Details for: NOL4

Gene ID: 8715

Symbol: NOL4

Ensembl ID: ENSG00000101746

Description: nucleolar protein 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 6.45
    Marker Score: 4858
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 4.06
    Marker Score: 2098
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.48
    Marker Score: 10276
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.44
    Marker Score: 92479
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.42
    Marker Score: 18521
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.38
    Marker Score: 80474
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.38
    Marker Score: 47326
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.35
    Marker Score: 10889
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.28
    Marker Score: 48560
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.26
    Marker Score: 7585
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.24
    Marker Score: 11772
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.24
    Marker Score: 82451
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.06
    Marker Score: 19339
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.03
    Marker Score: 30338
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.01
    Marker Score: 7761
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.99
    Marker Score: 15038
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.98
    Marker Score: 8052
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.96
    Marker Score: 120777
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.94
    Marker Score: 4469
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.91
    Marker Score: 1109
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.91
    Marker Score: 19709
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.88
    Marker Score: 2324
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.85
    Marker Score: 5272
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.83
    Marker Score: 9817
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.78
    Marker Score: 16906
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.77
    Marker Score: 992
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.66
    Marker Score: 14250
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.62
    Marker Score: 3071
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.62
    Marker Score: 2280
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.56
    Marker Score: 2404
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.55
    Marker Score: 747
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.52
    Marker Score: 482
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.44
    Marker Score: 605
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.43
    Marker Score: 2908
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.43
    Marker Score: 472
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.38
    Marker Score: 911
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.37
    Marker Score: 1184
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.34
    Marker Score: 975
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.32
    Marker Score: 3112
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.31
    Marker Score: 787
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.15
    Marker Score: 465
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4804
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.14
    Marker Score: 1921
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.12
    Marker Score: 356
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.09
    Marker Score: 2217
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.08
    Marker Score: 414
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.06
    Marker Score: 289
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.05
    Marker Score: 712.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 794
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.03
    Marker Score: 1585
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.02
    Marker Score: 1275
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.01
    Marker Score: 15787
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71804
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48029
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.98
    Marker Score: 407
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.95
    Marker Score: 1539
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5328
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.8
    Marker Score: 755
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.79
    Marker Score: 253
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.78
    Marker Score: 236
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.77
    Marker Score: 931
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 701
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.74
    Marker Score: 255
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.72
    Marker Score: 1308
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.71
    Marker Score: 339
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.67
    Marker Score: 752
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.66
    Marker Score: 642
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.62
    Marker Score: 2599
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.61
    Marker Score: 388
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.58
    Marker Score: 253
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.58
    Marker Score: 301
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.57
    Marker Score: 2199
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.56
    Marker Score: 609
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.56
    Marker Score: 144
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.55
    Marker Score: 328
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.53
    Marker Score: 120
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.53
    Marker Score: 505
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.5
    Marker Score: 222
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.47
    Marker Score: 218
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.47
    Marker Score: 541
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 0.45
    Marker Score: 151
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.43
    Marker Score: 430
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.41
    Marker Score: 167
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.41
    Marker Score: 568

Other Information

**Key Characteristics:** NOL4 is a nucleolar protein that is primarily localized to the nucleolus, a region within the nucleus responsible for ribosome biogenesis and RNA processing. The protein exhibits high expression levels in various cell types, including photoreceptor cells, endocrine cells, and inhibitory interneurons. NOL4 contains a RNA-binding motif, which suggests its involvement in RNA processing and regulation. The protein's expression is regulated by various transcription factors, including NF-YA, a subunit of the nucleosome remodeling and histone deacetylase (NuRD) complex. **Pathways and Functions:** NOL4's functions are closely linked to its RNA-binding activity and its role in regulating gene expression. The protein interacts with various RNA molecules, including ribosomal RNA, transfer RNA, and small nuclear RNA (snRNA), which are involved in RNA processing and translation. NOL4's RNA-binding activity is mediated by its RNA recognition motif (RRM), which allows it to recognize and bind to specific RNA sequences. This interaction regulates the processing of RNA molecules, including pre-mRNA splicing, mRNA translation, and post-transcriptional regulation of gene expression. NOL4's functions extend beyond RNA binding, as it is also involved in regulating protein synthesis and cellular stress response. The protein interacts with various transcription factors, including NF-YA, to regulate the expression of genes involved in ribosome biogenesis and cellular stress response. NOL4's role in regulating protein synthesis is mediated by its interaction with the translation initiation factor eIF4E, which is involved in the initiation of protein synthesis. **Clinical Significance:** NOL4's dysregulation has been implicated in various diseases, including neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. The protein's role in regulating gene expression and RNA processing suggests that its dysregulation may contribute to the development of these diseases. Recent studies have shown that NOL4 is significantly reduced in the brains of patients with Alzheimer's disease, suggesting that the protein's dysregulation may contribute to the disease's pathogenesis. In addition to its role in neurodegenerative disorders, NOL4's dysregulation has also been implicated in various other diseases, including cancer and metabolic disorders. The protein's involvement in regulating gene expression and RNA processing suggests that its dysregulation may contribute to the development of these diseases. In conclusion, NOL4 is a crucial protein that plays a significant role in regulating gene expression, RNA processing, and protein synthesis. Its dysregulation has been implicated in various diseases, including neurodegenerative disorders, cancer, and metabolic disorders. Further studies are needed to fully elucidate the molecular mechanisms underlying NOL4's functions and its role in disease pathology.

Genular Protein ID: 3478002948

Symbol: NOL4_HUMAN

Name: Nucleolar protein 4

UniProtKB Accession Codes:

O94818 B4DSQ0 B7Z3Z7 F5H1E3 Q6IBS2 Q9BWF1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 10 SAM 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9813152

Title: NOLP: identification of a novel human nucleolar protein and determination of sequence requirements for its nucleolar localization.

PubMed ID: 9813152

DOI: 10.1006/bbrc.1998.9606

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9853615

Title: Selection system for genes encoding nuclear-targeted proteins.

PubMed ID: 9853615

DOI: 10.1038/4315

Sequence Information:

  • Length: 638
  • Mass: 71357
  • Checksum: 02DF0130F10E0B3F
  • Sequence:
    • MESERDMYRQ FQDWCLRTYG DSGKTKTVTR KKYERIVQLL NGSESSSTDN AKFKFWVKSK 
GFQLGQPDEV RGGGGGAKQV LYVPVKTTDG VGVDEKLSLR RVAVVEDFFD IIYSMHVETG 
PNGEQIRKHA GQKRTYKAIS ESYAFLPREA VTRFLMSCSE CQKRMHLNPD GTDHKDNGKP 
PTLVTSMIDY NMPITMAYMK HMKLQLLNSQ QDEDESSIES DEFDMSDSTR MSAVNSDLSS 
NLEERMQSPQ NLHGQQDDDS AAESFNGNET LGHSSIASGG THSREMGDSN SDGKTGLEQD 
EQPLNLSDSP LSAQLTSEYR IDDHNSNGKN KYKNLLISDL KMEREARENG SKSPAHSYSS 
YDSGKNESVD RGAEDLSLNR GDEDEDDHED HDDSEKVNET DGVEAERLKA FNMFVRLFVD 
ENLDRMVPIS KQPKEKIQAI IDSCRRQFPE YQERARKRIR TYLKSCRRMK RSGFEMSRPI 
PSHLTSAVAE SILASACESE SRNAAKRMRL ERQQDESAPA DKQCKPEATQ ATYSTSAVPG 
SQDVLYINGN GTYSYHSYRG LGGGLLNLND ASSSGPTDLS MKRQLATSSG SSSSSNSRPQ 
LSPTEINAVR QLVAGYRESA AFLLRSADEL ENLILQQN

Genular Protein ID: 2508616106

Symbol: B3KRF4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KRF4

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 GenomeRNAi 1 InterPro 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 ProteomicsDB 1 RefSeq 3 SAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 419
  • Mass: 45825
  • Checksum: 91F2E6C7EBEB4595
  • Sequence:
    • MSCSECQKRM HLNPDGTDHK DNGKPPTLVT SMIDYNMPIT MAYMKHMKLQ LLNSQQDEDE 
SSIESDEFDM SDSTRMSAVN SDLSSNLEER MQSPQNLHGQ QDDDSAAESF NGNETLGHSS 
IASGGTHSRE MGDSNSDGKT GLEQDEQPLN LSDSPLSAQL TSEYRIDDHN SNGKNKYKNL 
LISDLKMERE ARENGSKSPA HSYSSYDSGK NESVDRGAED LSLNRGDEDE DDHEDHDDSE 
KVNETDGVEA ERLKAFNSRP IPSHLTSAVA ESILASACES ESRNAAKRMR LERQQDESAP 
ADKQCKPEAT QATYSTSAVP GSQDVLYING NGTYSYHSYR GLGGGLLNLN DASSSGPTDL 
SMKRQLATSS GSSSSSNSRP QLSPTEINAV RQLVAGYRES AAFLLRSADE LENLILQQN

Genular Protein ID: 2186541288

Symbol: B4DLW2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DLW2

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 Genevisible 1 GenomeRNAi 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 460
  • Mass: 50536
  • Checksum: 5659900CB2C33409
  • Sequence:
    • MHVETGPNGE QIRKHAGQKR TYKAISESYA FLPREAVTRF LMSCPECQKR MHLNPDGTDH 
KDNGKPPTLV TSMIDYNMPI TMAYMKHMKL QLLNSQQDED ESSIESDEFD MSDSTRMSAV 
NSDLSSNLEE RMQSPQNLHG QQDDDSAAES FNGNETLGHS SIASGGTHSR EMGDSNSDGK 
TGLEQDEQPL NLSDSPLSAQ LTSEYRIDDH NSNGKNKYKN LLISDLKMER EARENGSKSP 
AHSYSSYDSG KNESVDRGAE DLSLNRGDED EDDHEDHDDS EKVNETDGVE AERLKAFNSR 
PIPSHLTSAV AESILASACE SESRNAAKRM RLERQQDESA PADKQCKPEA TQATYSTSAV 
PGSQDVLYIN GNGTYSYHSY RGLGGGLLNL NDASSSGPTD LSMKRQLATS SGSSSSSNSR 
PQLSPTEINA VRQLVAGYRE SAAFLLRSAD ELENLILQQN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.