Details for: TSPAN16

Gene ID: 26526

Symbol: TSPAN16

Ensembl ID: ENSG00000130167

Description: tetraspanin 16

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 7.3331
    Cell Significance Index: -1.8600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 4.1303
    Cell Significance Index: -1.9500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 2.1152
    Cell Significance Index: 30.8300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.5711
    Cell Significance Index: -1.2500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.4776
    Cell Significance Index: 11.9100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2853
    Cell Significance Index: 4.8900
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.1581
    Cell Significance Index: 2.0000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1564
    Cell Significance Index: 3.4300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1506
    Cell Significance Index: 1.5600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1180
    Cell Significance Index: 1.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0945
    Cell Significance Index: 2.4300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0874
    Cell Significance Index: 1.2900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0854
    Cell Significance Index: 1.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0744
    Cell Significance Index: 14.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0479
    Cell Significance Index: 3.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0470
    Cell Significance Index: 1.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0454
    Cell Significance Index: 0.6200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0393
    Cell Significance Index: 0.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0384
    Cell Significance Index: 7.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0365
    Cell Significance Index: 1.0200
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0314
    Cell Significance Index: 0.3800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0283
    Cell Significance Index: 0.4300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0282
    Cell Significance Index: 0.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0240
    Cell Significance Index: 6.9100
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.0230
    Cell Significance Index: 0.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0221
    Cell Significance Index: 3.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0179
    Cell Significance Index: 2.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0156
    Cell Significance Index: 0.9600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0151
    Cell Significance Index: 0.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0120
    Cell Significance Index: 4.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0106
    Cell Significance Index: 0.4700
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.0079
    Cell Significance Index: 0.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0077
    Cell Significance Index: 11.8600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0072
    Cell Significance Index: 0.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0057
    Cell Significance Index: 10.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0033
    Cell Significance Index: 6.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0032
    Cell Significance Index: 0.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0027
    Cell Significance Index: 3.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0017
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0000
    Cell Significance Index: 0.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0011
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0017
    Cell Significance Index: -1.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0024
    Cell Significance Index: -1.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0031
    Cell Significance Index: -1.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0032
    Cell Significance Index: -1.7500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0059
    Cell Significance Index: -0.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0061
    Cell Significance Index: -0.7500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0070
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0087
    Cell Significance Index: -1.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0123
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0125
    Cell Significance Index: -1.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0135
    Cell Significance Index: -1.5700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0142
    Cell Significance Index: -0.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0154
    Cell Significance Index: -1.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0162
    Cell Significance Index: -1.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0165
    Cell Significance Index: -1.6900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0177
    Cell Significance Index: -0.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0209
    Cell Significance Index: -1.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0223
    Cell Significance Index: -0.7100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0225
    Cell Significance Index: -0.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0239
    Cell Significance Index: -1.1300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0255
    Cell Significance Index: -0.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0269
    Cell Significance Index: -0.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0314
    Cell Significance Index: -0.5800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0335
    Cell Significance Index: -0.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0337
    Cell Significance Index: -1.1800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0339
    Cell Significance Index: -0.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0365
    Cell Significance Index: -1.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0366
    Cell Significance Index: -0.7600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0371
    Cell Significance Index: -0.5200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0379
    Cell Significance Index: -0.4900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0390
    Cell Significance Index: -0.5600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0417
    Cell Significance Index: -1.0400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0420
    Cell Significance Index: -0.8300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0430
    Cell Significance Index: -0.9300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0434
    Cell Significance Index: -0.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0441
    Cell Significance Index: -1.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0442
    Cell Significance Index: -1.1800
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0447
    Cell Significance Index: -0.5200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0460
    Cell Significance Index: -0.5700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0463
    Cell Significance Index: -1.1300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0473
    Cell Significance Index: -0.9500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0504
    Cell Significance Index: -1.2600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0506
    Cell Significance Index: -0.4800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0529
    Cell Significance Index: -0.6600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0548
    Cell Significance Index: -0.6900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0563
    Cell Significance Index: -0.7500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0577
    Cell Significance Index: -1.7000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0578
    Cell Significance Index: -0.7300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0591
    Cell Significance Index: -0.5300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0624
    Cell Significance Index: -1.5900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0628
    Cell Significance Index: -1.3100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0628
    Cell Significance Index: -1.5700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0643
    Cell Significance Index: -0.9500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0659
    Cell Significance Index: -0.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0662
    Cell Significance Index: -1.7700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0666
    Cell Significance Index: -1.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0670
    Cell Significance Index: -1.9200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0702
    Cell Significance Index: -0.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TSPAN16 exhibits a unique combination of characteristics that distinguish it from other tetraspanins. Its expression in a wide range of cell types highlights its potential role in intercellular communication and coordination. The protein's ability to interact with various partners, including other tetraspanins, integrins, and receptors, underscores its involvement in complex signaling pathways. Furthermore, TSPAN16's expression in non-immune cells, such as cardiac endothelial cells and neurons, suggests that it may play a role in maintaining tissue-specific functions. **Pathways and Functions:** TSPAN16 is implicated in several key cellular processes, including: 1. **Cell Signaling:** TSPAN16 interacts with various signaling molecules, including integrins, receptors, and other tetraspanins, to regulate cell growth, differentiation, and survival. 2. **Adhesion and Migration:** The protein plays a crucial role in cell adhesion and migration, facilitating the interaction between cells and the extracellular matrix. 3. **Cell-Cell Communication:** TSPAN16 is involved in intercellular communication, facilitating the exchange of signaling molecules and ions between cells. 4. **Immune Function:** The protein is expressed in immune cells, such as innate lymphoid cells, and plays a role in regulating immune responses, including the activation and differentiation of immune cells. **Clinical Significance:** The identification of TSPAN16 as a significantly expressed protein in various cell types has significant implications for our understanding of human disease. Alterations in TSPAN16 expression or function have been implicated in several diseases, including: 1. **Cardiovascular Disease:** TSPAN16 has been shown to play a role in the regulation of endothelial function and blood pressure, highlighting its potential as a therapeutic target for cardiovascular disease. 2. **Neurological Disorders:** The protein's expression in GABAergic interneurons and other neural cells suggests that TSPAN16 may play a role in the development and progression of neurological disorders, such as epilepsy and Alzheimer's disease. 3. **Immune-Mediated Diseases:** TSPAN16's involvement in immune cell function and regulation highlights its potential as a therapeutic target for immune-mediated diseases, such as autoimmune disorders and cancer. In conclusion, TSPAN16 is a multifaceted protein that plays a crucial role in various cellular processes, including cell signaling, adhesion, and migration. Its expression in a wide range of cell types highlights its potential as a therapeutic target for several diseases, including cardiovascular disease, neurological disorders, and immune-mediated diseases. Further research is needed to fully elucidate the functions and clinical significance of TSPAN16.

Genular Protein ID: 945526994

Symbol: TSN16_HUMAN

Name: Tetraspanin-16

UniProtKB Accession Codes:

Q9UKR8 K7EN22 K7EPD8 Q8N6J7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 5 ExpressionAtlas 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10500248

Title: The molecular characterisation of a novel tetraspanin protein, TM4-B.

PubMed ID: 10500248

DOI: 10.1016/s0167-4781(99)00116-5

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 245
  • Mass: 26266
  • Checksum: 064CDE593AB2B48C
  • Sequence:
    • MAEIHTPYSS LKKLLSLLNG FVAVSGIILV GLGIGGKCGG ASLTNVLGLS SAYLLHVGNL 
CLVMGCITVL LGCAGWYGAT KESRGTLLFC ILSMVIVLIM EVTAATVVLL FFPIVGDVAL 
EHTFVTLRKN YRGYNEPDDY STQWNLVMEK LKCCGVNNYT DFSGSSFEMT TGHTYPRSCC 
KSIGSVSCDG RDVSPNVIHQ KGCFHKLLKI TKTQSFTLSG SSLGAAVIQR WGSRYVAQAG 
LELLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.