

Title: The human RNA 3'-terminal phosphate cyclase is a member of a new family of proteins conserved in Eucarya, Bacteria and Archaea.

PubMed ID: 9184239

DOI: 10.1093/emboj/16.10.2955

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2199762

Title: RNA 3'-terminal phosphate cyclase from HeLa cells.

PubMed ID: 2199762

DOI: 10.1016/0076-6879(90)81147-m

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25961792

Title: Regulation of axon regeneration by the RNA repair and splicing pathway.

PubMed ID: 25961792

DOI: 10.1038/nn.4019

Sequence Information:

  • Length: 366
  • Mass: 39337
  • Checksum: D129E680FF08BAD1
  • Sequence:
    • MAGPRVEVDG SIMEGGGQIL RVSTALSCLL GLPLRVQKIR AGRSTPGLRP QHLSGLEMIR 
DLCDGQLEGA EIGSTEITFT PEKIKGGIHT ADTKTAGSVC LLMQVSMPCV LFAASPSELH 
LKGGTNAEMA PQIDYTVMVF KPIVEKFGFI FNCDIKTRGY YPKGGGEVIV RMSPVKQLNP 
INLTERGCVT KIYGRAFVAG VLPFKVAKDM AAAAVRCIRK EIRDLYVNIQ PVQEPKDQAF 
GNGNGIIIIA ETSTGCLFAG SSLGKRGVNA DKVGIEAAEM LLANLRHGGT VDEYLQDQLI 
VFMALANGVS RIKTGPVTLH TQTAIHFAEQ IAKAKFIVKK SEDEEDAAKD TYIIECQGIG 
MTNPNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.