Details for: NOL4

Gene ID: 8715

Symbol: NOL4

Ensembl ID: ENSG00000101746

Description: nucleolar protein 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 66.0178
    Cell Significance Index: -63.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 5.9685
    Cell Significance Index: 334.9200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.8020
    Cell Significance Index: 67.2000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.7174
    Cell Significance Index: 33.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6206
    Cell Significance Index: 525.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.3877
    Cell Significance Index: 146.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.2553
    Cell Significance Index: 138.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.1772
    Cell Significance Index: 780.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.1090
    Cell Significance Index: 141.8100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.7440
    Cell Significance Index: 1206.2100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.2164
    Cell Significance Index: 17.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0727
    Cell Significance Index: 47.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9438
    Cell Significance Index: 35.7400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5493
    Cell Significance Index: 15.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3411
    Cell Significance Index: 308.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3163
    Cell Significance Index: 5.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1251
    Cell Significance Index: 23.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0761
    Cell Significance Index: 7.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0042
    Cell Significance Index: -3.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0046
    Cell Significance Index: -2.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0286
    Cell Significance Index: -16.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0325
    Cell Significance Index: -61.1400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0325
    Cell Significance Index: -1.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0363
    Cell Significance Index: -66.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0423
    Cell Significance Index: -65.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0430
    Cell Significance Index: -58.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0479
    Cell Significance Index: -7.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0897
    Cell Significance Index: -56.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0947
    Cell Significance Index: -69.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0976
    Cell Significance Index: -3.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0997
    Cell Significance Index: -75.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1077
    Cell Significance Index: -22.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1231
    Cell Significance Index: -55.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1237
    Cell Significance Index: -67.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1874
    Cell Significance Index: -4.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2035
    Cell Significance Index: -58.5400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2473
    Cell Significance Index: -26.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2617
    Cell Significance Index: -7.5400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2657
    Cell Significance Index: -3.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2773
    Cell Significance Index: -7.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2901
    Cell Significance Index: -13.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2960
    Cell Significance Index: -50.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.3039
    Cell Significance Index: -60.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.3295
    Cell Significance Index: -59.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4135
    Cell Significance Index: -21.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4456
    Cell Significance Index: -64.7800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4518
    Cell Significance Index: -9.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.4990
    Cell Significance Index: -68.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.5081
    Cell Significance Index: -62.4800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5159
    Cell Significance Index: -10.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.5291
    Cell Significance Index: -68.3600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5311
    Cell Significance Index: -11.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.6079
    Cell Significance Index: -71.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6150
    Cell Significance Index: -71.6800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6209
    Cell Significance Index: -70.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6220
    Cell Significance Index: -64.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6225
    Cell Significance Index: -71.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6517
    Cell Significance Index: -45.0700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6711
    Cell Significance Index: -9.6100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6773
    Cell Significance Index: -40.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.6818
    Cell Significance Index: -69.6500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6931
    Cell Significance Index: -14.7100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.7583
    Cell Significance Index: -7.2200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.7859
    Cell Significance Index: -7.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8797
    Cell Significance Index: -69.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.9078
    Cell Significance Index: -69.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.9100
    Cell Significance Index: -42.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9138
    Cell Significance Index: -29.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.9317
    Cell Significance Index: -69.4400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9737
    Cell Significance Index: -31.8800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.9757
    Cell Significance Index: -10.6300
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -1.0442
    Cell Significance Index: -9.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0548
    Cell Significance Index: -33.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.1162
    Cell Significance Index: -72.0100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -1.1389
    Cell Significance Index: -14.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.1846
    Cell Significance Index: -74.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.2526
    Cell Significance Index: -43.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.3145
    Cell Significance Index: -32.8600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.3327
    Cell Significance Index: -9.0300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.3331
    Cell Significance Index: -23.0500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.3408
    Cell Significance Index: -16.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.3865
    Cell Significance Index: -65.1700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.4013
    Cell Significance Index: -34.9600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -1.4074
    Cell Significance Index: -19.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.4282
    Cell Significance Index: -74.1900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.4765
    Cell Significance Index: -30.8200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.4889
    Cell Significance Index: -36.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.5122
    Cell Significance Index: -38.8700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.5826
    Cell Significance Index: -32.8300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.6260
    Cell Significance Index: -35.1300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -1.6796
    Cell Significance Index: -25.3100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.7471
    Cell Significance Index: -22.0500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -2.0596
    Cell Significance Index: -25.9900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -2.0651
    Cell Significance Index: -71.7600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -2.0710
    Cell Significance Index: -40.4200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -2.1582
    Cell Significance Index: -28.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -2.1900
    Cell Significance Index: -59.6100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -2.1912
    Cell Significance Index: -4.9400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -2.2681
    Cell Significance Index: -44.6400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -2.2774
    Cell Significance Index: -72.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NOL4 is a nucleolar protein that is primarily localized to the nucleolus, a region within the nucleus responsible for ribosome biogenesis and RNA processing. The protein exhibits high expression levels in various cell types, including photoreceptor cells, endocrine cells, and inhibitory interneurons. NOL4 contains a RNA-binding motif, which suggests its involvement in RNA processing and regulation. The protein's expression is regulated by various transcription factors, including NF-YA, a subunit of the nucleosome remodeling and histone deacetylase (NuRD) complex. **Pathways and Functions:** NOL4's functions are closely linked to its RNA-binding activity and its role in regulating gene expression. The protein interacts with various RNA molecules, including ribosomal RNA, transfer RNA, and small nuclear RNA (snRNA), which are involved in RNA processing and translation. NOL4's RNA-binding activity is mediated by its RNA recognition motif (RRM), which allows it to recognize and bind to specific RNA sequences. This interaction regulates the processing of RNA molecules, including pre-mRNA splicing, mRNA translation, and post-transcriptional regulation of gene expression. NOL4's functions extend beyond RNA binding, as it is also involved in regulating protein synthesis and cellular stress response. The protein interacts with various transcription factors, including NF-YA, to regulate the expression of genes involved in ribosome biogenesis and cellular stress response. NOL4's role in regulating protein synthesis is mediated by its interaction with the translation initiation factor eIF4E, which is involved in the initiation of protein synthesis. **Clinical Significance:** NOL4's dysregulation has been implicated in various diseases, including neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. The protein's role in regulating gene expression and RNA processing suggests that its dysregulation may contribute to the development of these diseases. Recent studies have shown that NOL4 is significantly reduced in the brains of patients with Alzheimer's disease, suggesting that the protein's dysregulation may contribute to the disease's pathogenesis. In addition to its role in neurodegenerative disorders, NOL4's dysregulation has also been implicated in various other diseases, including cancer and metabolic disorders. The protein's involvement in regulating gene expression and RNA processing suggests that its dysregulation may contribute to the development of these diseases. In conclusion, NOL4 is a crucial protein that plays a significant role in regulating gene expression, RNA processing, and protein synthesis. Its dysregulation has been implicated in various diseases, including neurodegenerative disorders, cancer, and metabolic disorders. Further studies are needed to fully elucidate the molecular mechanisms underlying NOL4's functions and its role in disease pathology.

Genular Protein ID: 3478002948

Symbol: NOL4_HUMAN

Name: Nucleolar protein 4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9813152

Title: NOLP: identification of a novel human nucleolar protein and determination of sequence requirements for its nucleolar localization.

PubMed ID: 9813152

DOI: 10.1006/bbrc.1998.9606

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9853615

Title: Selection system for genes encoding nuclear-targeted proteins.

PubMed ID: 9853615

DOI: 10.1038/4315

Sequence Information:

  • Length: 638
  • Mass: 71357
  • Checksum: 02DF0130F10E0B3F
  • Sequence:
  • MESERDMYRQ FQDWCLRTYG DSGKTKTVTR KKYERIVQLL NGSESSSTDN AKFKFWVKSK 
    GFQLGQPDEV RGGGGGAKQV LYVPVKTTDG VGVDEKLSLR RVAVVEDFFD IIYSMHVETG 
    PNGEQIRKHA GQKRTYKAIS ESYAFLPREA VTRFLMSCSE CQKRMHLNPD GTDHKDNGKP 
    PTLVTSMIDY NMPITMAYMK HMKLQLLNSQ QDEDESSIES DEFDMSDSTR MSAVNSDLSS 
    NLEERMQSPQ NLHGQQDDDS AAESFNGNET LGHSSIASGG THSREMGDSN SDGKTGLEQD 
    EQPLNLSDSP LSAQLTSEYR IDDHNSNGKN KYKNLLISDL KMEREARENG SKSPAHSYSS 
    YDSGKNESVD RGAEDLSLNR GDEDEDDHED HDDSEKVNET DGVEAERLKA FNMFVRLFVD 
    ENLDRMVPIS KQPKEKIQAI IDSCRRQFPE YQERARKRIR TYLKSCRRMK RSGFEMSRPI 
    PSHLTSAVAE SILASACESE SRNAAKRMRL ERQQDESAPA DKQCKPEATQ ATYSTSAVPG 
    SQDVLYINGN GTYSYHSYRG LGGGLLNLND ASSSGPTDLS MKRQLATSSG SSSSSNSRPQ 
    LSPTEINAVR QLVAGYRESA AFLLRSADEL ENLILQQN

Genular Protein ID: 2508616106

Symbol: B3KRF4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 419
  • Mass: 45825
  • Checksum: 91F2E6C7EBEB4595
  • Sequence:
  • MSCSECQKRM HLNPDGTDHK DNGKPPTLVT SMIDYNMPIT MAYMKHMKLQ LLNSQQDEDE 
    SSIESDEFDM SDSTRMSAVN SDLSSNLEER MQSPQNLHGQ QDDDSAAESF NGNETLGHSS 
    IASGGTHSRE MGDSNSDGKT GLEQDEQPLN LSDSPLSAQL TSEYRIDDHN SNGKNKYKNL 
    LISDLKMERE ARENGSKSPA HSYSSYDSGK NESVDRGAED LSLNRGDEDE DDHEDHDDSE 
    KVNETDGVEA ERLKAFNSRP IPSHLTSAVA ESILASACES ESRNAAKRMR LERQQDESAP 
    ADKQCKPEAT QATYSTSAVP GSQDVLYING NGTYSYHSYR GLGGGLLNLN DASSSGPTDL 
    SMKRQLATSS GSSSSSNSRP QLSPTEINAV RQLVAGYRES AAFLLRSADE LENLILQQN

Genular Protein ID: 2186541288

Symbol: B4DLW2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 460
  • Mass: 50536
  • Checksum: 5659900CB2C33409
  • Sequence:
  • MHVETGPNGE QIRKHAGQKR TYKAISESYA FLPREAVTRF LMSCPECQKR MHLNPDGTDH 
    KDNGKPPTLV TSMIDYNMPI TMAYMKHMKL QLLNSQQDED ESSIESDEFD MSDSTRMSAV 
    NSDLSSNLEE RMQSPQNLHG QQDDDSAAES FNGNETLGHS SIASGGTHSR EMGDSNSDGK 
    TGLEQDEQPL NLSDSPLSAQ LTSEYRIDDH NSNGKNKYKN LLISDLKMER EARENGSKSP 
    AHSYSSYDSG KNESVDRGAE DLSLNRGDED EDDHEDHDDS EKVNETDGVE AERLKAFNSR 
    PIPSHLTSAV AESILASACE SESRNAAKRM RLERQQDESA PADKQCKPEA TQATYSTSAV 
    PGSQDVLYIN GNGTYSYHSY RGLGGGLLNL NDASSSGPTD LSMKRQLATS SGSSSSSNSR 
    PQLSPTEINA VRQLVAGYRE SAAFLLRSAD ELENLILQQN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.