Details for: FPR3

Gene ID: 2359

Symbol: FPR3

Ensembl ID: ENSG00000187474

Description: formyl peptide receptor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 79.3338
    Cell Significance Index: -12.3400
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 10.8910
    Cell Significance Index: 121.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.0085
    Cell Significance Index: -12.3400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 7.8382
    Cell Significance Index: 113.8000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.6724
    Cell Significance Index: 72.2900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.1500
    Cell Significance Index: -12.4300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.4856
    Cell Significance Index: -5.4400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.9115
    Cell Significance Index: 23.6500
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 1.2282
    Cell Significance Index: 3.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4869
    Cell Significance Index: 13.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2634
    Cell Significance Index: 44.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.1837
    Cell Significance Index: 136.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.1590
    Cell Significance Index: 33.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1538
    Cell Significance Index: 106.3500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0497
    Cell Significance Index: 31.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0003
    Cell Significance Index: 0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0025
    Cell Significance Index: -4.6600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0055
    Cell Significance Index: -0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0083
    Cell Significance Index: -15.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0090
    Cell Significance Index: -13.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0094
    Cell Significance Index: -12.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0161
    Cell Significance Index: -11.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0163
    Cell Significance Index: -10.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0179
    Cell Significance Index: -1.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0191
    Cell Significance Index: -14.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0228
    Cell Significance Index: -4.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0270
    Cell Significance Index: -9.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0293
    Cell Significance Index: -13.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0293
    Cell Significance Index: -8.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0294
    Cell Significance Index: -5.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0548
    Cell Significance Index: -9.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0671
    Cell Significance Index: -9.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0724
    Cell Significance Index: -9.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0770
    Cell Significance Index: -3.8900
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0935
    Cell Significance Index: -0.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0969
    Cell Significance Index: -11.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0989
    Cell Significance Index: -11.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1070
    Cell Significance Index: -13.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1163
    Cell Significance Index: -13.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1225
    Cell Significance Index: -12.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1252
    Cell Significance Index: -17.1900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1309
    Cell Significance Index: -1.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1324
    Cell Significance Index: -10.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1434
    Cell Significance Index: -16.4300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1812
    Cell Significance Index: -2.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1913
    Cell Significance Index: -12.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1977
    Cell Significance Index: -12.1500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2049
    Cell Significance Index: -3.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2163
    Cell Significance Index: -6.0500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.2241
    Cell Significance Index: -3.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2330
    Cell Significance Index: -5.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2337
    Cell Significance Index: -12.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2346
    Cell Significance Index: -11.0300
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.2414
    Cell Significance Index: -2.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2469
    Cell Significance Index: -10.9200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.2697
    Cell Significance Index: -2.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2716
    Cell Significance Index: -15.2400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2813
    Cell Significance Index: -3.3100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2899
    Cell Significance Index: -3.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2934
    Cell Significance Index: -11.1100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2997
    Cell Significance Index: -5.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3067
    Cell Significance Index: -15.9300
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.3267
    Cell Significance Index: -2.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3314
    Cell Significance Index: -11.6100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3634
    Cell Significance Index: -3.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3842
    Cell Significance Index: -12.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3842
    Cell Significance Index: -12.5800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.4062
    Cell Significance Index: -5.5700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4125
    Cell Significance Index: -12.1500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4503
    Cell Significance Index: -16.5300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.4536
    Cell Significance Index: -5.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4556
    Cell Significance Index: -13.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4559
    Cell Significance Index: -16.0200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.4563
    Cell Significance Index: -4.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4770
    Cell Significance Index: -12.7800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4828
    Cell Significance Index: -13.8400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.4865
    Cell Significance Index: -5.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4877
    Cell Significance Index: -22.7400
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.4922
    Cell Significance Index: -5.8000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5035
    Cell Significance Index: -12.5600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5097
    Cell Significance Index: -12.7100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5098
    Cell Significance Index: -20.8900
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.5213
    Cell Significance Index: -5.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5303
    Cell Significance Index: -14.1600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5311
    Cell Significance Index: -15.1600
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.5322
    Cell Significance Index: -7.5700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5334
    Cell Significance Index: -13.5900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5400
    Cell Significance Index: -13.0800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.5401
    Cell Significance Index: -13.4900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5469
    Cell Significance Index: -11.8200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.5475
    Cell Significance Index: -7.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5602
    Cell Significance Index: -16.1400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5607
    Cell Significance Index: -6.3700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.5627
    Cell Significance Index: -11.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5640
    Cell Significance Index: -14.8300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5686
    Cell Significance Index: -12.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5827
    Cell Significance Index: -15.8600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.5843
    Cell Significance Index: -18.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5896
    Cell Significance Index: -14.1400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5985
    Cell Significance Index: -12.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** FPR3 is a GPCR that belongs to the class A/1 rhodopsin-like receptor family. It is composed of seven transmembrane domains and is characterized by its ability to bind formyl peptides and other ligands. 2. **Expression:** FPR3 is expressed in various cell types, including Mueller cells, amacrine cells, progenitor cells, lung macrophages, and immune cells such as Kupffer cells and macrophages. 3. **Function:** FPR3 is involved in chemotaxis, inflammation, and immune response. It plays a key role in recruiting immune cells to sites of infection or inflammation. **Pathways and Functions:** 1. **Chemotaxis:** FPR3 is involved in the chemotaxis of immune cells, including macrophages and neutrophils. It binds to formyl peptides, which are produced by bacteria during infection, and activates signaling pathways that promote the migration of these cells towards the site of infection. 2. **Inflammatory Response:** FPR3 is also involved in the inflammatory response. It binds to various ligands, including formyl peptides, and activates signaling pathways that lead to the production of pro-inflammatory cytokines and chemokines. 3. **G-protein coupled receptor signaling:** FPR3 activates G-protein coupled receptor signaling pathways, which are involved in various cellular processes, including chemotaxis, inflammation, and cell survival. 4. **Complement receptor activity:** FPR3 is also involved in complement receptor activity, which is involved in the elimination of pathogens and the clearance of immune complexes. **Clinical Significance:** 1. **Infectious Diseases:** FPR3 plays a crucial role in the immune response to bacterial infections, including pneumonia and sepsis. Dysregulation of FPR3 has been implicated in various infectious diseases, including tuberculosis and HIV. 2. **Inflammatory Disorders:** FPR3 is also involved in the pathogenesis of inflammatory disorders, including asthma and rheumatoid arthritis. Its dysregulation has been linked to the development of these diseases. 3. **Cancer:** FPR3 has been implicated in the development and progression of various cancers, including lung cancer and breast cancer. Its expression and activity are linked to the recruitment of immune cells to tumor sites. 4. **Neurological Disorders:** FPR3 has also been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. Its dysregulation has been linked to the development of these diseases. In conclusion, FPR3 is a multifaceted gene that plays a crucial role in various physiological and pathological processes. Its expression and activity are linked to chemotaxis, inflammation, and immune response, and dysregulation of FPR3 has been implicated in various diseases, including infectious diseases, inflammatory disorders, cancer, and neurological disorders. Further research is needed to fully understand the role of FPR3 in human health and disease.

Genular Protein ID: 4137120143

Symbol: FPR3_HUMAN

Name: N-formyl peptide receptor 3

UniProtKB Accession Codes:

P25089

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1612600

Title: Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.

PubMed ID: 1612600

DOI: 10.1016/0888-7543(92)90265-t

PubMed ID: 8198572

Title: Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes.

PubMed ID: 8198572

DOI: 10.1006/bbrc.1994.1685

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15465011

Title: N-Formylated humanin activates both formyl peptide receptor-like 1 and 2.

PubMed ID: 15465011

DOI: 10.1016/j.bbrc.2004.09.046

Sequence Information:

  • Length: 353
  • Mass: 39965
  • Checksum: FFB7150B6A833F4C
  • Sequence:
    • METNFSIPLN ETEEVLPEPA GHTVLWIFSL LVHGVTFVFG VLGNGLVIWV AGFRMTRTVN 
TICYLNLALA DFSFSAILPF RMVSVAMREK WPFGSFLCKL VHVMIDINLF VSVYLITIIA 
LDRCICVLHP AWAQNHRTMS LAKRVMTGLW IFTIVLTLPN FIFWTTISTT NGDTYCIFNF 
AFWGDTAVER LNVFITMAKV FLILHFIIGF SVPMSIITVC YGIIAAKIHR NHMIKSSRPL 
RVFAAVVASF FICWFPYELI GILMAVWLKE MLLNGKYKII LVLINPTSSL AFFNSCLNPI 
LYVFMGRNFQ ERLIRSLPTS LERALTEVPD SAQTSNTDTT SASPPEETEL QAM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.