Details for: LINC01657

Gene ID: 101928751

Symbol: LINC01657

Ensembl ID: ENSG00000224718

Description: long intergenic non-protein coding RNA 1657

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 2.1214
    Cell Significance Index: 19.8500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2834
    Cell Significance Index: 4.1300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.1045
    Cell Significance Index: 2.6600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.0697
    Cell Significance Index: 0.9100
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.0597
    Cell Significance Index: 0.7900
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.0325
    Cell Significance Index: 0.3900
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.0224
    Cell Significance Index: 0.1600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.0155
    Cell Significance Index: 0.1500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0100
    Cell Significance Index: 0.1100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0025
    Cell Significance Index: 0.0400
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.0023
    Cell Significance Index: 0.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0017
    Cell Significance Index: 0.0700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0015
    Cell Significance Index: 0.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0006
    Cell Significance Index: -0.3400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0013
    Cell Significance Index: -0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0016
    Cell Significance Index: -0.3300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0023
    Cell Significance Index: -0.0500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0036
    Cell Significance Index: -0.0400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0050
    Cell Significance Index: -0.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0052
    Cell Significance Index: -0.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0053
    Cell Significance Index: -0.3000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0066
    Cell Significance Index: -0.0700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0068
    Cell Significance Index: -0.0900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0084
    Cell Significance Index: -0.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0090
    Cell Significance Index: -0.3200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0098
    Cell Significance Index: -0.1200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0099
    Cell Significance Index: -0.1300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0107
    Cell Significance Index: -0.2600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0126
    Cell Significance Index: -0.1500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0146
    Cell Significance Index: -0.2900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0151
    Cell Significance Index: -0.3000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0152
    Cell Significance Index: -0.2600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0155
    Cell Significance Index: -0.3300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0159
    Cell Significance Index: -0.3100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0162
    Cell Significance Index: -0.3500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0173
    Cell Significance Index: -0.2300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0178
    Cell Significance Index: -0.2100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0179
    Cell Significance Index: -0.3600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0181
    Cell Significance Index: -0.2300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0188
    Cell Significance Index: -0.2300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0193
    Cell Significance Index: -0.2700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0201
    Cell Significance Index: -0.2300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0202
    Cell Significance Index: -0.2400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0206
    Cell Significance Index: -0.1800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0207
    Cell Significance Index: -0.2800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0209
    Cell Significance Index: -0.2800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0214
    Cell Significance Index: -0.2700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0222
    Cell Significance Index: -0.2700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0229
    Cell Significance Index: -0.2500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0235
    Cell Significance Index: -0.2600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0235
    Cell Significance Index: -0.2700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0237
    Cell Significance Index: -0.2000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0249
    Cell Significance Index: -0.2600
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0254
    Cell Significance Index: -0.2800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0257
    Cell Significance Index: -0.3000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0258
    Cell Significance Index: -0.2600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0262
    Cell Significance Index: -0.3300
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0262
    Cell Significance Index: -0.3000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0262
    Cell Significance Index: -0.3400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0263
    Cell Significance Index: -0.2800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0266
    Cell Significance Index: -0.2800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0273
    Cell Significance Index: -0.3300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0277
    Cell Significance Index: -0.2600
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0277
    Cell Significance Index: -0.2900
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0282
    Cell Significance Index: -0.3400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0285
    Cell Significance Index: -0.2700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0288
    Cell Significance Index: -0.3000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0302
    Cell Significance Index: -0.3300
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0309
    Cell Significance Index: -0.3300
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0325
    Cell Significance Index: -0.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0354
    Cell Significance Index: -0.3400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0363
    Cell Significance Index: -0.2700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0370
    Cell Significance Index: -0.2900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0383
    Cell Significance Index: -0.3200
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0385
    Cell Significance Index: -0.3500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0386
    Cell Significance Index: -0.3400
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0392
    Cell Significance Index: -0.3500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0398
    Cell Significance Index: -0.3100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0478
    Cell Significance Index: -0.3000
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0504
    Cell Significance Index: -0.2700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0580
    Cell Significance Index: -0.2700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0624
    Cell Significance Index: -0.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LINC01657 is a lincRNA, which is a class of non-coding RNAs that do not encode proteins but instead play regulatory roles in gene expression. Its long intergenic nature implies that it is derived from a non-coding region of the genome, rather than from a protein-coding gene. The expression of LINC01657 is widespread, with significant levels detected in various cell types, including immune cells. This suggests that LINC01657 may play a general role in regulating immune responses, rather than being specific to a particular cell type. **Pathways and Functions:** The precise mechanisms by which LINC01657 regulates immune responses are not yet fully understood. However, several key pathways and functions have been implicated: 1. **Immune cell regulation:** LINC01657 has been shown to modulate the expression of genes involved in immune cell development, activation, and differentiation. This suggests that LINC01657 may play a critical role in regulating immune responses, potentially by influencing the balance between pro-inflammatory and anti-inflammatory signals. 2. **MicroRNA regulation:** LINC01657 has been identified as a microRNA (miRNA) target, which implies that it may regulate the expression of specific miRNAs involved in immune cell regulation. This provides a potential mechanism by which LINC01657 exerts its regulatory effects on immune responses. 3. **Epigenetic regulation:** LINC01657 has been shown to interact with epigenetic regulators, such as histone deacetylases (HDACs), which are involved in gene expression regulation. This suggests that LINC01657 may influence epigenetic marks on target genes, thereby modulating immune responses. **Clinical Significance:** The clinical significance of LINC01657 is an area of active research, with potential implications for the diagnosis and treatment of various diseases. Some potential applications include: 1. **Autoimmune diseases:** LINC01657 may play a role in the pathogenesis of autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, and lupus. Understanding the regulatory mechanisms of LINC01657 may provide new insights into the development of therapeutic strategies for these diseases. 2. **Cancer:** LINC01657 has been implicated in cancer development and progression, with potential roles in tumor immune evasion and metastasis. Further research is needed to fully understand the role of LINC01657 in cancer and to explore its potential as a therapeutic target. 3. **Immunotherapy:** LINC01657 may be a useful biomarker for predicting treatment response to immunotherapies, such as checkpoint inhibitors. Understanding the regulatory mechanisms of LINC01657 may also provide new insights into the development of innovative immunotherapeutic strategies. In conclusion, LINC01657 is a complex non-coding RNA that plays a mysterious yet crucial role in regulating immune responses. Further research is needed to fully understand its mechanisms of action and to explore its potential applications in the diagnosis and treatment of various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.