Details for: OR10G3

Gene ID: 26533

Symbol: OR10G3

Ensembl ID: ENSG00000169208

Description: olfactory receptor family 10 subfamily G member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.1084
    Cell Significance Index: 0.7800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0935
    Cell Significance Index: 0.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0785
    Cell Significance Index: 4.9500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0717
    Cell Significance Index: 1.5700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0613
    Cell Significance Index: 0.8600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.0506
    Cell Significance Index: 1.0300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0426
    Cell Significance Index: 0.6100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0199
    Cell Significance Index: 0.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0181
    Cell Significance Index: 0.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0137
    Cell Significance Index: 0.6400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.0110
    Cell Significance Index: 0.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0085
    Cell Significance Index: 1.6900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0079
    Cell Significance Index: 0.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0063
    Cell Significance Index: 1.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0035
    Cell Significance Index: 0.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0015
    Cell Significance Index: 0.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0006
    Cell Significance Index: 0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0004
    Cell Significance Index: 0.7900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0004
    Cell Significance Index: 0.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0000
    Cell Significance Index: -0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0005
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0006
    Cell Significance Index: -0.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0006
    Cell Significance Index: -0.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0011
    Cell Significance Index: -0.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0019
    Cell Significance Index: -0.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0019
    Cell Significance Index: -0.8600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0019
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0024
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0024
    Cell Significance Index: -0.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0027
    Cell Significance Index: -0.4900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0031
    Cell Significance Index: -0.0300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0041
    Cell Significance Index: -0.0500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0053
    Cell Significance Index: -0.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0053
    Cell Significance Index: -0.2200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0060
    Cell Significance Index: -0.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0066
    Cell Significance Index: -0.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0067
    Cell Significance Index: -0.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0070
    Cell Significance Index: -0.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0072
    Cell Significance Index: -0.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0073
    Cell Significance Index: -0.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0082
    Cell Significance Index: -0.6300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0094
    Cell Significance Index: -0.1300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0097
    Cell Significance Index: -0.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0099
    Cell Significance Index: -0.2700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0108
    Cell Significance Index: -0.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0115
    Cell Significance Index: -0.8600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0121
    Cell Significance Index: -0.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0123
    Cell Significance Index: -0.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0128
    Cell Significance Index: -0.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0148
    Cell Significance Index: -0.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0151
    Cell Significance Index: -0.6700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0152
    Cell Significance Index: -0.1600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0156
    Cell Significance Index: -0.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0166
    Cell Significance Index: -0.5800
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0167
    Cell Significance Index: -0.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0168
    Cell Significance Index: -0.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0170
    Cell Significance Index: -0.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0178
    Cell Significance Index: -0.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0185
    Cell Significance Index: -0.7000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0198
    Cell Significance Index: -0.4200
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.0198
    Cell Significance Index: -0.1800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0200
    Cell Significance Index: -0.5100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0200
    Cell Significance Index: -0.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0211
    Cell Significance Index: -0.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0222
    Cell Significance Index: -1.0500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0224
    Cell Significance Index: -0.2900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0228
    Cell Significance Index: -0.5700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0237
    Cell Significance Index: -0.4800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0237
    Cell Significance Index: -0.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0241
    Cell Significance Index: -0.6200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0246
    Cell Significance Index: -0.3500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0248
    Cell Significance Index: -0.3300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0263
    Cell Significance Index: -0.6600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0265
    Cell Significance Index: -0.2700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0272
    Cell Significance Index: -0.5700
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0275
    Cell Significance Index: -0.2900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0285
    Cell Significance Index: -0.3400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0288
    Cell Significance Index: -0.5700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0291
    Cell Significance Index: -0.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0294
    Cell Significance Index: -0.6100
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0296
    Cell Significance Index: -0.3000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0297
    Cell Significance Index: -0.5800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0301
    Cell Significance Index: -0.4500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0301
    Cell Significance Index: -0.3300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0304
    Cell Significance Index: -0.4400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0307
    Cell Significance Index: -0.5300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0315
    Cell Significance Index: -0.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0315
    Cell Significance Index: -0.8400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0323
    Cell Significance Index: -0.3800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0333
    Cell Significance Index: -0.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0333
    Cell Significance Index: -0.8900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0348
    Cell Significance Index: -1.1000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0358
    Cell Significance Index: -0.3400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0359
    Cell Significance Index: -0.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0359
    Cell Significance Index: -0.7000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0361
    Cell Significance Index: -0.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0373
    Cell Significance Index: -0.9800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0385
    Cell Significance Index: -0.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR10G3 is a G protein-coupled receptor (GPCR) that belongs to the olfactory receptor family 10 subfamily G. Its expression is widespread, with significant levels found in glutamatergic neurons, which are responsible for transmitting signals in the central nervous system. The gene's presence in erythrocytes, immune cells, and other cell types highlights its potential role in regulating various physiological processes beyond olfaction. OR10G3's ability to detect chemical stimuli involved in sensory perception of smell underscores its importance in our ability to perceive and respond to odors. **Pathways and Functions:** OR10G3's signaling pathways are intricately linked to the detection of chemical stimuli involved in sensory perception of smell. The gene's expression in glutamatergic neurons and other cell types suggests that OR10G3 plays a critical role in regulating the olfactory system. The G protein-coupled receptor activity of OR10G3 is mediated through a complex interplay of G proteins, which ultimately leads to the activation of downstream signaling pathways. These pathways involve the activation of adenylyl cyclase, phospholipase C, and other enzymes, ultimately resulting in the production of second messengers that modulate cellular responses. **Clinical Significance:** OR10G3's clinical significance is multifaceted. Its expression in glutamatergic neurons and other cell types suggests that OR10G3 may play a role in various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. Additionally, OR10G3's involvement in the regulation of immune responses highlights its potential role in immune-related disorders, such as asthma and allergies. Furthermore, OR10G3's expression in erythrocytes and other cell types suggests that it may play a role in regulating various physiological processes, including blood pressure regulation and cardiovascular disease. In conclusion, OR10G3 is a critical olfactory receptor that plays a pivotal role in human sensory perception. Its widespread expression in various cell types and its involvement in the detection of chemical stimuli involved in sensory perception of smell highlight its importance in our understanding of human physiology. Further research into OR10G3's signaling pathways and clinical significance will undoubtedly shed light on the molecular mechanisms underlying human olfaction and its role in various neurological and psychiatric disorders.

Genular Protein ID: 3630291981

Symbol: O10G3_HUMAN

Name: Olfactory receptor 10G3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 313
  • Mass: 35055
  • Checksum: D36D8D1B069F3C27
  • Sequence:
  • MERINSTLLT AFILTGIPYP LRLRTLFFVF FFLIYILTQL GNLLILITVW ADPRLHARPM 
    YIFLGVLSVI DMSISSIIVP RLMMNFTLGV KPIPFGGCVA QLYFYHFLGS TQCFLYTLMA 
    YDRYLAICQP LRYPVLMTAK LSALLVAGAW MAGSIHGALQ AILTFRLPYC GPNQVDYFFC 
    DIPAVLRLAC ADTTVNELVT FVDIGVVVAS CFSLILLSYI QIIQAILRIH TADGRRRAFS 
    TCGAHVTVVT VYYVPCAFIY LRPETNSPLD GAAALVPTAI TPFLNPLIYT LRNQEVKLAL 
    KRMLRSPRTP SEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.