Details for: DSC1

Gene ID: 1823

Symbol: DSC1

Ensembl ID: ENSG00000134765

Description: desmocollin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 11.7966
    Cell Significance Index: 13.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.3124
    Cell Significance Index: 82.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.9191
    Cell Significance Index: 93.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.8956
    Cell Significance Index: 177.5300
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 2.5708
    Cell Significance Index: 5.8000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3285
    Cell Significance Index: 32.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8127
    Cell Significance Index: 154.6600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.7493
    Cell Significance Index: 11.3800
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.7061
    Cell Significance Index: 2.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5815
    Cell Significance Index: 57.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5088
    Cell Significance Index: 10.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4665
    Cell Significance Index: 421.1800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.3723
    Cell Significance Index: 5.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3383
    Cell Significance Index: 36.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3249
    Cell Significance Index: 143.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3192
    Cell Significance Index: 51.9200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2455
    Cell Significance Index: 14.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1781
    Cell Significance Index: 12.3200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1716
    Cell Significance Index: 1.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1586
    Cell Significance Index: 12.1700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1536
    Cell Significance Index: 1.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1224
    Cell Significance Index: 1.6700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0933
    Cell Significance Index: 1.0900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0892
    Cell Significance Index: 1.5000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0732
    Cell Significance Index: 1.0800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0588
    Cell Significance Index: 0.5900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0443
    Cell Significance Index: 0.5600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0402
    Cell Significance Index: 1.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0322
    Cell Significance Index: 1.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0285
    Cell Significance Index: 1.2600
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.0253
    Cell Significance Index: 0.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0232
    Cell Significance Index: 4.6500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0180
    Cell Significance Index: 0.4500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0174
    Cell Significance Index: 0.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0166
    Cell Significance Index: 0.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0149
    Cell Significance Index: 0.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0148
    Cell Significance Index: 1.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0139
    Cell Significance Index: 2.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0135
    Cell Significance Index: 0.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0099
    Cell Significance Index: 18.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0098
    Cell Significance Index: 1.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0065
    Cell Significance Index: 8.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0057
    Cell Significance Index: 2.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0044
    Cell Significance Index: 6.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0032
    Cell Significance Index: 5.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0004
    Cell Significance Index: 0.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0020
    Cell Significance Index: -0.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0024
    Cell Significance Index: -1.7800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0025
    Cell Significance Index: -1.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0025
    Cell Significance Index: -1.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0031
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0032
    Cell Significance Index: -2.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0033
    Cell Significance Index: -1.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0033
    Cell Significance Index: -1.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0034
    Cell Significance Index: -1.8900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0040
    Cell Significance Index: -0.1000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0042
    Cell Significance Index: -0.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0058
    Cell Significance Index: -0.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0060
    Cell Significance Index: -1.0800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0060
    Cell Significance Index: -0.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0077
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0088
    Cell Significance Index: -1.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0090
    Cell Significance Index: -1.9000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0092
    Cell Significance Index: -0.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0109
    Cell Significance Index: -0.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0110
    Cell Significance Index: -1.2800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0120
    Cell Significance Index: -0.1900
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0126
    Cell Significance Index: -0.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0130
    Cell Significance Index: -1.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0137
    Cell Significance Index: -0.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0141
    Cell Significance Index: -1.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0151
    Cell Significance Index: -1.7400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0156
    Cell Significance Index: -0.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0174
    Cell Significance Index: -2.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0182
    Cell Significance Index: -1.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0188
    Cell Significance Index: -1.9200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0203
    Cell Significance Index: -0.2900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0220
    Cell Significance Index: -0.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0228
    Cell Significance Index: -0.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0231
    Cell Significance Index: -1.5500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0248
    Cell Significance Index: -0.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0256
    Cell Significance Index: -0.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0288
    Cell Significance Index: -1.7700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0291
    Cell Significance Index: -1.0700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0291
    Cell Significance Index: -1.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0312
    Cell Significance Index: -1.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0315
    Cell Significance Index: -2.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0335
    Cell Significance Index: -2.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0344
    Cell Significance Index: -1.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0347
    Cell Significance Index: -1.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0365
    Cell Significance Index: -1.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0408
    Cell Significance Index: -2.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0428
    Cell Significance Index: -2.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0436
    Cell Significance Index: -1.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0442
    Cell Significance Index: -1.1400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0452
    Cell Significance Index: -0.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0485
    Cell Significance Index: -1.7000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0488
    Cell Significance Index: -0.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane protein**: DSC1 is a type II transmembrane protein, with an extracellular N-terminus and a cytoplasmic C-terminus. 2. **Homophilic cell adhesion**: DSC1 mediates homophilic cell adhesion via the desmosomal cadherin complex, ensuring the structural cohesion of epithelial tissues. 3. **Calcium ion binding**: DSC1 has been shown to bind calcium ions, which is essential for its function in cell adhesion and signaling. 4. **Keratinization**: DSC1 is involved in the process of keratinization, which is critical for the formation of the cornified envelope in stratified epithelia. **Pathways and Functions:** 1. **Cell-cell adhesion**: DSC1 is a key component of the desmosomal complex, which mediates homophilic cell adhesion between adjacent epithelial cells. 2. **Calcium signaling**: DSC1 binds calcium ions, which triggers signaling pathways that regulate cell adhesion, migration, and proliferation. 3. **Keratinization**: DSC1 is involved in the process of keratinization, which is critical for the formation of the cornified envelope in stratified epithelia. 4. **Immune system regulation**: DSC1 has been implicated in the regulation of immune responses, particularly in the context of innate immunity. **Significantly Expressed Cells:** DSC1 is significantly expressed in various epithelial cells, including: 1. Blood vessel endothelial cells 2. Colon goblet cells 3. Enterocytes of epithelium of large intestine 4. Granulocyte monocyte progenitor cells 5. Intestinal crypt stem cells of small intestine 6. Transit amplifying cells of small intestine 7. Cardiac muscle myoblasts **Clinical Significance:** 1. **Epithelial barrier dysfunction**: Mutations in the DSC1 gene have been associated with epithelial barrier dysfunction, leading to various diseases, including skin disorders and inflammatory bowel disease. 2. **Immune system dysregulation**: DSC1 has been implicated in the regulation of immune responses, particularly in the context of innate immunity, and dysregulation of DSC1 has been associated with autoimmune diseases. 3. **Cancer**: DSC1 has been shown to be overexpressed in certain types of cancer, including squamous cell carcinoma and colorectal cancer, suggesting its potential role in tumorigenesis. In conclusion, DSC1 is a crucial component of the desmosomal complex, playing a vital role in maintaining epithelial cell integrity and function. Its dysregulation has been implicated in various diseases, including epithelial barrier dysfunction, immune system dysregulation, and cancer. Further research is needed to fully understand the complex functions of DSC1 and its role in maintaining epithelial homeostasis and immune function.

Genular Protein ID: 1749292223

Symbol: DSC1_HUMAN

Name: Desmocollin-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8507556

Title: Differential synthesis of type 1 and type 2 desmocollin mRNAs in human stratified epithelia.

PubMed ID: 8507556

PubMed ID: 8288219

Title: Cloning of the cDNA (DSC1) coding for human type 1 desmocollin and its assignment to chromosome 18.

PubMed ID: 8288219

DOI: 10.1006/geno.1993.1453

PubMed ID: 11027496

Title: Genomic organization and amplification of the human desmosomal cadherin genes DSC1 and DSC3, encoding desmocollin types 1 and 3.

PubMed ID: 11027496

DOI: 10.1006/bbrc.2000.3500

PubMed ID: 1713860

Title: Keratinization is associated with the expression of a new protein related to the desmosomal cadherins DGII/III.

PubMed ID: 1713860

DOI: 10.1016/0014-5793(91)80929-w

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 19759396

Title: Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes.

PubMed ID: 19759396

DOI: 10.1074/jbc.m109.047928

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 894
  • Mass: 99987
  • Checksum: 2E0C835F6FE2E77F
  • Sequence:
  • MALASAAPGS IFCKQLLFSL LVLTLLCDAC QKVYLRVPSH LQAETLVGKV NLEECLKSAS 
    LIRSSDPAFR ILEDGSIYTT HDLILSSERK SFSIFLSDGQ RREQQEIKVV LSARENKSPK 
    KRHTKDTALK RSKRRWAPIP ASLMENSLGP FPQHVQQIQS DAAQNYTIFY SISGPGVDKE 
    PFNLFYIEKD TGDIFCTRSI DREKYEQFAL YGYATTADGY APEYPLPLII KIEDDNDNAP 
    YFEHRVTIFT VPENCRSGTS VGKVTATDLD EPDTLHTRLK YKILQQIPDH PKHFSIHPDT 
    GVITTTTPFL DREKCDTYQL IMEVRDMGGQ PFGLFNTGTI TISLEDENDN PPSFTETSYV 
    TEVEENRIDV EILRMKVQDQ DLPNTPHSKA VYKILQGNEN GNFIISTDPN TNEGVLCVVK 
    PLNYEVNRQV ILQVGVINEA QFSKAASSQT PTMCTTTVTV KIIDSDEGPE CHPPVKVIQS 
    QDGFPAGQEL LGYKALDPEI SSGEGLRYQK LGDEDNWFEI NQHTGDLRTL KVLDRESKFV 
    KNNQYNISVV AVDAVGRSCT GTLVVHLDDY NDHAPQIDKE VTICQNNEDF AVLKPVDPDG 
    PENGPPFQFF LDNSASKNWN IEEKDGKTAI LRQRQNLDYN YYSVPIQIKD RHGLVATHML 
    TVRVCDCSTP SECRMKDKST RDVRPNVILG RWAILAMVLG SVLLLCILFT CFCVTAKRTV 
    KKCFPEDIAQ QNLIVSNTEG PGEEVTEANI RLPMQTSNIC DTSMSVGTVG GQGIKTQQSF 
    EMVKGGYTLD SNKGGGHQTL ESVKGVGQGD TGRYAYTDWQ SFTQPRLGEK VYLCGQDEEH 
    KHCEDYVCSY NYEGKGSLAG SVGCCSDRQE EEGLEFLDHL EPKFRTLAKT CIKK

Genular Protein ID: 3456259431

Symbol: Q9HB00_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11027496

Title: Genomic organization and amplification of the human desmosomal cadherin genes DSC1 and DSC3, encoding desmocollin types 1 and 3.

PubMed ID: 11027496

DOI: 10.1006/bbrc.2000.3500

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 840
  • Mass: 93835
  • Checksum: DF66432C933CC9D1
  • Sequence:
  • MALASAAPGS IFCKQLLFSL LVLTLLCDAC QKVYLRVPSH LQAETLVGKV NLEECLKSAS 
    LIRSSDPAFR ILEDGSIYTT HDLILSSERK SFSIFLSDGQ RREQQEIKVV LSARENKSPK 
    KRHTKDTALK RSKRRWAPIP ASLMENSLGP FPQHVQQIQS DAAQNYTIFY SISGPGVDKE 
    PFNLFYIEKD TGDIFCTRSI DREKYEQFAL YGYATTADGY APEYPLPLII KIEDDNDNAP 
    YFEHRVTIFT VPENCRSGTS VGKVTATDLD EPDTLHTRLK YKILQQIPDH PKHFSIHPDT 
    GVITTTTPFL DREKCDTYQL IMEVRDMGGQ PFGLFNTGTI TISLEDENDN PPSFTETSYV 
    TEVEENRIDV EILRMKVQDQ DLPNTPHSKA VYKILQGNEN GNFIISTDPN TNEGVLCVVK 
    PLNYEVNRQV ILQVGVINEA QFSKAASSQT PTMCTTTVTV KIIDSDEGPE CHPPVKVIQS 
    QDGFPAGQEL LGYKALDPEI SSGEGLRYQK LGDEDNWFEI NQHTGDLRTL KVLDRESKFV 
    KNNQYNISVV AVDAVGRSCT GTLVVHLDDY NDHAPQIDKE VTICQNNEDF AVLKPVDPDG 
    PENGPPFQFF LDNSASKNWN IEEKDGKTAI LRQRQNLDYN YYSVPIQIKD RHGLVATHML 
    TVRVCDCSTP SECRMKDKST RDVRPNVILG RWAILAMVLG SVLLLCILFT CFCVTAKRTV 
    KKCFPEDIAQ QNLIVSNTEG PGEEVTEANI RLPMQTSNIC DTSMSVGTVG GQGIKTQQSF 
    EMVKGGYTLD SNKGGGHQTL ESVKGVGQGD TGRYAYTDWQ SFTQPRLGEE SIRGHTLIKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.