Details for: DSC1

Gene ID: 1823

Symbol: DSC1

Ensembl ID: ENSG00000134765

Description: desmocollin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.26
    Marker Score: 2275
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1175
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.45
    Marker Score: 1442
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 875
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 860
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 490
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4823
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.12
    Marker Score: 17511
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 506
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.05
    Marker Score: 1989
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 801
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71835
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48060
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 377
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5337
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.85
    Marker Score: 1728
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.82
    Marker Score: 2904
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.78
    Marker Score: 10439
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 504
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.63
    Marker Score: 363
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.61
    Marker Score: 365
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 468
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 234
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 478
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.4
    Marker Score: 235
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.35
    Marker Score: 734
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.33
    Marker Score: 120
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.32
    Marker Score: 128
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.3
    Marker Score: 142
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.23
    Marker Score: 59
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.23
    Marker Score: 68
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.23
    Marker Score: 151
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.23
    Marker Score: 100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.21
    Marker Score: 142
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2
    Marker Score: 12235
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.19
    Marker Score: 106
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 82
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.17
    Marker Score: 227
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.17
    Marker Score: 184
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.16
    Marker Score: 3659
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.16
    Marker Score: 84
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.16
    Marker Score: 283
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.15
    Marker Score: 87
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.15
    Marker Score: 121
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.14
    Marker Score: 129
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.13
    Marker Score: 144
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.12
    Marker Score: 135.5
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.12
    Marker Score: 77
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.12
    Marker Score: 53
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.12
    Marker Score: 33
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.12
    Marker Score: 104
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.11
    Marker Score: 76
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.11
    Marker Score: 94
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.1
    Marker Score: 123
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.1
    Marker Score: 40
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.09
    Marker Score: 208
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.08
    Marker Score: 42
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.08
    Marker Score: 340
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.08
    Marker Score: 91
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.07
    Marker Score: 120
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.07
    Marker Score: 60
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.07
    Marker Score: 70
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.07
    Marker Score: 154
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.07
    Marker Score: 83
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.07
    Marker Score: 51
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.06
    Marker Score: 68
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.06
    Marker Score: 1281
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.06
    Marker Score: 554
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.06
    Marker Score: 24

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Other Information

**Key characteristics:** - DSC1 is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is expressed in high levels in epithelial cells, where it is involved in cell-cell adhesion. - DSC1 is also expressed in immune cells, where it plays a role in the formation of the cornified envelope. - It is a key regulator of epithelial cell migration and adhesion. **Pathways and functions:** - DSC1 is involved in the regulation of cell-cell adhesion. It is a key component of the adherens junction, a strong cell adhesion complex that holds epithelial cells together. - It is also involved in the formation of the cornified envelope, a unique cell shape in epithelial cells that is characterized by its tight packing and lack of gap junctions. - DSC1 is also involved in the regulation of angiogenesis, the formation of new blood vessels. - It is a key regulator of epithelial cell migration and adhesion, and its dysfunction can lead to a variety of diseases, including cancer and cardiovascular disease. **Clinical significance:** - DSC1 is a promising target for cancer immunotherapy. Antibodies against DSC1 have been shown to be effective in blocking the growth of cancer cells in vitro and in vivo. - Dysregulation of DSC1 has been linked to a number of human diseases, including cancer, cardiovascular disease, and developmental disorders. - Therefore, DSC1 is a promising target for the treatment of a variety of human diseases.

Genular Protein ID: 1749292223

Symbol: DSC1_HUMAN

Name: Desmocollin-1

UniProtKB Accession Codes:

Q08554 Q9HB01

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 3 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8507556

Title: Differential synthesis of type 1 and type 2 desmocollin mRNAs in human stratified epithelia.

PubMed ID: 8507556

PubMed ID: 8288219

Title: Cloning of the cDNA (DSC1) coding for human type 1 desmocollin and its assignment to chromosome 18.

PubMed ID: 8288219

DOI: 10.1006/geno.1993.1453

PubMed ID: 11027496

Title: Genomic organization and amplification of the human desmosomal cadherin genes DSC1 and DSC3, encoding desmocollin types 1 and 3.

PubMed ID: 11027496

DOI: 10.1006/bbrc.2000.3500

PubMed ID: 1713860

Title: Keratinization is associated with the expression of a new protein related to the desmosomal cadherins DGII/III.

PubMed ID: 1713860

DOI: 10.1016/0014-5793(91)80929-w

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 19759396

Title: Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes.

PubMed ID: 19759396

DOI: 10.1074/jbc.m109.047928

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 894
  • Mass: 99987
  • Checksum: 2E0C835F6FE2E77F
  • Sequence:
    • MALASAAPGS IFCKQLLFSL LVLTLLCDAC QKVYLRVPSH LQAETLVGKV NLEECLKSAS 
LIRSSDPAFR ILEDGSIYTT HDLILSSERK SFSIFLSDGQ RREQQEIKVV LSARENKSPK 
KRHTKDTALK RSKRRWAPIP ASLMENSLGP FPQHVQQIQS DAAQNYTIFY SISGPGVDKE 
PFNLFYIEKD TGDIFCTRSI DREKYEQFAL YGYATTADGY APEYPLPLII KIEDDNDNAP 
YFEHRVTIFT VPENCRSGTS VGKVTATDLD EPDTLHTRLK YKILQQIPDH PKHFSIHPDT 
GVITTTTPFL DREKCDTYQL IMEVRDMGGQ PFGLFNTGTI TISLEDENDN PPSFTETSYV 
TEVEENRIDV EILRMKVQDQ DLPNTPHSKA VYKILQGNEN GNFIISTDPN TNEGVLCVVK 
PLNYEVNRQV ILQVGVINEA QFSKAASSQT PTMCTTTVTV KIIDSDEGPE CHPPVKVIQS 
QDGFPAGQEL LGYKALDPEI SSGEGLRYQK LGDEDNWFEI NQHTGDLRTL KVLDRESKFV 
KNNQYNISVV AVDAVGRSCT GTLVVHLDDY NDHAPQIDKE VTICQNNEDF AVLKPVDPDG 
PENGPPFQFF LDNSASKNWN IEEKDGKTAI LRQRQNLDYN YYSVPIQIKD RHGLVATHML 
TVRVCDCSTP SECRMKDKST RDVRPNVILG RWAILAMVLG SVLLLCILFT CFCVTAKRTV 
KKCFPEDIAQ QNLIVSNTEG PGEEVTEANI RLPMQTSNIC DTSMSVGTVG GQGIKTQQSF 
EMVKGGYTLD SNKGGGHQTL ESVKGVGQGD TGRYAYTDWQ SFTQPRLGEK VYLCGQDEEH 
KHCEDYVCSY NYEGKGSLAG SVGCCSDRQE EEGLEFLDHL EPKFRTLAKT CIKK

Genular Protein ID: 3456259431

Symbol: Q9HB00_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9HB00

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 ExpressionAtlas 1 GO 3 Gene3D 1 GenomeRNAi 1 IntAct 1 InterPro 4 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PROSITE 3 PROSITE-ProRule 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 2 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11027496

Title: Genomic organization and amplification of the human desmosomal cadherin genes DSC1 and DSC3, encoding desmocollin types 1 and 3.

PubMed ID: 11027496

DOI: 10.1006/bbrc.2000.3500

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 840
  • Mass: 93835
  • Checksum: DF66432C933CC9D1
  • Sequence:
    • MALASAAPGS IFCKQLLFSL LVLTLLCDAC QKVYLRVPSH LQAETLVGKV NLEECLKSAS 
LIRSSDPAFR ILEDGSIYTT HDLILSSERK SFSIFLSDGQ RREQQEIKVV LSARENKSPK 
KRHTKDTALK RSKRRWAPIP ASLMENSLGP FPQHVQQIQS DAAQNYTIFY SISGPGVDKE 
PFNLFYIEKD TGDIFCTRSI DREKYEQFAL YGYATTADGY APEYPLPLII KIEDDNDNAP 
YFEHRVTIFT VPENCRSGTS VGKVTATDLD EPDTLHTRLK YKILQQIPDH PKHFSIHPDT 
GVITTTTPFL DREKCDTYQL IMEVRDMGGQ PFGLFNTGTI TISLEDENDN PPSFTETSYV 
TEVEENRIDV EILRMKVQDQ DLPNTPHSKA VYKILQGNEN GNFIISTDPN TNEGVLCVVK 
PLNYEVNRQV ILQVGVINEA QFSKAASSQT PTMCTTTVTV KIIDSDEGPE CHPPVKVIQS 
QDGFPAGQEL LGYKALDPEI SSGEGLRYQK LGDEDNWFEI NQHTGDLRTL KVLDRESKFV 
KNNQYNISVV AVDAVGRSCT GTLVVHLDDY NDHAPQIDKE VTICQNNEDF AVLKPVDPDG 
PENGPPFQFF LDNSASKNWN IEEKDGKTAI LRQRQNLDYN YYSVPIQIKD RHGLVATHML 
TVRVCDCSTP SECRMKDKST RDVRPNVILG RWAILAMVLG SVLLLCILFT CFCVTAKRTV 
KKCFPEDIAQ QNLIVSNTEG PGEEVTEANI RLPMQTSNIC DTSMSVGTVG GQGIKTQQSF 
EMVKGGYTLD SNKGGGHQTL ESVKGVGQGD TGRYAYTDWQ SFTQPRLGEE SIRGHTLIKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.