Details for: CPN1

Gene ID: 1369

Symbol: CPN1

Ensembl ID: ENSG00000120054

Description: carboxypeptidase N subunit 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.6642
    Cell Significance Index: 61.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0110
    Cell Significance Index: 200.6400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.9825
    Cell Significance Index: 16.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9511
    Cell Significance Index: 43.1100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.8137
    Cell Significance Index: 11.8600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6756
    Cell Significance Index: 16.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6454
    Cell Significance Index: 122.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5455
    Cell Significance Index: 53.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4701
    Cell Significance Index: 424.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4594
    Cell Significance Index: 11.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4343
    Cell Significance Index: 9.4100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.2912
    Cell Significance Index: 2.4800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2699
    Cell Significance Index: 6.7300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2688
    Cell Significance Index: 3.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2244
    Cell Significance Index: 3.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1949
    Cell Significance Index: 21.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1528
    Cell Significance Index: 3.2600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.1194
    Cell Significance Index: 1.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1168
    Cell Significance Index: 8.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1000
    Cell Significance Index: 16.2600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0827
    Cell Significance Index: 0.5600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0604
    Cell Significance Index: 0.6300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0538
    Cell Significance Index: 0.6800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0386
    Cell Significance Index: 0.5700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0382
    Cell Significance Index: 0.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0329
    Cell Significance Index: 0.9200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.0276
    Cell Significance Index: 0.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0139
    Cell Significance Index: 2.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0132
    Cell Significance Index: 0.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0090
    Cell Significance Index: 0.2600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0076
    Cell Significance Index: 0.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0067
    Cell Significance Index: 0.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0046
    Cell Significance Index: 3.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0027
    Cell Significance Index: 0.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0022
    Cell Significance Index: 4.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0021
    Cell Significance Index: 3.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0020
    Cell Significance Index: 0.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0020
    Cell Significance Index: 3.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0015
    Cell Significance Index: 2.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0008
    Cell Significance Index: 0.4900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0002
    Cell Significance Index: 0.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0020
    Cell Significance Index: -0.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0024
    Cell Significance Index: -0.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0026
    Cell Significance Index: -0.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0026
    Cell Significance Index: -0.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0032
    Cell Significance Index: -1.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0032
    Cell Significance Index: -1.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0036
    Cell Significance Index: -1.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0074
    Cell Significance Index: -0.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0076
    Cell Significance Index: -0.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0081
    Cell Significance Index: -0.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0093
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0094
    Cell Significance Index: -1.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0116
    Cell Significance Index: -1.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0144
    Cell Significance Index: -1.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0147
    Cell Significance Index: -2.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0170
    Cell Significance Index: -1.7700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0171
    Cell Significance Index: -0.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0190
    Cell Significance Index: -1.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0231
    Cell Significance Index: -0.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0255
    Cell Significance Index: -1.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0267
    Cell Significance Index: -1.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0280
    Cell Significance Index: -1.7200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0283
    Cell Significance Index: -0.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0317
    Cell Significance Index: -1.2000
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0321
    Cell Significance Index: -0.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0338
    Cell Significance Index: -1.5900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0362
    Cell Significance Index: -0.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0374
    Cell Significance Index: -2.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0384
    Cell Significance Index: -0.8400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0436
    Cell Significance Index: -1.3900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0468
    Cell Significance Index: -1.1700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0473
    Cell Significance Index: -1.5500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0485
    Cell Significance Index: -1.7000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0489
    Cell Significance Index: -0.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0515
    Cell Significance Index: -1.4700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0523
    Cell Significance Index: -1.5400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0528
    Cell Significance Index: -0.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0536
    Cell Significance Index: -1.4300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0536
    Cell Significance Index: -0.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0547
    Cell Significance Index: -1.9000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0558
    Cell Significance Index: -1.0900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0565
    Cell Significance Index: -1.2000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0565
    Cell Significance Index: -0.7100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0616
    Cell Significance Index: -0.8600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0627
    Cell Significance Index: -0.8200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0641
    Cell Significance Index: -1.6000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0662
    Cell Significance Index: -0.6900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0671
    Cell Significance Index: -1.4500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0690
    Cell Significance Index: -1.0400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0704
    Cell Significance Index: -1.1600
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0707
    Cell Significance Index: -0.8600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0720
    Cell Significance Index: -0.9600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0724
    Cell Significance Index: -1.8500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0728
    Cell Significance Index: -0.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0729
    Cell Significance Index: -2.0900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0752
    Cell Significance Index: -1.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic function:** Carboxypeptidase N is a metallocarboxypeptidase enzyme that catalyzes the hydrolysis of peptides, particularly those with a terminal C-terminal carboxy-terminal amino acid. The CPN1 gene encodes a subunit of this enzyme, which is essential for its catalytic activity. 2. **Cellular expression:** CPN1 is expressed in a diverse range of cell types, including amacrine cells, cardiac endothelial cells, blood vessel endothelial cells, colon goblet cells, enterocytes, mural cells, immature innate lymphoid cells, hepatoblasts, and kidney proximal convoluted tubule epithelial cells. This widespread expression suggests a critical role in maintaining tissue homeostasis. 3. **Pathway involvement:** CPN1 is involved in various biological pathways, including the bradykinin catabolic process, complement cascade, extracellular region, immune system, innate immune system, peptide metabolic process, protein binding, protein catabolic process, protein processing, regulation of complement cascade, response to glucocorticoid, and zinc ion binding. These pathways highlight the enzyme's role in regulating immune responses, maintaining tissue integrity, and modulating metabolic processes. **Pathways and Functions:** 1. **Bradykinin catabolic process:** CPN1 plays a crucial role in the degradation of bradykinin, a potent peptide involved in pain transmission and inflammation. The degradation of bradykinin by carboxypeptidase N helps regulate its levels and mitigate excessive inflammatory responses. 2. **Complement cascade:** CPN1 is involved in the regulation of the complement cascade, a series of immune responses that help eliminate pathogens from the body. The enzyme's activity helps modulate the activation and inactivation of complement proteins, thereby influencing immune responses. 3. **Peptide metabolic process:** CPN1 is essential for the degradation of peptides, including those involved in immune responses and tissue homeostasis. The enzyme's activity helps regulate peptide levels and maintain protein homeostasis. 4. **Protein processing:** CPN1 plays a role in the processing of proteins, including those involved in immune responses and tissue homeostasis. The enzyme's activity helps regulate protein levels and maintain tissue integrity. **Clinical Significance:** 1. **Immune system disorders:** Alterations in CPN1 expression or function may contribute to immune system disorders, such as autoimmune diseases or inflammatory conditions. 2. **Cancer:** CPN1 may play a role in cancer progression, as its expression is altered in various types of cancer. The enzyme's activity may influence tumor growth, invasion, and metastasis. 3. **Neurological disorders:** CPN1 expression is altered in neurological disorders, such as Alzheimer's disease and Parkinson's disease. The enzyme's activity may influence disease progression and pathology. 4. **Cardiovascular disease:** CPN1 expression is altered in cardiovascular disease, including atherosclerosis and heart failure. The enzyme's activity may influence disease progression and pathology. In conclusion, the CPN1 gene plays a critical role in regulating immune system function, peptide metabolism, and protein processing. Its widespread expression in multiple cell types highlights its importance in maintaining tissue homeostasis and overall health. Further research is needed to fully understand the clinical significance of CPN1 and its potential role in various diseases.

Genular Protein ID: 401483336

Symbol: CBPN_HUMAN

Name: Carboxypeptidase N catalytic chain

UniProtKB Accession Codes:

P15169 B1AP59

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 2 EMBL 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2912725

Title: cDNA cloning and complete primary structure of the small, active subunit of human carboxypeptidase N (kininase 1).

PubMed ID: 2912725

DOI: 10.1111/j.1432-1033.1989.tb14488.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3408501

Title: Amino acid sequence of the N-terminus and selected tryptic peptides of the active subunit of human plasma carboxypeptidase N: comparison with other carboxypeptidases.

PubMed ID: 3408501

DOI: 10.1016/0006-291x(88)90284-7

PubMed ID: 8267877

Title: On the specificity of carboxypeptidase N, a comparative study.

PubMed ID: 8267877

DOI: 10.1515/bchm3.1993.374.7-12.843

PubMed ID: 17157876

Title: Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain.

PubMed ID: 17157876

DOI: 10.1016/j.jmb.2006.11.025

PubMed ID: 12560874

Title: DNA polymorphism and mutations in CPN1, including the genomic basis of carboxypeptidase N deficiency.

PubMed ID: 12560874

DOI: 10.1007/s100380300003

Sequence Information:

  • Length: 458
  • Mass: 52286
  • Checksum: 9BEF3E459E291E39
  • Sequence:
    • MSDLLSVFLH LLLLFKLVAP VTFRHHRYDD LVRTLYKVQN ECPGITRVYS IGRSVEGRHL 
YVLEFSDHPG IHEPLEPEVK YVGNMHGNEA LGRELMLQLS EFLCEEFRNR NQRIVQLIQD 
TRIHILPSMN PDGYEVAAAQ GPNKPGYLVG RNNANGVDLN RNFPDLNTYI YYNEKYGGPN 
HHLPLPDNWK SQVEPETRAV IRWMHSFNFV LSANLHGGAV VANYPYDKSF EHRVRGVRRT 
ASTPTPDDKL FQKLAKVYSY AHGWMFQGWN CGDYFPDGIT NGASWYSLSK GMQDFNYLHT 
NCFEITLELS CDKFPPEEEL QREWLGNREA LIQFLEQVHQ GIKGMVLDEN YNNLANAVIS 
VSGINHDVTS GDHGDYFRLL LPGIYTVSAT APGYDPETVT VTVGPAEPTL VNFHLKRSIP 
QVSPVRRAPS RRHGVRAKVQ PQARKKEMEM RQLQRGPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.