Details for: DVL1

Gene ID: 1855

Symbol: DVL1

Ensembl ID: ENSG00000107404

Description: dishevelled segment polarity protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.01
    Marker Score: 674
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1
    Marker Score: 1746
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71779
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48003
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.93
    Marker Score: 2128
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.93
    Marker Score: 14498
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2723
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5043
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.82
    Marker Score: 560
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.78
    Marker Score: 759
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 569
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.74
    Marker Score: 557
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.74
    Marker Score: 487
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.71
    Marker Score: 254
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 284
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2947.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.69
    Marker Score: 441
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 627
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.67
    Marker Score: 1657
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.67
    Marker Score: 4281
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.67
    Marker Score: 987
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.65
    Marker Score: 1377
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.65
    Marker Score: 3185.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.65
    Marker Score: 713
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.64
    Marker Score: 21918
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.64
    Marker Score: 990
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.63
    Marker Score: 2160
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.63
    Marker Score: 5386
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.62
    Marker Score: 1253
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.61
    Marker Score: 303
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6
    Marker Score: 602
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.6
    Marker Score: 295
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.59
    Marker Score: 2198
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.59
    Marker Score: 544
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.59
    Marker Score: 2837
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.59
    Marker Score: 1582
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.58
    Marker Score: 629
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.58
    Marker Score: 1030
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.57
    Marker Score: 5449
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.56
    Marker Score: 1325
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.56
    Marker Score: 931
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.56
    Marker Score: 589
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.56
    Marker Score: 5776
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.56
    Marker Score: 4801
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.56
    Marker Score: 577
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.56
    Marker Score: 34138
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.55
    Marker Score: 3297
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.55
    Marker Score: 18931
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.54
    Marker Score: 654
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 431
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.54
    Marker Score: 5415
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.52
    Marker Score: 1174
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.51
    Marker Score: 215
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.5
    Marker Score: 211
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.5
    Marker Score: 3896
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.5
    Marker Score: 416
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.49
    Marker Score: 4581
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.48
    Marker Score: 1869
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.48
    Marker Score: 1133
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.46
    Marker Score: 657
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.46
    Marker Score: 1434
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.45
    Marker Score: 216
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.45
    Marker Score: 211
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.45
    Marker Score: 103
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.45
    Marker Score: 268
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.44
    Marker Score: 471
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.44
    Marker Score: 2312
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.43
    Marker Score: 2575
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.43
    Marker Score: 125
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.42
    Marker Score: 2765
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.42
    Marker Score: 16109
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.42
    Marker Score: 105
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.42
    Marker Score: 477
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.42
    Marker Score: 285
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.41
    Marker Score: 133
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.41
    Marker Score: 1667
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.41
    Marker Score: 128
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.41
    Marker Score: 1029
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.41
    Marker Score: 433
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.4
    Marker Score: 176
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.4
    Marker Score: 409
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.4
    Marker Score: 349
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.4
    Marker Score: 234
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.4
    Marker Score: 281.5
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.4
    Marker Score: 392
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.39
    Marker Score: 6920
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.39
    Marker Score: 1057
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.38
    Marker Score: 3344
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.38
    Marker Score: 494
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.38
    Marker Score: 8130
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.38
    Marker Score: 13957

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Other Information

**Key characteristics:** * DVL1 is a transmembrane protein that is localized to the cell membrane. * It is a key component of the destruction complex, which is responsible for the degradation of beta-catenin. * DVL1 is also a key component of the Frizzled binding complex, which is responsible for the inhibition of Wnt signaling. * It is a key regulator of the WNT signaling pathway, which is a major pathway for cell growth and differentiation. **Pathways and functions:** * DVL1 is involved in the regulation of beta-catenin-independent WNT signaling. * It is a key component of the destruction complex, which is responsible for the degradation of beta-catenin. * It is also a key component of the Frizzled binding complex, which is responsible for the inhibition of Wnt signaling. * It is a key regulator of the WNT signaling pathway, which is a major pathway for cell growth and differentiation. **Clinical significance:** * Mutations in DVL1 have been linked to a number of human diseases, including leishmaniasis, cancer, and developmental disorders. * DVL1 is a promising target for the treatment of these diseases. * Small molecule inhibitors of DVL1 have been shown to be effective in inhibiting cancer cell growth in vitro and in vivo. **Additional information:** * DVL1 is a member of the Dishevelled (DVL) family of proteins. * It is expressed in high levels in embryonic and adult tissues, where it is involved in cell migration and proliferation. * It is also expressed in cancer cells, where it is involved in cell migration and invasion.

Genular Protein ID: 1179292200

Symbol: DVL1_HUMAN

Name: Segment polarity protein dishevelled homolog DVL-1

UniProtKB Accession Codes:

O14640 Q5TA33 Q5TA35

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 62 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 8 RefSeq 2 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9192851

Title: Human dishevelled genes constitute a DHR-containing multigene family.

PubMed ID: 9192851

DOI: 10.1006/geno.1997.4713

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 11742073

Title: beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins.

PubMed ID: 11742073

DOI: 10.1073/pnas.211572798

PubMed ID: 14750955

Title: Identification and characterization of a novel Dvl-binding protein that suppresses Wnt signalling pathway.

PubMed ID: 14750955

DOI: 10.1111/j.1365-2443.2003.00692.x

PubMed ID: 15454084

Title: Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.

PubMed ID: 15454084

DOI: 10.1016/j.cell.2004.09.019

PubMed ID: 15852005

Title: Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways.

PubMed ID: 15852005

DOI: 10.1038/ng1552

PubMed ID: 21044957

Title: Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein.

PubMed ID: 21044957

DOI: 10.1074/jbc.m110.193383

PubMed ID: 25557784

Title: DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.

PubMed ID: 25557784

DOI: 10.1016/j.ajhg.2014.12.002

PubMed ID: 25817016

Title: DVL1 frameshift mutations clustering in the penultimate exon cause autosomal-dominant Robinow syndrome.

PubMed ID: 25817016

DOI: 10.1016/j.ajhg.2015.02.015

PubMed ID: 25817014

Title: Mutations in DVL1 cause an osteosclerotic form of Robinow syndrome.

PubMed ID: 25817014

DOI: 10.1016/j.ajhg.2015.02.010

PubMed ID: 25805136

Title: FOXKs promote Wnt/beta-catenin signaling by translocating DVL into the nucleus.

PubMed ID: 25805136

DOI: 10.1016/j.devcel.2015.01.031

PubMed ID: 26126266

Title: Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling.

PubMed ID: 26126266

DOI: 10.7554/elife.07091

PubMed ID: 27214281

Title: The polycystin complex mediates Wnt/Ca(2+) signalling.

PubMed ID: 27214281

DOI: 10.1038/ncb3363

Sequence Information:

  • Length: 695
  • Mass: 75187
  • Checksum: B009BDBCC57BD562
  • Sequence:
    • MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK SMDQDFGVVK 
EEIFDDNAKL PCFNGRVVSW LVLAEGAHSD AGSQGTDSHT DLPPPLERTG GIGDSRPPSF 
HPNVASSRDG MDNETGTESM VSHRRERARR RNREEAARTN GHPRGDRRRD VGLPPDSAST 
ALSSELESSS FVDSDEDGST SRLSSSTEQS TSSRLIRKHK RRRRKQRLRQ ADRASSFSSI 
TDSTMSLNIV TVTLNMERHH FLGISIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM 
LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PTPRSYFTVP RADPVRPIDP 
AAWLSHTAAL TGALPRYGTS PCSSAVTRTS SSSLTSSVPG APQLEEAPLT VKSDMSAVVR 
VMQLPDSGLE IRDRMWLKIT IANAVIGADV VDWLYTHVEG FKERREARKY ASSLLKHGFL 
RHTVNKITFS EQCYYVFGDL CSNLATLNLN SGSSGTSDQD TLAPLPHPAA PWPLGQGYPY 
QYPGPPPCFP PAYQDPGFSY GSGSTGSQQS EGSKSSGSTR SSRRAPGREK ERRAAGAGGS 
GSESDHTAPS GVGSSWRERP AGQLSRGSSP RSQASATAPG LPPPHPTTKA YTVVGGPPGG 
PPVRELAAVP PELTGSRQSF QKAMGNPCEF FVDIM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.