Details for: STXBP5L

Gene ID: 9515

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: STXBP5L

Ensembl ID: ENSG00000145087

Description: syntaxin binding protein 5L

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • pvalb GABAergic cortical interneuron CL4023018
    CSI 67.99
    rCSI 84.58%
    PRS 88.85
  • VIP GABAergic cortical interneuron CL4023016
    CSI 67.42
    rCSI 80.53%
    PRS 90.38
  • cerebellar granule cell CL0001031
    CSI 64.1
    rCSI 94.23%
    PRS 93.52
  • sst GABAergic cortical interneuron CL4023017
    CSI 62.68
    rCSI 80.81%
    PRS 91.1
  • sncg GABAergic cortical interneuron CL4023015
    CSI 49.69
    rCSI 79.91%
    PRS 90.87
  • interneuron CL0000099
    CSI 49.46
    rCSI 99.31%
    PRS 93.89
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 47.46
    rCSI 79.66%
    PRS 90.48
  • retinal bipolar neuron CL0000748
    CSI 40.61
    rCSI 76.07%
    PRS 92.04
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 40.43
    rCSI 87.7%
    PRS 88.92
  • inhibitory interneuron CL0000498
    CSI 38.85
    rCSI 89.68%
    PRS 91.62
  • conventional dendritic cell CL0000990
    CSI 35.99
    rCSI 30.05%
    PRS 91.03
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 35.9
    rCSI 85.85%
    PRS 90.3
  • rod bipolar cell CL0000751
    CSI 35.2
    rCSI 63.26%
    PRS 93.8
  • glioblast CL0000030
    CSI 34.74
    rCSI 55.42%
    PRS 92.32
  • oligodendrocyte precursor cell CL0002453
    CSI 34.68
    rCSI 76.31%
    PRS 84.78
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 34.47
    rCSI 60.88%
    PRS 90.13
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 34.44
    rCSI 39.78%
    PRS 92.15
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 33.44
    rCSI 81.27%
    PRS 88.78
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 30.65
    rCSI 55.69%
    PRS 93.12
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 30.55
    rCSI 39.21%
    PRS 94.54
  • ependymal cell CL0000065
    CSI 30.36
    rCSI 61.6%
    PRS 85.54
  • amacrine cell CL0000561
    CSI 29.92
    rCSI 86.71%
    PRS 91.77
  • neuron CL0000540
    CSI 28.15
    rCSI 74.97%
    PRS 88.07
  • vascular leptomeningeal cell CL4023051
    CSI 27.58
    rCSI 48.34%
    PRS 94.91
  • glycinergic amacrine cell CL4030028
    CSI 27.31
    rCSI 71.14%
    PRS 92.3
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 26.89
    rCSI 88.36%
    PRS 89.37
  • L6b glutamatergic cortical neuron CL4023038
    CSI 26.41
    rCSI 82.54%
    PRS 91.03
  • glutamatergic neuron CL0000679
    CSI 26.29
    rCSI 54.02%
    PRS 88.89
  • cerebral cortex neuron CL0010012
    CSI 25.9
    rCSI 100%
    PRS 91.53
  • cerebral cortex endothelial cell CL1001602
    CSI 24.96
    rCSI 43.17%
    PRS 94.21
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 24.96
    rCSI 78.06%
    PRS 92.14
  • neural cell CL0002319
    CSI 23.92
    rCSI 90.28%
    PRS 87.73
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 22.86
    rCSI 82.27%
    PRS 88.96
  • retinal cone cell CL0000573
    CSI 22.57
    rCSI 36.33%
    PRS 91.83
  • regulatory T cell CL0000815
    CSI 22.45
    rCSI 26.02%
    PRS 91.03
  • retinal ganglion cell CL0000740
    CSI 22.4
    rCSI 49.48%
    PRS 90.87
  • ON-bipolar cell CL0000749
    CSI 22.38
    rCSI 33.27%
    PRS 95.48
  • Bergmann glial cell CL0000644
    CSI 22.29
    rCSI 30.5%
    PRS 92.43
  • serotonergic neuron CL0000850
    CSI 21.19
    rCSI 94.68%
    PRS 86.79
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 20.91
    rCSI 79.01%
    PRS 90.32
  • GABAergic neuron CL0000617
    CSI 17.96
    rCSI 60.18%
    PRS 88.34
  • astrocyte of the cerebral cortex CL0002605
    CSI 17.7
    rCSI 39.67%
    PRS 90.71
  • retina horizontal cell CL0000745
    CSI 17.25
    rCSI 26.3%
    PRS 94.75
  • lung neuroendocrine cell CL1000223
    CSI 17.01
    rCSI 25.16%
    PRS 96.55
  • dopaminergic neuron CL0000700
    CSI 16.89
    rCSI 95.46%
    PRS 90.22
  • mature astrocyte CL0002627
    CSI 15.5
    rCSI 65.86%
    PRS 93.01
  • basal cell of epidermis CL0002187
    CSI 14.36
    rCSI 25.46%
    PRS 75.58
  • S cone cell CL0003050
    CSI 13.83
    rCSI 60.77%
    PRS 93.55
  • smooth muscle cell CL0000192
    CSI 13.31
    rCSI 31.75%
    PRS 93.84
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 13.14
    rCSI 77.34%
    PRS 90.54
  • GABAergic amacrine cell CL4030027
    CSI 12.69
    rCSI 43.47%
    PRS 88.6
  • enteroendocrine cell of small intestine CL0009006
    CSI 12.59
    rCSI 27.71%
    PRS 96.75
  • innate lymphoid cell CL0001065
    CSI 12.55
    rCSI 25.9%
    PRS 91.39
  • melanocyte of skin CL1000458
    CSI 11.95
    rCSI 16.29%
    PRS 76.24
  • basket cell CL0000118
    CSI 11.95
    rCSI 74.84%
    PRS 83.53
  • neuroendocrine cell CL0000165
    CSI 11.89
    rCSI 45.99%
    PRS 96.99
  • cerebellar neuron CL1001611
    CSI 11.36
    rCSI 100%
    PRS 88.78
  • flat midget bipolar cell CL4033033
    CSI 11.01
    rCSI 78.7%
    PRS 90.09
  • invaginating midget bipolar cell CL4033034
    CSI 10.84
    rCSI 64.01%
    PRS 90.47
  • OFFx cell CL4033036
    CSI 10.78
    rCSI 50.7%
    PRS 89.02
  • diffuse bipolar 6 cell CL4033032
    CSI 10.7
    rCSI 56.24%
    PRS 89.74
  • macroglial cell CL0000126
    CSI 10.58
    rCSI 27.2%
    PRS 94.03
  • central nervous system neuron CL2000029
    CSI 10.15
    rCSI 74.59%
    PRS 92.37
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 10.12
    rCSI 12.26%
    PRS 82.01
  • H1 horizontal cell CL0004217
    CSI 9.81
    rCSI 38.84%
    PRS 92.5
  • medium spiny neuron CL1001474
    CSI 9.42
    rCSI 81.16%
    PRS 91.81
  • diffuse bipolar 3b cell CL4033030
    CSI 9.32
    rCSI 61.87%
    PRS 92.2
  • helper T cell CL0000912
    CSI 9.26
    rCSI 13.09%
    PRS 92.03
  • suprabasal keratinocyte CL4033013
    CSI 8.81
    rCSI 14.37%
    PRS 76.41
  • diffuse bipolar 3a cell CL4033029
    CSI 8.44
    rCSI 57.42%
    PRS 90.89
  • diffuse bipolar 2 cell CL4033028
    CSI 8.39
    rCSI 65%
    PRS 91.25
  • brain vascular cell CL4023072
    CSI 8.08
    rCSI 83.64%
    PRS 92.39
  • diffuse bipolar 1 cell CL4033027
    CSI 8.07
    rCSI 60.66%
    PRS 89.07
  • H2 horizontal cell CL0004218
    CSI 7.72
    rCSI 38.39%
    PRS 93.08
  • type B pancreatic cell CL0000169
    CSI 6.6
    rCSI 14.62%
    PRS 96.37
  • diffuse bipolar 4 cell CL4033031
    CSI 6.18
    rCSI 70.8%
    PRS 86.73
  • cytotoxic T cell CL0000910
    CSI 4.37
    rCSI 25.05%
    PRS 93.8
  • ON parasol ganglion cell CL4033052
    CSI 4.22
    rCSI 59.93%
    PRS 91.33
  • pancreatic D cell CL0000173
    CSI 3.95
    rCSI 3.89%
    PRS 96.88
  • ON midget ganglion cell CL4033046
    CSI 3.29
    rCSI 66.93%
    PRS 91.07
  • direct pathway medium spiny neuron CL4023026
    CSI 3.28
    rCSI 78.55%
    PRS 88.06
  • indirect pathway medium spiny neuron CL4023029
    CSI 3.24
    rCSI 78.29%
    PRS 87.81
  • midbrain dopaminergic neuron CL2000097
    CSI 3.24
    rCSI 20.78%
    PRS 91.93
  • OFF midget ganglion cell CL4033047
    CSI 2.88
    rCSI 58.64%
    PRS 91.27
  • pancreatic A cell CL0000171
    CSI 2.68
    rCSI 2.81%
    PRS 96.96
  • starburst amacrine cell CL0004232
    CSI 1.89
    rCSI 15.94%
    PRS 87.03

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [STXBP5L](/details-gene/9515) (Syntaxin Binding Protein 5 Like) is a protein-coding gene located on chromosome 3q13.33. As its name suggests, it functions as a syntaxin-binding protein and is a component of the SNARE complex, playing a key role in vesicular transport, particularly [Exocytosis](/details-go/GO:0006887) from the Golgi to the plasma membrane ([GO:0006893](https://www.ebi.ac.uk/QuickGO/term/GO:0006893)). Expression data from the **Overall** context reveals that [STXBP5L](/details-gene/9515) is a highly significant gene within the central nervous system, showing prominent expression in various classes of neurons. Its critical importance is underscored by research linking homozygous mutations in [STXBP5L](/details-gene/9515) to a severe autosomal recessive infantile-onset neurodegenerative disorder ([Link](https://doi.org/10.1093/hmg/ddu614)). ## Cellular Roles and Expression Landscape The expression profile of [STXBP5L](/details-gene/9515) strongly indicates a specialized role in neuronal function. **Overall**, the gene demonstrates its highest significance in multiple subtypes of inhibitory neurons, including [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: 67.99), [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: 67.42), and [sst GABAergic cortical interneuron](/details-cell/CL4023017) (CSI: 62.68). This consistent high ranking across distinct interneuron populations suggests it is a fundamental component of the machinery governing inhibitory neurotransmitter release in the cortex. Beyond cortical interneurons, [STXBP5L](/details-gene/9515) is also highly significant in [cerebellar granule cell](/details-cell/CL0001031) (CSI: 64.10) and excitatory neurons like [L2/3 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4030059) (CSI: 40.43), indicating a broader role in regulating synaptic transmission across both inhibitory and excitatory circuits. Its expression in specialized neurons of the visual system, such as [retinal bipolar neuron](/details-cell/CL0000748) (CSI: 40.61), further highlights its general importance in neural signaling. The gene also shows notable significance in [oligodendrocyte precursor cell](/details-cell/CL0002453) (CSI: 34.68), which may suggest a less-characterized role in glial cell development or function. ## Pathways and Molecular Function The molecular functions attributed to [STXBP5L](/details-gene/9515) align perfectly with its cellular expression pattern. As a core component of the [Snare complex](/details-go/GO:0031201) located in the [cytoplasm](/details-go/GO:0005737) and at the [plasma membrane](/details-go/GO:0005886), its primary annotated molecular function is [Syntaxin binding](/details-go/GO:0019905). This interaction is critical for the biological process of [Exocytosis](/details-go/GO:0006887), the mechanism by which synaptic vesicles fuse with the pre-synaptic membrane to release neurotransmitters. Its involvement in [protein transport](/details-go/GO:0015031) and [Golgi to plasma membrane transport](/details-go/GO:0006893) suggests it operates in the later stages of the secretory pathway, ensuring the proper delivery and fusion of vesicles at their target destination. Additionally, its annotated [Gtpase activator activity](/details-go/GO:0005096) suggests it may regulate the timing and efficiency of vesicle fusion by interacting with small GTP-binding proteins that control membrane trafficking. ## Research Directions The established role of [STXBP5L](/details-gene/9515) in synaptic vesicle exocytosis and its link to severe neurodegenerative disease provide a strong foundation for further investigation into the complexities of neural circuit function and pathology. **Proposed Hypotheses:** 1. Given its high expression across diverse inhibitory interneuron subtypes ([pvalb](/details-cell/CL4023018), [VIP](/details-cell/CL4023016), [sst](/details-cell/CL4023017)), [STXBP5L](/details-gene/9515) may act as a tunable regulator of GABA release. Its specific protein interactions or post-translational modifications could differ between interneuron classes, thereby tailoring the kinetics and probability of neurotransmission to meet the distinct functional requirements of different cortical microcircuits. 2. The infantile-onset neurodegenerative disorder caused by loss-of-function mutations ([Link](https://doi.org/10.1093/hmg/ddu614)) may arise from a primary failure of inhibitory neurotransmission. The resulting imbalance between excitation and inhibition could lead to network hyperexcitability, excitotoxicity, and subsequent widespread neuronal death. **Key Experimental Approach:** To test the hypothesis that [STXBP5L](/details-gene/9515) differentially regulates neurotransmission in specific interneuron populations (Hypothesis 1), a powerful approach would be to use subtype-specific Cre-driver mouse lines (e.g., Pvalb-Cre, VIP-Cre, Sst-Cre) crossed with a floxed *Stxbp5l* allele to achieve conditional knockout of the gene in targeted cell types. Brain slices from these mice could then be analyzed using whole-cell patch-clamp electrophysiology. By recording inhibitory postsynaptic currents (IPSCs) in downstream pyramidal neurons, one could precisely measure changes in synaptic strength, vesicle release probability (via paired-pulse ratio analysis), and the frequency of spontaneous release events, revealing the specific consequences of [STXBP5L](/details-gene/9515) loss in each interneuron class. **Therapeutic Potential:** [STXBP5L](/details-gene/9515) is not a suitable target for inhibition, as loss-of-function is clearly pathogenic. Instead, it represents a candidate for gene replacement or augmentation therapies for the associated neurodegenerative disorder. A potential therapeutic strategy would involve the development of an adeno-associated virus (AAV)-based vector to deliver a functional copy of the [STXBP5L](/details-gene/9515) coding sequence to affected neurons in the central nervous system. Such an approach would aim to restore normal protein function, re-establish synaptic stability, and halt or reverse disease progression. The widespread neuronal expression of [STXBP5L](/details-gene/9515) suggests that a broadly-tropic AAV serotype would be required to achieve therapeutic benefit.

Genular Protein ID: 3898022225

Symbol: STB5L_HUMAN

Name: Syntaxin-binding protein 5-like

UniProtKB Accession Codes:

Q9Y2K9 Q4G1B4 Q6PIC3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 3 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14767561

Title: Identification and characterization of human LLGL4 gene and mouse Llgl4 gene in silico.

PubMed ID: 14767561

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25504045

Title: Homozygous mutation of STXBP5L explains an autosomal recessive infantile-onset neurodegenerative disorder.

PubMed ID: 25504045

DOI: 10.1093/hmg/ddu614

Sequence Information:

  • Length: 1186
  • Mass: 131887
  • Checksum: 8CBDB5FAB4B777DA
  • Sequence:
    • MKKFNFRKVL DGLTASSPGS GSSSGSNSGG GAGSGSVHPA GTAGVLREEI QETLTSEYFQ 
ICKTVRHGFP HQPTALAFDP VQKILAIGTR TGAIRILGRP GVDCYCQHES GAAVLQLQFL 
INEGALVSAS SDDTLHLWNL RQKRPAILHS LKFNRERITY CHLPFQSKWL YVGTERGNTH 
IVNIESFILS GYVIMWNKAI ELSTKTHPGP VVHLSDSPRD EGKLLIGYEN GTVVFWDLKS 
KRAELRVYYD EAIHSIDWHH EGKQFMCSHS DGSLTLWNLK SPSRPFQTTI PHGKSQREGR 
KSESCKPILK VEYKTCKNSE PFIIFSGGLS YDKACRRPSL TIMHGKAITV LEMDHPIVEF 
LTLCETPYPN EFQEPYAVVV LLEKDLIVVD LTQSNFPIFE NPYPMDIHES PVTCTAYFAD 
CPPDLILVLY SIGVKHKKQG YSNKEWPISG GAWNLGAQTY PEIIITGHAD GSIKFWDASA 
ITLQMLYKLK TSKVFEKQKV GEGKQTCEIV EEDPFAIQMI YWCPESRIFC VSGVSAYVII 
YKFSRHEITT EIVSLEVRLQ YDVEDIITPE PETSPPFPDL SAQLPSSRSL SGSTNTVASE 
GVTKDSIPCL NVKTRPVRMP PGYQAELVIQ LVWVDGEPPQ QITSLAVSSA YGIVAFGNCN 
GLAVVDFIQK TVLLSMGTID LYRSSDLYQR QPRSPRKNKQ FIADNFCMRG LSNFYPDLTK 
RIRTSYQSLT ELNDSPVPLE LERCKSPTSD HVNGHCTSPT SQSCSSGKRL SSADVSKVNR 
WGPGRPPFRK AQSAACMEIS LPVTTEENRE NSYNRSRSSS ISSIDKDSKE AITALYFMDS 
FARKNDSTIS PCLFVGTSLG MVLIISLNLP LADEQRFTEP VMVLPSGTFL SLKGAVLTFS 
CMDRMGGLMQ PPYEVWRDPN NIDENEKSWR RKVVMNSSSA SQEIGDHQYT IICSEKQAKV 
FSLPSQTCLY VHNITETSFI LQANVVVMCS SACLACFCAN GHIMIMSLPS LRPMLDVNYL 
PLTDMRIART FCFTNEGQAL YLVSPTEIQR LTYSQEMCDN LQDMLGDLFT PIETPEAQNR 
GFLKGLFGGS GQTFDREELF GEASAGKASR SLAQHIPGPG SIEGMKGAAG GVMGELTRAR 
IALDERGQRL GELEEKTAGM MTSAEAFSKH AHELMLKYKD KKWYQF

Genular Protein ID: 1069551674

Symbol: B4DKF6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DKF6

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 2 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 1162
  • Mass: 128996
  • Checksum: E5DE270C858C9FFB
  • Sequence:
    • MKKFNFRKVL DGLTASSPGS GSSSGSNSGG GAGSGSVHPA GTAGVLREEI QETLTSEYFQ 
ICKTVRHGFP HQPTALAFDP VQKILAIGTR TGAIRILGRP GVDCYCQHES GAAVLQLQFL 
INEGALVSAS SDDTLHLWNL RQKRPAILHS LKFNRERITY CHLPFQSKWL YVGTERGNTH 
IVNIESFILS GYVIMWNKAI ELSTKTHPGP VVHLSDSPRD EGKLLIGYEN GTVVFWDLKS 
KRAELRVYYD EAIHSIDWHH EGKQFMCSHS DGSLTLWNLK SPSRPFQTTI PHGKSQREGR 
KSESCKPILK VEYKTCKNSE PFIIFSGGLS YDKACRRPSL TIMHGKAITV LEMDHPIVEF 
LTLCETPYPN EFQEPYAVVV LLEKDLIVVD LTQSNFPIFE NPYPMDIHES PVTCTAYFAD 
CPPDLILVLY SIGVKHKKQG YSNKEWPISG GAWNLGAQTY PEIIITGHAD GSIKFWYASA 
ITLQMLYKLK TSKVFEKQKV GEGKQTCEIV EEDPFAIQMI YWCPESRIFC VSGVSAYVII 
YKFSRHEITT EIVSLEVRLQ YDVEDIITPE PETSPPFPDL SAQLPSSRSL SGSTNTVASE 
GVTKDSIPCL NVKTRPVRMP PGYQAELVIQ LVWVDGEPPQ QITSLAVSSA YGIVAFGNCN 
GLAVVDFIQK TVLLSMGTID LYRSSDLYQR QPRSPRKNKQ FIAGLTELND SPVPLELERC 
KSPTSDHVNG HCTSPTSQSC SSGKRLSSAD VSKVNRWGPG RPPFRKAQSA ACMEISLPVT 
TEENRENSYN RSRSSSISSI DKDSKEAITA LYFMDSFARK NDSTISPCLF VGTSLGMVLI 
ISLNLPLADE QRFTEPVMVL PSGTFLSLKG AVLTFSCMDR MGGLMQPPYE VWRDPNNIDE 
NEKSWRRKVV MNSSSASQEI GDHQYTIICS EKQAKVFSLP SQTCLYVHNI TETSFILQAN 
VVVMCSSACL ACFCANGHIM IMSLPSLRPM LDVNYLPLTD MRIARTFCFT NEGQALYLVS 
PTEIQRLTYS QEMCDNLQDM LGDLFTPIET PEAQNRGFLK GLFGGSGQTF DREELFGEAS 
AGKASRSLAQ HIPGPGSIEG MKGAAGGVMG ELTRARIALD ERGQRLGELE EKTAGMMTSA 
EAFSKHAHEL MLKYKDKKWY QF

Genular Protein ID: 655494211

Symbol: E9PFI2_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PFI2

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 2 GeneTree 1 HGNC 1 InterPro 8 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 2 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 3 SAM 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 1162
  • Mass: 128948
  • Checksum: 3714B91621A67D1C
  • Sequence:
    • MKKFNFRKVL DGLTASSPGS GSSSGSNSGG GAGSGSVHPA GTAGVLREEI QETLTSEYFQ 
ICKTVRHGFP HQPTALAFDP VQKILAIGTR TGAIRILGRP GVDCYCQHES GAAVLQLQFL 
INEGALVSAS SDDTLHLWNL RQKRPAILHS LKFNRERITY CHLPFQSKWL YVGTERGNTH 
IVNIESFILS GYVIMWNKAI ELSTKTHPGP VVHLSDSPRD EGKLLIGYEN GTVVFWDLKS 
KRAELRVYYD EAIHSIDWHH EGKQFMCSHS DGSLTLWNLK SPSRPFQTTI PHGKSQREGR 
KSESCKPILK VEYKTCKNSE PFIIFSGGLS YDKACRRPSL TIMHGKAITV LEMDHPIVEF 
LTLCETPYPN EFQEPYAVVV LLEKDLIVVD LTQSNFPIFE NPYPMDIHES PVTCTAYFAD 
CPPDLILVLY SIGVKHKKQG YSNKEWPISG GAWNLGAQTY PEIIITGHAD GSIKFWDASA 
ITLQMLYKLK TSKVFEKQKV GEGKQTCEIV EEDPFAIQMI YWCPESRIFC VSGVSAYVII 
YKFSRHEITT EIVSLEVRLQ YDVEDIITPE PETSPPFPDL SAQLPSSRSL SGSTNTVASE 
GVTKDSIPCL NVKTRPVRMP PGYQAELVIQ LVWVDGEPPQ QITSLAVSSA YGIVAFGNCN 
GLAVVDFIQK TVLLSMGTID LYRSSDLYQR QPRSPRKNKQ FIAGLTELND SPVPLELERC 
KSPTSDHVNG HCTSPTSQSC SSGKRLSSAD VSKVNRWGPG RPPFRKAQSA ACMEISLPVT 
TEENRENSYN RSRSSSISSI DKDSKEAITA LYFMDSFARK NDSTISPCLF VGTSLGMVLI 
ISLNLPLADE QRFTEPVMVL PSGTFLSLKG AVLTFSCMDR MGGLMQPPYE VWRDPNNIDE 
NEKSWRRKVV MNSSSASQEI GDHQYTIICS EKQAKVFSLP SQTCLYVHNI TETSFILQAN 
VVVMCSSACL ACFCANGHIM IMSLPSLRPM LDVNYLPLTD MRIARTFCFT NEGQALYLVS 
PTEIQRLTYS QEMCDNLQDM LGDLFTPIET PEAQNRGFLK GLFGGSGQTF DREELFGEAS 
AGKASRSLAQ HIPGPGSIEG MKGAAGGVMG ELTRARIALD ERGQRLGELE EKTAGMMTSA 
EAFSKHAHEL MLKYKDKKWY QF