Details for: FGF5

Gene ID: 2250

Symbol: FGF5

Ensembl ID: ENSG00000138675

Description: fibroblast growth factor 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 3.4
    Marker Score: 7035
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.56
    Marker Score: 13752
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.19
    Marker Score: 2207
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.04
    Marker Score: 15411
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.61
    Marker Score: 3693
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7541
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.13
    Marker Score: 1750
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.97
    Marker Score: 5071
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.96
    Marker Score: 1818
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.84
    Marker Score: 13097
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.81
    Marker Score: 257.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.77
    Marker Score: 1560
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.69
    Marker Score: 398
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.68
    Marker Score: 1597
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 496
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6
    Marker Score: 36644
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.59
    Marker Score: 312
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.59
    Marker Score: 354
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.54
    Marker Score: 543
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.5
    Marker Score: 526
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.47
    Marker Score: 1932
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.44
    Marker Score: 162.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.44
    Marker Score: 4151
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.37
    Marker Score: 178
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.36
    Marker Score: 124
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.34
    Marker Score: 154
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.3
    Marker Score: 98
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.3
    Marker Score: 77
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.29
    Marker Score: 160
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.26
    Marker Score: 174
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.25
    Marker Score: 109
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.23
    Marker Score: 71
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.22
    Marker Score: 132
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.22
    Marker Score: 241
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.22
    Marker Score: 724
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.2
    Marker Score: 119
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.2
    Marker Score: 136
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.18
    Marker Score: 82
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.17
    Marker Score: 516
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.17
    Marker Score: 44
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.17
    Marker Score: 106
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.15
    Marker Score: 1296
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.15
    Marker Score: 520
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.14
    Marker Score: 134
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.14
    Marker Score: 58
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.13
    Marker Score: 63
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.12
    Marker Score: 49
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.11
    Marker Score: 65
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.11
    Marker Score: 476.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.11
    Marker Score: 23
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.1
    Marker Score: 115
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.1
    Marker Score: 113
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.09
    Marker Score: 965
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.09
    Marker Score: 38
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.09
    Marker Score: 49
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.09
    Marker Score: 395
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.09
    Marker Score: 65
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.08
    Marker Score: 3191
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.08
    Marker Score: 288
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.08
    Marker Score: 708
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.08
    Marker Score: 204
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.08
    Marker Score: 51
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.07
    Marker Score: 64
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.07
    Marker Score: 111
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.06
    Marker Score: 636
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.06
    Marker Score: 36
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.06
    Marker Score: 103
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.06
    Marker Score: 190
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.06
    Marker Score: 141
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.05
    Marker Score: 48
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.05
    Marker Score: 50

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Other Information

**Key characteristics:** * FGF5 is a secreted protein that is produced by epithelial cells and some other cell types. * It is a potent activator of the PI3K/AKT signaling pathway. * It is also involved in the MAPK/MAPK3 signaling pathway, the FGFR signaling pathway, and the insulin receptor signaling pathway. * It is highly expressed in various tissues, including the skin, kidney, and lungs. **Pathways and functions:** * **PI3K/AKT signaling pathway:** FGF5 is a key activator of the PI3K/AKT pathway, which is involved in cell growth, proliferation, and survival. It does this by phosphorylating and activating AKT, which then phosphorylates various downstream targets that promote cell growth and survival. * **MAPK/MAPK3 signaling pathway:** FGF5 also activates the MAPK/MAPK3 pathway, which is involved in cell growth, differentiation, and migration. * **FGFR signaling pathway:** FGF5 is a potent activator of the FGFR signaling pathway, which is involved in cell proliferation and differentiation. * **Insulin receptor signaling pathway:** FGF5 also activates the insulin receptor signaling pathway, which is involved in growth and development. **Clinical significance:** FGF5 is a key tumor suppressor gene in many human cancers. Mutations in FGF5 are found in approximately 20% of all human cancers, and they are often associated with poor prognosis. FGF5 is a promising target for cancer therapy, and several drugs that block FGF signaling have been tested in clinical trials. However, the results of these trials have been disappointing, likely due to the fact that FGF5 is involved in both normal and cancer cells. Despite this, FGF5 remains a promising target for cancer therapy.

Genular Protein ID: 2403595967

Symbol: FGF5_HUMAN

Name: Fibroblast growth factor 5

UniProtKB Accession Codes:

P12034 B2R554 O75846 Q3Y8M3 Q8NF90

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 31 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1700424

Title: Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system.

PubMed ID: 1700424

DOI: 10.1073/pnas.87.20.8022

PubMed ID: 3211147

Title: The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.

PubMed ID: 3211147

DOI: 10.1128/mcb.8.8.3487-3495.1988

PubMed ID: 10823842

Title: Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genes.

PubMed ID: 10823842

DOI: 10.1074/jbc.m910099199

PubMed ID: 11454700

Title: Identification of fibroblast growth factor-5 as an overexpressed antigen in multiple human adenocarcinomas.

PubMed ID: 11454700

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8663044

Title: Receptor specificity of the fibroblast growth factor family.

PubMed ID: 8663044

DOI: 10.1074/jbc.271.25.15292

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 24989505

Title: FGF5 is a crucial regulator of hair length in humans.

PubMed ID: 24989505

DOI: 10.1073/pnas.1402862111

Sequence Information:

  • Length: 268
  • Mass: 29551
  • Checksum: 28B7268B26781BCF
  • Sequence:
    • MSLSFLLLLF FSHLILSAWA HGEKRLAPKG QPGPAATDRN PRGSSSRQSS SSAMSSSSAS 
SSPAASLGSQ GSGLEQSSFQ WSPSGRRTGS LYCRVGIGFH LQIYPDGKVN GSHEANMLSV 
LEIFAVSQGI VGIRGVFSNK FLAMSKKGKL HASAKFTDDC KFRERFQENS YNTYASAIHR 
TEKTGREWYV ALNKRGKAKR GCSPRVKPQH ISTHFLPRFK QSEQPELSFT VTVPEKKKPP 
SPIKPKIPLS APRKNTNSVK YRLKFRFG

Genular Protein ID: 3920359667

Symbol: Q8NBG6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8NBG6

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 3 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 125
  • Mass: 14536
  • Checksum: EDBB5B1C85B6BBCE
  • Sequence:
    • MSKKGKLHAS AKFTDDCKFR ERFQENSYNT YASAIHRTEK TGREWYVALN KRGKAKRGCS 
PRVKPQHIST HFLPRFKQSE QPELSFTVTV PEKKKPPSPI KPKIPLSAPR KNTNSVKYRL 
KFRFG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.