Details for: DVL1

Gene ID: 1855

Symbol: DVL1

Ensembl ID: ENSG00000107404

Description: dishevelled segment polarity protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 111.9932
    Cell Significance Index: -17.4200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 69.6253
    Cell Significance Index: -17.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.3841
    Cell Significance Index: -17.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.5565
    Cell Significance Index: -17.9800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.2162
    Cell Significance Index: -12.9500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.4863
    Cell Significance Index: -7.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 3.3600
    Cell Significance Index: 332.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.6207
    Cell Significance Index: 498.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6696
    Cell Significance Index: 271.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4777
    Cell Significance Index: 42.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3985
    Cell Significance Index: 19.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2233
    Cell Significance Index: 55.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0903
    Cell Significance Index: 29.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0268
    Cell Significance Index: 111.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9849
    Cell Significance Index: 59.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7884
    Cell Significance Index: 17.0800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6212
    Cell Significance Index: 5.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6027
    Cell Significance Index: 31.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5410
    Cell Significance Index: 37.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5180
    Cell Significance Index: 102.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4577
    Cell Significance Index: 91.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4523
    Cell Significance Index: 12.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4440
    Cell Significance Index: 20.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4369
    Cell Significance Index: 302.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3330
    Cell Significance Index: 60.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3146
    Cell Significance Index: 38.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2829
    Cell Significance Index: 154.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2746
    Cell Significance Index: 9.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2612
    Cell Significance Index: 163.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2098
    Cell Significance Index: 35.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1995
    Cell Significance Index: 5.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1942
    Cell Significance Index: 26.6700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1925
    Cell Significance Index: 69.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1789
    Cell Significance Index: 8.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1582
    Cell Significance Index: 69.9600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1494
    Cell Significance Index: 3.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1315
    Cell Significance Index: 2.8000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.1288
    Cell Significance Index: 0.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1168
    Cell Significance Index: 7.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0940
    Cell Significance Index: 2.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0792
    Cell Significance Index: 2.1600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0782
    Cell Significance Index: 1.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0716
    Cell Significance Index: 4.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0550
    Cell Significance Index: 7.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0526
    Cell Significance Index: 3.7200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0397
    Cell Significance Index: 0.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0386
    Cell Significance Index: 1.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0081
    Cell Significance Index: 15.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0033
    Cell Significance Index: 0.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0032
    Cell Significance Index: -4.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0032
    Cell Significance Index: -4.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0064
    Cell Significance Index: -4.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0080
    Cell Significance Index: -5.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0099
    Cell Significance Index: -7.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0115
    Cell Significance Index: -1.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0117
    Cell Significance Index: -8.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0145
    Cell Significance Index: -8.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0183
    Cell Significance Index: -1.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0214
    Cell Significance Index: -9.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0390
    Cell Significance Index: -2.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0433
    Cell Significance Index: -2.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0470
    Cell Significance Index: -9.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0523
    Cell Significance Index: -15.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0559
    Cell Significance Index: -6.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0639
    Cell Significance Index: -6.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0733
    Cell Significance Index: -8.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0746
    Cell Significance Index: -2.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0865
    Cell Significance Index: -12.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1155
    Cell Significance Index: -13.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1365
    Cell Significance Index: -8.3700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1368
    Cell Significance Index: -15.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1388
    Cell Significance Index: -3.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1595
    Cell Significance Index: -16.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1602
    Cell Significance Index: -7.0900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1714
    Cell Significance Index: -4.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1790
    Cell Significance Index: -14.1800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1825
    Cell Significance Index: -3.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1878
    Cell Significance Index: -9.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2189
    Cell Significance Index: -8.2900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2297
    Cell Significance Index: -5.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2333
    Cell Significance Index: -13.0900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.2591
    Cell Significance Index: -1.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2758
    Cell Significance Index: -6.0400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2869
    Cell Significance Index: -6.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2887
    Cell Significance Index: -15.0400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.3105
    Cell Significance Index: -3.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3136
    Cell Significance Index: -8.0600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3168
    Cell Significance Index: -4.5100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.3212
    Cell Significance Index: -2.7300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3249
    Cell Significance Index: -4.5600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3352
    Cell Significance Index: -3.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3643
    Cell Significance Index: -12.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3884
    Cell Significance Index: -13.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4006
    Cell Significance Index: -12.7600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4069
    Cell Significance Index: -9.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4107
    Cell Significance Index: -15.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4145
    Cell Significance Index: -13.5700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4182
    Cell Significance Index: -6.6400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4228
    Cell Significance Index: -5.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DVL1 is a member of the Dishevelled family of proteins, which are known for their involvement in Wnt signaling. The protein consists of three domains: the N-terminal domain, a central region, and a C-terminal domain. The C-terminal domain interacts with Frizzled receptors and Axin, while the central region interacts with β-catenin and other signaling molecules. DVL1's unique structure allows it to modulate multiple signaling pathways, including canonical and non-canonical Wnt signaling, which are essential for development, cell fate determination, and tissue homeostasis. **Pathways and Functions:** DVL1's involvement in various signaling pathways is a testament to its multifunctional nature. Some of the key pathways and functions attributed to DVL1 include: 1. **Wnt Signaling Pathway:** DVL1 interacts with Frizzled receptors and Axin, modulating the activity of β-catenin and other signaling molecules. This interaction is crucial for the regulation of gene expression, cell fate determination, and tissue homeostasis. 2. **Axon Extension and Guidance:** DVL1 plays a critical role in axon extension and guidance, particularly in the development of the nervous system. Its interaction with β-catenin and other signaling molecules regulates the expression of genes involved in axon growth and guidance. 3. **Dendritic Morphogenesis:** DVL1 is also involved in the regulation of dendritic morphogenesis, a process critical for the development of the nervous system. Its interaction with β-catenin and other signaling molecules regulates the expression of genes involved in dendritic growth and branching. 4. **Synaptic Organization:** DVL1 plays a crucial role in the organization of synapses, a process critical for neuronal function and behavior. Its interaction with β-catenin and other signaling molecules regulates the expression of genes involved in synaptic plasticity and learning. **Clinical Significance:** DVL1's involvement in various signaling pathways and its expression in multiple tissues make it a potential therapeutic target for various diseases. Some of the clinical implications of DVL1 dysregulation include: 1. **Neurodevelopmental Disorders:** DVL1's role in axon extension and guidance makes it a potential target for the treatment of neurodevelopmental disorders, such as autism and schizophrenia. 2. **Cancer:** DVL1's involvement in Wnt signaling makes it a potential target for the treatment of cancer, particularly in the development of therapies that target the Wnt/β-catenin pathway. 3. **Neurodegenerative Diseases:** DVL1's role in synaptic organization and plasticity makes it a potential target for the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's. In conclusion, DVL1 is a multifunctional protein with far-reaching implications in development and disease. Its involvement in various signaling pathways, including Wnt signaling, axon extension, and synaptic organization, makes it a critical component of cellular processes. Further research into DVL1's functions and clinical implications is necessary to fully appreciate its significance in human health and disease.

Genular Protein ID: 1179292200

Symbol: DVL1_HUMAN

Name: Segment polarity protein dishevelled homolog DVL-1

UniProtKB Accession Codes:

O14640 Q5TA33 Q5TA35

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 62 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 8 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9192851

Title: Human dishevelled genes constitute a DHR-containing multigene family.

PubMed ID: 9192851

DOI: 10.1006/geno.1997.4713

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 11742073

Title: beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins.

PubMed ID: 11742073

DOI: 10.1073/pnas.211572798

PubMed ID: 14750955

Title: Identification and characterization of a novel Dvl-binding protein that suppresses Wnt signalling pathway.

PubMed ID: 14750955

DOI: 10.1111/j.1365-2443.2003.00692.x

PubMed ID: 15454084

Title: Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.

PubMed ID: 15454084

DOI: 10.1016/j.cell.2004.09.019

PubMed ID: 15852005

Title: Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways.

PubMed ID: 15852005

DOI: 10.1038/ng1552

PubMed ID: 21044957

Title: Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein.

PubMed ID: 21044957

DOI: 10.1074/jbc.m110.193383

PubMed ID: 25557784

Title: DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.

PubMed ID: 25557784

DOI: 10.1016/j.ajhg.2014.12.002

PubMed ID: 25817016

Title: DVL1 frameshift mutations clustering in the penultimate exon cause autosomal-dominant Robinow syndrome.

PubMed ID: 25817016

DOI: 10.1016/j.ajhg.2015.02.015

PubMed ID: 25817014

Title: Mutations in DVL1 cause an osteosclerotic form of Robinow syndrome.

PubMed ID: 25817014

DOI: 10.1016/j.ajhg.2015.02.010

PubMed ID: 25805136

Title: FOXKs promote Wnt/beta-catenin signaling by translocating DVL into the nucleus.

PubMed ID: 25805136

DOI: 10.1016/j.devcel.2015.01.031

PubMed ID: 26126266

Title: Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling.

PubMed ID: 26126266

DOI: 10.7554/elife.07091

PubMed ID: 27214281

Title: The polycystin complex mediates Wnt/Ca(2+) signalling.

PubMed ID: 27214281

DOI: 10.1038/ncb3363

Sequence Information:

  • Length: 695
  • Mass: 75187
  • Checksum: B009BDBCC57BD562
  • Sequence:
    • MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK SMDQDFGVVK 
EEIFDDNAKL PCFNGRVVSW LVLAEGAHSD AGSQGTDSHT DLPPPLERTG GIGDSRPPSF 
HPNVASSRDG MDNETGTESM VSHRRERARR RNREEAARTN GHPRGDRRRD VGLPPDSAST 
ALSSELESSS FVDSDEDGST SRLSSSTEQS TSSRLIRKHK RRRRKQRLRQ ADRASSFSSI 
TDSTMSLNIV TVTLNMERHH FLGISIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM 
LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PTPRSYFTVP RADPVRPIDP 
AAWLSHTAAL TGALPRYGTS PCSSAVTRTS SSSLTSSVPG APQLEEAPLT VKSDMSAVVR 
VMQLPDSGLE IRDRMWLKIT IANAVIGADV VDWLYTHVEG FKERREARKY ASSLLKHGFL 
RHTVNKITFS EQCYYVFGDL CSNLATLNLN SGSSGTSDQD TLAPLPHPAA PWPLGQGYPY 
QYPGPPPCFP PAYQDPGFSY GSGSTGSQQS EGSKSSGSTR SSRRAPGREK ERRAAGAGGS 
GSESDHTAPS GVGSSWRERP AGQLSRGSSP RSQASATAPG LPPPHPTTKA YTVVGGPPGG 
PPVRELAAVP PELTGSRQSF QKAMGNPCEF FVDIM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.